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Considerable research has been dedicated to studying teachers' digital competence, yet limited insights have been gained regarding its impact on online teacher autonomy support. Based on the Technological Pedagogical Content Knowledge (TPACK) framework, this study utilized a multiple regression analysis model to explore how teachers' digital competence affects online teacher autonomy support. Drawing on data from 652 Chinese primary school teachers, the study revealed that teachers' digital competence positively influenced online teacher autonomy support via teachers' cognitive empathy. Teachers' emotional empathy strengthened the direct effect of cognitive empathy on online teacher autonomy support, and its indirect effect on teachers' digital competence on online teacher autonomy support. The findings inform TPACK framework development and practical considerations in online teaching, deepening understanding of the impact of digital competence on online teacher autonomy support.

In the current socio-digital epoch, the intricate interplay between social media addiction and its potential ramifications on romantic relationships remains largely enigmatic, especially within specific demographic subsets. This study aims to elucidate the repercussions of social media addiction on love relationship closeness and satisfaction among Chinese undergraduates. A cohort of 583 Chinese undergraduates was meticulously analyzed, encompassing an almost equal gender distribution and spanning across diverse academic ranks and relationship durations. Utilizing the "Social Media Addiction Scale -- Adult Form (SMAS-AF)" and validated scales for assessing relationship intimacy and satisfaction, the research painted a multifaceted picture. Findings revealed a high inclination towards social media addiction (X=4.20), with specific aspects of engagement demonstrating profound agreement among participants. An analytic exploration of the addiction demonstrated a pronounced influence on cognitive faculties and emotional regulation while revealing less consistent challenges in curtailing usage. In the romantic realm, while relationship closeness yielded a moderate mean score of 3.38, love relationship satisfaction signaled a moderate-to-high satisfaction degree (X=3.83). Interestingly, while gender and academic progression remained non-determinants for addiction levels, relationship length emerged as a significant variable. Correlational analyses showcased a stark negative association between social media addiction and relationship closeness (r=-0.491) but, surprisingly, a positive correlation with relationship satisfaction (r=0.129). Such dichotomous outcomes advocate for deeper investigation, perhaps suggesting a paradigm wherein intensified digital engagement might enhance superficial relationship contentment at the potential cost of depth and closeness.

This mixed-method analysis investigates thesis-writing burnout among 117 Chinese postgraduates, probing the patterns, magnitude, and influencing factors. A measurable burnout trend emerges across thesis-writing stages - Thesis-Writing Proposal (TTP), Thesis-Writing 3-Chapter (TW3C), and Thesis-Writing 5-Chapter (TW5C) - peaking (X=4.41) during TW3C, reflecting heightened exhaustion and cynicism. Notably, burnout varies with demographic attributes, specifically gender and marital status. Concurrently, exhaustion and cynicism levels fluctuate with thesis-writing progression, while professional efficacy gradually escalates. Participants convey a shift from profound exhaustion and cynicism in TTP and TW3C stages to resilience, manageable fatigue, and self-assuredness during TW5C. Predisposing factors encompass uncertainty, anxiety, and advisory attributes, spanning styles, diligence, and personality traits. These aspects, especially autocratic and laissez-faire approaches, exacerbate stress and impact motivation and research methods. These findings underscore the multifaceted nature of academic burnout during thesis-writing among Chinese postgraduates, necessitating stage-specific interventions. Such tailored strategies facilitate burnout prevention, promote thesis completion, and yield profound implications for Chinese conventional postgraduate education. The research also establishes the vital role of advisors in modulating stress levels, underscoring the need for proactive support measures and fostering a conducive academic environment. This study augments understanding of academic burnout, offering valuable insights to counteract its detrimental effects and bolster postgraduate students' academic journey.

Anxiety has a significant effect on oral communication, particularly when it occurs in the form of a public address. The quality of a public academic speaker's oral presentation may highly be determined by a variety of emotive elements. However, this has received much too little attention in the realm of academic dissertation oral defense presentations, despite the fact that this process may be incredibly nerve-wracking for both novice and experienced postgraduates, EFL learners in particular. In the current study, 68 Chinese EFL Ph.D. candidates consented to complete a revamped version of the Personal Report of Public Speaking Anxiety (PRPSA). Chinese EFL postgraduates reported an average high level of public speaking anxiety (X=4.34) during their doctoral dissertation defense presentations, as measured by three categorical variables: public speaking apprehension (X=4.40), self-behavior management (X=4.35), and fear of negative evaluation (X=4.26). Throughout Ph.D. candidate participants' dissertation defense, fifteen anxiety-related questionnaire items were recognized to be the most anxiety-provoking conditions in terms of public speaking anxiety. In addition, differences in gender and graduate study specialization were not significantly associated with Chinese EFL Ph.D. candidates' experiences with public speaking anxiety. Despite the findings, research has revealed that Ph.D. candidates in English as a Foreign Language from China exhibit statistically significant levels of anxiety related to public speaking, and as a result, pedagogical recommendations have been proposed.

In this mixed-method investigation, the researchers delved into the intricate dynamics underlying Chinese postgraduates' procrastination behavior, academic engagement, and self-confidence, unveiling a multifaceted interplay among these factors. Quantitative findings revealed an intermediate-high level of procrastination, particularly in relation to writing assignments, exam preparations, and weekly reading tasks, while attendance tasks and general school activities elicited lower procrastination levels. Further analysis elucidated a substantial negative correlation between procrastination behaviors and both academic engagement and self-confidence, indicating the pernicious influence of this pervasive phenomenon on students' academic experiences. Qualitative insights garnered through thematic analysis explicated the complex reasons behind procrastination, including being overwhelmed by intricate tasks, lack of genuine interest, competitive milieu, insecurities, distractions, cultural and familial pressures, and struggles with time management, prioritization, and perfectionism. Furthermore, inadequate mentorship and anxiety surrounding future career prospects emerged as significant contributors to procrastination. Evidently, this detrimental factor not only impeded postgraduates' academic immersion but also eroded their self-confidence, exacerbating the detrimental repercussions on their scholarly performance. Thus, the findings underscore the imperative for targeted interventions, encompassing mentorship, time management skills, and emotional support, to mitigate the deleterious effects of procrastination on Chinese postgraduates' academic engagement and self-confidence.

The perennial challenge of reading fluency, notably profound among Asian EFL learners, stems largely from linguistic disparities, conventional teaching paradigms, and ingrained cognitive practices. This study critically investigates the challenges Chinese undergraduates face with English reading fluency, notably due to linguistic disparities and historically rooted teaching methodologies. Leveraging the Read-Aloud Instructional Strategy (RAIS), this quasi-experimental study sampled 73 students from a private university in Thailand. Baseline assessments depicted similar fluency levels across groups. Post-intervention, the instructor-centered approach demonstrated profound efficacy, with the mean fluency score soaring to 4.35, compared to the student-centered mean of 2.69 and the near-static comparison group at 2.04. Additionally, confidence metrics evinced a remarkable ascent to 3.46 for the instructor-led group, a notable rise to 2.19 for the student-centered cohort, juxtaposed against the comparison group's minimal shift to 1.71. Furthermore, the instructor-centered method substantially ameliorated reading anxiety (d=1.378) and showcased stronger, albeit weak to moderate, post-intervention correlations between fluency, confidence, and anxiety. This comprehensive study underscores the transformative potential of RAIS, particularly the instructor-centered paradigm, in concurrently augmenting reading fluency, confidence, and reducing anxiety among Chinese EFL undergraduates. The implications herein suggest the exigency of reassessing prevalent pedagogical methodologies in Asian EFL environments.

Purpose: This study aims to examine the effects of vocational training programs for people with disabilities on their income. Design/methodology/approach: It conducted a multinomial regression analysis of 10,469 survey responses from 31 provincial administrative areas in mainland China. Findings: It finds the following antecedents all influence the trainees' self-reported income, including their perception of the quality of the program, the training subject, the degree of consistency between their current job and this subject, their employment sector, their motivation and access to training resources and the geographical location of the program. Research limitations/implications: The findings are not representative of people with disabilities across mainland China because the respondents were not randomly sampled. Practical implications: The findings suggest that to increase the income of people with disabilities, the training can be designed according to the needs of employers by teaching subjects relevant to the needs of the labor market, reaching out to motivated trainees and enhancing the quality of training. Training institutions, employers and governments are recommended to work together to integrate class-based learning with workplace-based learning and practices. More training resources can be devoted to the self-employed people with disabilities or those who operate in the informal sector and are in less-developed areas. Social implications: The improvement of employment opportunities and income of people with disabilities supports the safeguarding of their social economic rights and the building of an inclusive society. Originality/value: Few studies have empirically explored and explained the effects of vocational training programs on people with disabilities' income. This article fills this gap by assessing the performance of China's vocational training programs funded by the Federation of Disabled Persons at all levels.

Needs analysis guides course and curriculum design. In addition to mandatory courses, it is necessary for intensive language schools and institutes. Recent university graduates in China are increasingly enrolling in language training at public and private language schools to hone their communication abilities. On the other hand, English courses as the workplace prerequisites for Chinese university graduates have been scientifically researched and found to be exceedingly rare. The research's fundamental premise serves that there is a substantial link between the demands of Chinese recent graduates and university English course design. The aim of this research is to assess the goals, needs, and perceived utility of university English courses among recent on-the-job Chinese graduates over an eight-month period. After evaluating the questionnaire and interview replies, it was concluded that these Chinese young graduates in China had similar learning demands, with listening and speaking skills taking primacy. Additionally, various characteristics were discovered that show why an English course designed for future workplace purposes is advantageous to university students. The results are examined in terms of their pedagogical importance for curriculum creation and classroom practice in English courses at the university.

Building on the control-value theory, the present study examined the independent and joint predictive effects of three emotions--enjoyment, anxiety, and boredom--on L2 achievement over time. The participants of the study were a group of junior secondary English learners in rural China, a population that has hitherto never featured in L2 learning research. Questionnaire data and achievement data were collected at four different time points (Time 1-Time 4: T1-T4) from a large sample of 954 learners. Structural equation modeling results show that: (a) the three emotions at T1 predicted English achievement at T2 (one week after T1) and T3 (five weeks after T1) independently, while only enjoyment predicted achievement at T4 (nine weeks after T1); (b) when combined, enjoyment was the strongest and most enduring predictor across T2-T4, followed by anxiety predicting achievement at T2-T3 negatively, while boredom completely lost its predictive power across T2-T4.

Aim: To construct a popularization of an emergency science capacity index system for nurses based on the iceberg model. Design: A mixed‐method research design incorporating quantitative and qualitative components was used. Methods: In this study, the first draft of the questionnaire was developed through literature analysis and semi‐structured interviews. According to the Delphi expert inclusion criteria, 20 experts with rich experience in the field of science popularization were selected, and the system of emergency science popularization ability of nurses was ultimately developed through two rounds of consultation according to the Delphi method. The weights of various indicators were determined through hierarchical analysis. Results: Following two rounds of Delphi surveys, a total of 3 primary, 6 secondary, and 26 tertiary indicators were identified. The indicators were found to be highly significant, with variation coefficients ranging from 0.063 to 0.140. The Kendall's harmonization coefficients for the primary, secondary, and tertiary indicators were 0.350, 0.341, and 0.146, respectively. The popularization of the emergency science capacity system has a certain scientific and practical significance, which is of guidance to the competency of nurses in public health emergencies. Patient or public contribution: No patient or public contribution. This study did not involve patients, service users, caregivers, or members of the public. [ABSTRACT FROM AUTHOR]

Background Neurological recovery after endovascular treatment (EVT) for large vessel occlusion stroke often has diverse timelines. Understanding the temporal progression of functional independence after EVT, especially delayed functional independence (DFI) and highly delayed functional independence (HDFI), in patients who do not improve early is essential for prognostication and rehabilitation. We aimed to analyze the prevalence and predictors of DFI and HDFI after EVT in acute vertebrobasilar artery occlusions (VBAO). Methods Patients with VBAO who received EVT in China were retrospectively enrolled. Early functional independence (EFI) was defined as a modified Rankin Scale (mRS) score of 0-2 at discharge. The incidence and predictors of DFI (mRS score 0-2 at 90 days in non-EFI patients) and HDFI (mRS score 0-2 at 1 year in non-DFI patients) were analyzed. Results 2422 patients met the study criteria. EFI was observed in 20% (483) of patients. Among non-EFI patients, DFI was observed in 21% (395/1880). HDFI was observed in 13% (191/1439) of non-DFI patients. Younger age (P=0.006), lower pre-EVT National Institutes of Health Stroke Scale (NIHSS) score (P<0.001), higher posterior circulation-Alberta Stroke Program Early CT Score (PC-ASPECTS) (P=0.012), and absence of symptomatic intracranial hemorrhage (sICH) (P<0.001) were predictors of DFI. Predictors of HDFI were younger age (P<0.001) and lower pre-EVT NIHSS score (P<0.001). Conclusion A considerable proportion of patients have DFI and HDFI. The independent predictors of DFI were younger age, lower pre-EVT NIHSS score, higher PC-ASPECTS, and absence of sICH. Predictors of HDFI included younger age and lower pre-EVT NIHSS score. [ABSTRACT FROM AUTHOR]

Cooper's (1989) LPP framework focuses on 'who' the policy planner is and 'who' implements the policy to 'whom.' These are particularly significant factors in a highly centralized education system such as China's, where the effect of different individuals as actors in LPP remains largely unexplored. This article examines the controversy around the predominant status of College English and the resulting adjustments that have been made in a new English education policy -- "Guidelines on College English Teaching" (GCET) -- in 2017, and categorizes the relevant stakeholders into five groups from macro to micro levels and examines their agency roles through investigating their attitudes, interpretations and reactions towards the change in the status of College English in the GCET. The results show that multiple layers of individuals have been endowed with disproportionate powers in status planning. Compared with English teachers and people with expertise, people with influence in society and university administrators constitute the more powerful forces in effecting language policy making.

Sustainable human resource management (HRM) is critical to sustainable corporate development. However, there is little systematic research examining the determinants of sustainable HRM adoption. We fill this void by identifying and introducing a configurational approach to examine when firms adopt sustainable HRM. Based on institutional theory, we develop a typology of institutional contexts associated with sustainable HRM adoption. We posit that institutional conditions in configuration facilitate firms' adoption of sustainable HRM. Thus, we hypothesize a primary institutional configuration where institutional support, institutional quality, and institutional infrastructure combine to promote the adoption of sustainable HRM. We further propose alternative types of configurations conducive to the adoption of sustainable HRM by introducing two organizational conditions: strategic leadership support and resource slack. A fuzzy‐set qualitative comparative analysis on data from 57 cases in China supports our hypotheses. We find that the combination of institutional conditions promotes the adoption of highly sustainable HRM, and the two alternative types provide functional substitutes for the primary type: (a) strategic leadership support substitutes for the combination of institutional support and institutional infrastructure, and (b) resource slack substitutes for institutional infrastructure. We build an institutional configurational model to advance a holistic understanding of the theoretical drivers of sustainable HRM, contributing to the research on sustainable HRM, institutional theory, leadership, and resource slack. [ABSTRACT FROM AUTHOR]

Background: The diagnosis of tuberculous pleurisy (TP) presents a significant challenge due to the low bacterial load in pleural effusion (PE) samples. Cell-free Mycobacterium tuberculosis DNA (cf-TB) in PE samples is considered an optimal biomarker for diagnosing TP. This study aimed to evaluate the applicability of cf-TB testing across diverse research sites with a relatively large sample size. Methods: Patients suspected of TP and presenting with clinical symptoms and radiological evidence of PE were consecutively enrolled by treating physicians from 11 research sites across 6 provinces in China between April 2020 and August 2022. Following centrifugation, sediments obtained from PE were used for Xpert MTB/RIF (Xpert) and mycobacterial culture, while the supernatants were subjected to cf-TB testing. This study employed a composite reference standard to definite TP, which was characterized by any positive result for Mycobacterium tuberculosis (MTB) through either PE culture, PE Xpert, or pleural biopsy. Results: A total of 1412 participants underwent screening, and 1344 (95.2%) were subsequently enrolled in this study. Data from 1241 (92.3%) participants were included, comprising 284 with definite TP, 677 with clinically diagnosed TP, and 280 without TP. The sensitivity of cf-TB testing in definite TP was 73.6% (95% CI 68.2–78.4), significantly higher than both Xpert (40.8%, 95% CI 35.3–46.7, P < 0.001) and mycobacterial culture (54.2%, 95% CI 48.4–59.9, P < 0.001). When clinically diagnosed TP was incorporated into the composite reference standard for sensitivity analysis, cf-TB testing showed a sensitivity of 46.8% (450/961, 95% CI 43.7–50.0), significantly higher than both Xpert (116/961, 12.1%, 95% CI 10.2–14.3, P < 0.001) and mycobacterial culture (154/961, 16.0%, 95% CI 13.8–18.5, P < 0.001). The specificities of cf-TB testing, Xpert, and mycobacterial culture were all 100.0%. Conclusions: The performance of cf-TB testing is significantly superior to that of Xpert and mycobacterial culture methods, indicating that it can be considered as the primary diagnostic approach for improving TP detection. Trial registration The trial was registered on Chictr.org.cn (ChiCTR2000031680, https://www.chictr.org.cn/showproj.html?proj=49316). [ABSTRACT FROM AUTHOR]

In this paper, the No. 30201 working face of a specific colliery was determined as the study area in the Yushen mining area, China. The objective of this paper is to determine the optimal position for pressure regulation measures during the final mining stage. A mechanical calculation model for stabilized coal pillar was developed. The analytical solution for the front abutment pressure function was obtained. Limit equilibrium theory and beam theory were employed to compute the critical width value of the stabilized coal pillar. The analysis focused on examining the spatiotemporal relationship between the rotational deformation of the main roof and the stability of the retracement channel. The study utilized numerical simulation to investigate the failure characteristics of the surrounding rock and the stress redistribution in the stabilized coal pillar within the working face. Through comprehensive analysis, a reasonable width of 15 m for the stabilized coal pillar was determined and successfully implemented in field practices. A method of using Artificial Neural Network (ANN) to select the stabilized coal pillar width was proposed. The input characteristics of ANN were determined through theoretical analysis. Four models of BP, WOA-BP, PSO-BP, and CPSO-BP were trained. The calculation accuracy of each model is evaluated by three quantitative metrics: MAE, MRE, and RMSE. The MAE value of the CPSOBP model is 0.9489, showing a reduction of 70.87% compared to the BP model, 55.84% compared to the WOA-BP model, and 51.26% compared to the PSOBP model. The MRE value is 0.0559, which is 71.51%, 56.29%, and 53.24% lower than the other models, respectively. The RMSE value is 1.0617, which is 68.92%, 56.13%, and 53.03% lower than other models, respectively. The four models were employed to compute the width of the stabilized coal pillar. The values for the BP, WOA-BP, PSO-BP, and CPSO-BP models were 12.7 m, 16.3 m, 14.1 m, and 15.2 m, respectively, indicating that the CPSO-BP model can effectively determine the width of the stabilized coal pillar. [ABSTRACT FROM AUTHOR]

This article discusses a relatively under-explored phenomenon that we call Tranßcripting -- writing, designing and digitally generating new scripts with elements from different scriptal and semiotic systems. The data are drawn from examples of such scripts created by multilingual Chinese users in everyday online social interaction. We analyse the dynamic processes of how such scripts are created that transcend language boundaries as well as transforming the subjectivities of the writer and the reader. We are particularly interested in the playful subversiveness of such practices, and discuss it against the background of uni-scriptal language ideology in China. We are also interested in the methodological challenges of researching such practices, including the challenge of drawing distinctions between the 'ordinary' and the 'unordinary'. We analyse the data from a translanguaging perspective.

The Qinghai-Tibet Plateau is an important ecological security barrier in China. Considering the rich local waste biomass with a single treatment method and low level of resource utilization, biochar utilization of solid waste biomass can be carried out based on the research that biochar has abundant material sources. According to the application methods of various types of solid waste resources that have not been carried out, this review analyzes and discusses various types of waste biomass resources in the plateau region, such as sewage plant sludge, food waste, green leaves, barley straw, yak manure, and the unique Tibetan tea and Tibetan medicine residue waste, and reviews the biochar methods and applications for similar raw materials at home and abroad. Further, the technical outlook of solar pyrolysis technology and UV radiation modification technology and the development of hybrid pyrolysis to enhance the performance of biochar materials and heavy metal passivation are proposed by utilizing the solar energy resources of the Tibetan Plateau. Collectively, it provides a reference for prevention and restoration methods for the fragile ecological environment of the Qinghai-Tibet Plateau, reduces the pressure of waste disposal in the region, and realizes the resource utilization of waste. [ABSTRACT FROM AUTHOR]

Heterogeneous institutional investors' shareholding preferences have been driven to change by the deepening of ESG investment philosophy. Therefore, we examine the impact of corporate ESG performance on institutional investors' shareholding preferences and its mechanism of action. We conduct mixed OLS and mediation effect tests using data on ESG responsibility scores and institutional investors' shareholding ratios of A‐share listed companies in China from 2010 to 2020 as samples. We find that corporate ESG performance can significantly and robustly increase institutional investors' shareholdings; the mediation effect analysis shows that overall corporate ESG performance contributes to increases in corporate book and market values, thus encouraging institutional investors to increase their shareholdings. The heterogeneity analysis shows that independent institutional investors attach more importance to corporate ESG responsibility performance, and long‐term institutional investors attach more importance to corporate environmental performance; moreover, institutional investors have more significant ESG shareholding preferences for Chinese SOEs. Our study can strengthen the encouragement of institutional investors to integrate ESG investment concepts from multiple perspectives, such as research and analysis, portfolio management, risk control, and due diligence management, to design and develop targeted ESG investment tools, give full play to the role of shareholders and guide the sound development of listed companies from the perspective of investment strategy objectives. [ABSTRACT FROM AUTHOR]

Climate change significantly impacted on the survival, development, distribution, and abundance of living organisms. The Chinese serow Capricornis milneedwardsii, known as the "four unlike," is a Class II nationally protected species in China. In this study, we predicted the geographical suitability of C. milneedwardsii under current and future climatic conditions using MaxEnt. The model simulations resulted in area under the receiver operating characteristic curve (AUC) values above 0.9 for both current and future climate scenarios, indicating the excellent performance, high accuracy, and credibility of the MaxEnt model. The results also showed that annual precipitation (Bio12), slope, elevation, and mean temperature of wettest quarter (Bio8) were the key environmental variables affecting the distribution of C. milneedwardsii, with contributions of 31.2%, 26.4%, 11%, and 10.3%, respectively. The moderately and highly suitable habitats were mainly located in the moist area of China, with a total area of 34.56 × 104 and 16.61 × 104 km2, respectively. Under future climate change scenarios, the areas of suitability of C. milneedwardsii showed an increasing trend. The geometric center of the total suitable habitats of C. milneedwardsii would show the trend of northwest expansion and southeast contraction. These findings could provide a theoretical reference for the protection of C. milneedwardsii in the future. This study used the MaxEnt model to predict the current and future potential geographical distribution of Capricornis milneedwardsii, a vulnerable species endemic to China, under different climate change scenarios. Results suggest that the distribution of C. milneedwardsii is likely to expand in the future, with highly suitable areas increasing under both RCP 4.5 and RCP 8.5 scenarios. These findings could provide a theoretical reference for the protection of C. milneedwardsii in the future. [ABSTRACT FROM AUTHOR]

Rationale/Aim: Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke in Asia and is significantly associated with stroke recurrence. The Balloon angiopLasty for intracranial Atherosclerotic minor Stroke/TIA (BLAST) study aims to evaluate the safety and effectiveness of early submaximal balloon angioplasty (SBA) combined with standard medical therapy vs. standard medical therapy alone in patients with minor stroke or transient ischemic attack (TIA) due to ICAS. Methods: The BLAST study is a multicenter prospective cohort study which will enroll patients with minor stroke or TIA due to symptomatic ICAS within 1 week of symptom onset from 20 centers in China. Eligible patients will receive either SBA with standard medical therapy or standard medical therapy alone based on the decision of the patient or legal representative. Participants will be followed up for 1 year. Study outcomes: The primary outcome is a composite of stroke or death within 30 days or ischemic stroke in the culprit artery territory from 30 days to 1 year. Secondary outcomes include stroke or death within 30 days, ischemic stroke in the culprit artery territory from 30 days to 1 year, restenosis rate of the culprit artery at 1 year, and neurological improvement at 90 days (assessed by mRS score). Safety outcomes include intracranial hemorrhage within 30 days and endovascular complications. Sample size estimate: According to previous studies, the incidence of the composite clinical outcomes is 15% in the group receiving medical therapy alone. We assumed the incidence would decrease to 5% in the SBA combined with the medical therapy group. The target sample size is 416 patients (208 per group), with 90% power and 5% type I error, allowing for a 10% loss to follow-up. Implications: The BLAST study will provide evidence regarding whether early SBA can reduce stroke recurrence and mortality in patients with minor stroke/TIA due to ICAS compared with medical therapy alone. [ABSTRACT FROM AUTHOR]

Purpose: This study analyzes the relationship between human papillomavirus (HPV) infection, vaginal microecology, and cervical lesions to provide a basis for the prevention and treatment of cervical cancer (CC) in the Xinjiang region. Methods: Real‐time quantitative PCR was used for HPV genotyping and viral load. The Gram staining and dry biochemical enzyme kit were utilized to diagnose vaginal secretions. The χ2 test and Logistic regression analysis were used for statistical analysis. Results: The HPV infection rate among women in the Xinjiang region was 30.29%, of which the single HPV infection accounts for 77%. HPV16 and HPV52 were the main infection types. There was significant differences in the HPV infection rate and infection types among the Han, Uighur, Hui, and Kazakh ethnic groups. The viral load of HPV16 and HPV52 increases with the upgrade of cervical lesions. There were significant differences in vaginal microecology evaluation indicators H2O2, SNA, LE, GUS, trichomonas, clue cells, and lactobacilli among different ethnic groups. HPV negative patients with varying grades of cervical lesions exhibit a notable variance in H2O2 and LE, which is statistically significant. Single HPV infection and high viral load HPV significantly increase the risk of CC. Conclusions: This study indicates that HPV infection and vaginal microecology differ among ethnic groups, which have a strong correlation with the progression of CC, offering guidance on CC screening and interventions in the Xinjiang area. [ABSTRACT FROM AUTHOR]

This study investigated the growth of forecast errors stemming from initial conditions (ICs), lateral boundary conditions (LBCs), and model (MO) perturbations, as well as their interactions, by conducting seven 36 h convectionallowing ensemble forecast (CAEF) experiments. Two cases, one with strong-forcing (SF) and the other with weak-forcing (WF), occurred over the Yangtze-Huai River basin (YHRB) in East China, were selected to examine the sources of uncertainties associated with perturbation growth under varying forcing backgrounds and the influence of these backgrounds on growth. The perturbations exhibited distinct characteristics in terms of temporal evolution, spatial propagation, and vertical distribution under different forcing backgrounds, indicating a dependence between perturbation growth and forcing background. A comparison of the perturbation growth in different precipitation areas revealed that IC and LBC perturbations were significantly influenced by the location of precipitation in the SF case, while MO perturbations were more responsive to convection triggering and dominated in the WF case. The vertical distribution of perturbations showed that the sources of uncertainties and the performance of perturbations varied between SF and WF cases, with LBC perturbations displaying notable case dependence. Furthermore, the interactions between perturbations were considered by exploring the added values of different source perturbations. For the SF case, the added values of IC, LBC, and MO perturbations were reflected in different forecast periods and different source uncertainties, suggesting that the combination of multi-source perturbations can yield positive interactions. In the WF case, MO perturbations provided a more accurate estimation of uncertainties downstream of the Dabie Mountain and need to be prioritized in the research on perturbation development. [ABSTRACT FROM AUTHOR]

Introduction: With global warming, the disaster losses caused by extreme precipitation events are increasing. The poor natural conditions and climate change make the arid and semi-arid mountainous grassland area a sensitive region of climate change. The study on the spatio-temporal variation characteristics of extreme precipitation events in this region is helpful to improve the ability of climate prediction and disaster prevention and reduction in grassland. Methods: Based on the daily precipitation data of four meteorological monitoring stations in the Yinshanbeilu from 1970 to 2020, the trend analysis, M-K test and wavelet analysis were used to select seven typical extreme precipitation indicators to analyze the temporal and spatial characteristics of extreme precipitation. Results and Discussion: The results showed that the precipitation in the Yinshanbeilu increased in the past 51a, and the number of heavy rain days increased significantly. The significance test of CDD and CWD showed that the number of continuous dry days and continuous wet days decreased abruptly. The spatial analysis showed that the high value areas of R95p, R95d and PRCRTOT were all located in Siziwang Banner, and it could be concluded that the extreme precipitation risk was the highest in Siziwang Banner, while the low value areas of SDII, Rx1day, R95p and PRCRTOT were all located in Sonid Right Banner, which could be inferred that the Sonid Right Banner was relatively dry. The first main cycle of the seven indexes of extreme precipitation almost runs through the whole time series, and the starting point of the minimum main cycle changes inconsistent. In addition to the number of consecutive dry days, the other indices have a good correlation with annual precipitation, flood season and monthly precipitation from June to September, and July is the peak period of extreme precipitation events. [ABSTRACT FROM AUTHOR]

Background: Global research hotspots and future research trends in the neurobiological mechanisms of late-life depression (LLD) as well as its diagnosis and treatment are not yet clear. Objectives: This study profiled the current state of global research on LLD and predicted future research trends in the field. Methods: Literature with the subject term LLD was retrieved from the Web of Science Core Collection, and CiteSpace software was used to perform econometric and co-occurrence analyses. The results were visualized using CiteSpace, VOSviewer, and other software packages. Results: In total, 10,570 publications were included in the analysis. Publications on LLD have shown an increasing trend since 2004. The United States and the University of California had the highest number of publications, followed consecutively by China and England, making these countries and institutions the most influential in the field. Reynolds, Charles F. was the author with the most publications. The International Journal of Geriatric Psychiatry was the journal with the most articles and citations. According to the co-occurrence analysis and keyword/citation burst analysis, cognitive impairment, brain network dysfunction, vascular disease, and treatment of LLD were research hotspots. Conclusion: Late-life depression has attracted increasing attention from researchers, with the number of publications increasing annually. However, many questions remain unaddressed in this field, such as the relationship between LLD and cognitive impairment and dementia, or the impact of vascular factors and brain network dysfunction on LLD. Additionally, the treatment of patients with LLD is currently a clinical challenge. The results of this study will help researchers find suitable research partners and journals, as well as predict future hotspots. [ABSTRACT FROM AUTHOR]

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Siraitia grosvenorii (Swingle) C. Jeffrey (S. grosvenorii), a perennial indigenous liana from the Cucurbitaceae family, has historically played a significant role in southern China's traditional remedies for various ailments. Its dual classification by the Chinese Ministry of Health for both medicinal and food utility underscores its has the potential of versatile applications. Recent research has shed light on the chemical composition, pharmacological effects, and toxicity of S. grosvenorii. Its active ingredients include triterpenoids, flavonoids, amino acids, volatile oils, polysaccharides, minerals, vitamins, and other microconstituents. Apart from being a natural sweetener, S. grosvenorii has been found to have numerous pharmacological effects, including alleviating cough and phlegm, preventing dental caries, exerting anti-inflammatory and anti-allergic effects, anti-aging and anti-oxidative, hypoglycemic, lipid-lowering, anti-depression, anti-fatigue, anti-schizophrenic, anti-Parkinson, anti-fibrotic, and anti-tumor activities. Despite its versatile potential, there is still a lack of systematic research on S. grosvenorii to date. This paper aims to address this gap by providing an overview of the main active components, pharmacological efficacy, toxicity, current status of development and application, development dilemmas, and strategies for intensive exploitation and utilization of S. grosvenorii. This paper aims to serve as a guide for researchers and practitioners committed to exploiting the biological resources of S. grosvenorii and further exploring its interdisciplinary potential. [ABSTRACT FROM AUTHOR]

With the rapid development of intensive poultry breeding in China, the demand for poultry feed raw materials is increasing rapidly. However, the shortage of cereal feed and the persistently high price make it urgent for poultry feed production industry to explore cheaper energy alternative feed. Cassava has the characteristics of high yield, rich starch and fiber, high energy value, etc. It can replace corn or other energy feed in poultry breeding. The effective use of cassava products has been proved to reduce the feed cost of poultry production. However, the utilization of cassava is limited by many factors, such as low protein and anti-nutritional factors. Using correct processing and scientific formula, the addition level of cassava in poultry diet can be improved. In this paper, the nutritional characteristics, feed utilization, and application of cassava in poultry diet were reviewed, which provided a reference for the application of cassava in poultry diet. [ABSTRACT FROM AUTHOR]

The purpose of the experiment was to study the feasibility of fox carcass as meat and bone meal and evaluate the safety of fox meat and bone meal. Three healthy blue foxes (39 in total) weighing about 15 kg were randomly selected from 13 fox breeding areas in China. Fox carcass (including viscera and toe claws) was made into meat and bone meal by grinding, high-pressure hydrolysis, degreasing, drying, and crushing. Routine nutrients, heavy metals, veterinary drug residues, and canine distemper virus were determined, respectively, and the safety was evaluated. The results showed that the content of crude protein in meat and bone meal was between 55% and 67%, which meets the requirements of crude protein in the first-class index of Bone Meal and Meat and Bone Meal for Feed. The concentrations of lead, arsenic, mercury, cadmium, and chromium meet the requirements of the national standard for the hygiene and safety standards of meat and bone meal. Sulfamethazine, sulfamethoxazole, sulfamethoxazine, sulfadiazine, penicillin, oxytetracycline, and gentamicin meet the standard requirements of maximum residue limits of veterinary drugs in food. The results showed that fox meat and bone meal was rich in nutritional value, and its hygiene and safety indexes met the raw material standard of protein feed. [ABSTRACT FROM AUTHOR]

Background: Kidney transplantation is considered the most effective treatment for end-stage renal failure. Recent studies have shown that the significance of the immune microenvironment after kidney transplantation in determining prognosis of patients. Therefore, this study aimed to conduct a bibliometric analysis to provide an overview of the knowledge structure and research trends regarding the immune microenvironment and survival in kidney transplantation. Methods: Our search included relevant publications from 2013 to 2023 retrieved from the Web of Science core repository and finally included 865 articles. To perform the bibliometric analysis, we utilized tools such as VOSviewer, CiteSpace, and the R package "bibliometrix". The analysis focused on various aspects, including country, author, year, topic, reference, and keyword clustering. Results: Based on the inclusion criteria, a total of 865 articles were found, with a trend of steady increase. China and the United States were the countries with the most publications. Nanjing Medical University was the most productive institution. High-frequency keywords were clustered into 6 areas, including kidney transplantation, transforming growth factor β, macrophage, antibodymediated rejection, necrosis factor alpha, and dysfunction. Antibody mediated rejection (2019-2023) was the main area of research in recent years. Conclusion: This groundbreaking bibliometric study comprehensively summarizes the research trends and advances related to the immune microenvironment and survival after kidney transplantation. It identifies recent frontiers of research and highlights promising directions for future studies, potentially offering fresh perspectives to scholars in the field. [ABSTRACT FROM AUTHOR]

Background and Objective: The dynamic assessment of disease activity during the follow-up of patients with Crohn's disease (CD) remains a significant challenge. In this study, we aimed to identify the role of dynamic contrast-enhanced ultrasound (DCE-US) in the evaluation of activity of CD. Methods: In the retrospective study, patients diagnosed with CD in our hospital were included. All the diagnoses were confirmed by clinical symptoms and ileocolonoscopical results. All patients underwent intestinal ultrasound and contrast-enhanced ultrasound (CEUS) examinations within 1 week of the ileocolonoscopy examinations. Acuson Sequoia (Siemens Healthineers, Mountain View, CA, USA) and Resona R9 Elite (Mindray Medical Systems, China) with curved array and Line array transducers were used. The CEUS examination was performed with SonoVue (Bracco SpA, Milan, Italy). DCE-US analysis was performed by UltraOffice (version: 0.3-2010, Mindray Medical Systems, China) software. Two regions of interest (ROIs) were set in the anterior section of the infected bowel wall and its surrounding normal bowel wall 2 cm distant from the inflamed area. Time–intensity curves (TICs) were generated and quantitative perfusion parameters were obtained after curve fittings. The Simple Endoscopic Score for Crohn's disease (SES-CD) was regarded as the reference standard to evaluate the activity of CD. The receiver operating characteristic curve (ROC) analyses were used to determine the diagnostic efficiency of DCE-US quantitative parameters. Results: From March 2023 to November 2023, 52 CD patients were included. According to SES-CD score, all patients were divided into active group with the SES-CD score > 5 (n = 39) and inactive group SES-CD score < 5 (n = 13). Most of the active CD patients showed bowel wall thickness (BWT) > 4.2 mm (97.4%, 38/39) or mesenteric fat hypertrophy (MFH) on intestinal ultrasound (US) scan (69.2%, 27/39). Color Doppler signal of the bowel wall mostly showed spotty or short striped blood flow signal in active CD patients (56.4%, 22/39). According to CEUS enhancement patterns, most active CD patients showed a complete hyperenhancement of the entire intestinal wall (61.5%, 24/39). The TICs of active CD showed an earlier enhancement, higher peak intensity, and faster decline. Among all CEUS quantitative parameters, amplitude-derived parameters peak enhancement (PE), wash-in area under the curve (WiAUC), wash-in rate (WiR), wash-in perfusion index (WiPI), and wash-out rate (WoR) were significantly higher in active CD than in inactive CD (p < 0.05). The combined AUROC of intestinal ultrasound features and DCE-US quantitative perfusion parameters in the diagnosis of active CD was 0.987, with 97.4% sensitivity, 100% specificity, and 98.1% accuracy. Conclusions: DCE-US with quantitative perfusion parameters is a potential useful noninvasive imaging method to evaluate the activity of Crohn's disease. [ABSTRACT FROM AUTHOR]

Background: We aimed to evaluate the diagnostic capabilities of Chinese laboratories for inherited metabolic disorders (IMDs) using gas chromatography-mass spectrometry (GC-MS) on urine samples. Meanwhile, based on the result of the pilot external quality assessment (EQA) scheme, we hope to establish a standardized and reliable procedure for future EQA practice. Methods: We recruited laboratories that participated in the EQA of quantitative analysis of urinary organic acids with GC-MS before joining the surveys. In each survey, a set of five real urine samples was distributed to each participant. The participants should analyze the sample by GC-MS and report the "analytical result", "the most likely diagnosis", and "recommendation for further tests" to the NCCL before the deadline. Results: A total of 21 laboratories participated in the scheme. The pass rates were 94.4% in 2020 and 89.5% in 2021. For all eight IMDs tested, the analytical proficiency rates ranged from 84.7% - 100%, and the interpretational performance rate ranged from 88.2% - 97.0%. The performance on hyperphenylalaninemia (HPA), 3-methylcrotonyl-CoA carboxylase deficiency (MCCD), and ethylmalonic encephalopathy (EE) samples were not satisfactory. Conclusions: In general, the participants of this pilot EQA scheme are equipped with the basic capability for qualitative organic acid analysis and interpretation of the results. Limited by the small size of laboratories and samples involved, this activity could not fully reflect the state of clinical practice of Chinese laboratories. NCCL will improve the EQA scheme and implement more EQA activities in the future. [ABSTRACT FROM AUTHOR]

The South American tomato pinworm, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae), has invaded most Afro-Eurasian countries. Since its first detection in China in late 2017, this pest has been now present in nearly 20 provinces/prefectures in China and is threating tomato and other Solanaceous crops such as potato, eggplant, and tobacco. Here, we provide a timely review on the current distribution, damage, management, and research in China. A standard survey form was designed and 30 answered surveys from 25 provinces have been received. The data showed that the damage has been witnessed in most of the regions despite that the severities vary among the regions. The management is chemicalcontrol biased, and more efforts are needed to increase the adoption of non-chemical alternatives in the Integrated Pest Management packages. An Integrated Pest Management (IPM) package called "CAMEFA" was developed and demonstrated in Yunnan and Xinjiang, the two earliest regions for the invasion. Yet, the adoption by local growers is still limited. Besides T. absoluta, we suggest a multi-pest approach by combining IPM tactics coping with other major insect pests sharing the crop. Lastly, international projects are deemed to serve as key lever for promoting IPM of T. absoluta and other invasive insect pests. [ABSTRACT FROM AUTHOR]

Background: Japanese encephalitis (JE) is a notifiable infectious disease in China. Information on every case of JE is reported to the superior health administration department. However, reported cases include both laboratoryconfirmed and clinically diagnosed cases. This study aimed to differentiate between clinical and laboratory-confirmed cases of Japanese encephalitis virus (JEV) infection, and improve the accuracy of reported JE cases by analyzing the acute-phase serum and cerebrospinal fluid of all reported JE cases in the Sichuan province from 2012 to 2022. Methods: All acute-phase serum and/or cerebrospinal fluid samples of the reported JE cases were screened for IgM(ImmunoglobulinM)to JEV using the enzyme-linked immunosorbent assay (ELISA), and the detection of the viral genes of JEV and 9 other pathogens including enterovirus (EV), using reverse transcription PCR was attempted. Epidemiological analyses of JE and non-JE cases based on sex, age, onset time, and geographical distribution were also performed. Results: From 2012 to 2022, 1558 JE cases were reported in the Sichuan province. The results of serological (JEV-specific IgM) and genetic testing for JEV showed that 81% (1262/1558) of the reported cases were confirmed as JEV infection cases (laboratory-confirmed cases). Among the 296 cases of non-JEV infection, 6 viruses were detected in the cerebrospinal fluid in 62 cases, including EV and the Epstein-Barr virus (EBV), constituting 21% (62/296) of all non-JE cases. Among the 62 non-JEV infection cases with confirmed pathogens, infections with EV and EBV included 17 cases each, herpes simplex virus (HSV-1/2) included 14 cases, varicella- zoster virus included 6 cases, mumps virus included 2 cases, and human herpes viruses-6 included 1 case. Additionally, there were five cases involving mixed infections (two cases of EV/EBV, one case of HSV-1/HSV-2, one case of EBV/HSV-1, and one case of EV/herpes viruses-6). The remaining 234 cases were classified as unknown viral encephalitis cases. Our analysis indicated that those aged 0–15 y were the majority of the patients among the 1558 reported JE cases. However, the incidence of laboratory-confirmed JE cases in the >40 y age group has increased in recent years. The temporal distribution of laboratory-confirmed cases of JE revealed that the majority of cases occurred from May to September each year, with the highest incidence in August. Conclusion: The results of this study indicate that there is a certain discrepancy between clinically diagnosed and laboratory-confirmed cases of JE. Each reported case should be based on laboratory detection results, which is of great importance in improving the accuracy of case diagnosis and reducing misreporting. Our results are not only important for addressing JE endemic to the Sichuan province, but also provide a valuable reference for the laboratory detection of various notifiable infectious diseases in China and other regions outside China. [ABSTRACT FROM AUTHOR]

Chinese fir (Cunninghamia lanceolata) is a special fast-growing commercial tree species in China with high economic value. In recent years, leaf blight disease on C. lanceolata has been observed frequently. The diversity of Fusarium species associated with leaf blight on C. lanceolata in China (Fujian, Guangxi, Guizhou, and Hunan provinces) was evaluated using morphological study and molecular multi-locus analyses based on RNA polymerase second largest subunit (RPB2), translation elongation factor 1-alpha (TEF-1a), and RNA polymerase largest subunit (RPB1) genes/region as well as the pairwise homoplasy index tests. A total of five Fusarium species belonging to four Fusarium species complexes were recognized in this study. Two known species including Fusarium concentricum and F. fujikuroi belonged to the F. fujikuroi species complex, and three new Fusarium species were described, i.e., F. fujianense belonged to the F. lateritium species complex, F. guizhouense belonged to the F. sambucinum species complex, and F. hunanense belonged to the F. solani species complex. To prove Koch's postulates, pathogenicity tests on C. lanceolata revealed a wide variation in pathogenicity and aggressiveness among the species, of which F. hunanense HN33-8-2 caused the most severe symptoms and F. fujianense LC14 led to the least severe symptoms. To our knowledge, this study also represented the first report of F. concentricum, F. fujianense, F. fujikuroi, F. guizhouense, and F. hunanense causing leaf blight on C. lanceolata in China. [ABSTRACT FROM AUTHOR]

Background: Potentially substantial impacts on the prognosis have been observed in individuals undergoing endovascular treatment due to cytochrome P450 2c19 (CYP2C19) polymorphism. In an attempt to improve prognosis and lower the recurrence rate, this study investigated the CYP2C19 polymorphism in acute ischemic stroke patients. Materials and Methods: A retrospective analysis was performed on 292 patients with cerebral infarction who had acute endovascular recanalization at the Department of Neurology of Chongqing Hospital of Traditional Chinese Medicine between May 2017 and 2019. The patients were categorized into rapid-, medium-, and slow-metabolism groups based on CYP2C19 gene polymorphism, and their prognosis was monitored. In addition, the prognosis of 188 patients selectively receiving carotid artery stenting at a selected time was also observed. Results: Among the 292 cerebral infarction cases receiving acute endovascular recanalization, the patients in the CYP2C19 rapid-metabolism group regularly took clopidogrel and aspirin combined with antiplatelet therapy and suffered from reoccurrence of apoplexy and cerebral hemorrhage; the 90-day good prognosis had a statistical difference (P < 0.05, prognostic assessment includes hospitalization and 6 months after discharge) and the other adverse events had no statistical difference (including mortality). The 188 patients selectively receiving carotid artery stenting had a recurrence of apoplexy, cerebral hemorrhage, and restenosis rate with a statistical difference (P < 0.05), and the other adverse events had no statistical difference. Conclusions: In conclusion, the findings of the current study indicate that irrespective of whether patients are undergoing selective carotid artery stenting or acute endovascular recanalization, those with rapid CYP2C19 metabolism have a significantly lower likelihood of experiencing adverse prognostic events compared to those with intermediate and slow metabolism. Furthermore, this group also has a more favorable prognosis than the other two groups. [ABSTRACT FROM AUTHOR]

Gold deposits in Precambrian cratons were mostly generated during the formation and stabilization of the cratons, but the North China craton is unusual in that its gold deposits were mainly formed ~1.7 b.y. after its stabilization. A magmatic-hydrothermal origin or mantle-derived fluid source has been proposed for the giant gold deposits of the Jiaodong District in the eastern North China craton, but direct evidence is sparse, and the mineralization processes remain controversial. Here, we present the results of a comprehensive geological, geochronological, and geochemical study of the gold mineralized Xiejia diorite beneath the Linglong ore field at Jiaodong to link the gold mineralization to underlying magmatism. Magmatic zircon and titanite grains from the Xiejia diorite have laser ablation--inductively coupled plasma--mass spectrometry (LA-ICP-MS) U-Pb ages of 121.3 ± 0.9 Ma to 120.8 ± 1.1 Ma and 121.7 ± 3.9 Ma, respectively, which are indistinguishable from the time of gold deposition throughout the Jiaodong District as constrained by previous studies. The diorite has a shoshonitic composition and is characterized by strong enrichment in large ion lithophile elements (LILEs) and light rare earth elements (LREEs) along with significant depletion in high field strength elements (HFSEs) and heavy rare earth elements (HREEs). Samples of the diorite have high initial 87Sr/86Sr ratios, but low εNd(t) and εHf(t) values and low Pb isotope ratios. These geochemical characteristics are akin to those of contemporaneous mafic dikes in most gold mines at Jiaodong, indicating that the Xiejia diorite was most likely derived from an enriched lithospheric mantle source. The upper part of the diorite intrusion is pervasively altered and mineralized, containing an average of 0.32 g/t Au, but locally up to 7.59 g/t. Hydrothermal titanite from the mineralized diorite has a LA-ICPMS U-Pb age of 122.3 ± 4.3 Ma, which is consistent with the gold-bearing pyrite Re- Os isochron age of 122.5 ± 6.7 Ma. Ore-related sericite aggregates from the Dongfeng gold deposit above the Xiejia diorite have a 40Ar/39Ar plateau age of 122.6 ± 1.3 Ma. Pyrite from the mineralized diorite yielded δ34SCDT values of 2.1‰-9.7‰, which are comparable with those of pyrite (δ34SCDT = 5.8‰-8.1‰, where CDT indicates the Canyon Diablo troilite standard) from gold ores of Dongfeng. Pyrite grains from both groups also have similar Pb isotope compositions. The S and Pb isotope data are consistent with values of mafic dikes that are spatially and temporally associated with gold veins in the Linglong ore field. The results presented here thus indicate a possible genetic link between gold mineralization in the Xiejia diorite and underlying magma presumably represented by the Xiejia diorite. The auriferous fluids exsolved from that magma and migrated upward along the Potouqing fault to form the Dongfeng gold deposit above the Xiejia diorite. The mineralized diorite thus links shallow gold mineralization to deep-seated mantle-derived magmatism generated during the extensive destruction of the North China craton induced by the rollback of the subducted paleo-Pacific plate. [ABSTRACT FROM AUTHOR]

PURPOSE: Through three neurocritical care unit (NCCU) surveys in China, we tried to understand the development status of neurocritical care and clarify its future development. METHODS: Using a cross‑sectional survey method and self‑report questionnaires, the number and quality of NCCUs were investigated through three steps: administering the questionnaire, sorting the survey data, and analyzing the survey data. RESULTS: At the second and third surveys, the number of NCCUs (76/112/206) increased by 47% and 84%, respectively. The NCCUs were located in tertiary grade A hospitals or teaching hospitals (65/100/181) in most provinces (24/28/29). The numbers of full‑time doctors (359/668/1337) and full‑time nurses (904/1623/207) in the NCCUs increased, but the doctor–bed ratio and nurse–bed ratio were still insufficient (0.4:1 and 1.3:1). CONCLUSION: In the past 20 years, the growth rate of NCCUs in China has accelerated, while the allocation of medical staff has been insufficient. Although most NCCU hospital bed facilities and instruments and equipment tend to be adequate, there are obvious defects in some aspects of NCCUs. [ABSTRACT FROM AUTHOR]

This aim of this study was to investigate women's knowledge about HPV along with their experience and acceptability of self-sampling in Jiangsu province, China. A total of 862 women aged 25–63 years old from Jiangsu province who purchased an HPV self-sampling test kit were invited to complete a questionnaire designed by the authors. Participants had high acceptability for HPV self-sampling with a mean score of 4.2 (95% [CI], 4.1–4.22) out of 5 points. 27% of participants preferred clinician-sampling, 33% preferred self-sampling, other 40% expressed no preference. Women with good knowledge about HPV and with a good experience with HPV self-sampling were more acceptable for self-sampling (P < 0.05). The biggest concern about HPV self-sampling of the participants includes 'specimens' spoilage', 'incorrect sampling', 'can't get results in time', and so on. HPV self-sampling can be used to improve cervical cancer screening coverage and participation rates in China. Cancer screening and can be an alternative primary screening for cervical cancer. •What the results of this study add? This study adds new findings about Chinese women's experience and acceptability of HPV self-sampling. We found that most women had high acceptability for HPV self-sampling in Jiangsu province, China, and high knowledge about HPV as well as good •What is already known on this subject? HPV self-sampling testing was proven to be useful for improving the uptake rate of cervical experience of self-sampling can improve the acceptability for self-sampling in women. •What the implications are of these findings for clinical practice and/or further research? Further research should assess the acceptability of women with less education or who never screened. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study. METHODS: A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 community older adults. After the baseline survey, the last follow-up was March 31, 2021 with an average 8.13 years of follow-up. Cox proportional hazard model was used to estimate the hazard ratios (HR) with 95% CI for cardiovascular disease (CVD) death and all-cause death in associations with baseline lipid indicators. RESULTS: A total of 4499 participants were recruited, and the mean levels of uric acid, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol (TC), triglyceride, and low-density lipoprotein cholesterol (LDL-C) showed an upward trend with the increasing remnant cholesterol (RC) quarters (Ptrend < 0.05), while the downward trend was found in high-density lipoprotein cholesterol (HDL-C). During the total 36,596 person-years follow-up, the CVD mortality and all-cause mortality during an average 8.13 years of follow-up was 3.87% (95% CI: 3.30%-4.43%) and 14.83% (95% CI: 13.79%-15.86%) with 174 CVD death participants and 667 all-cause death participants. After adjusting for confounders, the higher level of TC (HR = 0.854, 95% CI: 0.730-0.997), LDL-C (HR = 0.817, 95% CI: 0.680-0.982) and HDL-C (HR = 0.443, 95% CI: 0.271-0.724) were associated with lower risk of CVD death, and the higher level of HDL-C (HR = 0.637, 95% CI: 0.501-0.810) were associated with lower risk of all-cause death. The higher level of RC (HR = 1.276, 95% CI: 1.010-1.613) increase the risk of CVD death. Compared with the normal lipid group, TC ≥ 6.20 mmol/L group and LDL-C ≥ 4.10 mmol/L group were no longer associated with lower risk of CVD death, while RC ≥ 0.80 mmol/L group was still associated with higher risk of CVD death. In normal lipid group, the higher levels of TC, LDL-C and HDL-C were related with lower CVD death. CONCLUSIONS: In community older adults, higher levels of TC and HDL-C were associated with lower CVD mortality in normal lipid reference range. Higher RC was associated with higher CVD mortality, which may be a better lipid indicator for estimating the CVD death risk in older adults. [ABSTRACT FROM AUTHOR]

In this study, civil gas energy accidents reported by the China Gas Network and related organizations from 2012 to 2021 were collected, and a comprehensive multidimensional correlation analysis was conducted considering factors such as accident timing, geography, causes, and casualties. The results identified July and August, Mondays and Sundays, and the morning, mid-day, and evening cooking times as the high-incidence months, days, and times for gas accidents, respectively. Gas accidents were found to occur more frequently in eastern coastal areas, provincial capitals, and larger cities, while residential and construction sites were identified as high-risk areas for gas accidents. Explosions were the most prevalent type of gas accident, followed by leaks, fires, and poisoning. Third-party construction and valve issues were identified as the primary factors contributing to gas leakage, whereas cooking was identified as the most common ignition source. An analysis of the Pearson correlation coefficient indicated a significant correlation among the gas accident factors. Moreover, a time-series prediction model was developed to forecast gas accidents in China, with the results demonstrating fluctuating gas accidents. This study proposes targeted preventive measures in terms of publicity, education, equipment, and facilities to provide scientific support to government units to improve civil gas energy security measures. [ABSTRACT FROM AUTHOR]

Purpose: This present study aims to explore the influence of metformin and postoperative insulin pump use on colorectal cancer (CRC) patients with type II diabetes mellitus (T2DM) who received surgery in terms of short-term and long-term outcomes. Methods: 613 CRC patients who had comorbid T2DM and received surgery at a single clinical center from Jan, 2011 to Dec, 2021 were included in this study. Univariate and multivariate logistic regression analyses were used to find predictive factors for overall complications and major complications. Cox regression analyses was used to find prognostic factors for overall survival (OS) and disease-free survival (DFS). All statistical analysis was performed using SPSS (version 22.0) software. The Kaplan-Meier curve was used to show the OS and DFS between the insulin pump group and the no insulin pump group. Results: Multivariate logistic regression analysis reported that lower body mass index (BMI) (p<0.01, OR = 0.922, 95% CI = 0.870-0.977) and metformin use (p=0.03, OR = 0.643, 95% CI = 0.431-0.959) were independent protective factors for overall complications, and insulin pump after surgery (p<0.01, OR = 3.991, 95% CI = 2.434-6.544) was an independent risk factor for overall complications. As for major complications, metformin use (p=0.042, OR = 0.274, 95% CI = 0.079-0.956) and insulin pump after surgery (p=0.03, OR = 2.892, 95% CI = 1.107-7.552) remained independent protective factors and independent risk factors, respectively. Moreover, in Cox regression analyses, age (OS: p<0.01, HR = 1.032, 95% CI = 1.008-1.057; DFS: p<0.01, HR = 1.030, 95% CI = 1.008-1.052), tumor stage (OS: p<0.01, HR = 1.709, 95% CI = 1.244-2.346; DFS: p<0.01, HR = 1.696, 95% CI = 1.276-2.254), and Insulin pump after surgery (OS: p<0.01, HR = 2.923, 95% CI = 1.887-4.527; DFS: p<0.01, HR = 2.671, 95% CI = 1.779-4.009) were independent prognostic factors for both OS and DFS. After comparing the OS and DFS between the insulin pump group and the no insulin pump group, patients who received postoperative insulin pump had worse OS and DFS in all tumor node metastasis (TNM) stages (p<0.01). Conclusion: Diabetic CRC patients who used metformin had a lower risk of postoperative complications. However, there was no difference from patients not using metformin in terms of survival. Furthermore, patients receiving postoperative insulin pump had more postoperative complications and worse survival in all TNM stages. [ABSTRACT FROM AUTHOR]

Future food farming technology faces challenges that must integrate the core goal of keeping the global temperature increase within 1.5 °C without reducing food security and nutrition. Here, we show that boosting the production of insects and earthworms based on food waste and livestock manure to provide food and feed in China will greatly contribute to meeting the country’s food security and carbon neutrality pledges. By substituting domestic products with mini-livestock (defined as earthworms and insects produced for food or feed) protein and utilizing the recovered land for bioenergy production plus carbon capture and storage, China’s agricultural sector could become carbon-neutral and reduce feed protein imports to near zero. This structural change may lead to reducing greenhouse gas emissions by 2,350 Tg CO2eq per year globally when both domestic and imported products are substituted. Overall, the success of mini-livestock protein production in achieving carbon neutrality and food security for China and its major trading partners depends on how the substitution strategies will be implemented and how the recovered agricultural land will be managed, e.g., free use for afforestation and bioenergy or by restricting this land to food crop use. Using China as an example, this study also demonstrates the potential of mini-livestock for decreasing the environmental burden of food production in general. [ABSTRACT FROM AUTHOR]

Introduction: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a growing threat. It is urgent to investigate the multidrug resistance and high virulence of CRPA to provide a basis for infection control and rational use of antibiotics. Methods: A retrospective study of 56 nonduplicated CRPA isolates was conducted. Results: CRPA mainly came from the intensive care unit (ICU) and was mostly isolated from sputum samples. The carbapenem resistance rates of P. aeruginosa were 21.37% (2016), 10.62, 5.88, 10 and 13.87% from 2016 to 2020, respectively. Carbapenem-resistant enzymes and aminoglycoside-modifying enzyme- encoding genes were detected in all isolates, and extended-spectrum β-lactamase and cephalosporin enzyme-encoding genes were present in 96.43 and 80.38% of isolates, respectively. The detection rate of OprM showed a statistically significant difference (p<0.05) between the ICU and other wards. Genes related to biofilms, membrane channel proteins, I integrons and efflux systems were detected in all isolates, with detection rates greater than 90%. CRPA was strongly virulent, and over 80% of isolates carried hypervirulence-associated genes (exoU, exoS, exoT, and exoY). The drug resistance rates of cefepime and piperacillin/tazobactam showed a statistically significant difference (p<0.05) between strains with exoU (+) and exoU (-) (p<0.05). Notably, out of the 7 individuals who died, 4 had extensively drug-resistant P. aeruginosa (57.14%). Discussion: The detection rates of various resistance and virulence genes were high, and the coexistence phenomenon was serious. In clinical practice, antibiotics should be used reasonably based on different drug resistance genes to ensure the rationality and safety of patient medication. [ABSTRACT FROM AUTHOR]

In recent years, environmental DNA (eDNA) technology has become an accepted approach for investigating rare and endangered species because of its economic efficiency, high sensitivity, and non-invasiveness. The Asian giant softshell turtle (Pelochelys cantorii) is a first-class protected aquatic animal in China, and traditional resource survey methods have not identified its natural populations for many years. In this study, primers and a TaqMan probe targeting ND5 were designed, reaction conditions were optimized, a standard curve was constructed using synthetic DNA, and an eDNA quantitative PCR (qPCR) detection method was established. The eDNA detection technology for P. cantorii revealed that the number of species in the experimental pools showed a significant linear relationship with the eDNA concentration (p < 0.05). The eDNA concentration was negatively correlated with the length of time after the removal of P. cantorii and retention in the water body for 9 days. The qPCR detection method for P. cantorii eDNA established in this study can be applied to the qualitative detection of P. cantorii in water bodies, as well as to preliminary evaluation of its relative biomass. This can serve as a baseline for the investigation of natural P. cantorii population and the evaluation of its wild release effects. [ABSTRACT FROM AUTHOR]

This study applied a quantile analysis to test the relationship between analyst coverage and overinvestment in Chinese firms and further sought to demonstrate the mediating effect of corporate governance on overinvestment. The empirical results show that analyst coverage causes overinvestment across all quantiles; however, corporate governance can diminish the effect of firm overinvestment in the higher quantile analysis. Additionally, the difference-in-differences method was used to explore the effectiveness of the Chinese government's 2013 corporate governance reform, with the results confirming that that governance reform has been effective in inhibiting a firm's overinvestment. The findings of this study indicate that analysts act as market supervisors in the Chinese capital market, improving corporate governance; however, their coverage does not appear to benefit firms or shareholders. This research highlights the need to review the role of analysts in the market to ensure they can reduce information asymmetry between managers and shareholders without causing overinvestment behavior. [ABSTRACT FROM AUTHOR]

Introduction: Root rot caused by the fungal pathogen Fusarium sp. poses significant challenges to tobacco cultivation in China, leading to major economic setbacks. The interplay between this pathogen and the wider soil microbial community remains poorly understood. Methods: High-throughput sequencing technology was utilized to evaluate soil prokaryotic, fungal, and protistan communities. We compared microbial communities in infected soils to those in healthy soils from the same field. Additionally, the influence of pH on the microbial communities was assessed. Results: Infected soils displayed elevated levels of soil nutrients but diminished observed richness across prokaryotic, fungal, and protistan groups. The pathogenic fungi Fusarium solani f sp. eumartii's abundance was notably increased in infected soils. Infection with F. solani significantly altered the soil's microbial community structure and interactions, manifested as a decrease in network scale and the number of keystone species. An evaluation of prokaryotes' role in F. solani's invasion revealed an increased number of connecting nodes in infected soils. Additionally, relationships between predatory protists and fungi were augmented, whereas predation on F. solani declined. Discussion: The study underscores the significance of comprehending the interactions among soil microorganisms and brings to light the susceptibility of soil microbial communities to pathogen invasion. It offers insights into the multifaceted relationships and potential vulnerabilities within the soil ecosystem in the context of Fusarium sp. invasion. [ABSTRACT FROM AUTHOR]

Water, energy and food are inextricably linked in agricultural system. Social and environmental issues arising from socio-economic development pose new challenges for sustainable agricultural development. Achieving sustainable agriculture from the perspective of water, energy and food resource conservation is of critical importance to the national strategy for high-quality development of the Yellow River Basin in China. In this study, the mass productivity and economic productivity of water and energy in agricultural system were considered, and an integrated assessment index system for agricultural system based on the Water-Energy-Food Nexus (WEFN) was proposed in three dimensions: reliability, coordination and resilience. Based on these indicators, the agricultural water-energy-food nexus index (AWEFNI) and integrated risk index (IRI) were performed to assess the current status of agricultural development in the middle and upper reaches of the Yellow River. Results indicate that the AWEFNI in the middle and upper reaches of the Yellow River is increasing year by year, and the level of sustainable agricultural development is improving, but the overall level is lower. The AWEFNI values vary widely among provinces. The reliability of single subsystem in the study area accounts for more than 1/3 of the AWEFNI, with poor water endowment， rich food and energy resource endowments, the coordination of the AWEFN is weakening. The resilience of the third subsystem is gradually declining. The contradiction in water and energy supply and demand in Ningxia is the most prominent among the five provinces, and the level of AWEFN development is the lowest, so the regulation policies should be implemented as soon as possible to promote the synergistic development of AWEFN around the region. [ABSTRACT FROM AUTHOR]

In order to understand the difference of quality for Chinese and CIMMYT wheat varieties (lines), we selected 153 wheat germplasm from both China and CIMMYT to explore the contribution relationship of different allelic variation combinations to wheat quality through genotyping and phenotyping, including grain hardness, polyphenol oxidase (PPO) activity, lipoxygenase (LOX) activity, yellow pigment (YP) content and protein content. In terms of flour milling quality, Chinese wheat varieties were mainly carrying Pina-D1a/Pinb-D1b, accounting for 32.0% of the total tested varieties, while the CIMMYT wheat lines were mainly carrying Pina-D1b/Pinb-D1a with 45.8% of the total collection. The distribution frequencies of subunit 1/2* and 5 + 10 were 47.0% and 42.5%, respectively, in CIMMYT varieties, however they were only 31.4% and 13.7% respectively of the Chinese wheat tested varieties. In addition, the proportion of phytoene synthase (PSY) allele, PPO allele and LOX active allele were roughly the same between Chinese and CIMMYT varieties. Based on the present study, we found that Pina gene had a greater impact on grain hardness value than Pinb gene; The influence of PPO-A1 gene on polyphenol oxidase activity was more significant than PPO-D1 gene. The high protein content of varieties mostly containing hardness genes and 1/2*/5 + 10 subunit combinations. Based on the present study, we found that the quality gene distribution of Chinese and CIMMYT varieties was quite different, for instance, the high-quality HMW-GS subunits of Chinese varieties were lower than CIMMYT lines. It will be much useful for Chinese wheat breeders to develop good quality wheat variety by crossing with 3 good strong gluten CIMMYT wheat lines by molecular marker-assisted selection. [ABSTRACT FROM AUTHOR]