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Skin fibroblasts were donated by a healthy 52-year-old Han Chinese woman. The induced pluripotent stem cell (iPSC) line was constructed using an episomal reprogramming method that made the generated iPSCs integration-free. This iPSC line expressed the common pluripotency markers, could be differentiated into three germ layers, and showed normal karyotype in vivo. The iPSC line can be used to generate different cell types, which could be used as a control in drug development and studies on pathological mechanisms., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)