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Identity issues have been an area of focus in language learning motivation scholarship. However, the role of national identity in language learning motivation has not received sufficient attention. In response to the timely call for reflections on nationalism and language education, this study examines how political nationalism and cultural nationalism shape Chinese learners' motivation to learn Japanese. Our analysis suggests that cultural nationalism considerably enhances Chinese learners' motivation whereas the motivational impact of political nationalism is bifurcate. Our research helps illuminate the mechanism of the rooted L2 self and national interest in language learning motivation, especially in the Chinese context.

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Capitalizing on a unique setting in China where auditors disclose their prosocial activities, we examine the role that auditor social responsibility plays in shaping their performance. In one direction, behavior consistency theory implies that individual auditors exhibiting more social commitment in their off-the-job activities behave similarly during engagements, enhancing the quality of their audits. In the other direction, accounting firms' internal structures along with external disciplinary forces mute the impact of heterogeneous auditor characteristics on their performance. In a staggered difference-in-differences design, we report a significant fall in the magnitude of companies' discretionary accruals and the incidence of financial reporting irregularities after their auditors begin contributing to social welfare, relative to companies whose auditors refrain from contributing during the same timeframe. Additional evidence implies that the higher audit quality stems from auditors better protecting their independence and improving their competence in the post-contribution period. Collectively, our results provide insights into the importance of auditors' prosocial attitudes to their external monitoring. [ABSTRACT FROM AUTHOR]

Background: Posterior circulation Acute Stroke Prognosis Early Computed Tomography Scores (pc-ASPECTS) is a rapid method of measuring early ischemic changes. However, there was no agreement study about pc-ASPECTS. Objectives: The purpose of the present study was to evaluate the agreement on pc-ASPECTS based on non-contrast CT (NCCT) and CT angiography (CTA) source images in patients with acute basilar artery occlusion (BAO). Methods: We prospectively enrolled consecutive patients with acute BAO from January 2022 to August 2022 at the First Affiliated Hospital of University of Science and Technology of China. The NCCT and CTA were scored independently by 15 raters during 2 different reading sessions at least 3 weeks apart. The pc-ASPECTS based on NCCT and CTA were analyzed on the full scale or were dichotomized (0–6 vs. 7–10, 0–7 vs. 8–10, and 0–8 vs. 9–10). The level of agreement was measured using Fleiss κ statistics. Results: The median (IQR) CT-based pc-ASPECTS was 8 (6.75–9). The interrater agreement for CT-based pc-ASPECTS (κ = 0.133 [0.132–0.133]) and CTA-based pc-ASPECTS (κ = 0.204 [0.203–0.204]) was slight for all raters. Dichotomizations obtaining the highest concordance for the CT-based pc-ASPECTS (0–6 vs. 7–10) and the CTA-based pc-ASPECTS (0–8 vs. 9–10) failed to increase the interrater agreement to a substantial level (κ = 0.350 [0.348–0.351] and 0.396 [0.395–0.398], respectively). Intrarater agreement for global CT-based pc-ASPECTS was less than substantial for the 14/15 raters and reached the level of substantial for the 3/15 raters with dichotomization. Conclusions: Agreement between clinicians assessing CT-based and CTA-based pc-ASPECTS cannot be sufficient to make reproducible clinical decisions and assessments. The dichotomization failed to improve interrater and intrarater agreement to the level of substantial. [ABSTRACT FROM AUTHOR]

Simple Summary: Three trichomonad species (Tritrichomonas foetus, Tetratrichomonas buttreyi, and Pentatrichomonas hominis) may affect pig production. Moreover, P. hominis is a zoonotic species. In the current investigation, 362 fecal samples collected from pigs in three representative counties in Shanxi Province, North China, were molecularly tested for the three trichomonad species. The results showed that T. buttreyi was detected as the most common species, with a prevalence of 49.72%. Its prevalence was associated with region and age. Only one sample was tested positive for T. foetus, and this isolate showed minor allelic variations compared with those reported previously. For T. buttreyi, eight distinct sequence types were obtained, and only two displayed 100% nucleotide homology with the corresponding sequences reported previously. For the first time, we reported the prevalence and genetic characterization of T. foetus and T. buttreyi in pigs in Shanxi Province, North China, which provides baseline information for planning control strategies. Several trichomonad species have already been identified in pigs, and their pathogenic potential may not be ruled out. To date, however, no information is available regarding the prevalence of trichomonads in pigs in Shanxi Province, North China. In the present study, a total of 362 fecal samples collected from pigs in three representative counties (Qi, Jishan, and Shanyin) in this province were examined for Tetratrichomonas buttreyi, Tritrichomonas foetus, and Pentatrichomonas hominis using a nested polymerase chain reaction (PCR) with primers targeting the small subunit ribosomal RNA (SSU rRNA) gene. The overall prevalence of T. buttreyi was 49.72%, and region and age were found to be significantly associated with T. buttreyi infection, respectively. Only one pig fecal sample from Qi County was found to be positive for T. foetus, and all samples were negative for P. hominis. Molecular evolutionary analysis revealed that some T. buttreyi isolates showed complete genetic identity with those reported previously, and some T. buttreyi isolates and one T. foetus isolate showed minor allelic variations compared with those reported previously. This is the report of the molecular epidemiology of T. foetus and T. buttreyi in pigs in Shanxi Province, North China. These findings not only enrich the knowledge on the distribution of these trichomonad species in pigs in China but also provide baseline information for planning future research and control strategies. [ABSTRACT FROM AUTHOR]

As a result of the advantages of the steel fiber reinforced concrete pavement structure, which includes high strength, high stiffness, and high stability, a large number of steel fiber concrete pavements will be used for highway construction in China. As a result, numerous cracks develop, which significantly reduces the life of the road; therefore, the study of the jointing problem is vital. As concrete research on the influence of the load transfer capacity and service life of prefabricated steel fiber reinforced concrete joints on the structural design and use function of the whole and pavement panels, the paper proposes two joint forms, tongue-and-groove and overlap. Using experiments and software, the stress and reflection of prefabricated road panels of the two joint forms are analyzed for different axial loads. The analysis reveals that the maximum tensile stress, shear stress, and deflection of the precast panels of both joint forms increase linearly as the axle load of the vehicle increases, while the service life decreases relatively. The load transfer capacity is independent of the axle load magnitude, and the load transfer capacity difference between the two types of joints is minimal and excellent. [ABSTRACT FROM AUTHOR]

Toona ciliata is a deciduous or semi-deciduous tree species and belongs to the Toona genus of the Meliaceae family. Owing to low natural regeneration and over-exploitation, the species is listed as an endangered species at level II in China and its conservation has received increasing concern. Here, we sampled 447 individuals from 29 populations across the range-wide distribution of the T. ciliata complex in China and assessed their genetic variation using two chloroplast DNA markers. The results showed that the overall haplotype diversity and nucleotide diversity per site were high at h = 0.9767 and π = 0.0303 for the psbA-trnH fragment and h = 0.8999 and π = 0.0189 for the trnL-trnL fragment. Phylogenetic analysis supported the division of the natural distribution of T. ciliata complex into western and eastern regions. The genetic diversity was higher in the western region than in the eastern region, showing significant phylogeographic structure. Genetic differentiation among populations was moderate ( Φ s t = 42.87 % ), and the effects of isolation by distance (IBD) were significant. A neutrality test and mismatch distribution analysis indicated that the distribution of the T. ciliata complex generally did not expand, although a few local populations could likely expand after bottleneck effects. The overall results were complementary to and consolidated previous studies using mitochondrial and nuclear DNA markers. We finally discussed strategies for the genetic conservation of the T. ciliata complex. [ABSTRACT FROM AUTHOR]

The ecology of plant species relies on the synchronous functioning of leaves and roots, but few studies have simultaneously examined the community trait dispersion (CTD) patterns of both organs. We measured 16 analogous leaf and root traits on 44 co-occurring woody species in a subtropical forest in southern China, aiming to examine whether leaf and root traits were coordinated, organized into parallel trait axes, exhibited similar CTD, and displayed consistent responses in CTD and community-weighted means of (CWM) traits over environmental gradients. While the first axes of leaf and root trait variation similarly exhibited a fast–slow continuum, leaf traits covered a secondary "carbon economics" axis, contrasting to root traits depicting a collaboration axis reflecting species' mycorrhizal dependency. Analogous leaf and root chemical traits were generally coordinated but less so for morphological traits. At the community level, changes in the CWM of the first axes were generally consistent among organs with more conservative traits found as increasing elevation but not for the second axis. While root traits became thinner and more conservative as soil phosphorus concentration decreased, leaf traits rarely varied. When different trait axes were combined, leaf traits were overdispersed but tended to converge with increased elevation and soil potassium and phosphorus levels, whereas root traits were clustered but tended to diverge along the same gradients. Our study highlights fine filtering of different suites of traits above- and belowground, which in turn might reduce overall niche overlap among species and promote coexistence with diverse functional designs. [ABSTRACT FROM AUTHOR]

Simple Summary: Since 2019, COVID-19 has had major effects around the world. Lung cancer and COVID-19 are both diseases of the respiratory system, and it is interesting to look into how they affect each other. However, very few studies look at how COVID-19 and lung cancer together. The point of this study was to look into the short- and long-term relationships between COVID-19 and lung cancer in order to find out how COVID-19 affects the outcome of lung cancer patients. We discovered that lung cancer patients infected with COVID-19 may have their disease progress more quickly. This suggests lung cancer patients infected with COVID-19 may need to have their tumor treatment evaluated more often so their treatment plans can be changed as needed. Background: COVID-19 has been ravaging the globe for more than three years. Due to systemic immunosuppression of anti-tumor therapy, application of chemotherapy and adverse effects of surgery, the short- and long-term prognosis of cancer patients to COVID-19 are of significant concern. Method: This research included three parts of data. The first part of the data came from the public database that covered Veneto residents. The second part of the data included participants in Guangzhou. The third part of the data was used for MR analysis. We assessed the associations by logistic, linear or Cox regression when appropriate. Result: Lung cancer patients with COVID-19 had shorter progression-free survival (PFS) after COVID-19 (Model II: HR: 3.28, 95% CI: 1.6~6.72; Model III: HR: 3.39, 95% CI: 1.45~7.95), compared with lung cancer patients without COVID-19. Targeted therapy patients recovered from SARS-CoV-2 infection more quickly (Model I: β: −0.58, 95% CI: −0.75~−0.41; Model II: β: −0.59, 95% CI: −0.76~−0.41; Model III: β: −0.57; 95% CI: −0.75~−0.40). Conclusions: PFS in lung cancer patients is shortened by COVID-19. The outcome of COVID-19 in lung cancer patients was not significantly different from that of the healthy population. In lung cancer patients, targeted therapy patients had a better outcome of COVID-19, while chemotherapy patients had the worst. [ABSTRACT FROM AUTHOR]

This cross-sectional study aims to assess the level of academic burnout among Chinese medical students during the controlled COVID-19 pandemic and identify the potential demographic factors affecting academic burnout. It also explored the relationship between career calling, family functioning, resource support, and academic burnout, as well as investigated whether family functioning and resource support could moderate the relationship between career calling and academic burnout among Chinese medical students. The study was conducted in five Chinese cities in 2021. A total of 3614 valid questionnaires were collected to assess the relationship between academic burnout, career calling, family functioning, and resource support, and determine whether demographic factors contribute to academic burnout. Hierarchical multiple regression analysis was used to explore factors correlated with academic burnout and test the moderating effect of family functioning and resource support on the relationship between career calling and academic burnout. The mean academic burnout score was 3.29 ± 1.17. Sex, major, academic performance ranking, monthly living expenses, physical health, and sleep quality significantly affected academic burnout (p < 0.05). Academic burnout was negatively correlated with career calling, resource support, and family functioning. Family functioning and resource support moderated the relationship between career calling and academic burnout. Simple slope analysis revealed that high family functioning and resource support strengthened the impact of career calling on academic burnout. Most medical students in China experienced relatively high levels of academic burnout during the controlled COVID-19 pandemic. Furthermore, specific demographic factors contribute to academic burnout. Family functioning and resource support moderate the relationship between career calling and academic burnout. These findings emphasize the importance of implementing career-calling education, supplementing family functioning in the form of school support, and providing sufficient smart learning resources among medical students in the post-pandemic era. The results revealed that career calling was strongly and negatively correlated with academic burnout during the controlled COVID-19 pandemic. High family functioning and resource support strengthened the impact of career calling on academic burnout during the controlled COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

This study investigates the emotional management strategies employed by the Chinese maintream media Huanqiu Shibao (HQSB), through the use of nationalistic rhetoric during the Covid-19 pandemic. By conducting a discourse analysis of the coverage of Covid-19 on HQSB's WeChat account, this research reveals two primary emotional management strategies: defensive nationalism and aggressive nationalism. Defensive nationalism utilizes fear and positive emotions to uphold and defend Chinese politics, while aggressive nationalism employs disgust to counter external criticisms and delegitimize the US democratic system and international leadership. By examining how HQSB emotionally differentiates the world, the study unveils that tactics Chinese mainstream media use to construct national identity, drawing a divisive line between a despised 'them' and an innocent 'us'. The Covid-19 pandemic presents a unique opportunity to reflect on the emotionalisation of Chinese digital propaganda and the evolution of state-led nationalism during a public health crisis. The research concludes that the use of emotion in HQSB's Covid-19 coverage aligns with China's broader strategy of nation-building and global influence promotion. It underscores the need for greater awareness of the emotional mobilization used in political communication, particularly during times of crisis. [ABSTRACT FROM AUTHOR]

Understanding the characteristics of lead–zinc mine occurrences and mastering effective investigative techniques are paramount in modern ore prospecting. This research focuses on the forested region of Yichun city in China, with a specific emphasis on the strategic mineral resource of a lead–zinc mine. The study examines the distribution patterns of this mineral and employs advanced aeromagnetic exploration methods. Firstly, we analyzed the geological structure and features of the region by leveraging the latest high-precision aeromagnetic data collected using dynamic delta wing technology. This analysis was complemented by an assessment of the geological conditions of the research area, existing lead–zinc deposits, ground magnetic surveys, and verification studies. With the goal of establishing a meaningful correlation between aeromagnetic anomalies and lead–zinc deposits, we employed various potential field conversion techniques, including the reduction to the pole, vertical derivatives, upward continuation, and residual anomaly analysis techniques. Secondly, we investigated the metallogenic sites within this region and provided a comprehensive summary of the metallogenic circumstances and characteristics related to aeromagnetic prospecting. Thirdly, we employed human–computer interaction fitting inversion techniques to predict the potential for lead–zinc mine prospecting in areas exhibiting aeromagnetic anomalies. The study underscores the significance of high-amplitude and large-scale aeromagnetic anomalies in the study area. Furthermore, we examined the interplay between intrusive rocks, strata, and structural elements within the region to identify favorable conditions for lead–zinc mineralization. As a result of our analysis and discussions, a location was predicted where a lead–zinc mine may exist. The research methodology outlined in this article provides valuable insights for future lead–zinc mine exploration efforts in areas characterized by similar geological conditions. [ABSTRACT FROM AUTHOR]

Air pollution is an important factor affecting human health and daily life. The Chinese government is making vigorous efforts to control air pollution. The upgrading of the industrial structure is a problem-solving tool in the environment and economic growth cases. This paper aims to explore the relationships among environmental regulation, the upgrading of the industrial structure and air pollution. The PVAR (Panel Vector Auto Regression) model and moderating effect model are used to conduct empirical analysis based on panel data of 30 provinces in China from 2004 to 2020. The analysis of the results provides the following findings. Firstly, environmental regulations can significantly reduce emissions, but the deterioration of air quality does not have a significant impact on the improvement of environmental regulations. Secondly, industrial structure upgrading can reduce air pollution, but the worsening of the air quality will hinder the upgrading of industrial structures. Thirdly, environmental regulation can promote industrial structure upgrading. Lastly, industrial structure upgrading is a moderating variable and can positively moderate the impact of environmental regulations on air pollution. [ABSTRACT FROM AUTHOR]

There is a continuous and relatively stable rainy period every spring in southern China (SC). This spring precipitation process is a unique weather and climate phenomenon in East Asia. Previously, the variation characteristics and associated mechanisms of this precipitation process have been mostly discussed from the perspective of seasonal mean. Based on the observed and reanalysis datasets from 1982 to 2021, this study investigates the diversity of the interannual variations of monthly precipitation in spring in SC, and focuses on the potential influence of the tropical sea surface temperature (SST) anomalies. The results show that the interannual variations of monthly precipitation in spring in SC have significant differences, and the correlations between each two months are very weak. All the interannual variations of precipitation in three months are related to a similar western North Pacific anomalous anticyclone (WNPAC), and the southwesterlies at the western flank of WNPAC bring abundant water vapor for the precipitation in SC. However, the WNPAC is influenced by tropical SST anomalies in different regions each month. The interannual variation of precipitation in March in SC is mainly influenced by the signal of El Niño-Southern Oscillation, and the associated SST anomalies in the equatorial central-eastern Pacific regulate the WNPAC through the Pacific-East Asia (PEA) teleconnection. In contrast, the WNPAC associated with the interannual variation of precipitation in April can be affected by the SST anomalies in the northwestern equatorial Pacific through a thermally induced Rossby wave response. The interannual variation of precipitation in May is regulated by the SST anomalies around the western Maritime Continent, which stimulates the development of low-level anomalous anticyclones over the South China Sea and east of the Philippine Sea by driving anomalous meridional vertical circulation. [ABSTRACT FROM AUTHOR]

Maintaining rice yield and reducing nitrogen (N) input are two important targets in sustainable agriculture practices. The adoption of a nitrogen-saving variety (NSV) provides a unique opportunity to achieve this. However, limited options in NSV japonica rice and a lack of information on their responses to N reduction make management decisions difficult. This study aims to explore the responses of yield and nitrogen use efficiency (NUE) in NSV to N reduction. Two newly released NSVs and two popular general varieties (GVs) of japonica rice were field tested in Yangzhou, located at the lower reaches of Yangtze River of China, in two consecutive years. The results showed that for NSVs, with a 40–60% reduction in common practice N rate (300 Kg ha−1), the rice yield could maintain a record average level (p < 0.05), whereas the yield for the GV would drop 20–30% (p < 0.05). This indicates that combining the practices of adoption of NSV and N reduction to 120–180 Kg N ha−1 could balance the yield and N consumption. Moderate N reduction promotes the N accumulation and NUE, and it increases the number of tillers, the productive tiller percentage and the total amount of spikelets in the population, and increases the carbon and N metabolism of the population in the NSV. Compared with GV, NSV showed higher NUE and non-structural carbohydrate re-mobilization in the reduced N rate. The results showed that the practice of N reduction has to adopt NSV at the same time in order to maintain the grain yield level in rice. [ABSTRACT FROM AUTHOR]

The origins of Cenozoic granites in the Himalaya are key to understanding the evolution of the Himalayan orogen. However, it is unclear whether these granites represent primary melts, and the nature of their magma source is controversial. Here, we present a systematic element and Sr–Nd–B–Mo isotope study of Cenozoic granites from the Yardoi area in the eastern Tethyan Himalaya, China. These granites can be divided into two groups: mid‐Eocene porphyritic two‐mica granites with low SiO2 contents (65.9−69.6 wt.%) and adakitic geochemical signatures, and mid‐Eocene to Miocene equigranular granites with high SiO2 contents (71.6−75.5 wt.%). The high‐SiO2 granites (HSG) have similar Sr−Nd isotope compositions to the low‐SiO2 granites (LSG), but they have distinct δ11B values of −19.4‰ to −11.4‰ and −10.6‰ to −6.89‰. This indicates that the two groups have different sources, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metasedimentary rocks with less enriched Nd isotope compositions. The δ98/95Mo of the LSG and HSG are highly variable with values of −0.68‰ to 0.12‰ and −1.13‰ to 0.46‰, respectively. δ11B values of the HSG correlate positively with δ98/95Mo and Sr/Y values and correlate negatively with K2O, Rb, Zr, and Rb/Sr, reflecting the addition of external metamorphic fluids during anatexis of the metapelites. The B–Mo isotope data robustly suggest source‐controlled compositional diversity of the Himalayan granites, which could provide clues to the physical and geochemical responses during the evolution of a large orogen. Plain Language Summary: Partial melts derived from crustal anatexis exhibit large compositional diversity. The relative influence of source compositions and magmatic differentiation on such heterogeneity is a subject of ongoing debate. B−Mo isotopes have the potential to trace the source compositions of crustal magmas. In this study, we present whole‐rock geochemical and B–Mo isotopic compositions of Cenozoic granites in the eastern Tethyan Himalaya. Samples with diverse mineralogical and geochemical features and ages (mid‐Eocene, early Oligocene, and Miocene) were investigated and can be divided into low‐SiO2 granites (LSG) and high‐SiO2 granites (HSG). Boron isotopes reveal different source compositions for the two groups, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metapelites. B–Mo isotopes combined with the variations in element contents/ratios provide evidence for the involvement of external fluids during the formation of the HSG. Our new data suggest that the geochemical diversity of anatectic melts is dominated by the nature of the source, including source lithology and fluid effects. This implies that the Himalayan granites could be potentially in tracing the thermal and tectonic evolution of the Himalayan orogen. Key Points: Boron isotopes reveal different source compositions for the Himalayan Cenozoic granitesB–Mo isotopes provide evidence for the involvement of external fluids during crustal anatexisHimalayan Cenozoic granites can potentially trace the evolution of a large orogen [ABSTRACT FROM AUTHOR]

China's healthcare system has been challenged by patient dissatisfaction with primary care and an increased tendency toward visiting high-level general hospitals, which undermine the vision of a hierarchical diagnosis and treatment system. Using the game theory, we built a model that incorporated patients' preferences and use of healthcare facilities to predict the utilization of primary care at the population level. We modeled patient behavior as an incomplete information game, whose equilibrium represents patient choice. A discrete choice model was built to describe patient satisfaction to compare the expected and actual utility. We proposed the quick fictitious play algorithm for the game model that could improve computation efficiency, using survey data from Jilin Province in the year of 2008 and 2013 in estimation, and data from 2018 to test the model's prediction accuracy, with a prediction error of approximately 5%. We subsequently used the prediction model to simulate various scenarios, to shed light on policy recommendations, to make a theoretical contribution that estimates patient utility under ordered multi-classification choice sets, and provided policy recommendations for proceeding toward a hierarchical diagnosis and treatment system. [ABSTRACT FROM AUTHOR]

Aeolian dust is closely related to land degradation, desertification, and sand and dust storm weather, and is a significant factor influencing the Earth's biogeochemical cycles. Here we present an investigation of the recent synoptic features of atmospheric dust in China and analyze its spatiotemporal change based upon meteorological observation data and satellite products. It shows that aeolian dust frequency in China has decreased gradually from 1984 to 2020. The outbreak frequency of dust storms declined significantly by 97.7%, followed by severe dust storm, dust in suspension, and blowing dust with 88.8%, 75%, and 64.3% reduction, respectively. The main dust sources influencing China are the Mongolian Gobi Desert, the Taklimakan Desert, the Hexi Corridor, the Alxa Plateau Desert, the Qaidam basin Desert, and the northeast‐southwest stretching semiarid farming‐pasture ecotone. Atlantic multidecadal oscillation (AMO) and Pacific decadal oscillation (PDO) may play an important role in teleconnection with aeolian dust event occurrence in China. Their correlation coefficients are −0.6 and 0.37, respectively. For more than 40 years, China has made huge investments in ecological restoration projects, and enacted national policies and laws to mitigate desertification. Significant environmental improvement has consequently ensued in China in the early 21st century, and the aeolian dust events were reduced to a record minimum in 2020. In contrast to the growing nationwide greenness, China is now facing up to an incremental dust risk generated from extraterritorial source regions such as the Mongolian Gobi Desert and Central Asian desiccated salt lakes. [ABSTRACT FROM AUTHOR]

Panax ginseng was a traditional Chinese medicine with various pharmacological activities and one of its important activities was hypoglycemic activity; therefore, panax ginseng has been used in China as an adjuvant in the treatment of diabetes mellitus. In vivo and in vitro tests have revealed that ginsenosides, which are derived from the roots and rhizomes of panax ginseng have anti-diabetic effects and produce different hypoglycemic mechanisms by acting on some specific molecular targets, such as SGLT1, GLP-1, GLUTs, AMPK, and FOXO1. α-Glucosidase is another important hypoglycemic molecular target, and its inhibitors can inhibit the activity of α-Glucosidase so as to delay the absorption of dietary carbohydrates and finally reduce postprandial blood sugar. However, whether ginsenosides have the hypoglycemic mechanism of inhibiting α-Glucosidase activity, and which ginsenosides exactly attribute to the inhibitory effect as well as the inhibition degree are not clear, which needs to be addressed and systematically studied. To solve this problem, affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was used to systematically select α-Glucosidase inhibitors from panax ginseng. The ligands were selected through our established effective data process workflow based on systematically analyzing all compounds in the sample and control specimens. As a result, a total of 24 α-Glucosidase inhibitors were selected from panax ginseng, and it was the first time that ginsenosides were systematically studied for the inhibition of α-Glucosidase. Meanwhile, our study revealed that inhibiting α-Glucosidase activity probably was another important mechanism for ginsenosides treating diabetes mellitus. In addition, our established data process workflow can be used to select the active ligands from other natural products using affinity ultrafiltration screening. [ABSTRACT FROM AUTHOR]

Summary: Lipu taro (Colocasia esculenta (L.) Schott) is a popular tuber crop in China. This study investigated the physicochemical and digestive properties of Lipu taro flour (LTF) and Lipu taro starch (LTS). The results showed that LTF was composed of LTS (79.13%) and non‐starch substances including protein (7.71%), lipid (0.32%), dietary fibre (2.13%), ash (1.05%) and moisture (9.17%). LTF had higher content of enzyme‐resistant starch (ERS, 36.52%) and the anon‐starch substances of protein and dietary fibre can inhibit the activity of digestive enzymes, which led to that LTF had a lower digestive degree during the in vitro gastrointestinal digestion than that of LTS. Moreover, LTS shared similar nutritional compositions including total starch (about 88%) and moisture (about 11%) to the commercial starches including rice, corn and wheat starches (RS, CS and WS, respectively). However, LTS showed the smallest particle size (0.485–7.211 μm) which conferred it the smallest DPn value (16725) compared with other high‐rapidly digestible starches (RDS) of RS and CS. The physical characteristics might have prevented the bonding of LTS to the digestive enzymes, leading to its lower digestive degree than that of RS and CS, and was comparable to the low‐RDS starch of WS. The results suggested that the consumption of LTF and LTS may not induce high glucose levels in human, suggesting Lipu taro is a healthy food. [ABSTRACT FROM AUTHOR]

Background: Air pollution is an important factor affecting residents' health. Methods: Based on the health data of 9959 residents from 28 provinces in China in the 2017 Chinese General Social Survey (CGSS), this paper uses a hierarchical linear model (HLM) to scientifically analyze the impact of air pollution on residents' health and to explore the moderating role of air pollution in various factors influencing residents' health. Results: Air pollution has significant negative effects on residents' health (coef. −0.103, p < 0.01), while frequency of exercise (coef. 0.070, p < 0.01), education level (coef. 0.012, p < 0.1) and income level (coef. 0.383, p < 0.01) have positive effects on residents' health. Air pollution has a negative moderating effect on the positive impact of exercise frequency on residents' health (coef. −0.015, p = 0.004). Conclusions: Air pollution causes serious damage to residents' health and it is necessary to control air pollution. Increasing residents' income, education level and exercise frequency can help improve residents' health level. Air pollution significantly reduce the positive impact of exercise frequency on residents' health. In order to effectively improve their own health, it is a better choice for residents to exercise when the air quality is good. [ABSTRACT FROM AUTHOR]

A new feather mite species Proctophyllodes gracilitussp. nov. is described from the mountain bulbul Ixos mcclellandii (Horsfield) (Passeriformes: Pycnonotidae) in China. The new species belongs to the mecistocaulus species-group and differs from the most similar species, P. stenophyllusGaud & Mouchet, 1957, by having the following characters: in males of P. gracilitus, the terminal lamellae are thinner and longer (45–49×4–5) and the posterior part of the hysteronotal shield has circular lacunae; and in females setae h1 are situated at the level of posterior margin of supranal concavity, setae h2 are longer than terminal appendages, do not have enlargement in base, and setae h3 are about 2/3rds the length of terminal appendages. In addition, Proctophyllodes weigoldiVitzthum, 1922 has been collected from the willow tit Poecile montanus (Baldenstein) (Passeriformes: Paridae) that is a new host record for this species. This species is redescribed, because it was found that specimens from Po. montanus have some minor morphological differences from specimens of the common blackbird Turdus merula Linnaeus (Passeriformes: Turdidae) (a type host) and eyebrowed thrush Turdus obscurus Gmelin (Passeriformes: Turdidae). [ABSTRACT FROM AUTHOR]

Background: Since initially detected in late December 2019, the novel coronavirus disease 2019 (COVID-19) outbreak rapidly swept the world, which has profoundly affected healthcare system and clinical practice in the management of gastrointestinal diseases. Objectives: We aimed to evaluate the impact of COVID-19 pandemic on the pattern of hospital admissions and healthcare services for acute pancreatitis (AP). Design: We conducted a retrospective observational cohort study using the anonymized electronic medical records. Methods: This single-center, retrospective observational study from a regional medical center in the northeast of China included all consecutively admitted patients with AP from 23 January to 10 June 2020 (during the COVID-19 outbreak in Harbin), compared with the equivalent period of the previous year, in terms of demographics, clinical characteristics, and in-hospital outcomes. Results: In this article, we observed a reduction in AP admissions after the beginning of COVID-19 outbreak. With the prolonged time from symptom onset to hospitalization [32.0 (22.0–72.0) versus 18.0 (12.0–24.0) h; p < 0.001], a higher proportion of AP patients developed acute renal failure (14.0% versus 7.4%, p = 0.004) and acute necrotic collection (16.5% versus 11.2%; p = 0.038) in the COVID-19 era. The percentage of alcohol etiology significantly decreased after the implementation of social restriction measures (11.5% versus 20.4%; p = 0.002), whereas biliary etiology was numerically more common amidst the COVID-19 era (41.6% versus 32.6%; p = 0.014). No significant differences were found in the rates of intensive care unit admission and mortality between the two groups. Conclusion: This study preliminarily demonstrated the descending trend and delay in hospital presentations for AP during the outbreak of COVID-19. Given that the pandemic may persist for several years, adjustments of medical services according to the varying degrees of local breakouts are imperative to provide appropriate care for AP patients and diminish the risk of viral transmission. Registration: ClincialTrials.gov number ChiCTR2100043350. [ABSTRACT FROM AUTHOR]

A species complex is an assemblage of closely related species with blurred boundaries, and from which species could arise from different speciation processes and/or a speciation continuum. Such a complex can provide an opportunity to investigate evolutionary mechanisms acting on speciation. The Chrysanthemum zawadskii species complex in China, a monophyletic group of Chrysanthemum, consists of seven species with considerable morphological variation, diverse habitats and different distribution patterns. Here, we used Hyb‐Seq data to construct a well‐resolved phylogeny of the C. zawadskii complex. Then, we performed comparative analyses of variation patterns in morphology, ecology and distribution to investigate the roles of geography and ecology in this complex's diversification. Lastly, we implemented divergence time estimation, species distribution modelling and ancestral area reconstruction to trace the evolutionary history of this complex. We concluded that the C. zawadskii complex originated in the Qinling–Daba mountains during the early Pliocene and then spread west and northward along the mountain ranges to northern China. During this process, geographical and ecological factors imposing different influences resulted in the current diversification and distribution patterns of this species complex, which is composed of both well‐diverged species and diverging lineages on the path of speciation. [ABSTRACT FROM AUTHOR]

Background Rapidly progressive immunoglobulin A nephropathy (RPIgAN) is a severe clinical phenotype of IgAN associated with a poor outcome. The recently published Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Guideline for the Management of Glomerular Diseases has proposed a new definition for RPIgAN that is based simply on a ≥50% decline in the estimated glomerular filtration rate (eGFR) over ≤3 months. Methods In 1677 IgAN patients followed at a single centre in China, we evaluated the utility of this new definition to identify the highest-risk IgAN patients who might be suitable for combination immunosuppressive therapy. Results The proportion of a ≥50% decline in eGFR over ≤3 months was 5.2%. The majority of these patients had reversible causes, with only 2.3% (39/1677) meeting the KDIGO 2021 criteria for RPIgAN. These patients had a significantly higher risk for end-stage kidney disease (ESKD) than non-RPIgAN patients (logrank P < 0.001). RPIgAN was an independent risk factor for ESKD [hazard ratio 3.99 (95% confidence interval 2.25–7.09); P <0.001]. A minority of the RPIgAN patients (25.6%) had ≥50% crescents. There was no significant difference in the risk for ESKD between patients in the RPIgAN group with ≥50% crescents and ˂50% crescents (logrank P = 0.27). Patients with RPIgAN and ≥50% crescents had a higher risk for ESKD than patients with non-RPIgAN and ≥50% crescents (logrank P = 0.04). Conclusions These data support the validity of the KDIGO 2021 definition but require independent validation in other non-Chinese cohorts. [ABSTRACT FROM AUTHOR]

Trichosporon asahii is an uncommon cause of fungal sepsis among neonates, but it is an important life-threatening opportunistic systemic pathogen. We report a case of T. asahii sepsis in a 980-g female baby born at 27 weeks of gestation. The extremely preterm initially presented with recurrent feeding intolerance and bloating; she subsequently developed oxygen saturation fluctuations, apnea, and a decreased heart rate. Blood culture was positive, and the causative agent was identified as T. asahii by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). According to reported minimum inhibitory concentration (MIC) values, the infant received a high dose of fluconazole (FLC, 12 mg/kg, qod) and was successfully treated. [ABSTRACT FROM AUTHOR]

Simple Summary: The tea grey geometrid Ectropis grisescens is a significant insect pest of tea plants in China. Parapanteles hyposidrae and Protapanteles immunis are Ectropis grisescens larval parasitoids. Here, we studied the parasitism performance of these two parasitoid species on different host densities under different temperatures as well as the interference effect of parasitoid density. We found that both parasitoid species, Pa. hyposidrae and Pr. immunis, exhibited a type II functional response towards the tea grey geometrid E. grisescens at four tested temperatures. With increasing the density of E. grisescens larvae, the number of parasitized larvae increased until a maximum was reached. Pr. immunis performed better than Pa. hyposidrae under higher temperatures. The parasitism rate by a single female parasitoid decreased with increasing parasitoid density at different temperatures, resulting in a reduction of searching efficiency. The findings of this study showed that Pr. immunis could be a better effective biocontrol agent than Pa. hyposidrae against the tea grey geometrid. The tea grey geometrid Ectropis grisescens has long been a significant insect pest of tea plants in China. Two parasitoids, Parapanteles hyposidrae and Protapanteles immunis (Hymenoptera: Braconidae: Microgastrinae), are the most important parasitoids in the larval stage of E. grisescens. Yet, the potential of these two parasitoids for controlling the tea grey geometrid is not known. Here, we studied the parasitism performance of these two parasitoid species on different host densities under different temperatures as well as the interference effect of parasitoid density. The results showed that both parasitoid species, Pa. hyposidrae and Pr. immunis, exhibited a Type II functional response towards the tea grey geometrid E. grisescens at four tested temperatures. With increasing the density of E. grisescens larvae, the number of parasitized larvae increased until a maximum was reached. The highest number of hosts parasitized by Pa. hyposidrae or Pr. immunis reached 14.5 or 14.75 hosts d−1 at 22 °C, respectively. The estimated values of instantaneous searching efficiency (a) and handling time (h) for Pa. hyposidrae or Pr. immunis were 1.420 or 3.621 and 0.04 or 0.053 at 22 °C, respectively. Pr. immunis performed better than Pa. hyposidrae under higher temperatures. The parasitism rate by a single female parasitoid decreased with increasing parasitoid density at different temperatures, resulting in a reduction of searching efficiency. The findings of this study showed that Pr.immunis could be a better effective biocontrol agent than Pa. hyposidrae against the tea grey geometrid. [ABSTRACT FROM AUTHOR]

Chinese perch (Siniperca chuatsi), an important fish for the aquaculture industry of China, is often affected by viral diseases. A stable and sensitive cell line can play an important role in virus identification and isolation, functional gene identification, virus pathogenic mechanism and antiviral immunity study. In the present study, a new cell line (S. chuatsi skin cell, SCSC) derived from the skin of S. chuatsi was established. The SCSC mainly consisted of fibroblastic‐like cells, which grew well in M199 medium supplemented with 10% foetal bovine serum at 25°C. Chromosome analysis revealed that the SCSC (44%) has a diploid chromosome number of 2n = 48. The SCSC can be transfected and expressed exogenous gene efficiently. It also showed high sensitivity to several aquatic animal viruses from different families including Rhabdoviridae, Iridoviridae and Reoviridae. In addition, RT‐PCR showed that S. chuatsi rhabdovirus (SCRV) started genome replication as early as 3 h post infection in the cells, which also induced the up‐regulation of a variety of immune‐related genes including these related to interleukin family, pattern recognition receptors, JAK–STAT pathway and interferon regulatory factors. In summary, current study provided a new tool in research of fish viruses and its interaction with host. [ABSTRACT FROM AUTHOR]

A ring species consists of two reproductively isolated forms connected by a chain of intergrading populations encircling a geographic barrier. The mountains encircling the Sichuan Basin in southwestern China harbor great species diversity and endemism, and they are candidate regions for ring species. Here, we examined a potential ring species complex with a ring distribution surrounding the Sichuan Basin and the reproductive barrier between sibling species Rhodiola yunnanensis and R. henryi of the R. yunnanensis complex. In this study, we test the hypothesis that R. yunnanensis and R. henryi diverged by the ring‐species model using an amplicon sequencing strategy targeting the introns of 27 single‐copy nuclear genes and 14 chloroplast DNA sequences. Our studies indicated that the R. yunnanensis complex is monophyletic, originates at the late Miocene, and forms its current ring distribution pattern after the LIG. In addition, clear genetic intergradation was not found among R. henryi populations within the distribution ring. All these findings suggest that the divergence of two sibling species was not driven by the geographic isolation, and they were not originated from the ring‐species model; however, the basin‐surrounding distribution pattern and reproductive barrier between them meet some criteria for being a ring species. [ABSTRACT FROM AUTHOR]

Riptortus pedestris Fabricius (Hemiptera: Alydidae) is an economically important pest of soybean that causes serious damage in the Huang-Huai-Hai region of China, which is the main soybean-producing area. However, the basic biological and ecological attributes of the Chinese populations of R. pedestris are still unknown. Temperature is a critical factor influencing insect population dynamics; therefore, understanding the effects of temperature on individual development and population growth of R. pedestris is helpful to forecast the pest's phenology as part of its control. In this study, we determined age–stage, two-sex life table parameters of R. pedestris at five constant temperatures (19, 22, 25, 28, and 31 °C) under laboratory conditions. The results demonstrated that the developmental period, preadult time, adult longevity, adult preoviposition period (APOP), and total preoviposition period (TPOP) were all significantly shortened when the temperature increased from 19 to 31 °C. The developmental time from egg to adult was 55.00 d at 19 °C but decreased to 24.43 d at 31 °C. The developmental threshold temperatures of the egg, nymph, female adult, male adult, and total generation (from egg to adult death) were 13.31, 10.91, 16.21, 17.13, and 13.44 °C, respectively, and the corresponding stage-specific day degree totals were 95.91, 260.51, 114.22, 147.35, and 582.04. The net reproductive rate (R0 = 2.36 offspring), fecundity (58.00 ± 28.59 eggs), and population trend index (I) (7.89) were found to be optimal at 25 °C. These results could be useful for predicting the population dynamics of R. pedestris and improving the management of this pest in field crops. [ABSTRACT FROM AUTHOR]

Codonopsis Radix, a popular food homology medicine, is widely used in clinical traditional Chinese medicine and food supplement, raw products and three types of processed products are the main forms of decoction pieces in China. However, there is no scientific basis for comprehensive chemical characterization of raw and three types of processed products. Herein, we investigated qualitatively and quantificationally secondary and primary metabolites in raw Codonopsis Radix and three types of processed products by metabolomics and glycomics employing multiple chromatography‐mass spectrometry technology combined with chemometric analysis further to look for differential compounds and propose the processing‐induced chemical mechanisms. The results indicated that Codonopsis Radix became dark‐colored and the smell of burnt incense odor was observed after processing. The principal component analysis demonstrated that secondary metabolome and glycome were significantly altered between raw and processed products, and 36 differential secondary metabolites and 11 differential primary metabolites were finally screened through orthogonal partial least‐squares‐discriminant analysis. The main types of compounds are alkaloids, terpenoids, glycosides, amino acids, monosaccharides, oligosaccharides, and furfural derivatives. Meanwhile, Chemical mechanisms could be involved, including oxidation, glycosidic hydrolysis, esterification, dehydration, and Maillard reaction. This work supplies a chemical basis for the application of various types of Codonopsis Radix decoction pieces. [ABSTRACT FROM AUTHOR]

Yarlung Zangbo Grand Canyon National Nature Reserve has the most complete vertical vegetation belts in China. However, identification and distribution of vertical vegetation belts is still uncertain and in debate. To explore the above issues, 190 plots were surveyed within the reserve from 2019 to 2021. Based on the vegetation plot data, cluster analysis, ordination analysis, and biodiversity statistics were performed to reveal the structure of vertical vegetation belts–the driving factors of vegetation distribution–to describe the main biodiversity patterns. Five vertical vegetation belts were identified by clustering. NMDS ordination showed that the main factor of vegetation distribution is elevation. Based on the results of the analysis and previous literature, a new scheme of vertical vegetation belts in the south slope of the reserve was proposed. There was a lower montane seasonal rainforest belt (600–1100 m), a lower montane evergreen broadleaf forest belt (1100–1800 m), a middle montane semi-evergreen broadleaf forest belt (1800–2400 m), a subalpine evergreen needleleaf forest belt (2400–3800 m), a alpine shrubland and meadow belt (3800–4400 m), an alpine sparse vegetation belt (4400–4800 m), and a nival belt (4800–7782 m). Among them, the seasonal rainforest belts are the northernmost distribution of this type, and the semi-evergreen broadleaf forest belts exist only in the Eastern Himalayas. The study showed a unimodal pattern in plant species diversity, the peak of which is about 1900 m. The middle montane semi-evergreen broadleaf forest belt had the highest species diversity in the reserve. This study settled the issues regarding the vertical vegetation belts, the main drivers of vegetation and assessment of plant species diversity in the south slope of the Yarlung Zangbo Grand Canyon National Nature Reserve. It provides essential support for the management and conservation of these ecosystems in the reserve. [ABSTRACT FROM AUTHOR]

In order to adapt to the healthy development of China's road network and the prosperity of the rural economy, rural roads are facing the need to continue to promote the construction of roads that reach deeper nodes. It is urgent to conduct in-depth and systematic research on the planning methods of China's rural networked roads. A road network model oriented to rural road network planning is proposed. First, the traffic demand is predicted, and then remote sensing technology and computer technology are used to evaluate the technical performance of the rural road network. The experimental results show that the comprehensive evaluation index value is 0.8 by combining the weight of each index, and the planning scheme is comprehensively evaluated. The evaluation results show that the program better supports the local social and economic development. [ABSTRACT FROM AUTHOR]

Purpose: Despite the growing research into luxury symbolism and its influence on consumer behavior, few studies have investigated the underlying psychological processes that occur in different cultural contexts. This study investigates the relationships among luxury symbolism, psychological underpinnings of self-congruity, self-affirmation and customer loyalty, especially regarding how these relationships differ between consumers in China and those in the US. Design/methodology/approach: Sample data were collected through surveys administered to 653 participants (327 in China and 326 in the US). A multi-group structural equation model was adopted to examine the conceptual model and proposed hypotheses. Findings: The results show that luxury symbolism positively influences self-consistency, social consistency, social approval and self-esteem, and subsequently impacts self-affirmation and customer loyalty. However, for US consumers, self-esteem and social approval have significantly negative impacts on self-affirmation, while for Chinese consumers, social approval has no significant impact on self-affirmation. The authors also find that interdependent self-construal positively moderates the relationship between luxury symbolism, and social approval and social consistency. Independent self-construal positively moderates the relationship between luxury symbolism and self-consistency, and negatively influences the relationship between luxury symbolism and self-esteem. Originality/value: Based on the theory of self-congruity and self-affirmation, this study fills a literature gap by revealing the psychological underpinnings regarding luxury symbolism and customer loyalty. It extends extant studies in luxury consumption by introducing self-construal (independent self vs interdependent self) as an important cultural moderator in luxury symbolism. This paper provides insights for luxury practitioners to create efficient marketing strategies by satisfying consumers' psychological needs in different cultures. [ABSTRACT FROM AUTHOR]

Objective: The present study aimed to analyze the risk factors and clinical outcomes of the incomplete endoscopic resection of rectal neuroendocrine tumors (rNETs).Methods: This study retrospectively analyzed the cases of 428 patients with rNETs who had undergone endoscopic treatment in the Department of Gastroenterology at the PLA General Hospital, China, between January 2010 and September 2019.Results: Of the 428 patients with rNETs, 266 were men (62.1%) and 162 were women (37.9%). Of these, 54 had been pathologically diagnosed with positive incisal margins without lymphatic vessel invasion, and the incomplete resection (R1) rate was 12.6%. Among the R1 patients, 28 had received endoscopic submucosal dissection, 22 had received endoscopic mucosal resection, two had received snare resection, and two had undergone removal with forceps. In addition, there were 31 cases of grade G1 R1 resection (11.2%; 31/277), 13 cases of grade G2 R1 resection (23.2%; 13/56), and 10 cases whose grading was not described. The univariate analysis showed the pathological grade was statistically correlated with R1 resection (P < 0.05), and the grade G2 R1 resection rate was higher than that of grade G1. The multivariate logistic regression analysis showed that grade G2 was an independent risk factor leading to R1 resection (P = 0.02). All patients with R1 resection were followed up for 10-110 months, with an average of 38 months. No salvage treatment was performed. The endoscopic monitoring showed there were no recurrences during the follow-up period.Conclusion: Endoscopic resection is a good option for rNETs, with a high complete resection rate and good prognosis, with rare recurrence even if endoscopic resection is not complete. [ABSTRACT FROM AUTHOR]

China has been accused of its quid pro quo policy which requires multinational firms to transfer technologies in return for market access. What is less well‐known is that developed countries have imposed export controls on a large variety of high‐tech products to China. We develop a simple two‐country model to understand the motives and consequences of these nontraditional trade and FDI policies. Under certain regularity conditions, we show that the coexistence of export controls and quid pro quo is the unique Nash equilibrium in this game. Comparing to the world without policy interventions, both countries are worse off in the noncooperative equilibrium. Therefore, both countries can benefit from international cooperation on knowledge sharing. [ABSTRACT FROM AUTHOR]

In accordance with the multilingual turn in SLA (May, S. 2014. Introducing the 'multilingual turn'. In The Multilingual Turn: Implications for SLA, TESOL and Bilingual Education, ed. S. May, 1–6. New York, NY: Routledge), researchers are now directing more attention to the motivational dynamics associated with learning multiple languages, including the interrelationships between motivation and learners' sense of self. In contrast to research focused on language learners' psychological relationship to languages from the perspective of self-systems, this research instead takes a more identity-focused perspective that looks at motivation in light of learners' orientations towards ideological discourses associated with languages. It draws on longitudinal qualitative interviews and supplementary data from five Chinese university students in Shanghai who are majoring in Japanese while continuing to study English. The analysis highlights that the learners experienced a number of important identity-tensions as they attempted to reconcile ideological discourses on language with their own multi-layered identity positions and perspectives towards language learning. The discussion details the ways that learners mobilise their interpretive resources to evaluate instrumental and humanistic orientations towards language within macro-, meso- and micro- contexts and make agentive decisions that shape their motivational trajectories and multilingual identities. [ABSTRACT FROM AUTHOR]

This study closely examined the motivational language selves of Chinese university students in the process of multilingual learning. Semi-structured interviews were conducted with twelve Japanese specialist majors. The qualitative data revealed the complex interplay between the participants' language selves and complicated contextual influences. The participants seemed to have strong ideal English self especially in the workplace and relatively weaker ideal Japanese self. They had strong ought-to Japanese self and their ought-to English self was suspended to some extent. Apart from their English and Japanese selves, they also constructed a multilingual self. The cultural, social and pedagogical contexts in which the participants were embedded exerted mixed influences on their self constructions. The findings suggest the neoliberal emphasis on the instrumental value of language and the negative impact of English as a global language on Japanese learning in such social discourse. This article is concluded with some pedagogical implications for language teachers. [ABSTRACT FROM AUTHOR]

Fusarium oxysporum f. sp. medicaginis (Fom) and Rhizoctonia solani (Rs) are the major soil-borne fungal pathogens that pose severe threats to commercial alfalfa production in China. However, the effects of Fom and Rs co-infection on alfalfa and whether co-infection alters disease resistance responses among diverse varieties remain unknown. A collection of 80 alfalfa varieties (Medicago sativa) originated from seven countries were used to study the effects of Fom and Rs co-infection on alfalfa and host resistance responses. The co-infection resulted in more severe disease and reductions in growth and biomass allocation across varieties in comparison with either single infection by Fom or Rs; in addition, root morphology was much more strongly altered by the co-infection. Principal component analysis based on all plant traits showed that varieties under the co-infection were related to the single infection by Rs, being separated from Fom, and hierarchical clustering found differential response patterns among varieties upon co-infection compared with either single infection, with most varieties being highly susceptible to the co-infection. Furthermore, varieties that were most resistant to either single infection were not effective to co-infection, and there was no individual variety with resistance to both pathogens singly and co-infected. This study reveals for the first time that the co-infection by Fom and Rs alters disease resistance responses among diverse alfalfa varieties and provides useful information for developing alfalfa varieties with resistance to the co-occurrence of different soil-borne pathogens. [ABSTRACT FROM AUTHOR]

Background: Given the context of rapid technological change and COIVD-19 pandemics, E-learning may provide a unique opportunity for addressing the challenges in traditional face-to-face continuing medical education (CME). However, the effectiveness of E-learning in CME interventions remains unclear. This study aims to evaluate whether E-learning training program can improve TB health personnel's knowledge and behaviour in China. Methods: This study used a convergent mixed method research design to evaluate the impact of E-learning programs for tuberculosis (TB) health workers in terms of knowledge improvement and behaviour change during the China-Gates TB Project (add the time span). Quantitative data was collected by staff surveys (baseline n = 555; final n = 757) and management information systems to measure the demographic characteristics, training participation, and TB knowledge. Difference-in-difference (DID) and multiple linear regression models were employed to capture the effectiveness of knowledge improvement. Qualitative data was collected by interviews (n = 30) and focus group discussions (n = 44) with managers, teachers, and learners to explore their learning experience. Results: Synchronous E-learning improved the knowledge of TB clinicians (average treatment effect, ATE: 7.3 scores/100, P = 0.026). Asynchronous E-learning has a significant impact on knowledge among primary care workers (ATE: 10.9/100, P < 0.001), but not in clinicians or public health physicians. Traditional face-to-face training has no significant impact on all medical staff. Most of the learners (57.3%) agreed that they could apply what they learned to their practice. Qualitative data revealed that high quality content is the key facilitator of the behaviour change, while of learning content difficulty, relevancy, and hardware constraints are key barriers. Conclusions: The effectiveness of E-learning in CME varies across different types of training formats, organizational environment, and target audience. Although clinicians and primary care workers improved their knowledge by E-learning activities, public health physicians didn't benefit from the interventions. [ABSTRACT FROM AUTHOR]

aim of this study was to adapt a Chinese version of the ATIHCTS among Chinese health care professionals and to test its validity. Methods: The English version of the ATIHCTS was translated into Chinese, back-translated, and modified for cultural adaptation according to Brislin's guideline. A total of 306 health professionals in a Shanghai tertiary hospital were investigated using the Chinese version of the ATIHCTS to test its validity. Results: The Chinese version of the ATIHCTS was adjusted based on expert review and pilot testing. According to expert opinions, the text that did not conform to the Chinese language habits and the Chinese medical environment was adjusted. A total of five adjustments were made. After the pilot testing, minor corrections were made to improve the sentence structure of the scale instructions to make it easier to understand. Factor analysis was subsequently conducted with 306 respondents. The Chinese version of the ATIHCTS had 14 items. Exploratory factor analysis extracted two common factors, quality of care and time constraints, with the cumulative variance contribution rate reaching 70.011% and the load value of each entry on its common factor > 0.4. In addition, for scale confirmatory factor analysis (CFA), the chi-square/degrees of freedom ratio (X2/df) was 1.46, the normed fit index (NFI) was 0.97, the Tucker-Lewis index (TLI) was 0.99, the incremental fit index (IFI) was 0.99, the comparative fit index (CFI) was 0.99, and the root mean square error of approximation (RMSEA) was 0.04. The fitting values all met the judgment criteria, and the scale had good structural validity. Cronbach's α of the Chinese version of the ATIHCTS was 0.861, and the Cronbach's α values of each factor were 0.949 and 0.838, respectively. The split-half reliability was 0.644, and the Guttman split-half coefficients of each factor were 0.904 and 0.779, respectively. Conclusion: The Chinese version of the ATIHCTS has good validity. It is a valuable tool for evaluating attitudes toward interprofessional health care teams among the health care professionals in China. [ABSTRACT FROM AUTHOR]

As representative varieties of the four phases of the super rice breeding project in China, Lianyoupei 9 (LYP9), Y Liangyou 1 (YLY1), Y Liangyou 2 (YLY2), and Y Liangyou 900 (YLY900) achieved higher yield under optimal cultivation techniques. However, the impact of these high-yield rice varieties on greenhouse gas (GHG) emissions under high-yield cultivation management practices remains poorly understood. In this study, we conducted field experiments to investigate CH4 and N2O emissions from paddies containing four elite rice varieties, managed with field drying at the ineffective tillering stage and alternate wet/dry irrigation at the grain-filling stage. The plants were fertilised with nitrogen (N) at three different rates. The results showed that CH4 emission was highest at the tillering stage. N2O emission flux was dramatically increased by field drying at the ineffective tillering stage, and with the rate of N application. Rice variety was among the most important factors affecting CH4 emission and global warming potential (GWP). N2O emission was mainly related to N application rate rather than rice variety. YLY2 achieved higher yield than LYP9, YLY1, and YLY900, and lower GHG emission than YLY900. Our results indicate that rice variety should be considered as a key factor to reduce GHG emissions from rice paddies under high-yield cultivation practices. Based on its high yield and low GHG emission at the study site, YLY2 may be an optimal rice variety. [ABSTRACT FROM AUTHOR]

Background: Age‐related cataracts (ARC) is the most common blinding eye disease worldwide, and its incidence tend to become younger. However, the relationship between genetic factors and mechanisms is not fully understood. The aim of the study was to further clarify the relationship between ARC and genetic mechanisms in East Asian populations and to elucidate the pathogenesis. Methods: The study collected 191 sporadic cataracts and 208 healthy people from the eastern provinces of China, with an average age of about 60 years. All participants were subjected to a comprehensive ophthalmic clinical examination and peripheral blood samples were collected and their genomic DNA was extracted. Mutations were screened among 792 candidate genes to enhance understanding of the disease through targeted capture and high‐throughput sequencing. Results: We identified novel candidate susceptibility gene, which may serve as a potential susceptibility factor leading to an increase in the incidence of age‐related cataracts. Three novel loci are associated with age‐related cataracts significant significance: rs129882 in DBH (p = 5.27E‐07, odds ratio = 3.9), rs1800280 in DMD (p = 2.85E‐06, odds ratio = 1.4) and rs2871776 in ATP13A2 (p = 4.18E‐05, odds ratio = 0.04). Gene–gene interaction analysis revealed that the most significant interactions between genes include the interaction between DBH and TUB (rs17847537 in TUB, rs129882 in DBH, p‐value = 2.12E‐14), and the interaction between DBH and DMD (rs1800280 in DMD, rs129882 in DBH, p‐value = 2.12E‐14). Pathway analysis shows that the most significant processes are concentrated in response to light stimulation (adjusted p‐Value = 5.56E‐03), response to radiation (adjusted P‐Value = 5.56E‐03), abiotic stimulus (adjusted p‐Value = 5.56E‐03). eQTL analysis shows that DBH rs129882 could regulate the expression of DBH mRNA in various tissues including retina. Conclusion: Our study indicates rs129882 and rs1800280 loci are associated with age‐related cataracts, which enlarge the gene map of age‐related cataracts. [ABSTRACT FROM AUTHOR]

Background: Panel‐based targeted exome sequencing was used to analyze the genetic and clinical findings of targeted genes in a cohort of northeast Chinese with retinitis pigmentosa. Methods: A total of 87 subjects, comprising 23 probands and their family members (total patients: 32) with confirmed retinitis pigmentosa were recruited in the study. Panel‐based targeted exome sequencing was used to sequence the patients and family members, all subjects with retinitis pigmentosa underwent a complete ophthalmologic examination. Results: Of the 23 probands, the clinical manifestations include night blindness, narrowing of vision, secondary cataracts, choroidal atrophy, color blindness, and high myopia, the average age of onset of night blindness is 12.9 ± 14 (range, 0–65; median, 8). Posterior subcapsular opacities is the most common forms of secondary cataracts (nine cases, 39.1%), and peripheral choroidal atrophy is the most common form of secondary choroidal atrophy (12 cases, 52.2%). Of these probands with complication peripheral choroidal atrophy, there were eight probands (66.7%, 8/12) caused by the pathogenic variation in USH2A gene. A total of 17 genes and 45 variants were detected in 23 probands. Among these genes, the commonest genes were USH2A (40%; 18/45), RP1 (15.6%; 7/45), and EYS (8.9%; 4/45), and the top three genes account for 56.5% (13/23) of diagnostic probands. Among these variants, comprising 22 (48.9%) pathogenic variants, 14 (31%) likely pathogenic variants, and nine (20%) uncertain clinical significance variants, and 22 variants was discovered first time. Most of the mutations associated with RP were missense (53.3%, 24/45), and the remaining mutation types include frameshift (35.6%, 16/45), nonsense (6.7%, 3/45), and spliceSite (4.4%, 2/45). Among the probands with mutations detected, compound heterozygous forms was detected in 13 (56.5%, 13/23) probands, and digenic inheritance (DI) forms was detected in five (21.7%, 5/23) probands. Conclusion: Panel‐based targeted exome sequencing revealed 23 novel mutations, recognized different combinations forms of variants, and extended the mutational spectrum of retinitis pigmentosa and depicted common variants in northeast China. [ABSTRACT FROM AUTHOR]

The genus Coniopteris was a dominate member of most Middle Jurassic floras globally. Strata in northern Xinjiang Province are well-known for containing abundant fern and ginkgo fossils, especially Coniopteris, usually identified as the Coniopteris-Phoenicopsis flora. We report a new species named Coniopteris sandaolingensis X. C. Yuan et B. N. Sun sp. nov in this paper which was collected from the Xishanyao Formation within the Turpan-Hami Basin. This species is recognized and described based on the architecture of its fronds and reproductive organ features. The fertile pinnae in this species are also slightly contracted, which suggests that currently known specimens belong to either Coniopteris or Eboracia to some extent, while its characteristic cup-like indusia show that it belongs to Coniopteris. This species is unique, however, because the first pinnule on the basiscopic side is forked into two equal lanceolate lobes. The results of our comparisons based on fossil Dicksoniaceae lead us to conclude that both present fossil and C. bella are likely transitional species that might provide insights into exactly how Coniopteris has evolved into other genera. The fossils discussed here led us to infer that the climate during the early Middle Jurassic of Sandaoling is warm and humid. [ABSTRACT FROM AUTHOR]

Four new species of the feather mite genus Mesalgoides (Acariformes: Psoroptoididae: Pandalurinae) are described from passerine birds (Passeriformes) in China: Mesalgoides morrisoniasp. nov. from Alcippe morrisonia Swinhoe (Leiothrichidae), M. vinaceasp. nov. from Carpodacus vinaceus Verreaux (Fringillidae), M. flammicepissp. nov. from Cephalopyrus flammiceps (Burton) (Paridae), and M. erythacasp. nov. from Pyrrhula erythaca Blyth (Fringillidae). [ABSTRACT FROM AUTHOR]

Question: Understanding the mechanisms determining species composition is one of the central goals in ecology. The limestone landscape of southwestern China is one of the most widely known landscapes developed on carbonate bedrock in the world. We explored the following question: What are the patterns of species composition and phylogenetic structures of the communities developed on the acid and limestone soils? Location: Southwestern China. Methods: Using 536 plots on acid and limestone soils, we identified distinct vegetation types on both soil types based on hierarchical clustering and ordination. Variation partitioning partitioned the effects of climate, geographic distance and soil on species composition. Generalized linear models determined the effects of climate and soil on phylogenetic diversities. Results: The typical vegetation on acid soils is evergreen broad‐leaved forests characterized by Castanopsis species, while typical vegetation on limestone soils is mixed evergreen and deciduous forests characterized by a high proportion of deciduous trees and calciphytes. Soil type was much more important in driving species composition than climate and spatial distance. The standardized mean pairwise phylogenetic distance (ses.MPD) and mean nearest taxon distance (ses.MNTD) were significantly lower on limestone soils than on acid soils, indicating a more clustered phylogenetic structure. The effect of soil on ses.MPD was stronger than on ses.MNTD, and ses.MNTD increased with increasing annual temperature and precipitation seasonality on acid soils but decreased on limestone soils, suggesting that soil affected phylogenetic structure at relatively deep branches, while climate combined with soil mainly affects the relatively recent branches, as ses.MPD measures phylogenetic structure at deep branches and ses.MNTD that at shallow branches. Conclusions: This study highlights the importance of soil in shaping community structure at a regional scale, and it also reveals the unique features of limestone vegetation and supports the validity of limestone vegetation types in the Chinese vegetation classification system. [ABSTRACT FROM AUTHOR]

Oil and gas pipelines are of great importance in China, and pipeline security problems pose a serious threat to society and the environment. Pipeline safety has therefore become an integral part of the entire national economy. Landslides are the most harmful type of pipeline accident, and have directed increasing public attention to safety issues. Although some useful results have been obtained in the investigation and prevention of pipeline-landslide hazards, there remains a need for effective monitoring and early warning methods, especially when the complexity of pipeline-landslides is considered. Because oil and gas pipeline-landslides typically occur in the superficial soil layers, monitoring instruments must be easy to install and must cause minimal disturbance to the surrounding soil and pipeline. To address the particular characteristics of pipeline-landslides, we developed a multi-parameter integrated monitoring system called disaster reduction stick equipment. In this paper, we detail this monitoring and early warning system for pipeline-landslide hazards based on an on-site monitoring network and early warning algorithms. The functionality of our system was verified by its successful application to the Chongqing Loujiazhuang pipeline-landslide in China. The results presented here provide guidelines for the monitoring, early warning, and prevention of pipeline geological hazards. [ABSTRACT FROM AUTHOR]