Search

Background Ribonucleotide reductase subunit M2 (RRM2) plays a key role in cell and hepatitis B virus (HBV) replication. Nevertheless, its clinical implications for managing liver diseases have been inadequately studied. Methods A total of 412 participants were enrolled, including 60 healthy control individuals, 55 patients with chronic hepatitis B (CHB), 173 patients with cirrhosis, and 124 patients with hepatocellular carcinoma (HCC). Serum RRM2 was measured via ELISA. Results The level of serum RRM2 in patients with CHB, cirrhosis, and HCC was higher than that in healthy controls (P < .05). A large difference in serum RRM2 was found between HBV-related and non–HBV-related patients in the cirrhosis group (P < .001), compared with the difference between HBV-related HCC and non–HBV-related HCC (P  = .86). In the HBV-related cirrhosis group, the serum RRM2 level showed significant positive correlations with HBV DNA, hepatitis B surface antigen, hepatitis B e antigen, Child-Pugh scores, and MELD scores and played a strong role in diagnosing HBV-related cirrhosis in CHB, compared with fibrosis-4 score and aspartate aminotransferase–to-platelet ratio index. Conclusions Serum RRM2 is a reliable biomarker for accurate HBV-related cirrhosis diagnosis and evaluation. Also, serum RRM2 could reflect the expression state of HBV replication in patients with HBV-related cirrhosis. [ABSTRACT FROM AUTHOR]

The shared parking scheme improves the utilization rate of existing parking resources and contributes to the sustainable development of cities, but many private parking spaces that are not included in the shared parking scheme have a low utilization rate in China. In order to better promote the shared parking scheme, it is necessary to study the intention of the owners of private parking spaces to share their parking spaces. Therefore, this paper used the Unified Theory of Acceptance and Use of Technology (UTAUT) and Benefit-Risk Analysis Model (BRA) as the combined theoretical framework (C-UTAUT-BRA). Hypothesis testing using the Multiple Indicators and Multiple Causes (MIMIC) model was performed using an empirical assessment of the shared parking scheme in China. The results show that (1) the sharing behavioral intention (BI) is directly affected by perceived benefit (PB), perceived risk (PR), social influence (SI), and facilitating condition (FC) and indirectly affected by effort expectancy (EE), of which the total effect of PB is the largest; (2) exogenous variables have an indirect effect on BI through other psychological latent variables; among them, different sociodemographic and economic characteristics have a significant influence on different latent variables, while the built environment has no significant effect on latent variables. This research contributes to theory building in shared parking participation intention and informs business and government leaders on how to promote the shared parking scheme through the action mechanism of influencing factors on BI. [ABSTRACT FROM AUTHOR]

The implementation of shared parking program can effectively increase the utilization rate of existing parking space resources. At present, shared parking program has not been widely practiced in China, and the prerequisite for this prospect to be implemented is whether the private parking space owner group can quickly and widely accept shared parking program. In this study, considering the differences in the economic development, urban planning, and parking pressure in cities of different levels, the theory of planned behavior and the benefit-risk perception model (C-TPB-BRA) are combined as the theoretical framework to explore the intention to share parking space from the perspective of the owners of private parking spaces in cities of different levels. Based on China's empirical data, structural equation models are built to verify the hypotheses proposed. Our results show that (a) the intention of private parking space owners in different levels of cities to participate in shared parking and the mechanism of action of the psychological factors are different, and not all psychological factors have a direct impact on the intention to share. In first-tier, second-tier, and third-tier cities, Subjective Norm (SN) and Perceived Behavioral Control (PBC) indirectly affect Behavior Intention (BI) through Attitude (ATT), Perceived Benefit (PB), and Perceived Risk (PR). In the fourth-tier cities, SN and PBC directly affect BI. Except for BI, other psychological factors influence each other significantly; (b) the psychological factors affecting the intention to supply shared parking spaces in first-tier, second-tier, third-tier, and fourth-tier cities, respectively, are PB > ATT > PR, PB > PR > ATT, PB > PR > ATT, and PB > SN > PBC > ATT > PR. Our research results could help determine the internal factors that affect the intention of parking space suppliers and their mechanisms of action to participate in shared parking, and on that basis, our findings could also help governments and platform operators to promote shared parking development plans. [ABSTRACT FROM AUTHOR]