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Objective: To investigate the influencing factors for non/low-response to hepatitis B vaccine in infants of HBsAg-positive mothers. Methods: A total of 286 HBsAg-positive pregnant women and their infants were recruited from the Third People's Hospital of Taiyuan during July 2011 to January 2013. The infants were immunized with hepatitis B vaccine according to the 0-1-6 month vaccination schedule and followed up for 12 months. The serum HBV DNA level of mothers, neonates and infants were detected by electro chemilum inescence immunoassay kits and fluorescene quantiative polymerase chain rection. Results: Among 286 infants, the rate of non/low-response to hepatitis B vaccine was 18.53 % (53/286). Non-conditional logistic regression analysis indicated that the mother's HBV DNA level ≥1×10(7) copies/ml ( OR =2.592, 95 %CI : 1.121-5.996) and natural birth ( OR =1.932, 95 %CI : 1.021-3.654) were the risk factors for non/low-response to hepatitis B vaccine, the risks were 2.592 times and 1.932 times higher compared with the infants whose mothers were HBV DNA negative and the infants whose mothers had cesarean delivery. There was no multiplicative or additive interaction between high HBV DNA load and natural birth ( OR =1.055, 95 %CI : 0.209-5.321), ( RERI =1.617, 95 %CI : -4.038-7.272; AP =0.364, 95 %CI : -0.527-1.225; SI =1.195, 95 %CI : 0.270-13.135). After stratified analysis of mother's HBV DNA level, delivery mode of mothers was not associated with non/low-response of their infants. Conclusion: The mother's load of HBV DNA≥1×10(7) copies/ml might be the factor for non/low-response to hepatitis B vaccine in infants of HBsAg positive mothers.

In order to estimate the occurrence of Preterm Delivery (PD) and factors associated with PD, 1141 perinatal cases at first affiliated hospital were collected by the method of systematic random sampling. The occurrence rate of PD was 6.0%. Multivariate analysis revealed that the history of premature birth, twin pregnancy, polyhydramnios, placenta praevia, premature rupture of fetal membranes and Bart's fetal hydrops were the main risk factors with statistical significance. Path analysis showed that the history of premature birth had indirect positive effect (elevating risk of PD) on PD through premature rupture of the fetal membranes and Bart's fetal hydrops. Similarly, twin pregnancy had indirect positive effect through premature rupture of the fetal membranes and polyhydramnios. It is suggested that proper health care of the pregnant mother attending to the risk factors should be emphasized to prevent the occurrence of PD.