1. Ethnic variation in genotype frequencies of a p53 intron 7 polymorphism.
- Author
-
Berggren P, Kumar R, Steineck G, Ichiba M, and Hemminki K
- Subjects
- Asian People genetics, China epidemiology, DNA genetics, DNA, Neoplasm genetics, Ethnicity statistics & numerical data, Finland epidemiology, Gene Frequency, Genotype, Humans, Hungary epidemiology, India epidemiology, Italy epidemiology, Japan epidemiology, Poland epidemiology, White People genetics, Ethnicity genetics, Genes, p53 genetics, Genetic Variation genetics, Introns genetics, Polymorphism, Genetic genetics
- Abstract
Using a PCR-restriction enzyme-based method we found large ethnic variations when a C-->T polymorphism in the human p53 gene at position 14181 in intron 7 was studied in Finnish, Polish, Hungarian, Italian, Japanese, Indian and Chinese populations. The largest variations were found between Caucasian and Asian, genotype frequencies varied from C 0.95 and T 0.05 in the Finnish population to C 0.67 and T 0.33 in the Chinese population, the relative risk (RR) for T being 6.5 (95% CI 3.4-12.3, P < 0.001). Variations were also found between Finnish and Italian and between Italian and Chinese (RR for T 2.4, 95% CI 1.2-4.9 and 2.7, 95% CI 1.7-4.2, respectively).
- Published
- 2001
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