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China's development is inseparable from the reform of education, so ECE is very important in the development of Chinese society. Based on this reason, this paper introduces the three reform waves of communist Chinese society under the influence of western culture. Because the professional level of kindergarten teachers does not match the concepts and requirements of the three preschool curriculum reforms in Chinese society, this paper analyzes the solutions based on this problem and holds that the leadership of kindergarten teachers should be vigorously developed. [ABSTRACT FROM AUTHOR]

Background: With China's population ageing rapidly, stroke is becoming one of the major public health problems. Nurses are indispensable for caring for older patients with acute and convalescent stroke, and their working experiences are directly linked to the quality of care provided. The study aims to investigate registered nurses' experiences of caring for older stroke patients. Methods: A qualitative descriptive design was adopted. Data were collected via semi-structured interviews with 26 registered nurses about their lived experiences of caring for older stroke patients. Thematic analysis was used to analyze the data. Results: Two main themes were identified. First, the nurses identified an obvious gap between their ideal role in elderly care and their actual practice. The unsatisfactory reality was linked to the practical difficulties they encountered in their working environment. Second, the nurses expressed conflicting feelings about caring for older stroke patients, displaying a sense of accomplishment, indifference, annoyance, and sympathy. Caring for older stroke patients also affects nurses psychologically and physically. The nurses were clear about their own roles and tried their best to meet the elderly people's needs, yet they lack time and knowledge about caring for older stroke patients. The factors influencing their working experiences extend beyond the personal domain and are linked to the wider working environment. Conclusions: Sustaining the nursing workforce and improving their working experiences are essential to meet the care needs of older people. Understanding nurses' lived working experiences is the first step. At the individual level, nurse mangers should promote empathy, relieve anxiety about aging, and improve the job satisfaction and morale of nurses. At the institutional level, policymakers should make efforts to improve the nursing clinical practice environment, increase the geriatric nursing education and training, achieve a proper skill mix of the health workforce, and overall attract, prepare and sustain nurses regarding caring for older people in a rapidly aging society. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to explore a suitable method for analyzing road transport accidents that involve hazardous materials and to explore the main factors that influence the occurrence of accidents of varying severity.Methods: The 2015-2019 reported crash data from the Ministry of Transport of the People's Republic of China were obtained, and road transport crashes involving hazardous materials were extracted as the analysis data. The dataset was classified into three injury severity categories: property damage only (PDO), injured (INJ), and fatal (FAT). A statistical model and three machine learning-based models were developed: a random parameters logit model (RPLM), multilayer perceptron (MLP), decision tree C5.0 (C5.0) and support vector machine (SVM). The four models were trained/estimated using the training/estimation dataset, and the best model was used to model accidents of the three different severity levels. The main factors that influence the occurrence of accidents at each crash severity level were obtained.Results: C5.0 had the best modeling performance. The direct accident form (DAF), indirect accident form (IAF) and road segment (RS) were determined to be the critical determinants of PDO accidents. The DAF, IAF, road type, RS and time had a substantial effect on INJ accidents. The DAF, IAF, hazardous material type (HMT) and road surface condition were important factors in the occurrence of FAT accidents.Conclusions: Different data have unique characteristics, and the best modeling and analysis method should be chosen accordingly. The safety of road transport of hazardous materials in China is poor, and the losses caused by accidents are substantial. Strengthening the monitoring of travel speed and travel time; improving driver safety awareness, driving skills and the ability to mitigate emergencies; improving the configuration of vehicle safety equipment and the linkage with the control center and rescue center; improving the environmental differences between inside a tunnel and outside a tunnel; reducing the design of long downhill and steep slope sections; reducing the transport plan in unsafe environments; and improving the ability of road management to mitigate bad environments can be effective measures to reduce the severity of road transport accidents involving hazardous materials. [ABSTRACT FROM AUTHOR]

This article investigates how government intervention in the urban land supply affects China's housing market over time using panel data from 35 cities between 2004 and 2014. We find that the restriction of urban land supply has varied effects upon real estate destocking over different time periods and under the influence of the development status of different cities. In cities with relatively high housing-price-to-income ratios (>9), the effect of residential land quota control is not substantial within three years, whereas that of land supply price regulation is significant. In contrast, in cities with relatively low housing-price-to-income ratios (<7), quantitative control of land supply has a significant positive effect on real estate destocking. For cities whose ratios lie between 7 and 9, regulation of both land supply and land price negatively impact the housing market. Moreover, we cannot neglect the fact that these government interventions in the land market will have crucial consequences on housing consumption due to subjective psychological expectations. Based on these findings, we argue that top-down policy intervention should be more prudent, and that future government regulations need to be refined to consider specific local conditions. [ABSTRACT FROM AUTHOR]

Objective:Due to the sheer size and capacity of the tanker and the properties of cargo transported in the tank, hazmat tanker accidents are more disastrous than other types of vehicle accidents. The aim of this study was to provide a current survey on the situation of accidents involving tankers transporting hazardous materials in China. Methods:Detailed descriptions of 708 tanker accidents associated with hazmat transportation in China from 2004 to 2011 were analyzed to identify causes, location, types, time of occurrence, hazard class for materials involved, consequences, and the corresponding probability. Results:Hazmat tanker accidents mainly occurred in eastern (38.1%) and southwest China (12.3%). The most frequent hazmat tanker accidents involved classes 2, 3, and 8. The predominant accident types were rollover (29.10%), run-off-the-road (16.67%), and rear-end collisions (13.28%), with a high likelihood of a large spill occurring. About 55.93% of the accidents occurred on freeways and class 1 roads, with the spill percentage reaching 75.00% and the proportion of spills that occurred in the total accidents amounting to 77.82%, of which 61.72% are considered large spills. The month with the highest accident probability was July (12.29%), and most crashes occurred during the early morning (4:00–6:00 a.m.) and midday (10:00 a.m.–12:00 p.m.) hours, 19.63% versus 16.10%. Human-related errors (73.8%) and vehicle-related defects (19.6%) were the primary reasons for hazmat tanker crashes. The most common outcomes of a hazmat tanker accident was a spill without further events (55.51%), followed by a release with fire (7.77%), and release with an explosion (2.54%). Conclusions:The safety situation of China's hazmat tanker transportation is grim. Such accidents not only have high spill percentages and consistently large spills but they can also cause serious consequences, such as fires and explosions. Improving the training of drivers and the quality of vehicles, deploying roll stability aids, enhancing vehicle inspection and maintenance, and developing good delivery schedules may all be considered effective measures for mitigating hazmat tanker accidents, especially severe crashes. [ABSTRACT FROM AUTHOR]

• The theory of planned behavior was used to investigate the behavior of delivery riders running red lights. • The structural equation model was used to predict delivery riders running red lights. • Attitude, conformity tendency and the traffic environment were significant predictors in the modified TPB model. • The results of multiple group analysis show that differences between the means of psychological variables of different population groups. • Some intervention measures are obtained by analyzing the influencing factors of running red lights. Delivery riders, an occupation that has emerged from China's booming E-commerce industry, have attracted widespread attention due to their red-light running (RLR) and high accident rates. This study aimed to utilize the theory of planned behavior (TPB) to investigate the psychological characteristics of delivery riders' RLR intentions. A survey questionnaire was designed to collect data, including information regarding the extended variables, the basic components of the TPB and demographic characteristics. The survey was conducted in Xi'an, and 228 complete questionnaires were collected. Structural equation modeling was used to examine the data, and a multiple group analysis of the demographic variables was conducted. The results showed that the expanded TPB model had a better model fit and higher variance explanation than the original TPB model. Extended constructs, i.e., conformity tendency (CT) and the traffic environment (TE), were significant predictors, and attitude was the strongest predictor of all the examined variables related to RLR intentions. Finally, the path parameters of the expended TPB model were adapted for different demographic groups, and some differential effects were also found. These results could provide a basis for the design of intervention measures and safety education schemes by delivery platforms and traffic management departments to reduce RLR behavior among delivery riders. [ABSTRACT FROM AUTHOR]

As an important source of atmospheric methane, methane emissions from coastal wetlands are affected by many factors. However, the methane emission process and interrelated coupling mechanisms in coastal wetland soils of a variety of environments remain unclear owing to complex interactions between intensified anthropogenic activities and climate change in recent years. In this study, we investigated methane cycling processes and the response mechanisms of environmental and microbial factors in soils at different depths under four typical coastal wetland vegetation types of the Yellow River Delta, China, using laboratory culture and molecular biology techniques. Our results show that methane generation pathways differed among the different soil layers, and that the methane emission process has a special response to soil N compounds (NO 3 −, NH 4 +). We found that nitrogen can indirectly affect methane emission by impacting key physicochemical properties (pH, oxidation reduction potential, etc.) and some functional communities (mcrA , ANME-2d, sulfate-reducing bacteria (SRB), narG , nosZ II). Methane production processes in shallow soils compete closely with sulfate reduction processes, while methane emissions facilitated in deeper soils due to denitrification processes. We believe that our results provide a reference for future research and wetland management practices that seek to mitigate the global greenhouse effect and climate change. [Display omitted] • Soil nitrogen has an important driving role in wetland methane emissions. • Sulfur and nitrogen cycles are differently coupled to methane emission processes in shallow versus deep soils. • Coastal wetland vegetation mainly affects soil methane emission through soil water content and soil salinity. • Vegetation increases methane production pathways and methane emissions. [ABSTRACT FROM AUTHOR]

Glucocorticoids (GCs), as important endocrine disrupting compounds and emerging contaminants, could have irreversible adverse effects on aquatic organisms even at ng/L levels. However, previous studies have only focused on the dissolved concentrations of GCs in the water, and limited data are available for their occurrences in the solid phase. In this study, the occurrence, distribution, and environmental risks of 61 natural and synthetic GCs in surface water of the Yellow River Delta (YRD) were simultaneously analyzed by investigating water, suspended particulate matter (SPM) and sediment samples at 64 sites in six major rivers in the wet season. Overall, 51 GCs were detected in all samples from different matrices, and their concentrations were in the range of not detected (ND)-274 ng/L in water, ND-42 ng/g dry weight (dw) in SPM and ND-9.98 ng/g dw in sediment. Natural GCs were the dominant compounds in all samples, followed by synthetic halogenated esters. High concentrations of GCs were observed in discharge outlet samples from livestock farming, aquaculture and industrial production, and the composition differences of GCs between human/animal sources and industrial sources could be used as indicators to identify pollution sources. Most GCs were distributed in the water phase, while compounds with higher log octanol/water partition coefficients (log K ow ) tended to be adsorbed to SPM and sediment. The spatial distribution of GCs was primarily affected by anthropogenic activities and hydrodynamic conditions. Four synthetic compounds (budesonide [BD], fluocinolone acetonide [FOA], fluticasone propionate [FP], and clobetasol propionate [CBSP]) were identified as the main contributors to GC activity with a combined contribution of 57 %-95 %. Risk assessment using the risk quotient revealed that low to moderate risks are posed to aquatic organisms in surface water., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

Progestins (PGs) are a group of steroid hormones known to have endocrine-disrupting effects. These compounds can enter the aquatic environment via the discharge of treated or untreated wastewater and the disposal of sludge from sewage treatment plants (STPs); thus, their removal in STPs are of great importance. The present study simultaneously investigated the occurrences and fates of 62 PGs in a municipal STP in Beijing, China. Progesterone (P) and its metabolites were found to be the predominant compounds, with total dissolved concentrations of 1866 ng/L in the influent. About 11 P metabolites were newly detected, accounting for 25-55% and 75-91% of the total concentrations in wastewater and sludge, respectively. For the other three groups of PGs derived from different parent compounds, P derivatives were first detected in the STP with the highest concentration in the wastewater and sludge, followed by 19-nortestosterone (NT) derivatives and 17α-hydroxyprogesterone (17α-OHP) derivatives. The removal efficiencies in the dissolved phase of wastewater were relatively high for P and its metabolites (95-99%) and P derivatives (91-99%). And the relative persistence of NT (68-99%) and 17α-OHP derivatives (79-99%) was observed during the wastewater treatment processes. Mass balance analysis showed that the lost mass proportions were as high as 41-99%, the mass fractions in sludge were in the range of 0-55%, and 0.24-25% of the initial mass loadings was present in the effluent. These results indicated that biodegradation was the major removal mechanism of PGs in the STP., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Background: Major depressive disorder (MDD) is a common psychiatric disorder. With systematic antidepressant treatment, 50-75% of patients have a treatment response but require 4-6 weeks to have their symptoms alleviated. Therefore, researchers anticipate the development of novel fast-acting antidepressants. Previous studies have revealed that the decrease of bio-energetic metabolism may contribute to the occurrence of depression, while our team has found adenosine triphosphate (ATP) and phosphocreatine (PCr) to be fast-acting antidepressants in the depressed-animal model. ATP and PCr have already been widely prescribed clinically as energy supplements for cells. This will be the first clinical attempt of the intravenous administration of ATP and PCr combined with orally administered fluoxetine in MDD., Methods: This is a single-center, randomized, double-blind, placebo-controlled pilot study. A total of 42 patients will be divided randomly into three groups. Patients will receive an intravenous administration of ATP or PCr or saline twice daily combined with orally administered fluoxetine (20 mg/day) for the first 2 weeks and fluoxetine monotherapy for the following 4 weeks. Follow-up assessment will be completed at week 10. Feasibility outcomes will include percentages of patient eligibility, intention to use medication, willingness to participate, drug adherence, completion of the scheduled assessment, retention, drop-out, etc. Physical examination results, Side Effect Rating Scale, adverse events, results from blood tests, electroencephalogram, and electrocardiograph will be recorded for safety evaluation of the augmentation therapy. The trends of efficacy will be evaluated by the reduction rate of the Hamilton Depression Rating Scale, the mean change of the Clinical Global Impression Scale, and the Patients Health Questionaire-9 items., Discussion: In our study, ATP and PCr will be given by intravenous infusion. Thus patients will be hospitalized for the initial 2 weeks for safety concern. Hospitalization will be an impact factor for the recruitment, participation, drop-out, efficacy, results, etc. The evaluation of our feasibility outcomes, study setting, safety of augmentation therapy and possible efficacy trends among groups, will facilitate a full-scale trial design and sample size calculation., Trial Registration: NCT03138681 . Registered on 3 May 2017. First patient: 4 May 2017.

Objective: This study aimed to investigate the clinicopathologic features and prognostic factor in patients with epithelioid trophoblastic tumor (ETT)., Methods: From January 2002 to June 2010, the clinicopathologic characteristics, treatments, outcomes, and prognosis of 9 patients with ETT were analyzed retrospectively in our institution., Results: Of 9 patients, 8 (88.9%) had metastases. The histopathologic results of 7 patients (77.8%) with poor outcomes showed diffuse multifocal disease within the uterus, full-thickness myometrial invasion, uterine serosal involvement, and extensive necrosis. The size of the uterus exceeded 8 weeks of gestation in 7 patients. Two of them had poorly differentiated carcinoma. All patients were treated with multimodality treatment that combined with surgery and chemotherapy. After the initial treatments, 5 patients with International Federation of Gynecology and Obstetrics stage I achieved complete remission (CR), 1 patient achieved partial remission, and 3 patients (33.3%) had no response to treatments and died of progressive disease. After following up for 6 to 107 months (mean, 24 months), 4 (44.4%) of the 5 patients with initial CR had relapse: 3 of them achieved a second CR and the other 1 was under treatment., Conclusions: Epithelioid trophoblastic tumor is a rare and special type of intermediate trophoblastic tumor with a high degree of malignancy and poor prognosis. Multifocal lesions in bulky uterus, combined with full-thickness myometrial invasion and uterine serosal involvement, could be related to poor outcomes in patients with ETT. The prognosis of ETT could be improved by increasing diagnostic accuracy, identifying prognostic factor at an early stage, and providing early intensive multimodality treatment to patients with poor prognostic factors.