6 results on '"S. Inoue"'
Search Results
2. Patterns of exposure to adverse childhood experiences and their associations with mental health: a survey of 1346 university students in East Asia.
- Author
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Ho GWK, Bressington D, Karatzias T, Chien WT, Inoue S, Yang PJ, Chan ACY, and Hyland P
- Subjects
- Adolescent, China, Depression, Female, Hong Kong, Humans, Japan, Male, Mental Disorders, Surveys and Questionnaires, Taiwan, Universities, Violence, Young Adult, Adverse Childhood Experiences, Mental Health, Students psychology
- Abstract
Introduction: Adverse childhood experiences (ACEs) constitute a significant global mental health burden. Prior studies typically investigated the impact of ACEs on mental health using a cumulative risk approach; most ACEs studies were also conducted in Western settings., Purpose: This study aimed to examine ACEs using a pattern-based approach and assess their associations with mental health outcomes by early adulthood in East Asia., Methods: The present study included measures of exposure to 13 categories of ACEs, depression, anxiety, maladjustment, and posttraumatic stress in a sample of 1346 university students from Hong Kong, China, Taiwan, and Japan., Results: Latent class analysis indicated three distinct patterns of ACE exposure: Class 1: Low ACEs (76.0%); Class 2: Household Violence (20.6%); and Class 3: Household Dysfunction (3.4%). Those representing Class 3 had significantly more ACEs compared with those in Classes 1 or 2. Controlling for age and sex, those in Class 2 reported significantly higher depression and maladjustment symptoms compared with those in Class 1; both Classes 2 and 3 had significantly higher anxiety symptoms and odds for meeting diagnostic criteria for posttraumatic stress disorders compared with those in Class 1., Conclusions: Study findings suggest that young adults' mental health, at least under certain contexts, is more closely linked with the nature and pattern of ACE co-occurrence, rather than the number of ACEs.
- Published
- 2020
- Full Text
- View/download PDF
3. A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.
- Author
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Huang L, Zhang H, Cheng CY, Wen F, Tam PO, Zhao P, Chen H, Li Z, Chen L, Tai Z, Yamashiro K, Deng S, Zhu X, Chen W, Cai L, Lu F, Li Y, Cheung CM, Shi Y, Miyake M, Lin Y, Gong B, Liu X, Sim KS, Yang J, Mori K, Zhang X, Cackett PD, Tsujikawa M, Nishida K, Hao F, Ma S, Lin H, Cheng J, Fei P, Lai TY, Tang S, Laude A, Inoue S, Yeo IY, Sakurada Y, Zhou Y, Iijima H, Honda S, Lei C, Zhang L, Zheng H, Jiang D, Zhu X, Wong TY, Khor CC, Pang CP, Yoshimura N, and Yang Z
- Subjects
- Cells, Cultured, China, Cohort Studies, Endothelium, Vascular cytology, Endothelium, Vascular metabolism, Ethnicity, Gene Expression Profiling, Guanine Nucleotide Exchange Factors metabolism, Humans, Polymorphism, Single Nucleotide, Subcellular Fractions metabolism, Guanine Nucleotide Exchange Factors genetics, Mutation, Missense, Wet Macular Degeneration genetics
- Abstract
Polypoidal choroidal vasculopathy (PCV), a subtype of 'wet' age-related macular degeneration (AMD), constitutes up to 55% of cases of wet AMD in Asian patients. In contrast to the choroidal neovascularization (CNV) subtype, the genetic risk factors for PCV are relatively unknown. Exome sequencing analysis of a Han Chinese cohort followed by replication in four independent cohorts identified a rare c.986A>G (p.Lys329Arg) variant in the FGD6 gene as significantly associated with PCV (P = 2.19 × 10(-16), odds ratio (OR) = 2.12) but not with CNV (P = 0.26, OR = 1.13). The intracellular localization of FGD6-Arg329 is distinct from that of FGD6-Lys329. In vitro, FGD6 could regulate proangiogenic activity, and oxidized phospholipids increased expression of FGD6. FGD6-Arg329 promoted more abnormal vessel development in the mouse retina than FGD6-Lys329. Collectively, our data suggest that oxidized phospholipids and FGD6-Arg329 might act synergistically to increase susceptibility to PCV.
- Published
- 2016
- Full Text
- View/download PDF
4. Molecular epidemiology of rabies virus in Vietnam (2006-2009).
- Author
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Nguyen AK, Nguyen DV, Ngo GC, Nguyen TT, Inoue S, Yamada A, Dinh XK, Nguyen DV, Phan TX, Pham BQ, Nguyen HT, and Nguyen HT
- Subjects
- Animals, Brain virology, Cerebrospinal Fluid virology, China, Cluster Analysis, Dog Diseases epidemiology, Dog Diseases virology, Dogs, Humans, Incidence, Malaysia, Molecular Epidemiology, Philippines, Phylogeny, RNA, Viral genetics, Rabies virology, Rabies virus genetics, Reverse Transcriptase Polymerase Chain Reaction, Saliva virology, Sequence Analysis, DNA, Thailand, Vietnam epidemiology, Rabies epidemiology, Rabies veterinary, Rabies virus classification, Rabies virus isolation & purification
- Abstract
This study was aimed at determining the molecular epidemiology of rabies virus (RABV) circulating in Vietnam. Intra vitam samples (saliva and cerebrospinal fluid) were collected from 31 patients who were believed to have rabies and were admitted to hospitals in northern provinces of Vietnam. Brain samples were collected from 176 sick or furious rabid dogs from all over the country. The human and canine samples were subjected to reverse transcription-polymerase chain reaction analysis. The findings showed that 23 patients tested positive for RABV. Interestingly, 5 rabies patients did not have any history of dog or cat bites, but they had an experience of butchering dogs or cats, or consuming their meat. RABV was also detected in 2 of the 100 sick dogs from slaughterhouses. Molecular epidemiological analysis of 27 RABV strains showed that these viruses could be classified into two groups. The RABVs classified into Group 1 were distributed throughout Vietnam and had sequence similarity with the strains from China, Thailand, Malaysia, and the Philippines. However, the RABVs classified into Group 2 were only found in the northern provinces of Vietnam and showed high sequence similarity with the strain from southern China. This finding suggested the recent influx of Group 2 RABVs between Vietnam and China across the border. Although the incidence of rabies due to circulating RABVs in slaughterhouses is less common than that due to dog bite, the national program for rabies control and prevention in Vietnam should include monitoring of the health of dogs meant for human consumption and vaccination for workers at dog slaughterhouses. Further, monitoring of and research on the circulating RABVs in dog markets may help to determine the cause of rabies and control the spread of rabies in slaughterhouses in Vietnam.
- Published
- 2011
5. Trace elements and stable isotopes (delta13C and delta15N) in shallow and deep-water organisms from the East China Sea.
- Author
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Asante KA, Agusa T, Mochizuki H, Ramu K, Inoue S, Kubodera T, Takahashi S, Subramanian A, and Tanabe S
- Subjects
- Animals, China, Crustacea, Environmental Monitoring methods, Fishes, Food Contamination, Invertebrates, Maximum Tolerated Dose, Oceans and Seas, Zooplankton, Food Chain, Isotopes analysis, Trace Elements analysis, Water Pollutants, Chemical analysis
- Abstract
Trace elements (22) and stable isotope ratios (delta15N and delta13C) were analyzed in marine organisms from shallow (SW) and deep-water (DW) of the East China Sea to understand biomagnification and prey source of trace elements. In the benthic marine organisms from DW, delta15N values were negatively correlated with Ba, Cu, Ag, Mo, Sr, As, and Co concentrations. This may be due to the specific accumulation in lower trophic animals and/or the biodilution through the food web in DW. Relationships between delta15N and concentrations of Co, Cr, Bi, and Tl in fish and Ag, Bi, V, Hg, and Tl in crustaceans showed positive correlations, suggesting that trophic position was affecting the concentrations of those elements in phyla, with higher trophic animals retaining higher concentrations than the lower trophic animals. Positive correlations between delta13C and Rb were observed in marine organisms. Therefore, Rb may be a possible substitute of delta13C as tracer of prey source in the East China Sea although further investigation is required.
- Published
- 2008
- Full Text
- View/download PDF
6. Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.
- Author
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Omasu F, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, and Emi M
- Subjects
- Adult, Aged, China, Female, Genetic Predisposition to Disease, Genotype, Humans, Japan, LIM Domain Proteins, Middle Aged, Osteoporosis genetics, Protein Structure, Tertiary, Bone Density, Chromosomes, Human, Pair 5, DNA-Binding Proteins genetics, Genetic Variation, Polymorphism, Single Nucleotide
- Abstract
Twin and family studies had shown that genetic factors are important determinants of bone mass. Multiple genes might be involved. One candidate gene, the reversion-induced LIM gene ( RIL), is a PDZ and LIM-domain-containing protein and has been localized within the cytokine cluster of chromosome 5 (5q31.1). In a genetic study of 370 adult Japanese women, we investigated the correlation between radial bone mineral density (BMD) and a genetic variation (-3333T-->C) of the 5'-flanking region of RIL gene. A significant association was identified between the RIL variation -3333T-->C and radial BMD ( r=0.15, P=0.003). The variation of the RIL locus may be an important determinant of osteoporosis.
- Published
- 2003
- Full Text
- View/download PDF
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