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1. Discovery of severe fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination.

Author

He CQ and Ding NZ

Subjects
Bayes Theorem, China, Epitopes chemistry, Genome, Viral, Humans, Likelihood Functions, Models, Genetic, Phylogeny, Recombination, Genetic, Syndrome, Virulence, Bunyaviridae Infections complications, Bunyaviridae Infections virology, Fever complications, Fever virology, Orthobunyavirus metabolism, Thrombocytopenia complications, Thrombocytopenia virology
Abstract

This study analyzes available severe fever with thrombocytopenia syndrome virus (SFTSV) genomes and reports that a sublineage of lineage I bears a unique M segment recombined from two of three prevailing SFTSV lineages. Through recombination, the sublineage has acquired nearly complete G1 associated with protective epitopes from lineage III, suggesting that this recombination has the capacity to induce antigenic shift of the virus. Therefore, this study provides some valuable implications for the vaccine design of SFTSV.

Published
2012
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