1. Occupational stress trajectories and metabolic dysfunction-associated steatotic liver disease among female nurses: a prospective Cohort Study.
- Author
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Luo H, Xing L, Fu T, Xiao S, and Fan L
- Subjects
- Humans, Female, Prospective Studies, Adult, Longitudinal Studies, China epidemiology, Middle Aged, Risk Factors, Incidence, Occupational Stress epidemiology, Nurses psychology, Nurses statistics & numerical data
- Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent cause of chronic liver disease, and occupational stress may serve as a potential risk factor. This study aims to assess the association between occupational stress trajectories and incident MASLD among Chinese female nurses., Methods: We conducted a prospective longitudinal study using data from the Nurse' Health Cohort Study, involving 1,113 female nurses, free of MASLD at baseline (2018). Occupational stress was measured using the Chinese Nurse Job Stress Scale at four time points. Group-based trajectory modeling was used to identify distinct stress trajectories. Through doctors' diagnoses, we assessed incident MASLD over a subsequent 6-year period from 2019 to 2024. Cox proportional hazards regression models evaluated the association of stress trajectories and MASLD risk, adjusting for demographics, work-related factors, and medical conditions., Results: During follow-up, 256 nurses reported incident physician-diagnosed MASLD. Three occupational stress trajectories were identified: moderate decreasing (36.4%), moderate stable (55.9%), and moderate increasing (7.7%). Participants in the moderate increasing stress trajectory had a significantly higher risk of developing MASLD (adjusted HR: 3.14, 95% CI: 2.19-4.49, p < .001) compared to those in the moderate stable trajectory. This association between stress trajectory and MASLD risk was not modified by age or BMI (p
interaction >0.50)., Conclusions and Relevance: The study concludes that increasing stress levels over time are associated with a higher incidence of MASLD. These findings underscore the importance of stress management interventions in reducing the risk of MASLD progression. Further research is needed to explore the underlying mechanisms and to develop targeted strategies for stress reduction in clinical settings., Competing Interests: Declarations Ethics approval and consent to participate All experiments were performed in accordance with relevant guidelines and regulations (such as the Declaration of Helsinki). The present study was approved by the institutional review board at Shengjing Hospital of China Medical University (2018PS09K). Consent for publication Not applicable. Competing interests The authors declare no competing interests., (© 2024. The Author(s).)- Published
- 2024
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