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The initial release of near real-time (NRT) atmospheric and oceanic science products from Japanese Himawari-8/9 (H8/9) geostationary (GEO) satellites over the South China Sea (SCS) was unveiled in 2024. The primary objective behind crafting these NRT H8/9 satellite products is to facilitate weather and marine environment monitoring, enhance maritime security, and aid ocean navigation, among other purposes. As part of this investigation, a novel NRT data processing system was devised to generate a variety of regional H8/9 GEO satellite science products within a temporal resolution of 10 minutes and a gridded resolution of 0.05° × 0.05° from November 3, 2022 to the present. This algorithm system was built upon the preceding FengYun (FY) geostationary satellite algorithm testbed (FYGAT), which was the prototype of FY-4 GEO meteorological satellite science product operational processing system. These regional H8/9 GEO satellite science products encompass a range of crucial data such as cloud mask, fraction, height, phase, optical and microphysical properties, layered precipitable water, sea surface temperature, etc. We subjected these products to rigorous evaluations against high-quality analogous satellite products and reanalysis data spanning four months in 2023. The validations underscore a strong consistency between the H8/9 GEO satellite atmospheric and oceanic science products over the SCS and the referenced products. Nevertheless, slight discrepancies in these satellite science products were identified, primarily stemming from variations in sensor/dataset characteristics, retrieval algorithms, and geometric conditions. These outcomes demonstrate the suitability of the first edition of NRT atmospheric and oceanic science products of H8/9 satellites over the SCS in supporting the intended quantitative applications. This NRT GEO satellite data record is publicly accessible through the File Transfer Protocol (FTP) provided by the Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) in China. Free access to the dataset can be found at https://doi.org/10.6084/m9.figshare.25015853 (Liu, 2024). [ABSTRACT FROM AUTHOR]

Accurate nowcasting for cloud fraction is still intractable challenge for stable solar photovoltaic electricity generation. By combining continuous radiance images measured by geostationary satellite and an advanced recurrent neural network, we develop a nowcasting algorithm for predicting cloud fraction at the leading time of 0–4 h at photovoltaic plants. Based on this algorithm, a cyclically updated prediction system is also established and tested at five photovoltaic plants and several stations with cloud fraction observations in China. The results demonstrate that the cloud fraction nowcasting is efficient, high quality and adaptable. Particularly, it shows an excellent forecast performance within the first 2-hour leading time, with an average correlation coefficient close to 0.8 between the predicted clear sky ratio and actual power generation at photovoltaic plants. Our findings highlight the benefits and potential of this technique to improve the competitiveness of solar photovoltaic energy in electricity market. Accurate nowcasting of cloud cover or fraction and its movement remains a significant challenge for stable solar photovoltaic electricity generation. Here, the authors combine continuous radiance images with high spatio-temporal resolutions to develop a nowcasting algorithm for predicting cloud cover at a leading time of 0–4 h. [ABSTRACT FROM AUTHOR]

Background: The increasing prevalence of multimorbidity has created a serious global public health problem in aging populations. Certain multimorbidity patterns across different age ranges and their association with health status remain unclear. The main aim of this study is to identify multimorbidity patterns discrepancies and associated health status between younger-old and oldest-old. Methods: The Ethics Committee of Nanjing Medical University approved the study protocol (No.2019–473). Convenience sampling method was used to recruit older adults aged ≥ 60 years with multimorbidity from July to December 2021 from 38 Landsea long-term care facilities in China. The multimorbidity patterns were analyzed using network analysis and two-step cluster analysis. One-Way ANOVA was utilized to explore their association with health status including body function, activity of daily living, and social participation. A Sankey diagram visualized the flow of health status within different multimorbidity patterns. This study is reported following the STROBE guidelines. Results: A total of 214 younger-old (60–84 years) and 173 oldest-old (≥ 85 years) were included. Leading coexisting diseases were cardiovascular disease (CD), metabolic and endocrine disease (MED), neurological disease (ND), and orthopedic disease (OD). Cluster 1 (53, 24.8%) of CD-ND (50, 94.3%; 31, 58.8%), cluster 2 (39, 18.2%) of MED-ND-CD (39, 100%; 39, 100%; 37, 94.9%), cluster 3 (37, 17.3%) of OD-CD-MED-ND (37, 100%; 33, 89.2%; 27, 73.0%; 16, 43.2%), and cluster 4 (34, 15.9%) of CD-MED (34, 100%; 34, 100%) were identified in the younger-old. In the oldest-old, the primary multimorbidity patterns were: cluster 1 (33, 19.1%) of CD-respiratory disease-digestive disease-urogenital disease (CD-RD-DSD-UD) (32, 97.0%; 9, 27.3%; 8, 24.2%; 7, 21.2%), cluster 2 (42, 24.3%) of ND-CD-MED (42, 100%; 35, 83.3%; 14, 33.3%), cluster 3 (28, 16.2%) of OD-CD-MED (28, 100%; 25, 89.3%; 18, 64.3%), and cluster 4 (35, 20.2%) of CD-MED (35, 100%; 35, 100%). Younger-old with CD-ND or MED-ND-CD, and oldest-old with ND-CD-MED have worse health status compared with other multimorbidity patterns (e.g., CD-MED and OD-CD-MED). Conclusion: Discrepancies in common patterns of multimorbidity across age groups suggest that caregivers in long-term care facilities should consider changes in multimorbidity patterns with ageing when developing prevention plans for individualized management. Neurological disease concurrent with other diseases was the major determinant of health status, especially for the oldest-old. Interventions targeting multimorbidity need to be focused, yet generic. It is essential to assess complex needs and health outcomes that arise from different multimorbidity patterns and manage them through an interdisciplinary approach and consider their priorities to gain high-quality primary care for older adults living in long-term care facilities. [ABSTRACT FROM AUTHOR]

This study aimed to explore the role of glomerular lesions in patients who suffered from acute kidney injury (AKI) during hemorrhagic fever with renal syndrome (HFRS). The study comprised 66 patients with AKI during HFRS treated at the National Clinical Research Center of Kidney Diseases of China, Jinling Hospital, from January 2014 to December 2018. According to the kidney pathological findings, the 66 patients were divided into two groups: the tubulointerstitial injury group (HFRS-TI group, n = 43) and the tubulointerstitial injury with glomerular lesions group (HFRS-GL group, n = 23). The clinical and pathological characteristics of the 66 patients were analyzed. There were 9 cases of IgA nephropathy, 1 case of membranous nephropathy, 2 cases of diabetic nephropathy, and 11 cases of mesangial proliferative glomerulonephritis in the HFRS-GL group. There were more males in the HFRS-GL group than in the HFRS-TI group (92.3% vs. 69.8%, p <.05). A higher proportion of interstitial fibrosis (56.5% vs. 27.9%, p <.05) and more immunoglobulin and complement depositions (p <.001) were observed in the HFRS-GL group than in the HFRS-TI group. Rates of remission of AKI were lower in the HFRS-GL group than in the HFRS-TI group (73.9% vs. 95.3%, p <.05). The presence of glomerular lesions (HR = 5.636, 95% CI = 1.121–28.329, p =.036) and moderate tubulointerstitial injury (HR = 3.598, 95% CI = 1.278–10.125, p =.015) were found to be independent risk factors for kidney prognosis. Patients with AKI during HFRS can have glomerular lesions or glomerulonephritis. Patients with AKI during HFRS who have glomerular lesions or moderate renal tubulointerstitial injury proven by kidney biopsy have a relatively poor kidney prognosis. A kidney biopsy can help determine long-term prognosis in patients with AKI during HFRS. [ABSTRACT FROM AUTHOR]

Vegetables represent an important agricultural industry in China. New farmers and new technologies for vegetable production have emerged in recent years, which makes farmer training very necessary. On the other hand, massive open online courses (MOOCs) are currently widely used in universities. The purpose of this study is to investigate the importance of different sections of a university MOOC focused on olericulture to farmers with different demographic characteristics and provide a basis to improve university MOOCs for farmer training. The survey results suggest that the age, education level, gender, farmer scale, facility type and profit of farmer learners are important factors determining evaluations of the importance of different MOOC sections, indicating that services customized to different farmer populations are necessary. Among different sections of MOOC "Olericulture", farmers with younger age, higher education, larger farm, more advanced facility and more profit were more interesting in sections include cultural, social and theoretical knowledge, and less interesting in practical skill sections. Based on the survey, eight new sections including one marketing subsection (new agricultural supplies and market news), one social subsection (laws and regulations), two practical subsections (practice videos, photos and videos from other farms), and three comprehensive subsections (discussion of practical issues, mechanization, and smart olericulture) were added to the original MOOC, and the results indicate that this improvement is efficient in enhancing the importance evaluations and profits of all farmer learners, especially among those with high education levels. [ABSTRACT FROM AUTHOR]

Background: Pulmonary embolism is a severe cardiovascular disease and can be life-threatening if left untreated. However, the detection rate of pulmonary embolism using existing pretest probability scores remained relatively low and clinical rule out often relied on excessive use of computed tomographic pulmonary angiography. Methods: We retrospectively collected data from pulmonary embolism suspected patients in Zhongshan Hospital from July 2018 to October 2022. Pulmonary embolism diagnosis and severity grades were confirmed by computed tomographic pulmonary angiography. Patients were randomly divided into derivation and validation set. To construct the Pulmonary Embolism Comprehensive Screening Score (PECSS), we first screened for candidate clinical predictors using univariate logistic regression models. These predictors were then included in a searching algorithm with indicators of Wells score, where a series of points were assigned to each predictor. Optimal D-Dimer cutoff values were investigated and incorporated with PECSS to rule out pulmonary embolism. Results: In addition to Wells score, PECSS identified seven clinical predictors (anhelation, abnormal blood pressure, in critical condition when admitted, age > 65 years and high levels of pro-BNP, CRP and UA,) strongly associated with pulmonary embolism. Patients can be safely ruled out of pulmonary embolism if PECSS ≤ 4, or if 4 < PECSS ≤ 6 and D-Dimer ≤ 2.5 mg/L. Comparing with Wells approach, PECSS achieved lower failure rates across all pulmonary embolism severity grades. These findings were validated in the held-out validation set. Conclusions: Compared to Wells score, PECSS approaches achieved lower failure rates and better compromise between sensitivity and specificity. Calculation of PECSS is easy and all predictors are readily available upon emergency department admission, making it widely applicable in clinical settings. Trail registration: The study was retrospectively registered (No. CJ0647) and approved by Human Genetic Resources in China in April 2022. Ethical approval was received from the Medical Ethics Committee of Zhongshan Hospital (NO.B2021-839R). [ABSTRACT FROM AUTHOR]

Linked colour imaging (LCI) is a novel new image-enhanced endoscopy (IEE) technology that produces bright and vivid images. The aim of this study was to assess the ability of LCI to improve the diagnostic accuracy of early gastric cancer (EGC) relative to white light imaging (WLI). We performed this study on patients undergoing screening endoscopy from 12 medical institutions in China. Patients were randomly assigned to receive WLI followed by LCI or LCI followed by WLI. The primary outcome was to compared the diagnostic accuracy between LCI and WLI for EGC/high-grade intraepithelial neoplasms. Secondary outcomes included the numbers of suspicious lesions, neoplastic lesions and examination time by using LCI detected versus using WLI. A total of 1924 patients were randomly selected, and 1828 were included in the analysis. The diagnostic accuracy for EGC, which was 78.8% by using LCI and 68.4% by using WLI (p <.0001). More suspicious lesions were detected by LCI than by WLI (n = 1235 vs. 1036, p =.031), especially among differentiated EGC (p =.013). LCI greatly shortened the examination time compared with WLI (p =.019). LCI has better accuracy and shorter examination time in diagnosing EGC than WLI (Clinical trial registration: NCT03092414). Compared with white light imaging (WLI), the diagnostic accuracy, sensitivity and specificity increased by using LCI. More lesions were detected by LCI alone than by WLI alone, especially among differentiated EGC. LCI may be used as a screening tool for routine clinical observation. [ABSTRACT FROM AUTHOR]

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Given the importance of social capital for the success of knowledge-intensive firms (KIFs), scholars have investigated how social capital promotes product innovation through knowledge transfer. However, in contrast to the quantity of transferred knowledge, the role of knowledge quality has been largely ignored. Drawing on the knowledge-based view (KBV) of the firm, this study explores the influences of structural, relational, and cognitive social capital on product innovation and the mediating role of knowledge quality. A questionnaire-based survey was conducted from firm executives and core members of R&D department and data of 159 Chinese KIFs were obtained. Partial least squares-structural equation modeling was used for hypotheses testing. The results reveal that relational capital and cognitive capital have positive effects on product innovation performance, which are mediated by knowledge quality. However, the effect of structural social capital on knowledge quality is not significant. The results contribute to literature on firm innovation by examining how social capital indirectly affects product innovation performance through the quality of transferred knowledge. Moreover, the conclusions can help top management of KIFs to design more effective informal knowledge management approaches according to differentiated effects of three types of social capital on knowledge quality. [ABSTRACT FROM AUTHOR]

Uncaria, a perennial vine from the Rubiaceae family, is a typical Chinese traditional medicine. Currently, uncertainty exists over the Uncaria genus' evolutionary relationships and germplasm identification. The complete chloroplast genomes of four Uncaria species mentioned in the Chinese Pharmacopoeia and Uncaria scandens (an easily confused counterfeit) were sequenced and annotated. The findings demonstrated that the whole chloroplast genome of Uncaria genus is 153,780–155,138 bp in full length, encoding a total of 128–131 genes, containing 83–86 protein-coding genes, eight rRNAs and 37 tRNAs. These regions, which include eleven highly variable loci and 31–49 SSRs, can be used to create significant molecular markers for the Uncaria genus. The phylogenetic tree was constructed according to protein-coding genes and the whole chloroplast genome sequences of five Uncaria species using four methods. The topology of the two phylogenetic trees showed no difference. The sequences of U. rhynchophylla and U. scandens are clustered in one group, while the U. hirsuta and U. macrophylla are clustered in another group. U. sessilifructus is clustered together with the above two small clades. New insights on the relationship were revealed via phylogenetic research in five Uncaria species. This study will provide a theoretical basis for identifying U. rhynchophylla and its counterfeits, as well as the species of the Uncaria genus. This research provides the initial chloroplast genome report of Uncaria, contributes to elucidating the chloroplast genome evolution of Uncaria in China. [ABSTRACT FROM AUTHOR]

Purpose: Although scholars have provided sufficient empirical evidence on the effect of peer knowledge hiding on new product development (NPD) project team outcomes, little attention has been given to the relationship between project manager knowledge hiding and individual outcomes. Drawing on the job resources-demands model and a dyadic stressor perspective, this study aims to explore the effect of project manager knowledge hiding on subordinates' turnover intentions as well as the mediating roles of challenge- and hindrance-related stress. Design/methodology/approach: This study conducted a multiple-source survey of NPD project managers and their subordinates in China. Hypotheses were tested by using data collected from 171 manager–subordinate dyads in NPD projects. Findings: The findings revealed that project manager knowledge hiding was positively associated with subordinates' turnover intentions, challenge-related stress and hindrance-related stress. Project manager knowledge hiding imposed a positive indirect effect on turnover intentions through hindrance-related stress, whereas the mediating effect of challenge-related stress was not significant. Originality/value: To the best of the authors' knowledge, this study is one of the first to investigate the individual outcomes of top-down knowledge hiding as well as the mediating roles of challenge- and hindrance-related stress in the context of NPD projects. [ABSTRACT FROM AUTHOR]

Objective: Linked color imaging (LCI) is a recently developed technique that emphasizes differences in mucosal color. In this study we aimed to develop a LCI classification based on the Narrow‐band Imaging International Colorectal Endoscopic Classification for predicting colorectal polyp histology and evaluate the validity and performance of the endoscopists in differentiating hyperplastic polyps from adenomas using the LCI classification. Methods: A workshop involving six international experts from China and Japan with substantial experience with LCI developed the classification. Three experienced and seven less‐experienced endoscopists used the LCI images to predict the histology of polyps independently, recording their degrees of confidence in these predictions before and after completing the training test for the LCI classification. Results: Of the 50 polyps included, 30 (60.0%) were adenomas. Overall diagnostic accuracy before training was 75.4% (95% confidence interval [CI] 71.4%–79.1%), which increased to 85.2% (95% CI 81.8%–88.2%) after training. After training, the experienced and less‐experienced endoscopists achieved an overall accuracy of 87.3% and 84.3% for the prediction of polyp histology. Polyp prediction using the color criterion alone had the highest specificity and positive predictive value, whereas the vessel criterion achieved the highest accuracy and negative predictive value among all three individual LCI criteria. After training, both the experienced and less‐experienced endoscopists had high degrees of interobserver agreement. Conclusions: We developed and validated the first LCI classification for endoscopic differentiation of adenomas and hyperplastic polyps. The LCI classification significantly improved the diagnostic accuracy of colorectal polyps. [ABSTRACT FROM AUTHOR]

Begonia giganticaulis, a huge new species in Begonia sect. Platycentrum of Begoniaceae from southern Xizang (Tibet) of China, is described. Morphologically, it is mostly similar to B. longifolia and B. acetosella, but clearly differs from the former mainly by its dioecious and taller plants, sparse hairs on abaxial veins, longer inflorescence, unique shape of fruits, and differs from the latter mainly by its late and longer flowering time, 6-tepals of female flower and 3-loculed ovary. The phylogenetic analyses also support the separation of the new species from other taxa. Based on the current data, its conservation status is assigned to Endangered (B2a) according to the IUCN Red List Categories and Criteria. [ABSTRACT FROM AUTHOR]

The degradation of the eco-environment has been a challenge for sustainability in resource-based cities around the world. Although much attention has been drawn to this issue, few insights have been acquired regarding the spatial differentiation and mechanism of the factors influencing habitat quality in resource-based cities from the perspective of the interactions of natural and human factors. Using Tangshan City as a case study, this paper evaluates habitat quality by integrating Ecosystem Service Value Assessment and the InVEST-HQ model, identifies the spatial distribution of Tangshan's habitat quality with spatial auto-correlation, and explores the influencing factors and their mechanism of influence on the spatial differentiation with the geographical detector model and Space production theory. The results show that: (1) The total value of the habitat quality in Tangshan City in 2019 was 3.45×1010 yuan, and the habitat quality value was 24435.05 yuan ha–1. The habitat quality value presents a clustered distribution pattern of "hot in the north and the south, cold from the center to the west". (2) On the county scale, Qianxi County had the best habitat quality and Lubei District had the worst habitat quality; Shangying Township had the highest average habitat quality and Kaiping Street had the lowest average habitat quality in the township unit. (3) The results of geographical detectors show that natural environmental conditions are the important basic factors affecting the spatial differentiation of habitat quality in Tangshan City, while urbanization and industrialization factors are the most important external forces driving the spatial differentiation of habitat quality. The contributions of average elevation, average slope, raw material industrial density, and population density to the spatial differentiation of habitat quality are all above 0.40. The interactions of any two factors on habitat quality are enhanced. Areas with concentrated populations, rich industrial resources, and convenient transportation become low-value habitat quality areas; while areas with beautiful landscape patterns, abundant precipitation, and a comfortable climate become high-value habitat quality areas. Space production theory can be used to explain the mechanism of the formation of the spatial differentiation of habitat quality. [ABSTRACT FROM AUTHOR]

Objective: To investigate the prevalence of suicidal ideation among the first batch of students returning to a college during the COVID-19 epidemic, and to explore the correlation of suicidal ideation with family characteristics and social support. Methods: A cluster sampling survey with a self-designed questionnaire was conducted among the first batch of students returning to a college in Wuhu, China. The Positive and Negative Suicidal ideation (PANSI) and Social Support Scale (SSRS) were used to define students' suicidal ideation and social support, respectively. The influence of family characteristics and social support on the students' suicidal ideation was investigated using multivariate unconditional logistic regression analysis. Results: Two thousand seven hundred valid questionnaires were collected, including 673 males (24.9%) and 2,027 females (75.1%), in this study. A total of 146 students (5.4%) showed suicidal ideation. Male respondents reported higher rates (7.9%) than females (4.6%). Multivariate logistic regression analysis showed that a higher risk level of residence before returning to school and lower objective support were the risk factors for suicidal ideation in males. In contrast, a higher level of maternal education, a poorer relationship with the mother, and lower scores for subjective support and support availability had significant effects on females' suicidal ideation. Limitations: This is a cross-sectional study, and lacks comparison to the time point unaffected by COVID-19. Moreover, it was limited by COVID-19 epidemic prevention and control restrictions, and the differences in returning to school in different regions. Only one college was investigated in this study, and all of the respondents were sophomores, so there may be some limitations in the representativeness of the sample and extrapolation of the results. Conclusion: Family characteristics and social support have had an important influence on suicidal ideation among students returning to school during the COVID-19 epidemic. Some gender differences were identified. Targeted interventions are needed for early prevention and control. [ABSTRACT FROM AUTHOR]

Background: Botulinum toxin is a neurotoxin generated during the growth of Clostridium botulinum and can lead to a rare but life-threatening disease with neurologic symptoms. Relatively little is known about the many types of botulinum toxins in China. The clinical symptoms of the different types of botulism toxin-induced illnesses appear after an incubation period and vary greatly by the serotype and degree of exposure to the toxin.Case Report: We describe 4 patients who consumed vacuum-packaged salted fish and ham and then presented with severe gastrointestinal symptoms, resulting in vomiting and one death. Blood serum and urine samples tested by the botulinum neurotoxin Endopep-MS assay were positive for botulinum toxin types A, B, and E. The patient who consumed the largest amount of fish and ham died after 36 h, and the other patients were treated with botulism antitoxin after being diagnosed with a botulinum toxin-induced illness and recovered after 1 month. These cases illustrate the importance of early diagnosis and early treatment of botulism type E, in particular, because of the risk of respiratory failure and treatment delays, which can result in increased mortality and poorer overall outcomes. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Our cases illustrate the importance of early diagnosis and especially the treatment of illnesses related to botulism type E because of the risk of respiratory failure and because treatment delays can result in increased mortality and worsened overall outcomes. [ABSTRACT FROM AUTHOR]

Background: Early diagnosis of gastric cancer is difficult in China due to the lack of a valid method for endoscopic screening. Early gastric cancer, especially flat gastric cancer, lacks specific endoscopic features. Many cases appear to be similar to ordinary gastritis cases under normal white light endoscopy, which can lead to misdiagnosis. Aims: In order to find a new method to improve detection rate of early gastric cancer in China, we designed a trial to validate linked color imaging (LCI) for screening of early gastric cancer in a high-risk population, as compared to white light imaging (WLI). Method: Subjects were randomly allocated to either the LCI + WLI or WLI group and then subjected to gastroscopy and all endoscopies were made after special preparation. All endoscopists had knowledge of this experiment. The main indicator was the rate of detection of gastric neoplastic lesions. The difference in the detection rate between the two groups is reported. Results: The detection rate was 4.31% in the WLI group and 8.01% in the LCI + WLI group. This is a difference of 3.70% with a P value < 0.001 and an OR (95% CI) of 1.934 (1.362, 2.746). The lower limit of the 95% CI was greater than 0, and the superiority margin was 1%. Conclusion: The detection rate of gastric neoplastic lesions was higher in the LCI + WLI group than in the WLI group, LCI might be an effective method for screening early gastric cancer. [ABSTRACT FROM AUTHOR]

Background: Previous studies have demonstrated the close relationship between vitamin D, vitamin D receptor (VDR), and obesity. Nevertheless, few studies have reported wherther the relationship among these is associated with the risk of cardiovascular diseases (CVDs) in Chinese children and adolescents. Objective: The present study aimed to reveal the effects of obesity, serum vitamin D levels, and VDR FokI genotype on the risk of CVDs in children and adolescents in Sichuan, China. Methods: Children and adolescents were recruited into a cross-sectional study. Serum vitamin D levels, serum lipid levels, and VDR FokI gene polymorphisms were measured in the laboratory. The selected lipid factors were used as biomarkers of CVD risk. The impact of obesity, vitamin D levels and VDR FokI genotype on CVD risk factors were investigated. Results: Higher lipid levels were observed in children and adolescents in the obese group, when compared to the nonobese group. In the obese group, the C allele carriers had significantly lower concentrations of lipids, when compared to the TT genotype. C allele carriers who were vitamin D deficient had lower levels of total cholesterol (TC), triglycerides (TG), apolipoprotein B (Apo-B), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C), and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C), when compared to those with the TT genotype in obese children and adolescents. For vitamin D-insufficient obese children and adolescents, the TC, Apo-B, and TC/HDL-C in the C allele carriers were significantly lower, when compared to those in the TT genotype in obese children and adolescents. Conclusion: Obese children with low vitamin D levels, who are carriers of the C allele of the FokI gene, have lower levels of several biochemical markers of CVD risk, when compared to those who were TT homozygous. Obese children and adolescents may benefit from vitamin D supplementation, terms of lowering their CVD risk, particularly when they are carriers of the C allele of the FokI gene. [ABSTRACT FROM AUTHOR]

In this article, we explore the mediating effect of trust on the relationship between high‐performance work systems (HPWS) and employee outcomes. Using a mixed method design, we first conducted focus groups and interviews to gain an understanding of the HPWS in Chinese indigenous firms. Extracting data from the interviews, we then developed a survey which tested our hypotheses. As predicted, data from 907 questionnaires illustrated that employees' perceptions of the impact of enacted HPWS on building the trust relationship between manager/supervisor and employee in Chinese indigenous firms have a positive effect on employee job satisfaction and intention to stay. The results suggest that organisations may influence how employees perceive manager trustworthiness. It is likely that organisations can design systems that address employee needs, build trust, enhance employee satisfaction and deter them from leaving. Key points: This article explores the mediating effect of trust on the relationship between high‐performance work systems (HPWS) and employee outcomes.This article adopts a mixed method design with focus groups and interviews as well as 907 survey questionnaires to gain an understanding of the HPWS in Chinese indigenous firms.The results illustrate that employees' perceptions of the impact of enacted HPWS on building the trust relationship between manager/supervisor and employee in Chinese indigenous firms have a positive effect on employee job satisfaction and intention to stay.The results also suggest that organisations can influence how employees perceive manager trustworthiness.Organisations should design systems to address employee needs, build trust, enhance employee satisfaction and deter them from leaving. [ABSTRACT FROM AUTHOR]

Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier. [ABSTRACT FROM AUTHOR]

The road traffic accident is an important public health issue affecting social development and public safety. The purpose of this study is to describe the situation of traffic accidents, and to explore the relationship between fatal traffic accidents and risk factors in Suzhou city of Anhui province in China. The accident data was obtained from the Traffic Police Detachment of the Suzhou Public Security Bureau. Other vehicle, population and road information are derived from Suzhou Statistical Yearbook. Descriptive analysis was used to summarize road traffic accident participants' characteristics. The binary logistic regression model was used to analyze the factors that affected fatal traffic accident. There are 7,795 cases involved 18,774 road traffic participants. By logistic regression, we found that in Suzhou, overloading makes traffic accidents more likely to be the most fatal traffic accidents (adjusted OR = 5.33, 95%CI: 2.60-10.93). Speeding, drive after drinking, fatigue driving and pedestrian reasons might also increase the probability of fatal traffic accidents. These findings would help transportation authorities identify dangerous driving behaviors and take the necessary measures to improve road safety in undeveloped areas. [ABSTRACT FROM AUTHOR]

Aboveground forest biomass (Bagf) and height of forest canopy (Hfc) are of great significance for the determination of carbon sources and sinks, carbon cycling and global change research. In this paper, Bagf of coniferous and broadleaf forest in the Chinese Three Gorges region is estimated by integrating light detection and ranging (LiDAR) and Landsat derived data. For a better Bagf estimation, a synergetic extrapolation method for regional Hfc is explored based on a specific relationship between LiDAR footprint Hfc and optical data such as vegetation index (VI), leaf area index (LAI) and forest vegetation cover (FVC). Then, an ordinary least squares regression (OLSR) and a back propagation neural network (BP-NN) model for regional Bagf estimation from synergetic LiDAR and optical data are developed and compared. Validation results show that the OLSR can achieve higher accuracy of Hfc estimation for all forest types (R2 = 0.751, Root mean square error (RMSE) = 5.74 m). The OLSR estimated Bagf shows a good agreement with field measurements. The accuracy of regional Bagf estimated by the BP-NN model (RMSE = 12.23 t ha–1) is superior to that estimated by the OLSR method (RMSE = 17.77 t ha–1) especially in areas with complex topography. [ABSTRACT FROM AUTHOR]

This study aimed to explore the relationship of loneliness, perceived stress, and depressive symptoms among the Chinese rural empty nest elderly. The role of sense of coherence (SOC) as a moderating variable was investigated in a representative sample of older adults in Henan, China, from November 2016 to February 2017. Results indicated that perceived stress mediated the relationship between loneliness and depressive symptoms, and SOC acted as a moderator on this mediating model. The mediation effect of perceived stress was significant only when SOC was lower. The results emphasized the importance of perceived stress in older adults. SOC was a protective factor with regard to depressive symptoms, and improving SOC should be a focus of health promotion with the elderly. [ABSTRACT FROM AUTHOR]

This study investigated the distribution and changes in phosphorus (P) forms within surface and column sediments collected from the lakeshore area of Caohai, Dianchi Lake. Results showed that the sediments of the Caohai lakeshore area were high in total phosphorus (TP), with a maximum value of 2,452 mg•kg-1. The variation in P content within sediments from various regions was large. Inorganic phosphorus (IP) was the major part of TP. The Fe, Al, and Mn oxide and hydroxide (Fe/Al-P) content was higher than the calcium bound P content. This will facilitate the release of P into the water. [ABSTRACT FROM AUTHOR]

Spirea japonica var. acuminata Franch. (Rosaceae) is a Chinese herbal medicine distributed in southwest and east China. The first complete chloroplast genome of Spirea japonica var. acuminata Franch. was assembled and reported in this study. The genome is 153,822 bp in length and contained 125 encoded genes in total, including 80 protein-coding genes, eight ribosomal RNA genes, and 37 transfer RNA genes. The phylogenomic analysis showed that Spirea japonica var. acuminata Franch. was closely related to Spirea blumei, Spirea trilobata, Spirea mongolica and Spirea insularis according to the current sampling extent. [ABSTRACT FROM AUTHOR]

Background A satisfactory biopsy determines the state-of-the-art management of lung cancer in this era of personalized medicine. This study aimed to investigate the suitability and efficacy of computed tomography ( CT)-guided core needle biopsy in clinical management. Methods A cohort of 353 patients with clinically suspected lung cancer was enrolled in the study. Patient factors and biopsy variables were recorded. Epidermal growth factor receptor ( EGFR) gene mutations and echinoderm microtubule-associated protein-like 4 ( EML4)-anaplastic lymphoma kinase ( ALK) rearrangement were detected in tumor specimens. Adequacy of biopsic obtainment for clinical trial screening and tissue bank establishment were reviewed. Results Overall diagnostic accuracy of malignancy achieved 98.5%. The median biopsy time of the cohort was 20 minutes. In patients with non-small cell lung cancer ( NSCLC), 99.3% (287/289) were diagnosed as specific histologic subtypes, and two patients (0.7%) were determined as NSCLC not otherwise specified ( NOS). EGFR mutations were analyzed in 81.7% (236/289) of patients with NSCLC, and 98.7% (233/236) showed conclusive results. EML4- ALK gene fusion was tested in 43.9% (127/289) of NSCLC patients, and 98.4% (125/127) showed conclusive results: 6.4% (8/125) of those had gene fusion. Ninety-six NSCLC patients participated in clinical trial screening and provided mandatory tumor slides for molecular profiling. Pathological evaluation was fulfilled in 90 patients (93.8%); 99.4% (320/322) of patients with malignancy provided extra tissue for the establishment of a tumor bank. Conclusions CT-guided core needle biopsy provided optimal clinical management in this era of translational medicine. The biopsic modality should be prioritized in selected lung cancer patients. [ABSTRACT FROM AUTHOR]

The land surface broadband emissivity (LSBE) is a key parameter for estimating surface radiation, and there have been many studies of the LSBE at global or local scales. However, few studies have validated the surface emissivity database with multi-point field measurement data using infrared radiometry, especially in China. In this study, we focus on the validation of the emissivity product of the global land surface satellite (GLASS) LSBE database for northern China for the period from 2006 to 2011. Specifically, we have employed an eight-day averaged, gridded emissivity product in the 8–13.5 µm spectral range produced at a spatial resolution of 1000 m from the Moderate Resolution Imaging Spectrometer albedo product using a new algorithm. The GLASS LSBE database was validated over bare surfaces with field measurement data from sand samples collected at many pseudo-invariant sand dune sites located in western and northwestern China. By comparing measured emissivity for different land surface types at different sites and different times, it was shown that the results were consistent and that the accuracy of the field measurements was reliable. The results of the validation of GLASS LSBE with these field emissivity data showed very good agreement. [ABSTRACT FROM PUBLISHER]

Purpose: The purpose of this study is to examine the relationship between nurse staffing and patient outcomes in hospitals in mainland China. Methods: The study was conducted in 181 hospitals across all of the eight economic zones in mainland China using a four-stage sampling design. Two instruments, the China Nurse Survey and the patient satisfaction measurement from the Hospital Consumer Assessment of Healthcare Providers and Systems, were employed in data collection. In this article, 7,802 nurse surveys and 5,430 patient surveys from 600 medical and surgical units were analyzed. Results: The adjusted joint effects of nurse staffing on patient outcomes from logistic regression analyses showed that more nursing staff per patient had statistically significant positive effects on all necessary nursing care, nurses' reports of quality of care, their confidence on patients' self-care ability on discharge from the hospital, patient adverse events, as well as patients' report of satisfaction. When the nurse-to-patient ratio (total number of nurses on all shifts on the unit divided by total number of patients who stay on the unit) increased to the 0.5-<0.6 category, most patient outcomes were significantly improved, considering hospital and patient factors and nurse skill mix in the logistic regression models. Conclusions: The findings provide evidence on how inadequate nurse staffing might result in missed but needed nursing care and negative patient outcomes, while better staffing levels could be an effective strategy for improving patient outcomes. Clinical Relevance: We recommend that the nurse-to-patient ratio on medical and surgical units in Chinese hospitals be increased to at least 0.5-0.6 so as to secure patient safety and the quality of health services. Journal of Nursing Scholarship, 2011; XX:X, XXX-XXX. ©2011 Sigma Theta Tau International. [ABSTRACT FROM AUTHOR]

• NPS TP township loads for different cultivated land use-patterns were simulated. • The average GGE TP load was the highest, and the GES and GOCS loads were similar. • The NPS TP load with different cultivated land-use patterns was heterogeneous. • The correlations varied between the cultivated land uses and NPS TP loads. • Cultivated land-use classification can clarify the NPS pollution driving mechanism. Non-point source (NPS) pollution caused by unsustainable cultivated land use is becoming more severe. It is therefore critical to understand the complex relationships between cultivated land use forms and NPS pollutant loads from the perspective of integrated cultivated land use. This study used the cultivated land use pattern to integration represent the various forms of cultivated land use, and constructed a model to estimate NPS pollutant outputs at an administrative-region scale. This model was used to quantitatively simulate the NPS total phosphorus (TP) loads of townships with different cultivated land-use patterns in Chaohu Lake Basin, China, since 2000. The relationships between the TP loads and the different cultivated land use patterns were then assessed to clarify the corresponding function mechanisms and provide scientific support for effective NPS pollution controls. The cultivated land-use patterns of the townships in Chaohu Lake Basin were classified as suburban compound operations (SC); grain and economical crop scale operations (GES); grain and economical crop extensive operations (GEE); and grain, oil, and cotton scale operations (GOCS). The TP loads of townships with various cultivated land-use patterns were significantly different. The average TP load of GEE pattern townships was the highest (5.39 kg ha−1a−1), which was 1.85 times the lowest value of the SC pattern townships. The TP loads of GES and GOCS pattern were similar (3.52 kg ha−1a−1 and 3.19 kg ha−1a−1, respectively). The heterogeneous NPS TP loads are due to the face that cultivated land-use forms exhibit different marginal inhibition/promotion effects on NPS pollutant outputs with different patterns. Different correlations and significances were observed between various cultivated land-use form factors and NPS TP loads with different patterns. Therefore, accurate classifications and recognition of cultivated land-use patterns can be utilized to clarify the function mechanism between cultivated land use and NPS pollutant loads. [ABSTRACT FROM AUTHOR]

There are currently around 120 million rural–urban migrants in China. Elsewhere migration has been associated with increased vulnerability to mental health problems. This study was conducted to explore the mental health status and help seeking behaviours of migrant workers in Hangzhou city, Zhejiang Province, and to compare them with permanent urban and rural dwellers. A self-completion questionnaire including items relating to sociodemographics, health and lifestyles and mental health, was completed by 4453 migrant workers and 1957 urban workers in Hangzhou city, and by 1909 rural residents in Western Zhejiang Province. The mean age of the migrants was 27 years, (male 29 years, female 25 years). They worked long hours (28% >12 h per day, 81% 6 or 7 days per week) and their living conditions were very basic. On the SF-36 mental health scale migrants had lower scores (52.4) than rural residents (60.4, P < 0.0001) but scored higher than urban residents (47.2, P = 0.003). The difference between urbanites and migrants disappeared after adjustment for confounders ( P = 0.06). Independent predictors of better mental health status among migrants were being unmarried, migrating with a partner, higher salary, good self-reported health and good relationships with co-workers. There were small significant differences in suicide ideation and attempts between the three groups with suicide ideation commonest in migrants and suicide attempts most common in the rural population. Fewer than 1% across all three groups had received any professional help for depression or anxiety. Rural–urban migrant workers in this part of China are not especially vulnerable to poor mental health. This may result from a sense of well being associated with upward economic mobility and improved opportunities, and the relatively high social capital in migrant communities. [ABSTRACT FROM AUTHOR]

The genus Cucumis contains 52 species, including two economically significant crops, cucumber, and melon, as well as some important landraces. Cucumis melo L. 'Shengkaihua' is a widely cultivated landraces in China. It has high sugar content, early maturity, and strong genetic growth potential. Cucumis melo L. 'Shengkaihua' provides a valuable gene pool for crop improvement of Cucumis crops. In this study, the complete chloroplast (cp) genome sequence of C. melo L. 'Shengkaihua' was determined using next-generation sequencing. The entire cp genome was determined to be 156,017 bp in length. It contained large single-copy (LSC) and small single-copy (SSC) regions of 86,335 and 18,088 bp, respectively, which were separated by a pair of 25,797 bp inverted repeat (IR) regions. The genome contained 133 genes, including 88 protein-coding genes, 37 tRNA genes, and eight rRNA genes. The overall GC content of the genome is 36.9%. A phylogenetic tree reconstructed by 24 chloroplast genomes reveals that C. melo L. 'Shengkaihua' is most related to Cucumis melo var. inodorus. [ABSTRACT FROM AUTHOR]

In order to investigate the key characteristics of mesoscale convective systems (MCSs) initiated over the Tibetan Plateau (TP) in recent years and the main differences in circulation and environmental factors between different types of MCSs, an automatic MCS identification and tracking method was applied based on the data from China's Fengyun satellite and precipitation estimates. In total, 8820 MCSs were found to have been initiated over the TP during the summers from 2013 to 2019, and a total of 9.3% of them were able to move eastward out of the TP (EO). The number of MCSs showed a monthly variation, with a maximum in July and a minimum in June, while most EOs occurred in June. Compared with other types of MCSs, EOs usually had a lower cloud-top temperature, a greater rainfall intensity, a longer life duration, more rapid development, larger areas of rainfall and convective clouds, longer tracks and a wider influence range, indicating that EOs are more vigorous than the other types of MCSs. The movement of MCSs is mainly due to the mid- to high-level dynamic conditions, and moisture is an essential factor in their development and maintenance. [ABSTRACT FROM AUTHOR]

• 108 pesticides in Traditional Chinese Medicines were determined simultaneously. • Traditional Chinese Medicines are difficult matrices for residue analysis. • C18 and anhydrous MgSO 4 were used as the dSPE sorbent. • 92% of real samples were detected with pesticide residues. • Paclobutrazol showed a high residue level in O. japonicas. A robust and high-throughput method was developed for the determination of 108 pesticide residues in Traditional Chinese Medicines (TCMs) simultaneously using a combination of UHPLC-MS/MS analysis and the modified QuEChERS method. Extraction was carried out in acetonitrile containing 0.75% (v/v) acetic acid with ultrasonication for 15 min; MgSO 4 and C18 were used as the dispersive-solid phase extraction sorbents. The method exhibited good linearity (r2 > 0.9901), in addition to good selectivity, precision and repeatability. More than 92% of pesticides exhibited high rates or recovery in the 70–120% range. This method showed high sensitivity, with Limits of Quantitation in the 0.01–20 ng/mL range in Cortex Moutan, and 0.01–50 ng/mL in the other TCMs. The method was employed for the analysis of 39 real samples from different habitats, and pesticides were detected in 92.3% of the samples, with 26 pesticides being detected in these three TCMs. More than four pesticides were detected in a third of the samples. Among them, tebuconazole was detected in all the three TCMs with 0.22–22.02 μg/kg concentration, which was lower than the provisions in GB 2763-2019 (50 μg/kg). In addition, the paclobutrazol detection rate in Ophiopogon japonicus was 100%, and the detected concentrations of 9 samples exceeded the Maximum Residue Levels defined for vegetables (50 μg/kg). Considering there are no regulations that govern the limits of pesticide residues in the three TCMs in China, we recommend the acceleration of efforts to introduce appropriate regulations. [ABSTRACT FROM AUTHOR]

A previously healthy patient was transferred to our infectious department with a 9-day-history of continued fever. The patient was placed on assisted respiration support in addition to anti-viral medication. The diagnosis of SARS (Severe Acute Respiratory Syndrome) was made in view of the severe hypoxemia and the characteristic symptoms exhibited by the patient. Despite the best intensive therapy, he clinically deteriorated into multiorgan dysfunction syndrome (MODS) including additional dysfunction of kidney, liver, and heart. We initiated MARS therapy (extracorporeal liver support utilizing albumin dialysis) with intention to positively influence the organ functions in his MODS on the basis of recently published studies which suggested a positive impact of MARS in multiorgan failure secondary to respiratory illnesses and the possible influence on inflammatory mediators and cytokines. The application of 4 intermittent MARS treatments (8 h each, mean blood flow rate 180 ml/min) on 4 consecutive days resulted in an immediate improvement of clinical conditions within the treatment days. The further improvement of organ functions allowed withdrawing the patient from ventilatory support 13 days after start of MARS, and 44 days after admission he was discharged home with completely resolved organ functions and laboratory abnormalities. SARS is a severe form of the epidemic outbreak of atypical pneumonia which remains poorly defined regarding etiology and special therapy recommendations. However, the development and aggravation of this ARDS-like severe acute respiratory syndrome is pathologically associated with the systemic inflammatory response syndrome (SIRS) which may then mediate or cause MODS. To our knowledge, this is the first report of an application of MARS therapy in MODS which was probably induced by SARS in a patient in China which improved the clinical condition of the patient in multi-organ failure secondary to respiratory failure indicating that MARS might be an additional therapeutic option in multiorgan failure induced by SARS. [ABSTRACT FROM AUTHOR]

• A study framework integrating ecological processes, supply and demand was formed. • The core ecological source was determined considering multi-dimensional evaluation. • ES supply and demand corridors were built to meet human needs. • The article could provide important reference for ecological restoration planning. Optimizing the ecological connectivity and constructing the ecological supply and demand network are of great significance for maintaining the stability of ecosystem and human well-being. Considering the interaction between ecological process and supply–demand of ecosystem services, we simulate ecological processes by identifying ecological supply and demand corridors, and then connecting the supply and demand of ES, which further enrich and expand the traditional ecological network analysis framework. And take Wuhan metropolitan area of China as an example to conduct empirical research. From the supply side, we identify the regional ecological source based on the evaluation of the importance of ES and the structural connectivity analysis of ecological lands, and according to the spatial distribution characteristics of ecological land, the connectivity network is optimized by adding stepping-stone to improve resilience of the connectivity network. From the demand side, we construct the ecological demand network by identifying the demand area of ES, and build a long-distance spatial channel to improve the ability of the ecosystem to meet human needs. This empirical research could provide important reference for ecological restoration planning and territorial spatial planning. [ABSTRACT FROM AUTHOR]

Background Vitamin D is an essential micronutrient during the growth and development of the human body. Previously, most of the researches about the relationship of vitamin D and obesity were focused on adults. In this paper, the relationship between serum 25-hydroxyvitamin D [25(OH)D] and obesity among children and adolescents in China was analyzed. Methods From August 2012 to August 2014, 443 children and adolescents participated in this study. Serum 25(OH)D, lipid and glucose were measured in the laboratory. All the participants were classified into 2 groups (obese and non-obese group) on the basis of their BMI. They were then categorized into vitamin D deficiency, vitamin D insufficiency and vitamin D normal groups according to the serum concentrations of 25(OH)D. Results The concentration of serum 25(OH)D in the obese group was significantly lower than that of the non-obese group (P < 0.001). The concentration of total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, fasting insulin and homeostasis model assessment for insulin resistance showed significant differences between the obese and non-obese groups (P < 0.05). Conclusions Children and adolescents suffering from obesity are more likely to have lower concentrations of serum 25(OH)D. [ABSTRACT FROM AUTHOR]

Cloud effective radius (CER) and cloud optical thickness (COT) are two important variables to characterize the optical properties of clouds which facilitate the understanding of cloud radiation. In this study, Japanese Himawari-8 (H8) geostationary satellite cloud retrieval data are used to depict the spatial and temporal variations of CER and COT during day-time in various seasons over China from September 2015 to August 2020. Our results show that northern China tends to have relatively larger CER and smaller COT than southern China. Overall, the CER increases while the COT decreases during the day-time period. In particular, the CER diurnal variation in northern China is stronger than that in southern China in winter. However, the southern China generally has stronger COT diurnal variation than the northern China. For the local sub-regions, the largest diurnal variations of CER and COT occur over the Tibetan Plateau (TP). Specifically, the Southeastern TP usually has larger COT and smaller CER compared with the Western TP. This study implies the importance of considering diurnal variations of cloud properties in the evaluation of the radiative effects of clouds. • Daytime diurnal variations of cloud optical properties over China were derived. • Cloud effective radius and optical thickness showed opposing diurnal variations. • The largest diurnal variation of cloud properties was found over Tibetan Plateau. [ABSTRACT FROM AUTHOR]

Abstract: Incorporated into the WRF–Chem model are the three HONO sources, i.e., the reaction of photo-excited NO2 with water (NO2 * chemistry), heterogeneous reactions on aerosol surfaces, and HONO emissions. Four case simulations were performed in Beijing, Tianjin, and Hebei Province (BTH region) in August of 2007. Results indicate that the NO2 * chemistry yields 30–50 ppb enhancements in daily maximum 1-h surface O3 concentrations in major cities and 3–10 ppb increases in monthly mean daily maximum 8-h surface O3 concentrations in most areas of the BTH region. Heterogeneous reactions on aerosol surfaces lead to 5–20 ppb decreases in monthly mean NOy concentrations in major cities over the BTH region. Heterogeneous reactions and HONO emissions are the largest, and the second largest contributor, accounting for ∼59% and 26% of simulated HONO concentrations, respectively. The three HONO sources produce enhancements in monthly mean daytime (10:00–17:00) concentrations of NOy (total reactive N-containing compounds), NO2, HNO3, HONO, and HOx being −1 to −5 ppb, −1 to −3 ppb, −0.3 to 0.5 ppb, 20–50 ppt, and 1–3 ppt, respectively. Comparison with observations shows that inclusion of the three HONO sources into the WRF–Chem model can considerably improve HONO and O3 simulations in the BTH region. For HONO the mean, the normal mean bias, the root mean square error, and the correlation coefficient is greatly improved from 0.04 to 0.56 ppb, from −97% to −39%, from 1.10 ppb to 0.51 ppb, and from −0.56 to 0.86, respectively, by comparison with the gas chemical mechanism only considered in the WRF–Chem model. This suggests that the three important HONO sources be included in air quality models, particularly in the areas with high emissions of NOx and particulate matter. [Copyright &y& Elsevier]

AbstractDendritic cells (DCs) play a pivotal role in the pathogenesis of human immunodeficiency virus-1 (HIV-1). Reduced numbers of blood DCs have been observed in individuals with chronic HIV-1 infection. In the present study, we analyzed the expression levels of monocytes, myeloid dendritic cell (mDC) precursors, mDCs, and plasmacytoid dendritic cells (pDCs), in HIV-1-infected patients in China who were infected via different routes of transmission, including heterosexual and homosexual sexual contact, and blood transmission through importation of blood or blood products, to further elucidate their role in HIV. Compared with HIV-negative individuals (n = 40), relative levels of CD11c+CD14−mDCs, CD11c++CD123lowmDCs, and CD11c−CD123+pDCs in total peripheral blood mononuclear cells (PBMCs) were significantly lower in all HIV patients (n = 93), and in those with blood transmission (n = 26) and heterosexual transmission (n = 43), while relative levels of CD11c+CD14−mDCs were significantly lower in HIV patients infected via homosexual transmission (n = 24). The results of correlation analysis demonstrated a significant negative correlation between CD4+T-cell counts and the relative levels of CD11c++CD123lowmDCs in HIV-I patients infected via blood transmission. There was no significant correlation between CD4+T-cell counts and the expression level of other DC subpopulations in PBMCs from HIV patients. The results of this study suggest that HIV-1 patients with different routes of transmission exhibit altered expression levels of blood DC subpopulations, which contributes to dysregulated immune responses and pathogenesis of HIV-1. [ABSTRACT FROM AUTHOR]

• Economic input for nonpoint source pollution control has marginal diminishing effect. • Implementation of best management practices should consider ecological benefits. • This model is designed to generate the most efficient solution group. • Balanced cost-effectiveness can be achieved by an integrated control strategy. Non-point source (NPS) pollution has become a primary threat to the water environment. With the implementation of numerous control projects, striking a balance between economic costs and efficiency has become an urgent issue for decision-makers. To identify the optimization solutions for best management practices (BMPs) at the watershed scale, a genetic algorithm and the Soil and Water Assessment Tool (SWAT) model were combined to evaluate the trade-offs of NPS control strategies. The BMPs considered in this model included soil testing and fertilizer application technology, integrated pest management projects, conservation tillage, lakeside belt ecological construction, forest construction, and vegetation filter strips. The decision variables are the type and size of the BMPs, with the objective of minimizing costs while simultaneously maximizing both total phosphorus (TP) reduction and ecosystem service value. TP reduction was simulated usinga calibrated SWAT model that successfully assessed NPS pollution in the Dianchi lake watershed. Considering NPS generation and transfer, three NPS control scenarios were designed: source reduction, process retention, and integrated control. The upper limits of the costs for three scenarios were 157, 4921, and 5013 million yuan, respectively. It is suggested that the ecological benefits should be taken into account in the BMPs design. This finding is conducive to generating optimized control schemes that can effectively balance the trade-offs between socioeconomic costs and environmental sustainability. [ABSTRACT FROM AUTHOR]

Objectives This study aimed to examine the role of falls efficacy in the relationship between the locomotive function and quality of life. Methods From March to May in 2016, we conducted a cross-sectional survey among 830 community residents aged ≥60 years from Jinzhou,China.GLFS-25 (25-question Geriatric Locomotive Function Scale), FES-I(International edition of Falls Efficacy Scale),and SF-12 (12-item Short Form Health Survey) were used to estimate locomotive function, falls efficacy and quality of life, respectively. The higher score of GLFS-25, the worse the locomotive function. Results Median age was 68.69 years (ranges 60–88). Locomotive function, falls efficacy and quality of life all presented a linear relationship within each other, locomotive function score was negatively correlated with falls efficacy score (−0.461, P < 0.01). locomotive function score was negatively correlated with quality of life score (−0.523, P < 0.01).Falls efficacy score was positively correlated with quality of life score (0.415, P < 0.01).Falls efficacy exerted both a mediating and moderating role between locomotive function and quality of life, and the mediation effect accounted for 45.5% of the total effect. Conclusions Poorer locomotive function was associated with poorer quality of life, and greater falls efficacy was associated with better quality of life. In addition, falls efficacy was demonstrated to be both a mediator and moderator variable in the linkage between locomotive function and quality of life. Aged care professional practitioners and our policy makers should strengthen the awareness of the psychological role of the elderly falls efficacy. [ABSTRACT FROM AUTHOR]

Aerosol-cloud (AC) interactions remain uncharacterized due to difficulties in obtaining accurate aerosol and cloud observations. In this study, we quantified the aerosol indirect effects (AIE) on warm clouds over Eastern China based on near-simultaneous retrievals from MODIS/AQUA, CALIOP/CALIPSO, and CPR/CLOUDSAT between June 2006 and December 2010. The seasonality of aerosols from ground-based PM 10 (aerosol particles with diameter of 10 μm or less) significantly differed from that estimated using MODIS aerosol optical depth (AOD). This result was supported by the lower level frequency profile of aerosol occurrence from CALIOP, indicative of the significant role of CALIOP in the AC interaction. To focus on warm clouds, cloud layers with base (top) altitudes above 7 (10) km were excluded. The combination of CALIOP and CPR was applied to determine the exact position of warm clouds relative to aerosols out of the following six scenarios in terms of AC mixing states: 1) aerosol only (AO); 2) cloud only (CO); 3) single aerosol layer-single cloud layer (SASC); 4) single aerosol layer-double cloud layers (SADC); 5) double aerosol layers - single cloud layer (DASC); and 6) others. The cases with vertical distance between aerosol and cloud layer less (more) than 100 m (700 m) were marked mixed (separated), and the rest as uncertain. Results showed that only 8.95% (7.53%) belonged to the mixed (separated and uncertain) state among all of the collocated AC overlapping cases, including SASC, SADC, and DASC. Under mixed conditions, the cloud droplet effective radius (CDR) decreased with increasing AOD at moderate aerosol loading (AOD<0.4), and then became saturated at an AOD of around 0.5, followed by an increase in CDR with increasing AOD, known as boomerang shape. Under separated conditions, no apparent changes in CDR with AOD were observed. We categorized the AC dataset into summer- and winter-season subsets to determine how the boomerang shape varied with season. The response of CDR to AOD in summer exhibited similar but much more deepened boomerang shape, as compared with the all year round case. In contrast, CDR in winter did not follow the boomerang shape for its continued decreasing with increasing AOD, even after the saturation zone (AOD around 0.5) of a cloud droplet. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Hydroxycamptothecin (HCPT) is a unique antitumor drug that acts directly on topoisomerase I and inhibits its activity. However, the mechanism of HCPT-induced apoptosis is unclear. In the present study, the mechanism of HCPT-induced apoptosis in gastric cancer cells was investigated by detecting the expression of p53 , c -myc , bcl-2 , bcl-xl and bcl-xs genes in gastric cancer cells. METHODS: Apoptosis of gastric cancer cells (SGC-7901, MKN-45) was determined by terminal deoxyribonucleotidyl transferase-mediated dUTP– digoxigenin nick-end labeling (TUNEL) and flow cytometry. The mRNA and protein levels of the p53 , c-myc , bcl-2 , bcl-xl and bcl-xs genes were tested by reverse transcription–polymerase chain reaction analysis and immunocytochemical stain, respectively. RESULTS: Hydroxycamptothecin may induce apoptosis in different differentiated gastric cancer cells. The effect of HCPT-induced apoptosis on gastric cancer cells was dependent on the dose of HCPT used and the time of exposure to HCPT. Both SGC-7901 and MKN-45 cells manifested some morphological features of apoptosis after 12 h exposure to HCPT, including cell shrinkage, nuclear condensation, DNA fragmentation and formation of apoptotic bodies. Some typical subdiploid peaks before the G0 /G1 phase were observed. The apoptotic rates induced by 10 μg/mL HCPT in SGC-7901 and MKN-45 cells were 21.88 and 12.34%, respectively. The mRNA and protein levels of p53 and bcl-2 were downregulated after treatment with HCPT in SGC-7901 cells. However, the c-myc, bcl-xl and bcl-xs protein levels were unchanged in SGC-7901 cells. In MKN-45 cells, the mRNA and protein levels of p53 increased after treatment with HCPT, whereas the protein levels of bcl-2, c-myc, bcl-xl and bcl-xs remained unchanged. CONCLUSIONS: Our results indicate that HCPT-induced apoptosis in gastric cancer cells may be regulated through modulation of the expression of p53 and bcl-2 genes. [ABSTRACT FROM AUTHOR]

The waterfront along great rivers, located in water-land and human-nature interaction zone, is a type of rare resource, which is critical for urban and industrial development and eco-environmental protection. The development and protection of riverfronts is one of the key components of sustainable watershed development. Waterfront development control, followed by regulation zoning that is based on different socio-economic and iconological functions, is regarded as one of the most important governance instruments for sustainable riverfront management. Based on the natural and socioeconomic attributes, we constructed a theoretical framework and integrated index system to evaluate the ecological sensitivity, development potential, and current development patterns of riverfront resources. The evaluation is further used as evidence for riverfront use zoning and future development governance through a case study in the Yangtze riverfront in China. The results show that more than 40% of the riverfront along the Yangtze River has high ecological sensitivity to economic development. The lengths of the development-prohibited, development-restricted, and development-optimized riverfront accounted for 70.0%, 6.5%, and 23.5% of the total evaluated Yangtze riverfront, respectively. Based on the assessment and field research, several problems were observed, such as the misuse of deep-water riverfront, conflicts between drinking water sources and heavy industrial development, and waterfront development in nature preservation areas. The riverfront zoning results can be used to support future riverfront development regulation and use optimization. Finally, we inferred some policy suggestions for future riverfront governance. The theoretical framework and integrated index system were developed to evaluate the ecological sensitivity, development potentials, and current development patterns of riverfront resources. The Yangtze Riverfront in China was examined. The lengths of the development-prohibited, development-restricted, and development-optimized riverfront accounted for 70.0%, 6.5%, and 23.5% of the total evaluated length, respectively. The zoning results can be used to support future riverfront development regulation and use optimization. Image 1 • Riverfront is conceptualized as resource from ecological and economic values. • Yangtze Riverfront ecological sensitivity and development potentials were assessed. • About 50% of the Yangtze riverfront has high or medium ecological sensitivity. • Spatial mismatch problems of riverfront development were identified. • Regulation zones were proposed for future riverfront development and governance. [ABSTRACT FROM AUTHOR]

With the drying and warming of the climate and irrational grazing, various types of grasslands in Inner Mongolia have been degraded to different degrees, and different management modes will inevitably affect the plant diversity and vegetation carbon stock of soil grasslands. To clarify the changes and influencing factors of plant diversity and carbon stock in different types of grasslands under different management modes, plant species composition, aboveground biomass, and vegetation carbon were analyzed based on 18 sentinel monitoring stations across three different types of grasslands in Inner Mongolia. The results showed that grazing increased the dominance of typical grassland and desert grassland, whereas meadow grassland decreased, and the evenness index and Shannon Wiener diversity index increased less in meadow grassland and desert grassland. Grazing decreased graminaceous biomass in meadow grassland and typical grassland, whereas it increased in desert grassland. Above-ground vegetation and below-ground root carbon stocks were much higher than those in grazing areas, 1.5 and 1.2 higher, respectively, but vegetation carbon stocks in long-term grazing sites were significantly lower than those in short-term grazing. Further, the structural equations showed that the effects of geographic location, climatic factors, and soil factors on the biomass and vegetation carbon stocks of the three grassland types differed significantly. The results can provide a reference for the ecologically sustainable development of grassland and the optimization of management mode.

Background: Improving quality of life is vital for patients with atrial fibrillation (AF) after radiofrequency ablation. Quality of life can be affected not only by personal mastery but also by health promoting behavior as previously studied. However, it remains unclear whether health promoting behavior mediates the relationship between personal mastery and quality of life., Objectives: To explore whether health promoting behavior mediates the relationship between personal mastery and quality of life in patients with AF after radiofrequency ablation., Methods: A cross-sectional design and convenience sampling were conducted at a tertiary hospital in China. Self-reported questionnaires were used to assess personal mastery, health promoting behavior and quality of life. SPSS and AMOS software were used for statistical analysis., Results: A total of 202 patients with AF after radiofrequency ablation were enrolled (mean age 58.28 ± 12.70 years). The scores for personal mastery and quality of life were 22.52 ± 2.53 points and 62.58 ± 8.59 points, respectively, indicating a limited level. The health promoting behavior exhibited a moderate level, with scores averaging 103.82 ± 8.47 points. There was a positive correlation between the three variables (all P < 0.05). Health promoting behavior played a partial mediating role in the relationship between personal mastery and quality of life in patients with AF after radiofrequency ablation, accounting for 44.79 % of the total effect., Conclusions: In order to improve quality of life and prognosis, it is necessary to consider enhancing personal mastery and increasing patient compliance with health promoting behavior, which are important ways to improve their quality of life., Competing Interests: Declaration of competing interest All the authors indicated that there are no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)

The study aims to establish trimester-specific reference ranges for serum iodine (SI) in Chinese pregnant women and explore its associations with maternal and infantile thyroid function. Apparently healthy pregnant women were enrolled during their first antenatal visit. Fasting venous and spot urine samples were collected for determining serum and urinary iodine (UI) levels by a validated inductively coupled plasma mass spectrometry. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), and neonatal TSH levels were tested by electro-chemiluminescent assay. The reference ranges of SI were established by percentile method and reported as 2.5-97.5%. ROC analysis was applied to compare the discriminative ability of SI, UI, and UI to urinary creatine ratio (UI /UCr) in early pregnancy for various thyroid conditions. The trimester-specific reference ranges of SI for Chinese pregnant women were 60.91-114.53 μg/L for the first trimester (T1, n = 1029), 54.57-103.42 μg/L for the second trimester (T2, n = 379), and 52.03-110.40 μg/L for the third trimester (T3, n = 455). Maternal SI at T1 but not UI and UI/UCr was significantly correlated with FT3 (r = 0.393, P < 0.001), FT4 (r = 0.637, P < 0.001), and TSH (r = -0.299, P<0.001). Maternal SI change% from T1 to T2 (but not SI change% from T1 to T3) had marginal correlation with neonatal TSH (r=-0.106, P=0.046). ROC analysis showed that maternal SI at T1 had better predictability for several thyroid conditions than UIC and UI/UCr., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

The odonatan asiopterid Turanopteron sinensis sp. nov. and the juragomphid Oxfordgomphus trescellulae gen. et sp. nov. are described on the basis of two new fossil wings from the Middle-Upper Jurassic of Henan Province in China. These taxa belong to ancient, Toarcian epiproctophoran stem groups of Anisoptera Selys, 1854. They show important affinities with taxa from the Karatau entomofauna in Kazakhstan. These groups progressively decrease and were replaced by more modern clades of Anisoptera during the Late Jurassic.