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1. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America.

Author

Argent RH, Burette A, Miendje Deyi VY, and Atherton JC

Subjects
Bacterial Proteins genetics, Belgium epidemiology, China epidemiology, Duodenal Ulcer epidemiology, Helicobacter Infections epidemiology, Helicobacter pylori genetics, Helicobacter pylori isolation & purification, Humans, North America epidemiology, Prevalence, South Africa epidemiology, Stomach Neoplasms microbiology, Virulence, Virulence Factors genetics, Bacterial Proteins physiology, Duodenal Ulcer microbiology, Helicobacter Infections microbiology, Helicobacter pylori pathogenicity, Virulence Factors physiology
Abstract

A previous study suggested that Helicobacter pylori strains possessing dupA are positively associated with duodenal ulceration and negatively associated with gastric adenocarcinoma. We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration.

Published
2007
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