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Background: With the evolution of disease patterns and the continuous pursuit of persons for high-quality nursing services, new nurses are the reserve talents of the nursing team and shoulder a major mission. However, due to their low work performance and high turnover rate, this is not conducive to the stable development of nursing teams, and it is urgent to solve this problem. The purpose of this study was to explore the effect of work readiness on the work performance of new nurses, focusing on the mediating role of organizational justice and professional identity. Method: A cross-sectional design was employed. Using convenience sampling methods, 607 new nurses were surveyed in 5 hospitals in Henan Province, China, from January to February 2023. Data were collected using demographic characteristics questionnaire, the Work Performance Scale, the Work Readiness Scale for Graduate Nurses, the Organizational Justice Scale, and the Professional Identity Rating Scale for Nurses. AMOS 26.0 was used for model drawing and mediation path testing, and SPSS 25.0 was used for data analysis. Results: The mediation model shows a good fit (χ2 /df = 2.747, CFI = 0.987, GFI = 0.948, AGFI = 0.926, TLI = 0.984, IFI = 0.987, and RMSEA = 0.054). In this study, we found professional identity is a mediating variable between work readiness and the work performance of new nurses (β = 0.113, P<0.01), organizational justice is a mediating variable between work readiness and the work performance of new nurses (β = 0.269, P<0.01) and Organizational justice and professional identity play a chain mediating role in work readiness and work performance (β = 0.066, P<0.01). Conclusions: The study highlights the importance of improving the work performance of new nurses. To improve work performance, managers should create a fair atmosphere, formulate transparent policies, improve the organizational justice of new nurses, and promote the professional identity and work readiness of new nurses by holding activities or conducting lectures. This will help stabilize the nursing team, improve the medical environment, stimulate the work enthusiasm of new nurses, and contribute to the development of the hospital. [ABSTRACT FROM AUTHOR]

Background: New nurses are prone to workplace deviant behavior in the constrained hospital environment, which will not only directly affect the safety of patients, but also reduce the work efficiency of nurses and bring negative results to the hospital. The purpose of this study was to investigate the relationship between perceived organizational justice, emotional labor, psychological capital, and workplace deviant behavior of new nurses. Methods: A cross-sectional study was used in this study. A survey was conducted in 5 hospitals in Henan Province, Chain from February to April 2023. The sample size was 546. The questionnaire included general information, perceived organizational justice scale, emotional labor scale, psychological capital scale, and workplace deviant behavior scale. SPSS 26.0 and PROCESS Macro were used for data analysis. PROCESS Model 4 and Model 14 were used to verify the model. Results: This study displays that perceived organizational justice was negatively correlated with emotional labor and workplace deviant behavior, and emotional labor was positively correlated with workplace deviant behavior. Meanwhile, emotional labor plays a partial mediating role between perceived organizational justice and workplace deviant behavior, accounting for 32.7% of the total effect. Moreover, the path of emotional labor on workplace deviant behavior is moderated by psychological capital. Conclusion: This study further understood the workplace deviant behavior of new nurses, and provided a new perspective for solving this problem. Nurse managers can reduce workplace deviant behavior by enhancing the perceived organizational justice and psychological capital of new nurses and improving emotional labor. [ABSTRACT FROM AUTHOR]

Introduction: Cerebral venous thrombosis (CVT) is a rare subtype of stroke. However, existing scales were insufficient to evaluate the overall severity of CVT. The aim of this study is to develop and validate a CVT severity scale.Methods: Items 1– 11 were directly derived from NIHSS. New items were generated from a literature review and focus group discussion. A total of 170 CVT patients were prospectively recruited from 26 top tertiary hospitals in China Mainland from January 2021 to May 2022 to validate the CVT severity scale. The CVT severity scale, NIHSS, mRS and GCS were rated at admission. The lumbar puncture opening pressure was also recorded. Twenty randomly selected CVT patients were rated with the CVT severity scale again 24 hours later. The clinical outcome of CVT was evaluated by mRS at 6 months after baseline.Results: We successfully established a CVT severity scale with 18 items. Exploratory factor analysis showed that 18 items were attributed to factor 1 (focal neurological deficits), factor 2 (diffuse encephalopathy), factor 3 (intracranial hypertension) and factor 4 (cavernous sinus syndrome). CVT severity scale was positively correlated with ICP, NIHSS and mRS, and negatively correlated with GCS at baseline. CVT severity scale > 3 or factor 3 > 2 indicated intracranial hypertension. CVT severity scale > 10 indicated poor clinical outcome at 6 months of follow-up. Meanwhile, CVT severity scale showed high internal consistency and test–retest reliability.Conclusion: The CVT severity scale included 18 items encompassing 4 domains of focal neurological deficits, diffuse encephalopathy, IH and cavernous sinus syndrome. CVT severity scale correlated well with ICP, NIHSS, mRS and GCS. Patients with CVT severity scale > 10 can be defined as severe CVT. The CVT severity scale may serve as a valid and reliable tool for measuring the overall severity of CVT. [ABSTRACT FROM AUTHOR]

Background and purpose: Cortical vein thrombosis (CVT) is a rare form of cerebral venous sinus thrombosis (CVST) in adolescent patients that has received little attention. We aimed to analyze the clinical and radiological features of adolescents with CVST and investigate the effects of CVT involvement. Methods: Patients aged ≥ 10 to ≤ 18 years and diagnosed with CVST were identified at Xuanwu Hospital, Capital Medical University between January 2015 and August 2022 and divided into two groups according to the presence or absence of cortical vein involvement. Additionally, the patients were also categorized based on their sex. Clinical features, radiological characteristics, and 12-month follow-up outcomes were compared between the two groups. Results: Fifty-three adolescents, including 21 with CVT, were included (mean age: 15.2 ± 1.8 years; females, 54.7%). The CVT group was more likely to experience seizures (P = 0.028) and deterioration (28.6% vs. 6.2%, P = 0.047) during hospitalization than the non-CVT group. Poor short-term outcomes, based on the modified Rankin Scale (mRS) score at discharge, were more common in adolescents with CVT (P = 0.007). The proportions of patients showing edema (42.9% vs. 6.2%, P = 0.004) and mass effect (P = 0.015) were significantly higher in the CVT group. Recanalization was observed in 61.9% and 82.1% of the patients in the CVT and non-CVT groups, respectively, during the first imaging review (median, 22 days). After a 12-month follow-up, female adolescents had more frequent resident secondary headaches than male adolescents (52.9% vs. 12.5%; P = 0.014). Conclusions: Cortical vein involvement in adolescents with CVST was associated with a higher risk of epilepsy at presentation, deterioration during hospitalization, edema, and mass effect on acute imaging. Moreover, cortical vein involvement may lead to worse short-term outcomes. Sex differences require consideration in etiological analyses and prolonged follow-ups. [ABSTRACT FROM AUTHOR]

Epidemiological data on cerebral venous thrombosis in China are still lacking at present on the aspects of incidence, recurrence, risk factors, and so on. Herein, we aimed to fill the gap, based on the result of this multicenter prospective cohort study. A total of 26 top tertiary hospitals distributed in China Mainland will take part in this study. For the first time, a dataset of cerebral venous thrombosis cohort (including multiethnic patients of all ages in almost all regions of Mainland China, regardless of gender) will be built. Inclusion criteria were as follows: (1) aged ≥14 years, (2) neuroimaging-confirmed cerebral venous thrombosis, (3) symptom onset was within 30 days prior to enrollment, (4) signed the informed consent form. Demographic data, risk factors, clinical and neuroimaging features, ophthalmologic and aural results, blood tests, cerebrospinal fluid examination, therapeutic strategies, and adverse events were analyzed. Two milliliters of fasting venous blood and 2 mL of cerebrospinal fluid will be collected and stored. Furthermore, patients will be followed up at months 1, 3, 6, and 12 after baseline assessment. Primary outcome will be all-cause mortality. Secondary outcomes: (1) cerebrospinal fluid pressure and Frisen grade; (2) recanalization rate on imaging; (3) rating scales such as GCS, NIHSS, mRS, Mini-Mental State Examination, Montreal Cognitive Assessment, Patient Health Questionnaire 9-item, HIT-6, and Tinnitus Handicap Index. This study will for the first time provide strong evidence on the incidence rate, recurrence rate, and demographic data, as well as special risk factors, clinical outcomes, symptomatic and imaging features of cerebral venous thrombosis in Chinese population. The results of this study will also provide an important reference on prevention, early diagnosis, and customized treatment of cerebral venous thrombosis in Chinese patients. [ABSTRACT FROM AUTHOR]

Aims: Remote ischemic conditioning (RIC) has been demonstrated to reduce recurrent stroke in patients with intracranial artery stenosis. This study aimed to evaluate the effects of RIC in patients with the symptomatic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion. Methods: This study is based on a high‐volume single‐center prospective cohort study in China, which included patients with symptomatic ICA or MCA occlusion with impaired hemodynamics and receiving chronic RIC. Clinical follow‐up visits were performed regularly, and cardio‐cerebrovascular events were assessed. Results: In total, 131 patients (68 with ICA occlusion and 63 with MCA occlusion; mean age, 52.6 ± 13.7 years; stroke, 73.5%; transient ischemic attack TIA, 26.5%) qualified for the analysis; the mean follow‐up period was 8.8 years (range, 3–14 years). The compliance of RIC was 95.6 ± 3.7%, and no associated severe adverse events happened. The annual risk of ischemic stroke and ischemic cerebrovascular events was 2.4% and 3.3%, respectively. The cumulative probabilities of ischemic cerebrovascular events and major adverse cardiovascular and cerebrovascular events were 32.8% and 44.8% at 14 years, respectively. Conclusion: In patients with symptomatic ICA or MCA occlusion with impaired hemodynamics, chronic RIC is well‐tolerated, and it appears to be associated with a low annual risk of ischemic stroke and cardio‐cerebrovascular events. [ABSTRACT FROM AUTHOR]

Introduction: The present study was aimed to evaluate the performance and safety of the Glunovo® real-time continuous glucose monitoring system (CGMS) in monitoring interstitial fluid glucose in adult participants with diabetes (at least 18 years old) using venous blood glucose as control. Methods: This was a multicenter, self-controlled clinical trial, conducted in participants with diabetes from China, between March 2019 to October 2019. The CGMS was used by all the participants for a 14-day wear-in period. The real-time glucose values measured by Glunovo® CGMS were compared with venous blood glucose values measured by the Entwicklung, Konstruktion und Fertigung (EKF) blood glucose detector. The primary outcomes were the consistency rate of CGMS readings and venous blood glucose values (20/20% standard). Results: A total of 78 participants (41 men, 37 women) and 156 CGMS sensors were included in the study. Among the included participants, 25 and 53 participants had type 1 and type 2 diabetes, respectively, with median age of 52.50 years (range 32–62 years). The overall agreement rate (20/20%) was 89.71% (95% CI 89.18–90.24%). It was observed that 99.08% (95% CI 98.91–99.24%) and 99.82% (95% CI 99.74–99.89%) of the measuring points fell within the A + B zones of the Clarke error grid analysis and Parkes/consensus error grid analysis, respectively. The mean absolute relative difference was 10.30% ± 4.86%. The probability of a glucose measurement falling within a range, when stratified by venous glucose measurements, ranged from 7.14% for 19.44–22.22 mmol/L to 79.21% for 4.44–6.67 mmol/L. There were 73 (41.24%) and 27 (57.45%) successful CGMS alarms for hypoglycemic and hyperglycemic events, respectively. Conclusion: From the results, Glunovo® CGMS had excellent accuracy and limited clinical risk compared with venous blood glucose in the range of 2.2–22.2 mmol/L over 14 days. [ABSTRACT FROM AUTHOR]

Annual land use land cover (LULC) change information at medium spatial resolution (i.e. at 30 m) is required in numerous subjects, such as biophysical modelling, land management and global change studies. Annual LULC information, however, is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities. Here we integrate high temporal resolution and coarse spatial resolution satellite images (i.e., Moderate Resolution Imaging Spectroradiometer (MODIS) and Global Inventory Modelling and Mapping Studies (GIMMS) normalized difference vegetation index (NDVI)) with high spatial resolution datasets (China's Land-Use/cover Datasets (CLUDs) derived from 30-meter Landsat TM/ETM+/OLI) to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015. We also test the performance of a statistical based change detection algorithm (Breaks for Additive Seasonal and Trend), originally designed for tracking forest change, in classifying all-type LULC change. As a result, a nominal 30 m annual land use/land cover datasets (CLUD-A) from 1980 to 2015 was developed for the whole China. The mapping results were assessed with a change sample dataset, a regional annual validation sample set and a three-year China sample set. Of the detected change years, 75.61% matched the exact time of conversion within ±1 year. Annual mapping results provided a detail process of urbanization, deforestation, afforestation, water and cropland dynamics over the past 36 years. The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. [ABSTRACT FROM AUTHOR]

SUMMARY: The small athecate dinoflagellate Karlodinium zhouanum is a species recently described in the coastal waters of China. K. zhouanum is morphologically similar to Karlodinium veneficum, a typical ichthyotoxic blooming karlotoxin‐producing species, and it is impossible to distinguish between these two species based on light microscopy. In this study, strains of K. zhouanum isolated from the East China Sea were studied. By analyzing toxins, toxicity, lipid characteristics and typical molecular and physiological traits of this species, K. zhouanum was shown to be nontoxic to brine shrimp and widely spread over the coastal waters of China. No karlotoxin‐like toxin was detected by liquid chromatography‐mass spectrometry (LC–MS). Instead of gymnodinosterol, the critical sterol in toxic K. veneficum, 27(nor)‐24S‐4α‐Methyl‐5α‐ergosta‐8(14)‐en‐3β‐ol (NEE) was dominant in K. zhouanum, while gymnodinosterol was absent. These sterol characteristics may provide not only support for the species separation between toxic and nontoxic species of Karlodinium but also environmental survey tools to differentiate the contribution of nontoxic Karlodinium strains, which has been unclear until now. [ABSTRACT FROM AUTHOR]

This study aims to explore the effect of organizational justice on young nurses' turnover intention and the roles of organizational climate and emotional labour in this relationship. The shortage of nursing resources has become a growing problem in countries worldwide. As the main representatives of the nursing force, young nurses have high turnover intentions, which aggravates the possibility of nursing shortages. As an important variable affecting the turnover intention of young nurses, the mechanism underlying the impact of organizational justice should be studied in depth. A descriptive cross-sectional design was employed. From November to December 2022, an online questionnaire survey was conducted among 1160 young clinical nurses from 5 hospitals in Henan Province, China. The scales used in this study include the organizational justice scale, the turnover intention scale, the organizational climate scale and the emotional labour scale. AMOS 26.0 was used for model drawing and mediation path testing, and SPSS 25.0 was used for data analysis. This study complies with the STROBE Statement of Observational Studies. In general, the young nurses surveyed had high turnover intentions (14.82 +/- 4.44). Organizational justice has a negative predictive effect on young nurses' turnover intention (r = −0.465, P ＜0.01). Organizational climate and emotional labour play a chain mediating role in the relationship between organizational justice and young nurses' turnover intention (β = −0.051). Organizational justice is significantly related to the turnover intention of young nurses, and organizational climate and emotional labour play a chain mediating role in the relationship between organizational justice and turnover intention. Therefore, nursing managers should pay attention not only to organizational justice but also to the influence of organizational climate and emotional labour on the turnover intention of young nurses. [ABSTRACT FROM AUTHOR]

Environmental and green justice problems occur globally, especially in cities with unequal access to urban greenspaces. Recently, inequality in school greenspaces has drawn growing attention, given the importance of campus green environments in young students' health and academic performance. However, the commonly used Normalized Differences Vegetation Index (NDVI) method for measuring greenspace from satellite imagery is hindered by the saturation issue and tend to underestimate greenspace at high vegetation cover areas, causing large uncertainties in greenspace inequality studies at a national scale. Besides, despite the progress on the inequality of public greenspace exposure, our understandings of primary school greenspace provision and inequality, as well as the driving factors, for young students in a developing world (e.g., China) is still limited. To address these issues, we first adapted a spectral unmixing technique based on multi-sensor remote sensing for more accurate measurements of greenspace provision. Then, we evaluated the provision and inequality of greenspace for 19,681 primary schools in China's 31 major cities and examined the driving factors using an integrated path analysis. Our findings revealed that: (1) Our proposed multi-sensor remote sensing-based method for greenspace measurement is reliable across our study area with a R2 of 0.81 and RMSE of 0.14; in contrast, the traditional NDVI-based greenspace measurement saturated at the range of 0.7–1.0, leading to much lower accuracy (a R2 of 0.72 and RMSE of 0.24). (2) Most of the cities under study had low to moderate levels of inequality in primary school greenspace (Gini index < 0.5), but the overall greenspace provision was relatively low; Five cities under study facing high inequality in greenspace exposure (Gini index ≥ 0.5) as well as low greenspace provision (mean fraction cover < 0.25). (3) The monthly maximum temperature and the mean cover of greenspace in primary schools were identified as variables directly affecting the inequality in primary school greenspace (R2 = 0.76, p-value < 0.05), whereas the city-level government revenue manifests its effects through the mean cover of greenspace in primary schools and city-level mean greenspace cover. By developing a novel framework for examining the provision and inequality of greenspace in all primary schools in China's major cities, our study provides valuable insights for designing and evaluating school greening programs in support of healthier learning environment development for next generations. [ABSTRACT FROM AUTHOR]

• Accuracy in monitoring LNC was compared among 13 observation angles. • We tested four algorithms (VIs, BPNN, XGBoost, PLSR) for LNC monitoring performance. • Number of bands and their position affected the monitoring accuracy of LNC. • An appropriate algorithm and observation angle for monitoring LNC are proposed. Leaf nitrogen concentration (LNC) is a key indicator of crops' growth status, and the timely and accurate large-scale area monitoring of LNC is crucial for guiding field management. Here, we collected LNC data and hyperspectral data at the canopy scale, from 13 view zenith angles (VZAs) and two locations (Zhengzhou and Shangshui, in China) across 2 years (2012–2014). Four data processing methods—vegetation indices (VIs), back-propagation neural network (BPNN), eXtreme gradient boost (XGBoost), and partial least squares regression (PLSR)—were applied and compared for their ability to estimate LNC under 13 VZAs. These results revealed consistent trends in the performance of the four algorithms at 13 VZAs: the nadir direction is better than the extreme angle, and the best performance is obtained for the range of –30° to 0° (R2 ≥ 0.83; RMSE ≤ 0.41%). The number of bands is a critical factor affecting the accuracy of LNC monitoring: including red edge bands can alleviate angular effect to some extent. The accuracy of PLSR for monitoring LNC is not only superior near the nadir direction (R2 = 0.91), but also better than that provided VIs (16%–17%), BPNN (15%–16%), or XGBoost (29%–58%) at ± 60°. Therefore, it is strongly recommended the PLSR algorithm be used to process multi-angle remote sensing data to estimate the LNC of field crops. This work provides a timely reference basis for selecting the appropriate flight angle and the number and positioning of bands for unmanned aerial vehicle (UAV) and satellite applications in the future. [ABSTRACT FROM AUTHOR]

In response to the rapidly increasing application and abuse of psychological tests in China, the Psychometrics Division of the Chinese Psychological Society published the 2008 revisions of the Chinese Code of Ethical Use of Psychological Tests. We investigated the implementation status of the code 2½ years after its promulgation. Sample included 284 psychological professionals and psychology graduate students. The average accuracy rate for the appropriate use of psychological tests was 67.1% (range = 25.5–97.5%), with 10 items having accuracy rates below 45%. Participants remained uncertain about the clients' rights to information about the purpose, psychometric properties, and scores of the tests. The most frequent violations involved “using psychological tests without psychometric information for entertainment purposes” and “using SCL-90 to measure mental health of normal people.” [ABSTRACT FROM PUBLISHER]

The aim of this study was to verify the applicability of the critical nitrogen concentration dilution curve (Nc) of wheat grown under different irrigation conditions in the field, and discuss the feasibility of using the N nutrition index (NNI) to optimize N fertilizer application. The high-yield, medium-protein wheat varieties Zhoumai 27 and Zhoumai 22 were used in field experiments in two different locations (Zhengzhou and Shangshui) in Huang-Huai, China. Plants were grown under rainfed and irrigation conditions, with five N application rates. Nc models of the leaves, stems, and whole plant were constructed, followed by establishment of an NNI model and accumulative N deficit model (Nand). As previous research reported, our results also showed that the critical N concentration and biomass formed a power function relationship (N = aDW−b). When the biomass was the same, the critical N concentration was higher under irrigation than rainfed treatment. Meanwhile, the fitting accuracy (R2) of the Nc model was also higher under irrigation than rainfed treatment in both sites, and was higher in the stems and whole plant. The NNI calculated using the Nc model increased with increasing N application, reflecting N deficiency. Moreover, there was a significant negative linear correlation between NNI and Nand, and both indices could be uniformly modeled between locations and water treatments. The accuracy of the Nand model was highest in the whole plant, followed by the leaves and stems. The models constructed in this paper provide a theoretical basis for accurate management of N fertilizer application in wheat production. [ABSTRACT FROM AUTHOR]

Background and rationale: Cerebral venous thrombosis (CVT) is a rare cerebrovascular disorder that mainly affects young and middle‐aged adults. Epidemiological data on the incidence, risk factors, diagnosis, treatment, and prognosis of CVT are lacking in China. In addition, there is a lack of evidence from large, multicenter, real‐world studies on the efficacy and safety of endovascular. Aim: To understand the incidence, diagnosis and treatment status of CVT in China and to estimate the effectiveness and safety of endovascular treatment in the real‐world. Methods: A multicenter, retrospective observational cohort study will be conducted on CVT patient records from 104 hospitals, between January 1, 2018 and June 30, 2022, identified using a 2‐stage cluster sampling design based on per capita gross domestic product. Each enrolled participant is required to complete a further follow‐up, which includes the current situation and the assessment at 3 and 12 months after discharge. Study outcomes: The outcomes of this study will include the current status of the incidence, pathogenesis, etiology, clinical symptoms, diagnosis, and treatment of CVT in China, as well as the effectiveness and safety of endovascular treatment in the real‐world. Discussion: Results from this study will provide evidence on the incidence, specific risk factors, symptomatic and imaging features, and clinical outcomes of CVT in China as well as indicate whether endovascular treatment is superior to medical management alone for patients with acute CVT in the real‐world. Trial registration: http://www.clinicaltrials.gov. Identifier: NCT05448248 This is a protocal about our study. This protocal introduces the design, method and content of our research. [ABSTRACT FROM AUTHOR]

Plantation forests provide critical ecosystem services and have experienced worldwide expansion during the past few decades. Accurate mapping of tree species through remote sensing is critical for managing plantation forests. The typical temporal behaviors and traits of tree species in satellite image time series (SITS) generate temporal and spectral features in multiple phenological stages that are critical to improve tree species mapping. However, the diverse input features, sequential relations and complex structures in SITS drastically increase the dimension and difficulty of spectral-temporal feature extraction, which challenges the capacity of many general classifiers not explicitly adapted for spectral-temporal learning. As a result, there is still a lack of a method that could automatically extract spectral-temporal features with high separability and regional adaptability from high-dimensional SITS for tree species mapping of plantation forests. Moreover, the effects of varying temporal resolution and feature combination on the plantation tree species mapping are under-explored. Here, we developed a multi-head attention-based method for automatically extracting spectral-temporal features with high separability based on a modified Transformer network (Transformer4SITS) for improved plantation tree species mapping. The end-to-end network model consists of a feature extraction module to learn deep spectral-temporal features from SITS and a fusion module to combine multiple features for improving mapping accuracy. We applied this method to two representative plantation forests in southern and northern China for tree species mapping. The results show that: (1) Transformer4SITS method could self-adaptively extract typical spectral-temporal features of key phenological stages (e.g., greenness rising and falling) from SITS, and achieved significantly improved accuracies by at most 15% in comparison with all four baseline methods (i.e., long short-term memory, harmonic analysis, time-weighted dynamic time warping, linear discriminant analysis); (2) time series with higher temporal resolution tended to produce more accurate species maps consistently across two sites, with their overall accuracies (OA) respectively increasing from 91.05% and 84.33% (60-day) to 94.88% and 88.72% (5-day), but the effect of high temporal resolution respectively leveled off around 90-day and 50-day resolution across two sites; (3) the mapping results using all available bands and two-band spectral indices outperformed the results using a subset of them, but with only modest increase in the accuracy (i.e., OA increased from 93.63% and 86.01% to 94.88% and 88.72%. This study thus provides a state-of-the-art deep learning-based method for improved tree species mapping, which is critical for sustainable management and biodiversity monitoring of plantation forests across large scales. [ABSTRACT FROM AUTHOR]

Background: Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide, and it is associated with a high risk of recurrent stroke with currently recommended treatments. We aimed to evaluate the effect of chronic remote ischaemic conditioning on prevention of ischaemic events in patients with symptomatic ICAS.Methods: The RICA trial is a multicentre, randomised, double-blind, sham-controlled trial at 84 stroke centres in China. Patients aged 40-80 years with ischaemic stroke or transient ischaemic attack attributable to angiographically verified 50-99% stenosis of a major intracranial artery were randomly assigned (1:1), via an interactive web-based system by computer-generated randomisation code, to either remote ischaemic conditioning or sham remote ischaemic conditioning once daily for 12 months and voluntarily thereafter. All investigators and patients were masked to treatment allocation. The primary efficacy endpoint was the time to first occurrence of non-fatal or fatal ischaemic stroke, with survival analysed by the Kaplan-Meier method. Primary and safety analyses were done in the intention-to-treat population. The RICA trial is registered with ClinicalTrials.gov, number NCT02534545.Findings: Between Oct 28, 2015, and Feb 28, 2019, 3033 patients were enrolled and randomly assigned to either remote ischaemic conditioning (n=1517; intervention group) or sham remote ischaemic conditioning (n=1516; sham group). Median follow-up was 3·5 years (IQR 2·7-4·4). A non-fatal or fatal ischaemic stroke occurred in 257 (16·9%) patients in the intervention group compared with 288 (19·0%) patients in sham group. There was no difference in the survival distribution for time to first occurrence of non-fatal or fatal ischaemic stroke (hazard ratio 0·87, 95% CI 0·74-1·03; p=0·12). In the intervention group, 79 (5·2%) patients died from any cause, and in the sham group, 84 (5·5%) patients died from any cause (hazard ratio 0·93, 95% CI 0·68-1·27; p=0·65). No intervention-related serious adverse events were observed.Interpretation: No evidence was found for a difference between remote ischaemic conditioning and sham remote ischaemic conditioning in lowering the risk of ischaemic stroke in patients with symptomatic ICAS. The benefit of remote ischaemic conditioning might have been diluted by poor compliance. Future studies of remote ischaemic conditioning in this population should address challenges in patients' compliance and assess longer term treatment.Funding: Ministry of Science and Technology China, Beijing Municipal Education Commission, Beijing Municipal Finance Bureau.Translation: For the Chinese translation of the abstract see Supplementary Materials section. [ABSTRACT FROM AUTHOR]

The large yellow croaker (Larimichthys crocea) is one of the most economically important marine fishes on the southeast coast of China. However, high-density cultures, inbreeding depression, and environmental pollution have resulted in L. crocea often experiencing hypoxia, which has caused huge economic losses to the L. crocea farming industry. This study aimed to improve the hypoxia tolerance of farmed L. crocea using genomic selection (GS) for breeding. In this study, 399 and 354 samples from the reference and candidate populations, respectively, were genotyped using a 55 K liquid single-nucleotide polymorphism (SNP) array. Based on two different representations (survival status and survival time), the estimated values of heritability for the hypoxia tolerance trait in L. crocea using 38,472 clean SNPs were 0.65 and 0.62, respectively. A comparison of the genomic prediction accuracy under different GS models and SNP densities showed that GBLUP was the best GS model, and the 2500 SNPs selected using a genome-wide association study (GWAS)-based strategy were essentially close to all 38,472 SNPs. Based on the established optimal GS strategy (prediction accuracy was 0.4901 ± 0.0246), genomic estimated breeding values (GEBVs) were calculated for each candidate population. The tolerance capacity tests showed a significant improvement in hypoxia tolerance in the offspring of the candidate population with the top 10% GEBVs, having an 13.40% decrease and a 34.02% increase in the median lethal concentration (LC 50) and median lethal time (LT 50), respectively, compared to the control group. These results confirmed that GS is an effective genetic breeding technique when selecting for hypoxia tolerance in L. crocea. • The heritability for the hypoxia tolerance in L. crocea were 0.65 and 0.62, respectively. • GBLUP models are more suitable for genomic prediction of hypoxia tolerance traits in L. crocea. • The 2500 SNPs selected using a GWAS-based strategy were essentially close to all 38,472 SNPs. • The heritability for the hypoxia tolerance in L. crocea were 0.65 and 0.62, respectively. [ABSTRACT FROM AUTHOR]

Oriental liver fluke disease (clonorchiasis), caused by Clonorchis sinensis , is endemic in 81 counties in Guangdong province, China. This study was conducted following increasing lack of clonorchiasis awareness and increased consumption of raw freshwater fish and raw fish porridge at home and restaurants, which has been attributed to improved living standards in China, and is considered to have led to a higher C. sinensis infection rate in the country. A total of 61,517 individuals were investigated from 123 sites during a provincial survey in 1988, with average C. sinensis infection rate of 1.82% that increased to 4.08% (335/8217) in 1997. Higher infection rate was observed in adult men than women, with heavy infection rate in fishermen and businessmen because they have access and means to get raw fishes for consumption. Thus, clonorchiasis has become a serious public health problem in Guangdong province. Efforts targeting clonorchiasis prevention and control in Guangdong province started in the 1990s. These included carrying out large-scale surveys and chemotherapy in epidemic regions, research on promotion of environmental sanitation and methods for freshwater aquaculture. Establishment and promotion of clonorchiosis demonstration plots for comprehensive control measures, as well as the development of clonorchiasis-prevention community-out-patient clinics were initiated and their effectiveness was evaluated. However, there seem to be no obvious decline in the prevalence of C. sinensis with 4.90% (608/12,401) in 2015, at Guangdong province due to the people's habit of eating raw fishes in endemic areas. This has led to increasing calls to improve environmental sanitation in the aquaculture industry. It is, however, believed that control efforts on clonorchiosis in the province are at an early stage and require strengthening through the cooperation of different departments to work out effective strategies for sustainable field application of control mechanisms. [ABSTRACT FROM AUTHOR]

Background: Rivaroxaban, a direct Factor Xa inhibitor, is commonly used for cerebral venous thrombosis (CVT) correction. However, pharmacokinetic differences in Chinese may vary in sensitivity and tolerance, resulting in either insufficient or excessive anticoagulation. Herein, the optimizing dosages of rivaroxaban in Chinese patients with CVT were analyzed based on monitoring anti-Xa activity dynamically, to maintain therapeutic efficacy and reduce rivaroxaban-related bleeding., Methods: A real-world cohort study was conducted involving 112 CVT patients in Xuanwu Hospital, from August 2021 through January 2024. Patients were grouped according to their doses of rivaroxaban use (5, 10, 15, and 20 mg daily) based on dynamic plasma anti-Xa activity monitored using the chromogenic anti-Xa assay. Plasma levels of anti-Xa activity reached the therapeutic range, bleeding events and the dosage of rivaroxaban among these groups were analyzed., Results: The ratios of the patients whose plasma anti-Xa levels reached the standard therapeutic level (0.3-0.7 IU/mL) between the cohorts less than 20 mg/d and 20 mg/d showed no statistical difference, and no significant disparities were observed among 5, 10, 15, and 20 mg/d dose groups. There was a discernible increase in the proportion of patients with bleeding events in the 20 mg/d group, even though the results did not reach a statistical difference. Meanwhile, in patients with bleeding events, their plasma anti-Xa levels could exceed 0.7 IU/mL., Conclusion: Sensitivity and tolerance to rivaroxaban in Chinese may vary. Individualized therapy dosage under the guidance of anti-Xa activity monitoring may not only guarantee anticoagulation effect, but also reduce rivaroxaban-related bleeding events., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Normalized difference vegetation index (NDVI) is an important indicator reflecting vegetation cover and growth status. It is of significance for regional ecological conservation and natural resource management to investigate its spatial and temporal variation trends and response to ecological factors. We divided Liaoning Province into three ecological geographical regions, including northwest agro-pastoral zone, central agricultural zone, and eastern agroforestry zone. Based on remote sensing, vegetation, climate, topography and human activities, we used trend analysis and geographic probe model to examine the spatial and temporal trends of NDVI in Liaoning Province, and analyzed the intensity and interaction mechanism of each driver on the spatial distribution pattern of NDVI. The results showed that the annual average NDVI in Liaoning Province from 2001 to 2020 was 0-0.92, showing a distribution pattern of high in the east and low in the west, high in the inland and low in the coastal land. The overall trend of vegetation cover was increasing, and the NDVI increasing areas were mainly concentrated in the northwest agro-pastoral zone and the eastern agroforestry zone, the NDVI reduction areas were mainly concentrated at the border between the central agricultural zone and the eastern agroforestry zone, as well as in the coastal area of the eastern agroforestry zone. The annual average NDVI change varied among the three ecological-geographic zones. The NDVI of the northwest agro-pastoral zone from 2001 to 2020 were generally low, but showed a fluctuating trend of slow increase. The NDVI of the eastern agroforestry zone was high overall, and the interannual variation of NDVI was generally stable. The distribution of high and low NDVI in the central agricultural zone was staggered, and the interannual variation of NDVI showed a decreasing trend. Natural factors were the key drivers of NDVI changes in the three ecogeographic zones, with cumulative temperature and precipitation having the greatest influence. The interactions between the factors were all mutually and nonlinearly enhanced.

This study aims to conduct a comprehensive clinical and genetic investigation on a large family with members having various phenotypes, including acromesomelic dysplasia, type Maroteaux (AMDM), idiopathic short stature (ISS), Crouzon syndrome (CS). Prenatal diagnosis was performed on the high-risk fetus. We performed the whole-exome sequencing on three members with AMDM, ISS, or CS. Detailed genotypes and phenotypes were investigated on members of this 4-generation family. Genetic analysis identified three variants, which were designated as p.Val548del, p.Arg989Gln in natriuretic peptide receptor B/guanylate cyclase B ( NPR2 ), and p.Cys342Tyr in fibroblast growth factor receptor-2 ( FGFR2 ). Compound heterozygous variation consisting of p.Val548del and p.Arg989Gln caused AMDM. NPR2 heterozygous variant carriers exhibited normal height or ISS. The p.Cys342Tyr mutation of FGFR2 causes the typical clinical phenotype of CS. The fetus carried the heterozygous p.Val548del and p.Cys342Tyr mutations, with ultrasound results showing exophthalmos, parrot-beaked nose, low and flat frontal skull, and intrauterine growth retardation at the second and third trimesters of gestation. We are reporting those two novel mutations (p.Val548del and p.Arg989Gln) in NPR2 and a p.Cys342Tyr mutation in FGFR2 in an extended Chinese family. This finding extended the genotype-phenotype spectra of ISS, AMDM, and CS related to pathogenic variants.

Aims: Epidemiological data on diabetic retinopathy (DR) in Chinese population is still rather scarce, and risk factors for diabetic retinopathy are inconsistent because of study designs, grading standards, and population samples., Materials and Methods: This hospital-based retrospective study included 1052 type 2 diabetes patients. Diabetic retinopathy was diagnosed by nonmydriatic fundus photography and/or fundus examination apparatus. Logistic regression analysis was performed to evaluate the risk of diabetic retinopathy., Results: A total of 352 (33.5% prevalence) subjects were diagnosed with diabetic retinopathy based on our population. The patients in the DR group not only had significantly higher hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), urinary microalbumin-creatinine ratio (ACR), and systolic blood pressure but also had higher follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex hormone-binding globulin (SHBG) levels compared to those in the non-DR group. Moreover, we confirmed that diabetes duration and HbA1c are strongly associated with DR risk. We also found that serum LH was an independent risk factor in male diabetic retinopathy patients (OR = 1.086, 95% CI 1.024-1.152), and the levels of LH were significantly associated with diabetic retinopathy prevalence ( P = 0.018)., Conclusions: Our study strengthens the argument that diabetes duration and HbA1c are risk factors for patients with DR. Additionally; we firstly confirmed that serum LH was an independent risk factor in male diabetic retinopathy patients., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Qingmin Sun et al.)

Objectives: Extracranial venous anomalies, especially internal jugular vein stenosis (IJVS), have recently received increasing attention, however, its etiologies are uncertain. This study aimed to explore the probable risk factors of IJVS in Chinese PATIENTS AND METHODS: Eligible patients with IJVS confirmed by contrast-enhanced magnetic resonance venography (CE-MRV) were enrolled from October 2017 through October 2018. Probable risk factors were analyzed, including the conditions that may result in IJV wall damage, extraluminal compression, gender and age., Results: A total of 133 patients enrolled in the final analysis, including 73 females and 60 males, the mean age were 54.83 ± 15.25 years. In this IJVS cohort, the top two risks were previous hepatitis B virus (HBV) infection (48.9 %) and osseous compression (41.4 %). The IJVS cohort was divided into two subsets: extraluminal compression and non-compression. In the former, osseous compression (80.9 %) was the top risk factor, other risks including arterial (22.1 %) and lymph node compression (2.9 %). While, in the latter subset, the most common risk factor was previous HBV infection (46.2 %). In addition, cerebral venous sinus thrombosis (CVST) in non-compression subset was more common than that in extraluminal compression subset (21.5 % VS. 2.9 %, p = 0.001). When considered the gender (Male vs. Female), the ratios were 28.3 % vs. 0 % of smoking, p < 0.001, 16.67 % vs. 1.37 % of hyperhomocysteinemia, p = 0.002, and 11.67 % vs. 1.37 % of hyperuricemia, p = 0.023. In the subset with age less than 45 years, the top three risks included CVST (56.25 %), immunological diseases (55.56 %), and hyperhomocysteinemia (50.00 %), while, in the subset with the ages over 60 years, type-2 diabetes (66.66 %), carotid artery compression (53.33 %), previous HBV infection (52.31 %), and osseous compression (49.09 %) were more common than others., Conclusion: This study illustrates the probable risks of IJVS may be diverse, in which osseous compression and previous HBV infection may be the top two probable risks of IJVS in Chinese. This is the biggest difference from previous reports based on Caucasian., Competing Interests: Declaration of Competing Interest The authors report no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)

As an endemic primate species with one of the highest priorities in wildlife conservation in China, Sichuan snub-nosed monkeys (Rhinopithecus roxellana) have undergone a sharp decline and range reduction in recent centuries. Here, we used maximum entropy modelling (MaxEnt) integrated with four types of environmental variables, including three biological climate variables (Bio17, precipitation of the driest quarter; Bio6, min. temperature of the coldest month; and Bio2, mean diurnal range), three topographic variables (altitude, slope, and aspect), two anthropogenic variables (Human Footprint Index and human disturbance), and three vegetation-related variables (enhanced vegetation index, normalized difference vegetation index, and Wet Index) to identify the spatial distribution of suitable habitats for Sichuan snub-nosed monkeys in Baihe Nature Reserve (BNR), which is located in the Minshan Mountains. The average training AUC of our model performance is 0.929 ± 0.003. The model predicted 9.6 km 2 of high suitability habitats and 14.1 km 2 of moderate suitability habitats for Sichuan snub-nosed monkeys, adding up to only 11.7% of the total area of concern for the study in the BNR. The top four variables ranked in the model (altitude, Human Footprint Index, human disturbance, and Bio17) accounted for relative gain contributions of 23.3%, 19.3%, 14.2%, and 13.4%, respectively. The predicted suitable habitats were confined to an altitude range of 1971-3198 m, Human Footprint Index of mainly 3-5 values, low human disturbance (mainly livestock), and precipitation of the driest (or coldest) quarter of 9-22 mm. Additionally, the suitable habitats were mainly distributed in the core zone (36.1%), buffer zone (26.8%), and experimental zone (29.5%). The remaining habitats (7.6%) were distributed in the 0.5-km buffer zone of the reserve border. The predicted suitable habitats indicated limited suitable habitat space for the Sichuan snub-nosed monkeys, with most of the suitable habitat distributed outside the core zone in the BNR. Our findings highlighted that human activities in all three functional zones could be the most negative factor on suitable habitat distribution of Sichuan snub-nosed monkeys in the BNR.

Background: Obstructive sleep apnea (OSA) is a probable risk factor with speculative roles in the induction or aggravation of acute ischemic stroke (AIS)., Methods: The association between OSA and AIS severity was retrospectively analyzed using clinical data of first-onset AIS patients, admitted to our hospital between January 2013 and September 2016. Eligible patients were categorized based on the presence of OSA prior to stroke. Stroke severity and functional outcomes were evaluated using the National Institute of Health Stroke Severity Scale (NIHSS) and the modified Rankin scale (mRS), respectively., Results: No significant differences were observed among OSA and non-OSA groups for infarction volume, NIHSS at admission and discharge, or mRS at discharge and at the 3-month follow-up (all P > .05). OSA prior to stroke negatively correlated with infarction volume (P = .008), NIHSS at discharge (P = .006), and the 3-month mRS (P = .015). In addition to OSA, it was also found that infarction volume significantly correlated with large artery occlusion (LAO), anterior circulation involvement, neutrophil count, and fibrinogen level; NIHSS at discharge significantly correlated with LAO, transient ischemia attack (TIA), neutrophil count, and thrombolysis; and the 3-month mRS significantly correlated with LAO, TIA, age, neutrophil count, and thrombolysis., Conclusions: OSA before AIS does not increase the severity of stroke. The negative association between OSA and infarction volume, stroke severity, and clinical outcomes suggests an endogenous neuroprotective effect., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Athecate dinoflagellate Karlodinium veneficum is a universal toxic species possessing karlotoxins recognized especially as ichthyotoxic as well as cytotoxic and hemolytic. Blooms of K. veneficum, both single-species or accompanied with other species, occurred more frequently worldwide in recent years, including the coastal region of China. Normally, K. veneficum present in relatively low abundance in phytoplankton communities in estuary regions. Being small and difficult to identify with light microscopy, it has been ignored for a long time till its blooming and toxins being confirmed. How it presents in background level and what is its relationship with critical geological and hydrological environment factors are basically not clear. In this study, the paper reports the application of a real-time quantitative PCR (qPCR) method to investigate the abundance and distribution of K. veneficum in the coastal waters of Xiangshan Bay in the East China Sea (ECS), a typical bay area of harmful algae blooms and heavily affected by anthropogenic activities. The real-time qPCR assay came out being an efficient method at detecting even low cell densities of K. veneficum of different genotypes. A total of 38 field samples of surface (0.5 m) and bottom water (9-100 m in depth) were analyzed and 12 samples were found positive for K. veneficum. At least 3 genotypes of K. veneficum present in this region. Temperatures in sites of K. veneficum positive ranged from 21.7 to 23.4 °C, and salinity levels were between 21.1 and 26.3. The K. veneficum distributed quite extensively in the waters of Xiangshan Bay, cell abundance varied from a low of 4 cells/L to a maximum of 170 cells/L. Most of the samples containing K. veneficum were collected from bottom water in different sites. At three of the 19 sampling sites, K. veneficum was detected in both surface and bottom water samples. Especially at sampling site near Beilun port, where the water is typically muddy with low transparency, relative high cell numbers of K. veneficum were found in both surface and bottom waters. Mixotrophy and vertical migration of K. veneficum could be important eco-physiological factors to consider in terms of understanding these distribution characteristics. The ideal conditions for K. veneficum growth and aggregation in this area still needs further study., (Copyright © 2018 Elsevier B.V. All rights reserved.)

For non-human primates to optimize their survival chances, sleeping site selection is crucial as they spend much of their time sleeping. We studied sleeping site and tree selection by a group of wild Sichuan snub-nosed monkeys (Rhinopithecus roxellana) in the temperate forests of Baihe Nature Reserve, Sichuan, China, to assess if certain site and tree characteristics were selected. We identified a total of 39 sleeping sites and 111 sleeping trees over a period of 1 year. We compared nine sleeping site and six sleeping tree variables related to the environment, habitat, and vegetation structure. We found that certain characteristics of sleeping sites and sleeping trees predicted their selection by R. roxellana. On a larger spatial scale, sleeping sites were selected based mainly on four factors: canopy height, slope direction, slope gradient, and vegetation type. They also selected sites with trees that were taller and larger, had larger crown diameters and higher bole branches. On a smaller spatial scale, they selected larger trees with larger crown diameters. The selection of these characteristics could be explained in terms of predator avoidance and thermoregulation efficiency, although it was difficult to delineate which was more important. This could be due to some characteristics of R. roxellana, that is, large groups living in temperate climates, which required a balanced strategy for sleeping site and tree selection in order to optimize their survival chances., (© 2018 Wiley Periodicals, Inc.)

Circadian rhythms can affect physical or mental activities as well as the time of stroke onset. The impact of circadian rhythms on acute ischemic stroke (AIS) patients treated by recombinant alteplase (rt-PA) is still incongruent. This study aims to consider whether the outcomes of thrombolysis differ depending on stroke onset time and rt-PA infusion time in patients with AIS. A total of 447 AIS patients, who underwent rt-PA intravenous infusion within 4.5 hours after stroke onset, were enrolled in this study consecutively from June 2010 through December 2016. All of the patients were grouped based on the stroke onset time and rt-PA infusion time into two exact 12-hour intervals as daytime (06:01-18:00) and nighttime (18:01-06:00) and further divided into four subgroups at 6-hour time intervals (00:01-06:00, 06:01-12:00, 12:01-18:00 and 18:01-24:00). Major neurological improvement at 1 hour, 24 hours and 7 days, 7-day mortality rate and 24-hour hemorrhage transformation was recorded. The results showed that a total of 295 patients (66.4%) appeared with AIS and 252 (56.4%) were treated during daytime. Higher NIHSS at admission was observed when stroke occurred in nighttime, especially during 00:01-06:00. Patients with stroke onset in nighttime especially during 18:01-24:00 had a significant shorter onset-door time and onset-needle time. No differences of the major neurological improvement at 1 hour, 24 hours and 7 days, 24-hour hemorrhagic transformation and 7-day fatality rate were found among either 12-hour time frames or 6-hour time frames according to the time of stroke onset or rt-PA infusion. In conclusion, there was no evidence to predict that circadian rhythms could influence the outcomes of AIS patients treated with rt-PA in China, although stroke onset during nighttime might aggravate neurological impairment before treatment. Further, multicenter and prospective clinical trials with larger number of subjects are still needed to draw more reliable conclusions.

Objective: To diagnose and treat the first imported active case of Plasmodium knowlesi infection in China., Methods: The clinical information of the patient was collected. Microscopy of blood smear was conducted after Giemsa staining. Genomic DNA was extracted from blood, and PCR was conducted to amplify rDNA. The PCR products were sequenced and analyzed with BLAST, Results: The patient returned from a one-week tour in a tropical rain forest in Malaysia. The first disease attack occurred in Guangzhou on Oct. 16, 2014, with fever, shivering and sweating. The patient was initially diagnosed as malaria and hospitalized on Oct. 26, 2014. Microscopic observation revealed typical forms of P. knowlesi in blood smear. The red blood cells became enlarged, with big trophozoites appearing as a ring with dual cores and dark brown malaria pigment. The trophozoites were slightly bigger and thicker than P. falciparum. The schizont had 6-8 merozoites, with obvious brown malaria pigment. PCR resulted in a specific band of 1 099 bp. BLAST analysis showed that the sequence of the PCR product was 99% homologous to P. knowlesi (acession No. AM910985.1, L07560.1 and AY580317.1). The patient was diagnosed as P. knowlesi infection, and was then given an 8-day treatment with chloroquine and primaquine, together with dihydroartemisinin piperaquine phosphate tablet. The patient was discharged after recovery on Oct. 28, 2014., Conclusion: According to the clinical symptoms, epidemiological history and laboratory test, the patient has been confirmed as P. knowlesi infection. It may also be the first active case of knowlesi malaria reported in China.