Search

Background: Regorafenib is the first oral targeted drug as a second-line agent in patients with advanced hepatocellular carcinoma (HCC) who progressed on sorafenib treatment. Recently, several studies demonstrated that the combination of regorafenib and PD-1 inhibitors showed a synergistic effect. Our study aimed to evaluate the efficacy of regorafenib with PD-1 inhibitors (RP) and regorafenib alone (R) as second-line treatment for advanced HCC. Methods: From October 2018 to January 2022, our retrospective study evaluated advanced HCC patients who received regorafenib with PD-1 inhibitors or regorafenib alone as a second-line treatment at the Second Affiliated Hospital of Nanchang University, China. The efficacy and safety were compared between RP and R groups. Results: In total, 78 patients were enrolled in our study and were separated into two groups – RP group (48) and R group (30) – according to the criteria. The ORR of RP group and R group was 18.8% and 10%, respectively, and the DCR was 66.7% and 43.3%, respectively. The RP group had a longer mPFS (5.9 months vs 3.0 months, P< 0.001) and mOS (12.9 months vs 10.3 months, P=0.010) than the R group. Regorafenib monotherapy is an independent prognostic factor for OS and PFS. In OS, subgroup analysis showed that patients with AFP ≥ 400ng/mL, BCLC C stage and extrahepatic metastasis may benefit from RP, while in PFS, subgroup analysis showed that patients with BCLC C stage, AFP ≥ 400ng/mL, extrahepatic metastasis, ALBI ≥-2.60 and first-line treatment of sorafenib may benefit from RP. The incidence of grade 3/4 adverse reaction in the two groups was 22.9% and 23.3%, respectively, with no significant statistically difference (P=0.966). Conclusion: In the second-line therapy of advanced HCC, compared to regorafenib alone, the combination of regorafenib and PD-1 inhibitors showed promising efficacy and tolerable drug toxicity. [ABSTRACT FROM AUTHOR]

The march toward marrying good business practice with sustainability in the global marketing contexts is articulated with the hope of decoupling consumption and affluence from environmental deterioration. However, the key question, whether and how chief executive officers' (CEO) psychological characteristics exert its influence on corporate marketing activities with relation to environmental conservation, is still unsolved. The current study aimed at examining how the personality traits of CEOs affect corporate green marketing program (GMP), with primary regard to CEO narcissism. On the basis of a moderated mediation analysis on a batch of survey data from a sample of manufacturing firms in China, the findings showed that narcissistic CEOs are often associated with the higher level of the corporate green marketing program. Besides, corporate environmental strategy (ES) plays a role of mediator in the relationship between CEO narcissism and the implementation of green marketing. Furthermore, regulatory pressure not only significantly drives corporate environmental strategy and green marketing program but also moderates the relationships among CEO narcissism, corporate environmental strategy, and green marketing program. This study shines light on the establishment of management mode, which could illuminate both business practitioners and policymakers on the governance of sustainability. [ABSTRACT FROM AUTHOR]

Esterase is an industrial enzyme that is widely used in food, medicine, fine chemicals. The total genomic DNA was extracted from traditional fermented food in China to construct a metagenomic library that included a novel esterase gene (est_115). Sequence homology analysis showed that the highest homology with the carboxylester hydrolase from Pseudomonas lutea was 38%, indicating that esterase belongs to a new class of esterases. Then, an est_115 gene recombinant expression vector was constructed and expressed. The Est_115 had higher catalytic activity to p-nitrophenol ester, with a short acyl-carbon chain. The enzyme can maintain high catalytic activity and salt tolerance in 10%-18% NaCl, suggesting that this novel esterase can be used in processing food using high osmotic pressure. [ABSTRACT FROM AUTHOR]

A new species of entomopathogenic fungi, Lecanicillium cauligalbarum, was discovered from a survey of invertebrate-associated fungi in the Yao Ren National Forest Mountain Park in China. The synnemata of this species emerged from the corpse of a stemborer (Lepidoptera), which was hidden amongst pieces of wood on the forest floor. It differs from morphologically similar Lecanicillium species mainly in its short conidiogenous cells and ellipsoid to ovoid and aseptate conidia. Phylogenetic analysis of a combined data set comprising ITS, SSU, LSU, TEF, RPB1 and RPB2 sequence data supported the inclusion of L. cauligalbarum in the Lecanicillium genus and its recognition as a distinct species. [ABSTRACT FROM AUTHOR]

The primary objective of this study is to analyze the characteristics of commuting activities within the historical districts in cities of China. The impacts of various explanatory variables on commuters' travels are evaluated using the structural equation modeling (SEM) approach. The household survey was conducted in the historical districts in Yangzhou, China. Based on the data, various individual and household attributes were considered exogenous variables, while the subsistence activity characteristics, travel times, numbers of three typical home-based trip chains, trip chains, and travel mode were considered as the endogenous variables. Commuters in our study were classified into two main groups according to their working location, which were the commuters in the historic district and those out of the district. The modeling results show that several individual and household attributes of commuters in historic district have significant impacts on the characteristics of travel activities. Additionally, the characteristics of travel activities within the two groups are quite different, and the contributing factors related to commuting travels are different as well. [ABSTRACT FROM AUTHOR]

Purpose: Problems associated with organochlorine pesticides (OCPs)-contaminated sites have received wide attention. To address the associated environmental concerns, innovative ex situ techniques are urgently needed. Materials and methods: As regards long-term contamination by OCPs in Wujiang region, China, we investigated the feasibility of a cleanup strategy that employed hydroxypropyl-β-cyclodextrin (HPCD) and peanut oil to enhance ex situ soil washing for extracting OCPs, followed by the addition of supplemental nutrients to the residual soil. Results and discussion: Elevated temperature (50 °C) in combination with ultrasonication (35 kHz, 30 min) at 50 g L HPCD and 10 % peanut oil were effective in extracting, and therefore washing, the OCPs in soil. Ninety-three percent of total OCPs, 98 % of dichlorodiphenyltrichloroethanes, 93 % of chlordane as well as 85 % of Mirex were removed from soil after three successive washing cycles. Treating the residual soil with nutrients addition for 12 weeks led to significant increases ( p < 0.05) in the average well color development obtained by the BIOLOG Eco plate assay, Shannon-Weaver index, Simpson index, and EC ecotoxicological evaluation compared with the controls. This implied that this cleanup strategy at least partially restored the microbiological functioning of the OCPs-contaminated soil and has the advantage of being an environmental-friendly technology. Conclusions: The ex situ cleanup strategy through HPCD and peanut oil enhanced soil washing followed by nutrients addition could be effective in remediation of OCPs-contaminated soil. [ABSTRACT FROM AUTHOR]

Travel behaviors and activity patterns in the historic urban area of a city are expected to be different from the overall situations in the city area. The primary objective of this study is to analyze the residents' travel activity patterns in historic urban area. Based on survey data conducted in the historic urban area of Yangzhou, the travel activities of local residents in a whole day were classified into five types of patterns. The multinomial logit (MNL) model was developed to evaluate the impacts of explanatory variables on the choices of activity patterns. The results showed that the choice of activity pattern was significantly impacted by five contributing factors including the gender, age, occupation, car ownership, and number of electric bikes in household. The other variables, which were the family population, preschoolers, number of conventional bikes in household, motorcycle ownership, and income, were found to be not significantly related to the choice of activities. The results of this study from historic urban area were compared to findings of previous studies from overall urban area. The comparison showed that the impacts of factors on activity pattern in the historic urban area were different fromthose in the overall area. Findings of this study provide important suggestions for the policy makings to improve the traffic situations in historic urban areas of cities. [ABSTRACT FROM AUTHOR]

Based on data obtained from field investigations, this paper aims to analyze the influence of the river overflow on the desert riparian vegetation and discuss the function of the river overflow on the vegetation restoration at the lower Tarim River. The results show that (1) there are only 17 species, 13 genera and 9 families in the study areas before river overflow, while there are 34 species, 26 genera and 12 families after the overflowing in which 18 species emerged newly; (2) judging by the biodiversity indices, the species diversity and species richness in the river overflowed area increase more significantly than those in the un-overflow area; (3) judging by the importance of different species after years of river overflowing, the annual herbs germinate quickly at first, while the perennial herbs with deep roots or root clones become dominant in the plant community; (4) after several times of river overflowing, some arbors and shrubs such as Populus euphratica and Tamarix ramosissima germinate easily and can dominate gradually in the plant community. The results indicate that the river overflowing restores the severely degraded ecosystem in the lower Tarim River and the function is connected with restoration of eco-hydrological processes in the study areas. The results suggest that experimental overflowing has initiated a process of restoring ecosystem function within the riparian forest. [ABSTRACT FROM AUTHOR]

The ecological drivers that direct the assembly of viral and host bacterial communities are largely unknown, even though viral-encoded accessory genes help host bacteria survive in polluted environments. To understand the ecological mechanism(s) of viruses and hosts synergistically surviving under organochlorine pesticide (OCP) stress, we investigated the community assembly processes of viruses and bacteria at the taxon and functional gene levels in clean and OCP-contaminated soils in China using a combination of metagenomics/viromics and bioinformatics approaches. We observed a decreased richness of bacterial taxa and functional genes but an increased richness of viral taxa and auxiliary metabolic genes (AMGs) in OCP-contaminated soils (from 0 to 2,617.6 mg . kg-1 ). In OCP-contaminated soils, the assembly of bacterial taxa and genes was dominated by a deterministic process, of which the relative significance was 93.0% and 88.7%, respectively. In contrast, the assembly of viral taxa and AMGs was driven by a stochastic process, which contributed 83.1% and 69.2%, respectively. The virus-host prediction analysis, which indicated Siphoviridae was linked to 75.0% of bacterial phyla, and the higher migration rate of viral taxa and AMGs in OCP-contaminated soil suggested that viruses show promise for the dissemination of functional genes among bacterial communities. Taken together, the results of this study indicated that the stochastic assembly processes of viral taxa and AMGs facilitated bacterial resistance to OCP stress in soils. Moreover, our findings provide a novel avenue for understanding the synergistic interactions between viruses and bacteria from the perspective of microbial ecology, highlighting the significance of viruses in mediating bioremediation of contaminated soils. IMPORTANCE The interaction between viral communities and microbial hosts has been studied extensively, and the viral community affects host community metabolic function through AMGs. Microbial community assembly is the process by which species colonize and interact to establish and maintain communities. This is the first study that aimed to understand the assembly process of bacterial and viral communities under OCP stress. The findings of this study provide information about microbial community responses to OCP stress and reveal the collaborative interactions between viral and bacterial communities to resist pollutant stress. Thereby, we highlight the importance of viruses in soil bioremediation from the perspective of community assembly. [ABSTRACT FROM AUTHOR]

From December 16 to 21, 2016, continuous heavy haze occurred in the Beijing-Tianjin-Hebei region of China. To further understand the development mechanism of haze and improve the forecasting of haze events, a variety of data, background circulation, and the meteorological elements of this severe haze process were comprehensively analyzed. The results show that the process lasted for a long time, pollution intensity was high, influence area was wide, visibility was low, and external transport was the main cause. Aerosols were mainly distributed at a height of 600 m, and there was a certain extreme anomaly. The static weather index and air quality index showed a strong correlation. The air in the Beijing-Tianjin-Hebei region is controlled by zonal circulation in front of a high-pressure ridge, which maintains the westerly airflow. Cold-air activity is weak, and downflow is dominant. The water vapor content is low, the cloud cover is limited at high altitudes, and a warm ridge extends northwards at low altitudes. Limited static wind on the ground, high relative humidity, and low mixing-layer height are not conducive to the horizontal and vertical diffusion of pollutants.

As a main effector in the renin-angiotensin system, the angiotensin II plays a critical role in cell proliferation and angiogenesis. The change between angiotensin II and its precursor is conducted by the angiotensin-converting enzyme. The association between angiotensin-converting enzyme insertion/deletion polymorphism and the activity of angiotensin-converting enzyme was testified. Furthermore, previous researches proved the association between angiotensin-converting enzyme activity and the risk of prostate cancer. Therefore, we conducted a case-control study in the Han population of China to elaborate the relation between the angiotensin-converting enzyme insertion/deletion polymorphism and prostate cancer. DNA was extracted from blood samples collected from 189 pathologically diagnosed prostate cancer patients and 290 cancer-free subjects. The angiotensin-converting enzyme insertion/deletion genotype was determined by polymerase chain reaction analysis. Stratified analyses on age (<71 or ≥ 71), cancer stage (localized or advanced), Gleason score (<7 or ≥ 7) and PSA level (<20 ng/ml or ≥ 20 ng/ml) were performed. We found the II genotype (OR = 0.304 95%CI (0.180,0.515), P < 0.001) and I allele (OR = 0.547 95%CI(0.421,0.711), P < 0.001) were associated with a decreased risk of prostate cancer compared with the DD genotype and D allele. The DD genotype was related to patients with aggressive stage of prostate cancer (OR = 2.214 95%CI(1.169, 4.194), P = 0.014) and patients diagnosed of prostate cancer at a relatively early age (OR = 0.513 95%CI(0.272, 0.965), P = 0.037). The results of our experiment supported the hypothesis that the angiotensin-converting enzyme insertion/deletion polymorphism, a potential risk factor in carcinogenesis, played an important role in the Han population of China.