1. The screening and electron microscopy observation of mammary analogue secretory carcinoma in Chinese.
- Author
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Zhong Y, Liu L, Qi B, Song X, Shen L, and Li H
- Subjects
- Adult, Animals, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Carcinoma, Acinar Cell metabolism, China, Female, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence methods, Ki-67 Antigen metabolism, Male, Mammaglobin A metabolism, Mammary Analogue Secretory Carcinoma metabolism, Membrane Proteins metabolism, Middle Aged, Neoplasm Proteins metabolism, Proto-Oncogene Proteins c-ets genetics, Proto-Oncogene Proteins c-ets metabolism, Repressor Proteins genetics, Repressor Proteins metabolism, S100 Proteins metabolism, Salivary Gland Neoplasms metabolism, Young Adult, ETS Translocation Variant 6 Protein, Carcinoma, Acinar Cell diagnosis, Carcinoma, Acinar Cell pathology, Mammary Analogue Secretory Carcinoma diagnosis, Mammary Analogue Secretory Carcinoma pathology, Microscopy, Electron methods, Salivary Gland Neoplasms diagnosis, Salivary Gland Neoplasms pathology
- Abstract
Mammary analogue secretory carcinoma of salivary gland (MASC) is a tumor with histopathologic and immunophenotypic features mimicking secretory carcinoma of the breast harboring the ETV6 split. The expression of mammaglobin, S-100, Ki-67, P63 and ETV6 split were detected in twelve cases of acinar cell carcinoma and fourteen cases of mammary analogue secretory carcinoma of salivary gland by immunohistochemistry and fluorescence in situ hybridization respectively. The expression of ETV6 gene split was detected in fourteen mammary analogue secretory carcinomas of salivary gland with positive expression of mammaglobin. Eight of mammary analogue secretory carcinomas of salivary gland also tested positive for the ETV6 gene split via fluorescence in-situ hybridization (FISH). The concordance rate of the immunohistochemistry and FISH was 72.3%. Mammaglobin and ETV6 gene split detection could help to distinguish mammary analogue secretory carcinoma of salivary gland. The mammary analogue secretory carcinoma of salivary gland specimens were also examined under transmission electron microscope. And apical junctional complexes were observed in the loosely connected tumor cells., (Copyright © 2017. Published by Elsevier Ltd.)
- Published
- 2018
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