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In the context of global climate change and urban expansion, urban residents are encountering greater rainstorm waterlogging risk. Quantifying population exposure to rainstorms is an important component of rainstorm waterlogging risk assessments. This study utilized a two-dimensional hydrodynamic model to simulate the inundation water depth and inundation area resulting from rainstorms, with return periods of 5, 10, 50, and 100 years, in the Xiong'an New Area, and overlaid the gridded population data in 2017 and in 2035 under SSP2 to assess the change in population exposure. The results show that the average inundation depth and area increase were from 0.11 m and 207.9 km2 to 0.18 m and 667.2 km2 as the rainstorm return period increased from once in 5 years to once in 100 years. The greatest water depths in the main urban areas were mainly located in the low-lying areas along the Daqing River. The total population exposed to rainstorm waterlogging for the 5-, 10-, 50-, and 100-year return periods was 0.31, 0.37, 0.50, and 0.53 million, respectively, in 2017. However, this is projected to rise significantly by 2035 under SSP2, increasing 2–4-fold compared with that in 2017 for the four return periods. Specifically, the projected population exposure is expected to be 0.7, 1.0, 1.8, and 2.0 million, respectively. The longer the return period, the greater the increase in population exposure. The proportion of the population exposed at the 0.05–0.2 m water depth to the total population exposure decreases as the return periods increases, whereas the proportion changes in the opposite direction at the 0.2–0.6 m and >0.6 m depth intervals. Spatially, high-exposure areas are concentrated in densely populated main urban regions in the Xiong'an New Area. In the future, more attention should be paid to densely populated low-lying areas and extreme recurrence rainstorm events for urban flood-risk management to ensure population safety and sustainable urban development. [ABSTRACT FROM AUTHOR]

[Display omitted] • Contribution variations of various policies to PM 2.5 deaths are quantified by period and region. • Carbon and pollution controls can enable 79% to reside in low PM 2.5 areas by 2060. • Population aging could double PM 2.5 deaths by 2060 if other factors remain constant. • A joint effort for carbon and pollution could prevent 2.15 million PM 2.5 deaths by 2060. • Pollution controls can greatly reduce PM 2.5 before 2030, but climate policy becomes crucial after. To confront the challenges posed by air pollution and climate change, China has undertaken significant initiatives to develop strategies that address both issues concurrently. However, the health benefits of these initiatives have not been clearly articulated. In this study, the dynamic changes in health impacts under air pollution and carbon reduction actions in China are evaluated by employing the latest concentration–response models and projected PM 2.5 concentrations under future scenarios. From 2020 to 2060, the enforcement of clean air and climate mitigation policies is expected to increase the percentage of the population living with PM 2.5 concentrations meeting the 10 μg/m3 standard by 79 %. Without the implementation of relevant mitigation measures, PM 2.5 -associated deaths are projected to double due to an aging population. In comparison to the 2060 reference scenario, the joint implementation of clean air and carbon neutrality measures is expected to reduce nationwide PM 2.5 -associated mortality by 62 %, equivalent to 2.15 (95 % CI: 1.80–2.48) million deaths. Stringent pollution controls are crucial for reducing PM 2.5 -associated deaths before 2030, after which carbon neutrality actions become increasingly significant from 2030 to 2060. The challenges of mitigating future PM 2.5 -associated deaths vary greatly across regions, showing a critical response to pollution control and carbon reduction. The research proves the effectiveness of China's future air pollution control and carbon reduction policies in mitigating PM 2.5 -associated deaths. [ABSTRACT FROM AUTHOR]

China's “Developing a Water-saving Society” policy is an ambitious water conservation strategy. However, there has been little evidence of the policy's effectiveness in terms of saving water at a river basin level. In this paper, we used a basin-scale hydroeconomic input-output model to calculate the water consumption ( WC ) by producers and consumers ( WC p and WC c ), respectively in the first pilot area for implementation of this policy, the Heihe River Basin, which belongs to an arid area in inland China. The results show that, after implementation of the policy, WC c decreased sharply but WC p only decreased slightly. A structural decomposition analysis revealed that decreased water consumption intensity played an important role in reducing water consumption. However, this effect was largely offset by the increasing exports of virtual water in goods and services. Our results suggest that in arid river basins, measures in saving water must be accompanied with a cap on total water consumption which is set in accordance with the local water endowments and consideration of environmental water requirement. [ABSTRACT FROM AUTHOR]

Eight new lignans, dracomolphin A-E (1-8), together with eight known lignans (9-16) were isolated from the aerial part of Dracocephalum moldavica. The structures of the isolated compounds were established based on NMR and HRESIMS data. Dracomolphin A (1-4) was elucidated as a lignan possessed a 5-membered ketal ring formed between C-8' and C-3, C-4. The two stereogenic centers rendered dracomolphin A as a mixture of two diastereomeric pairs of enantiomers (1-4). All of the four isomers were separated successfully by using chiral HPLC and their stereochemical features were determined by CD spectra. Bioactivity screening revealed that compounds 1-4, 6, 7, 12, 15 and 16 were potential Nrf2 transcriptional activators. Dracomolphin E (8) reduced cell viability of lung cancer NCI-H292 cells associated with apoptosis., (Copyright © 2021 Elsevier B.V. All rights reserved.)