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Background: The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than in Western countries, are well confirmed in randomized controlled trials (RCTs). However, the safety and effectiveness of R-chemo in patients who are largely excluded from RCTs have not been well characterized. This real-world study investigated the safety and effectiveness of R-chemo as first-line treatment in Chinese patients with DLBCL.Methods: Treatment-naive DLBCL patients who were CD20 positive and eligible to receive R-chemo were enrolled with no specific exclusion criteria. Data collected at baseline included age, gender, disease stage, international prognostic index (IPI), B symptoms, extranodal involvement, performance status, and medical history. In the present study, data on safety, treatment effectiveness, and HBV infection management were collected 120 days after the last R-chemo administration.Results: Overall, R-chemo was well tolerated. The safety profile of R-chemo in patients with a history of heart or liver disease was well described without any additional unexpected safety concerns. The overall response rate (ORR) in the Chinese patients from this study was 94.2 % (complete response [CR], 55.0 %; CR unconfirmed [CRu] 18.2 %; and partial response [PR], 20.9 %). Compared to patients with no history of disease, the CR and PR rates of patients with a history of heart or liver disease were lower and higher, respectively; this tendency could be in part explained by treatment interruptions in patients with heart or liver diseases. HBsAg positivity and a maximum tumor diameter of ≥7.5 cm negatively correlated with CR + CRu, whereas age and HBsAg positivity negatively correlated with CR.Conclusions: This study further validated the safety and effectiveness of R-chemo in Chinese patients with DLBCL. Patients with a history of heart or liver disease may further benefit from R-chemo if preventive measures are taken to reduce hepatic and cardiovascular toxicity. In addition to IPI and tumor diameter, HBsAg positivity could also be a poor prognostic factor for CR in Chinese patients with DLBCL.Trial Registration: ClinicalTrials.gov # NCT01340443 , April 20, 2011. [ABSTRACT FROM AUTHOR]

Tertiary igneous rocks in Qikou Depression, East China are primarily basic rocks. Two types of igneous reservoirs including the effusive basaltic reservoir and the near-surface intrusive doleritic reservoir have been identified so far and each has different reservoir spaces. In this paper, the lithofacies and reservoir properties of Tertiary igneous rocks are described through a systematic analysis of the characteristics of seismic reflection and well logs and selected cores observation. Both of the two types of igneous rocks present strong and low-frequency reflection events on seismic profiles, however, intrusive diabases exhibit the characteristic of strata penetration with a small intersection angle. Effusive basaltic lavas are divided into upper, middle and lower subfacies. This can be distinguished from the well log curves. Observation of sampled cores finds that primary vesicles and amygdales are abundant in the upper and lower subfacies of basaltic lavas. These vesicles can be favourable reservoir space if connected by cracks formed in the late-stage. Intrusive diabases can also be separated into inner subfacies as well as the upper and lower marginal subfacies, of which the former is well crystallized because of slowly cooling, whereas the latter is vitreous due to fast descending temperature at the contact zone between intrusive rocks and host rocks. Hydrothermal metamorphism left the surrounding mudstones metamorphosed to form shrunk fissures and structural fractures as reservoir space, making mudstones of poor porosity and permeability to be metamorphic and have certain reservoir potential. [ABSTRACT FROM AUTHOR]