1. Lenvatinib plus pembrolizumab in the patients with advanced previously treated endometrial cancer: A cost‐effectiveness analysis in the United States and in China.
- Author
-
Liao, Xiaodong, Wu, Yajing, Lin, Dong, Gu, Dian, Luo, Shaohong, Huang, Xiaoting, Xu, Xiongwei, Weng, Xiuhua, and Lin, Shen
- Subjects
QUALITY-adjusted life years ,HEALTH services accessibility ,COST effectiveness ,HEALTH insurance reimbursement ,RESEARCH funding ,PROTEIN-tyrosine kinase inhibitors ,ANTINEOPLASTIC agents ,HEALTH policy ,DESCRIPTIVE statistics ,ENDOMETRIAL tumors ,CANCER chemotherapy ,MONOCLONAL antibodies ,COMPARATIVE studies ,DRUGS ,MEDICAL care costs ,INSURANCE companies - Abstract
Purpose: To investigate the cost‐effectiveness of lenvatinib plus pembrolizumab (LP) compared to chemotherapy as a second‐line treatment for advanced endometrial cancer (EC) from the United States and Chinese payers' perspective. Methods: In this economic evaluation, a partitioned survival model was constructed from the perspective of the United States and Chinese payers. The survival data were derived from the clinical trial (309‐KEYNOTE‐775), while costs and utility values were sourced from databases and published literature. Total costs, quality‐adjusted life years (QALYs) and incremental cost‐effectiveness ratio (ICER) were estimated. The robustness of the model was evaluated through sensitivity analyses, and price adjustment scenario analyses was also performed. Results: Base‐case analysis indicated that LP wouldn't be cost‐effective in the United States at the WTP threshold of $200 000, with improved effectiveness of 0.75 QALYs and an additional cost of $398596.81 (ICER $531392.20). While LP was cost‐effective in China, with improved effectiveness of 0.75 QALYs and an increased overall cost of $62270.44 (ICER $83016.29). Sensitivity analyses revealed that the above results were stable. The scenario analyses results indicated that LP was cost‐effective in the United States when the prices of lenvatinib and pembrolizumab were simultaneously reduced by 61.95% ($26.5361/mg for lenvatinib and $19.1532/mg for pembrolizumab). Conclusion: LP isn't cost‐effective in the patients with advanced previously treated endometrial cancer in the United States, whereas it is cost‐effective in China. The evidence‐based pricing strategy provided by this study could benefit decision‐makers in making optimal decisions and clinicians in general clinical practice. More evidence about budget impact and affordability for patients is needed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF