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Aims/Introduction. Steroid resistance and frequent relapse are problems in the treatment of minimal change disease (MCD). However, epidemiological factors that influence steroid-resistant and relapse of MCD are rarely reported. This study evaluated potential factors that influence the onset and relapse of MCD and the epidemiological features of southern Chinese patients with adult-onset MCD. Patients and Methods. Patients with adult-onset MCD were included from the Affiliated Hospital of Guangdong Medical University, which is located in the southernmost part of China’s mainland, between 2015 and 2016. Potential influencing factors were investigated. Results. Eighty-seven patients with incipient MCD were enrolled, and 85 of these patients were followed up; 71.8% (61/85) were steroid-sensitive and 28.2% (24/85) were steroid-resistant. In terms of seasonal distribution, the highest rate of incipient cases was in spring (39.1%, 34/87), which also showed a high rate of relapse cases (29.7%, 22/74). Among patients who were followed up for more than half a year and whose proteinuria completely resolved (69.4%, 59/85), 52.5% (31/59) were without relapse and 47.5% (28/59) were with relapse. Patients without relapse were older than those with relapse (P<0.05). Before disease onset, 20.7% (18/87) of patients with incipient MCD were diagnosed with infection, including 94.5% (17/18) with respiratory tract infection. Fourteen patients in complete remission posttreatment developed an infection before relapse, including 85.7% (12/14) with respiratory tract infection. Conclusion. Steroid resistance and frequent relapse are current challenges for the treatment of adult-onset MCD in southern China, and respiratory tract infection may be a risk factor for onset and relapse. Additionally, younger patients with MCD tend to have more frequent relapse. [ABSTRACT FROM AUTHOR]

Background: With the global aging problem is becoming increasingly severe, the elderly care has become an important issue that needs attention. Chinese government attaches great importance to the development of medical and health care institutions, and is committed to improving the comprehensive quality of elderly rehabilitation nursing staff in medical and health care institutions., Methods: From June to September 2019, a cross-sectional study among 193 elderly rehabilitation nursing staff was conducted in Liaoning Province, China. Using a self-designed questionnaire, the comprehensive quality of elderly rehabilitation nursing staff in medical and health care institutions was investigated by face to face. The multiple linear regression model was explored to analyze the influencing factors., Results: A total of 193 questionnaires were distributed, and 189 (97.93%) valid questionnaires were recovered. Age was from 19 to 65 years old, with an average age of (38.34 ± 9.76) years old. Bachelor degree or above accounted for 54.00%. 57.10% have engaged in elderly rehabilitation nursing for more than one year. There were 163 nurses with qualification certificates, accounting for 86.20%. The total score of comprehensive quality was 118.52 ± 22.90. The total Cronbach ' s α coefficient of the questionnaire was 0.967, and the content validity index was 0.991. Only 61 (32.30%) elderly rehabilitation nurses received professional training in elderly rehabilitation nursing. The results of multiple linear regression analysis showed that the educational level of elderly rehabilitation nursing staff (P = 0.002) and the number of years engaged in elderly rehabilitation nursing (P = 0.005) were the main influencing factors of comprehensive quality., Conclusions: The comprehensive quality of elderly rehabilitation nursing staff is at a medium level in Liaoning Province's medical and health care institutions. However, the professional nursing talents were very short, and the education level and years of experience in elderly care were the main influencing factors of the comprehensive quality., (© 2022. The Author(s).)

The healthy status of corals in the isolated atolls of the central South China Sea (SCS) remains unclear. Symbiodiniaceae density (SD) can effectively reflect the thermal tolerance and health of hard corals. Here, the SDs of 238 samples from the Huangyan Atoll (HA) were analyzed. The results revealed significantly intergeneric and geomorphological differences in SD. Intergeneric variation may reflect that corals with high SD have stronger thermal tolerance. Geomorphic analysis showed that the SDs at the outer reef slope were higher than in the lagoon. Hydrodynamics and sea surface temperature were likely the main influencing factors. Most notably, corals in SCS HA had higher SDs than those at neighboring reefs, indicating that their thermal tolerance were strong, which may be related to HA's local upwelling. These results suggest that the HA has the potential to serve as a refuge for corals, but increasing human disturbance limit its function., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Coral tissue thickness (CTT) is an effective indicator of the adaptability of corals to environmental stress, but the relationships between the spatial and intergeneric variation of coral tissue across latitudes and tolerance to environmental stress are not well understood. To investigate this, the CTT of 768 specimens of 10 typical coral genera and surrounding seawater parameters were measured in six coral reef regions (CRRs) across the 9-22°N latitudes in the South China Sea (SCS). Results showed significant differences in CTT between different genera of corals and CRRs. CTTs were significantly higher in the northern SCS than in the southern SCS. There was also notable intergeneric variation, with the abundance of branching Acropora and foliaceous Pavona being significantly lower than that of massive Porites, Galaxea, Favia, Favites, Hydnophora, Platygyra, and encrusting Montipora, Psammocora across these CRRs. Redundancy analysis showed that dissolved inorganic nitrogen (DIN), soluble reactive phosphorus (SRP), sea surface temperature (SST), turbidity, and transparency were the main factors affecting CTT. Overall CTT, irrespective of genus, was significantly positively correlated with DIN, SRP, and latitude, but was significantly negatively correlated with transparency and SST. Further analysis suggested that corals in the southern SCS are mainly threatened by thermal stress, whereas in the northern SCS, corals have often suffered from destructive anthropogenic disturbance. Although seawater conditions were normal during on-site investigation, a large number of branching corals (e.g., Acropora corals) have been lost in the last several decades due to destructive human activity. In contrast, massive and encrusting corals may have higher energy reserves and photo-protective capacities due to their thicker tissues, and consequently have higher tolerance to environmental stress. Therefore, the coral communities of the SCS have gradually been transformed from branching corals to massive/encrusting corals., (Copyright © 2019 Elsevier B.V. All rights reserved.)