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The bullwhip effect represents a major source of supply chain inefficiency. Traditional OM analytical approaches and theories view vertical integration as a countermeasure to the bullwhip effect. Despite its intuitive appeal, this relationship has yet to be rigorously examined. To be specific, a firm may choose backward integration to tighten its grip on the supply and production side, or forward integration to control over the demand and distribution side. The effect of different integration could be diverse depending on the firm's supply chain position, but research on this link is limited. Driven by a large dataset containing 292,080 detailed business information of listed firms in China, we empirically examine the impact of forward and backward vertical integration on the bullwhip effect, as well as the moderating role of the firms' supply chain positions. We find that: (1) forward vertical integration does reduce the bullwhip effect, and this mitigation effect is more pronounced for firms located further downstream; (2) the magnitude and direction of backward vertical integration effects are diverse. It has a strong mitigation effect on the bullwhip effect for upstream firms, and when firms are located further downstream, backward vertical integration will surprisingly increase the bullwhip effect. [ABSTRACT FROM AUTHOR]

Venture capital (VC) is a relatively newly emergent industry that is still subject to large uncertainties in China. Therefore, building a robust social network with other VC institutions is a good way to share information, various resources, and benefit from skill and knowledge complementarity to against risks. Strong evidences indicate that better networked VC institutions are of a better financial performance, however, most of previous works overlook the evolution of VC institutions and only focus on some simple topology indicators of the static syndication network, which also neglects higher-order network structure and cannot give a comprehensive evaluation. In this paper, based on VC investment records in the Chinese market, we construct temporal syndication networks between VC institutions year by year. As k-shell decomposition considers higher-order connection patterns, we employ k-shell as an evaluation of the influence of VC institutions in syndication networks. By clustering time series of k-shell values, the VC institutions in China fall into five groups that are quite different from each other on financial performances and investment behaviors. This, in turn, proves the power of our method that only based on proper sequential network properties, we can reveal their financial investment performance. Compared to other network centrality measurements, k-shell is a better indicator that is indicated by a smaller intra-group distance and a larger inter-group distance. • The evolution of topological feature of VC institutions can reveal their financial investment performance. • When evaluating the investment performance, k-shell is a better indicator than other popular centrality measures. • Investment behaviors and performance of VC institutions are closely related to social connection patterns. [ABSTRACT FROM AUTHOR]

BACKGROUND: The automotive industry is labor-intensive, and workers are involved in highly repetitive tasks, long hours, and medium to low workloads, resulting in work-related musculoskeletal disorders (WMSDs), which have become a major health concern for workers in this industry. China is a major automotive country with tens of thousands of auto repair workers, but their conditions of WMSDs have been poorly reported. OBJECTIVE: This work aimed to analyze the current prevalence of WMSDs and their associated risk factors among automobile maintenance workers. METHODS: A total of 539 respondents from 50 automotive repair and maintenance companies in China were selected to investigate the prevalence of WMSDs via the modified Nordic Musculoskeletal Disorders Questionnaire. Chi-square test and logistic regression models were applied to analyze their associated risk factors. RESULTS: The total prevalence of WMSDs among 539 workers was 32.8%. The top three body parts for prevalence were the lower back (17.1%), neck (16.3%), and shoulders (14.5%). The highest prevalence of WMSDs was found in the neck (23.6%) and lower back (14.3%) for sheet metal workers and mechanics, respectively, whereas painters had the highest prevalence of WMSDs in the lower back and feet (both at 15.4%). Logistic regression analysis showed that females were at higher risk of WMSDs than males (OR 5.027, [95% CI] [1.278–19.772], p < 0.05). Workers subjected to uncomfortable positions were at increased risk of WMSDs (OR 1.79, [95% CI] [1.333–2.410], p < 0.01). CONCLUSION: The prevalence of WMSDs is high among automotive maintenance workers, with the highest prevalence in the lower back (17.1%). Uncomfortable working postures and frequent repetitive movements with lower limbs and ankles at work may be important risk factors. [ABSTRACT FROM AUTHOR]

China's carbon emissions have a stable industrial concentration. In recent years, the carbon emissions of the six major high-carbon industries have accounted for approximately 80% of the national total and are thus priority areas for emission reduction. With the promotion of energy-saving and emission-reduction policies, the structure and scale of high-carbon industries in various regions have undergone changes, but their carbon reduction effects show significant regional differences. Based on China's provincial panel data from 2006 to 2020, this study discusses the structural characteristics of high-carbon industries with their proportion of energy-based industries and measures their scale characteristics with their output values. On this basis, a fixed-effects model is used to analyze the single and synergistic effects of the scale and structure of high-carbon industries on carbon emissions in each province. The results indicate that changes in the scale and structure of high-carbon industries significantly affect carbon emissions but show regional differences in both the single and synergistic effects. When considering these synergistic effects, the single effect of high-carbon industries on carbon emissions will be weakened. In regions with large-scale high-carbon industries, the increase in the proportion of energy-based industries significantly increases carbon emissions, but this effect gradually weakens as the overall scale expands. In areas with small-scale high-carbon industries, the increase in the proportion of energy-based industries has a relatively small effect on carbon emission growth that gradually increases with the overall scale. In addition, the implementation of the carbon emission trading policy has a significant moderating effect on the carbon emissions of high-carbon industries and strongly promotes its reduction. [ABSTRACT FROM AUTHOR]

Background: To promote influenza vaccination coverage, a Chinese megacity, Shenzhen provides free influenza vaccination to its residents aged 60 years and above through community health centres (CHCs) since October 2016. A community health centre-based experiment was conducted by asking primary care physicians (PCPs) working in the intervention health centres to proactively recommend influenza vaccination to their patients aged 60 and above during their patients' visits. Methods: This study used an experimental design and a survey design. The experimental design evaluated the effect of PCP recommendation on influenza vaccination. A total of 24 CHCs were randomly selected as the intervention (involving 3814 participants) and control (3072 participants) group evenly. The intervention study period was during the 2017–2018 flu season. The 2016–2017 flu season was considered as the baseline comparison. The survey design examined changes in knowledge, attitude, and practice of influenza vaccination among older participants before and after the free influenza vaccination implementation. We randomly invited 1200 participants aged 60 and above during their visits to CHCs in October 2016 and followed them up until October 2017; among them, 958 participants completed the follow-up survey using the same questionnaire. Results: In the 2017–2018 flu season, 1,100 more patients got vaccinated in the intervention group under PCP recommendation compared with the 2016–2017 flu season. Among the 958 older adults in the post-implementation period, 77.5% had heard about the influenza vaccine, which was 24.7% higher than in the pre-implementation period; 84.8% of participants were aware where to take influenza vaccines, with the most improvement of 37.2% among all knowledge related questions; 62.5% of them agreed that patients with chronic diseases should have influenza vaccine, which was 19.1% higher than those being surveyed before the implementation period. About 83.6% of participants agreed older adults should have influenza vaccine, but there were still 58.4% who considered themselves too healthy to get vaccinated. Conclusion: PCP recommendation improved influenza vaccine uptake and knowledge, attitude, and practice levels regarding influenza vaccination among older adults. More health policies and health education should be made to raise vaccination willingness and improve vaccination coverage among older adults. [ABSTRACT FROM AUTHOR]

Background: Congenital cranial dysinnervation disorders (CCDDs) are a group of diseases with high clinical and genetic heterogeneity. Clinical examinations combined with Magnetic resonance imaging (MRI) and whole exome sequencing (WES) were performed to reveal the phenotypic and genotypic characteristics in a cohort of Chinese CCDDs patients. Results: A total of 122 CCDDs patients from 96 families were enrolled. All patients showed restrictive eye movements, and 46 patients from 46 families (47.9%, 46/96) were accompanied by multiple congenital malformations. Multi-positional high-resolution MRI was performed in 94 patients from 88 families, of which, all patients had hypoplasia of the cranial nerves except HGPPS patients and 15 patients from 15 families (17.0%,15/88) were accompanied by other craniocerebral malformations. WES was performed in 122 CCDDs patients. Ten pathogenic variants were detected in KIF21A, TUBB3, and CHN1 genes in 43 families. Three variants were unreported, including KIF21A (c.1064T > C, p.F355S), TUBB3 (c.232T > A, p.S78T) and CHN1 (c.650A > G, p.H217R). Of the 43 probands harboring pathogenic variants, 42 were diagnosed with Congenital Fibrosis of Extraocular Muscles (CFEOM) and one was Duane Retraction Syndrome (DRS). No definite pathogenic variants in known candidate genes of CCDDs were found in sporadic DRS, Möbius Syndrome (MBS) and Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) patients. The CFEOM patients harboring R380C, E410K and R262H variants in TUBB3 gene and F355S variant in KIF21A gene exhibited syndromic phenotypes. Conclusions: This study broadened the phenotypic and genotypic spectrums of CCDDs, and it was the largest clinical and genetic investigation for CCDDs patients from China. KIF21A and TUBB3 were the common pathogenic genes in Chinese CFEOM. MRI coupled with WES can provide a supportive diagnosis in patients with clinically suspected CCDDs. [ABSTRACT FROM AUTHOR]

Data on safety and immunogenicity of coronavirus disease 2019 (COVID‐19) vaccinations in hepatocellular carcinoma (HCC) patients are limited. In this multicenter prospective study, HCC patients received two doses of inactivated whole‐virion COVID‐19 vaccines. The safety and neutralizing antibody were monitored. Totally, 74 patients were enrolled from 10 centers in China, and 37 (50.0%), 25 (33.8%), and 12 (16.2%) received the CoronaVac, BBIBP‐CorV, and WIBP‐CorV, respectively. The vaccines were well tolerated, where pain at the injection site (6.8% [5/74]) and anorexia (2.7% [2/74]) were the most frequent local and systemic adverse events. The median level of neutralizing antibody was 13.5 (interquartile range [IQR]: 6.9–23.2) AU/ml at 45 (IQR: 19–72) days after the second dose of vaccinations, and 60.8% (45/74) of patients had positive neutralizing antibody. Additionally, lower γ‐glutamyl transpeptidase level was related to positive neutralizing antibody (odds ratio = 1.022 [1.003–1.049], p = 0.049). In conclusion, this study found that inactivated COVID‐19 vaccinations are safe and the immunogenicity is acceptable or hyporesponsive in patients with HCC. Given that the potential benefits may outweigh the risks and the continuing emergences of novel severe acute respiratory syndrome coronavirus 2 variants, we suggest HCC patients to be vaccinated against COVID‐19. Future validation studies are warranted. [ABSTRACT FROM AUTHOR]

Recombinant human endostatin (Endostar) plus vinorelbine/cisplatin (NP) had been approved for the treatment of non-small cell lung cancers (NSCLC). But the real-world treatment pattern and effectiveness of Endostar plus other combination chemotherapy, namely docetaxel/platinum (DP), gemcitabine/platinum (GP), pemetrexed/platinum (PP), and paclitaxel/platinum (TP) in both treatment-naïve and re-treatment patients with advanced NSCLC were still unclear. A retrospective observational study was conducted based on the electronic medical record (EMR) system and advanced patients with NSCLC were identified from 7 cancer hospitals in China from 2012 to 2019. These patients were divided into five groups, Endostar plus NP, Endostar plus DP, Endostar plus GP, Endostar plus PP, and Endostar plus TP groups. The disease control rate (DCR), overall response rate (ORR), and the progression-free survival (PFS) were evaluated. Of the eligible 512 advanced patients with NSCLC, 10.35% were in Endostar plus NP group, while the numbers were 15.43%, 32.42%, 26.56%, 15.23% in Endostar plus DP group, Endostar plus GP group, Endostar plus PP group, and Endostar plus TP group, respectively. The ORRs were 31%, 28%, 22%, 41% and 27%, and the DCRs were 71%, 72%, 57%, 72% and 76%, respectively. The median of PFSs for the above groups were 7.9, 6.8, 5.6, 13.7, and 5.4 months. Compared with Endostar plus NP group, the hazard ratios (HRs) and 95%CIs of Endostar plus other chemotherapy were 1.86 (0.75–4.61), 2.15 (0.83–5.60), 1.33 (0.51–3.44), and 2.42 (0.86–6.81). This real-world study found the effectiveness of Endostar plus DP, Endostar plus GP, Endostar plus PP, and Endostar plus TP were of no statistically significant differences compared with Endostar plus NP and reflected the good effectiveness of Endostar plus different chemotherapy in advanced patients with NSCLC. [ABSTRACT FROM AUTHOR]

Background: Anaplastic thyroid carcinoma (ATC) is an endocrine tumor with a low incidence but a very poor prognosis. The vast majority of patients have a survival time of only three to six months, but a few survive for two years or more. In recent years, there have been major breakthroughs in targeted and immunotherapy in the field of oncology therapy. Although the preliminary study for ATC showed a promising prospect, more clinical trials are needed. It is the best approach to explore the measures that can improve survival time of ATC from the available clinical data, especially those with long survival. Methods: We report on an 82-year-old ATC patient who survived for 3 years and systematically review the clinical characteristics of 45 ATC patients with complete data from the two largest centers in northwest China. In particular, factors related to long-term survival were analyzed and summarized. Results: Three years prior, an 82-year-old woman was diagnosed with ATC by core needle biopsy following a physical examination. The thyroid tumor was resected within one month, and then the patient was treated with radiotherapy. The patient was still healthy after three years of follow-up. Analysis of prognostic factors for the 45 reviewed patients showed that those undergoing radical surgery (median overall survival (OS) = 472 days, p = 0.0261) and radiotherapy (median OS = 220 days, p = 0.0136) had better outcomes. In addition, patients younger than 65 years (median OS = 164.5 days, p = 0.0176) and with a lower tumor stage (IV A, median OS = 633.5 days, p = 0.0191) also had a better outcome. Conclusion: ATC is a highly malignant tumor, but timely early diagnosis and standardized treatment with radical surgery and radiotherapy as the core can achieve good results. Some patients can achieve long-term survival. [ABSTRACT FROM AUTHOR]

Background: Oseltamivir resistance in influenza virus (IFV) has been of widespread concern. An increase in the frequency of viruses with reduced inhibition was observed. Whether oseltamivir is effective is uncertain. We conducted this study to understand the real-world situation in northern China and the clinical efficacy for patients with IFV infection after the use of oseltamivir. Methods: The longitudinal study was performed on influenza-like illness (ILI) cases in a tertiary general hospital in Beijing, China during the flu season of 2018–2019. All ILI cases (≥18 years) were recruited into the study. We analyzed the effect of the oseltamivir therapy on the number of clinic visits, hospitalization frequency, and the duration of fever and cough. Results: A total of 689 ILI patients were recruited in this study with 355 in the oseltamivir therapy group and 334 in the supportive therapy group. Among the ILI patients, 388 patients were detected for IFV infection (364 IFV-A and 24 IFV-B) and divided into two groups with or without the oseltamivir therapy (302 vs. 86). There were no significant differences in the basic characteristics between the oseltamivir and supportive therapy groups in the ILI patients or in the IFV positive patients (all p < 0.05). After adjusting for the potential confounders, oseltamivir therapy reduced the times of clinic visits in the ILI and IFV positive patients (p = 0.043 and p = 0.011). No effectiveness with oseltamivir therapy was observed in the outcomes of hospitalization frequency, and the duration of fever and cough. Conclusion: Oseltamivir use may reduce the times of clinic visits. However, we did not observe the differences in the duration of fever, cough, and the frequency of hospitalization between oseltamivir therapy and supportive therapy. [ABSTRACT FROM AUTHOR]

Previous studies have focused on the determinants of basic public health services utilization, such as socioeconomic status and mobility characteristics, rather than on health literacy. Thus, this study aimed to estimate the effect of health literacy on the utilization of basic public health services among Chinese migrants. Based on the 2016 China Migrants Dynamic Survey data (N  =   2335), this study used propensity score matching approach to estimate the effect of health literacy on the utilization of basic public health services, including the establishment of health records and receipt of health education, and to explore heterogeneity in this effect based on educational attainment and urban–rural status. The findings show that high levels of health literacy increased the probability of establishing health records and receiving more health education. Also, high levels of health literacy had a positive effect on the utilization of basic public health services among Chinese migrants, especially those with less education or living in urban areas. Policy makers should more carefully consider the actual situation and needs of migrants who are living in urban areas or have less education, constructing more targeted service programs. [ABSTRACT FROM AUTHOR]

Purpose: Methane, produced and emitted when organic carbon accumulates in reservoir sediments, can be oxidised microbially before being released into the overlying water by a variety of electron acceptors. This research aimed to investigate the microbial drivers responsible for the specific pattern of methane production and oxidation, as well as the role of electron acceptors in regulating anaerobic oxidation of methane (AOM) along the sediment core of a freshwater reservoir. Materials and methods: A sediment core was obtained from the Hongfeng Reservoir, a eutrophic lake-type reservoir located in Guizhou Province, China. To estimate methane production/oxidation profiles, the core was stratified and the porewater properties of each sediment layer (organic matter, carbon isotopic compositions, and etc.) were analysed and integrated with microbial communities and the methane production activity. Results: Methanogens were detected throughout the sediment depth profile. Hydrogenotrophic Methanomicrobiales were identified as the primary producer of methane in the surface layer (<20 cm), whereas Methanobacteriales and aceticlastic Methanosarcinales were revealed as the primary producers in the deeper layer. Additionally, methane was oxidised along the sediment profile with various electron acceptors. The coexistence of sulfate- and iron-oxidising bacteria at the surface layer demonstrated the possibility of sulfate and iron-dependent methane oxidation. Both the potential activity of AOM and the nitrite peak indicated the presence of an active nitrite-AOM zone consisted in the intermediate layer (14–24 cm) underneath the sulfate-AOM zone. Conclusion: Methane production and oxidation co-exist along the sediment core of a freshwater reservoir. Notably, AOMs have a significant potential to reduce in situ methane emissions from freshwater sediment environments. Additionally, there are multiple electrons available for the microbial AOM, and correspondingly, the functional microorganisms participating in AOMs are distributed across the sediment habitat in a niche-specific manner. [ABSTRACT FROM AUTHOR]

An enterprise must be able to conduct in-depth analysis of the existing data as the information has certain grey characteristics, if it wants to occupy a dominant position in the fierce market competition. In this paper, a compound three-dimensional grey Lotka–Volterra model is developed to carry out the grey transformation of the original data, so that the data can have better simulation accuracy, and the observation noise of the original data can be reduced. The competitive situation analysis based on the three-dimensional grey Lotka–Volterra model can help enterprises better understand the market situation. This paper takes the luxury brand automobile market in mainland China as an example to conduct a competitive analysis and a balanced development simulation. It can be found that, based on Three Species System Analysis, there is a symbiotic relationship among automobile enterprises and that the three species model can be adopted in analyzing the competition and cooperation among enterprises. Through balanced development of a Symbiotic System Analysis, the results of symbiotic optimization under the achievable equilibrium state of three populations are obtained and they show that the proposed method can be used effectively to conduct the market competition analysis. It is thus of great importance to study the relationships among enterprises as it is helpful for enterprises to make strategic policies. [ABSTRACT FROM AUTHOR]

Background: The manifestations and prognoses of acute-on-chronic liver failure (ACLF) with different precipitating events remain heterogeneous. We aimed to investigate the characteristics and prognosis of patients with hepatotropic viral insult (HVI)-induced hepatitis B-related ACLF (HBV-ACLF).Methods: 452 patients with confirmed diagnosis of ACLF were screened in three medical centers in China, and 203 HBV-ACLF patients with definite acute precipitating events were retrospectively analyzed. According to the precipitating events, HBV-ACLF patients induced by HBV reactivation and super-infection with HAV were classified as the hepatotropic viral insult group and those induced by other factors, as the non-virus insult (NVI) group. The clinical characteristics, predictive scoring model, and prognosis of the two groups were compared.Results: Hepatitis B virus reactivation accounted for the largest proportion (39.9%) among all precipitating events. Exacerbation time frame of the HVI group was significantly longer than that of the NVI group (20 days vs. 10 days, P < 0.001). Comparison of intergroup prognosis showed that there was no significant difference in the 28 day mortality (20.9 vs. 13.7%, P = 0.125), while the 90 day and 1 year mortality in the HVI group were higher than those in the NVI group (36.3 vs. 24.4%, P = 0.014; 39.5% vs. 27.5%, P = 0.020, respectively). In the HVI group, the lactic acid-free APASL-ACLF Research Consortium (AARC) had better predictive value for 90 day mortality (0.741).Conclusions: The 90 day and 1 year survival rate was lower in HBV-ACLF patients induced by HVI than by NVI. The lactate-free AARC score was a better predictor of short- and long-term prognosis in patients with HVI-induced HBV-ACLF. [ABSTRACT FROM AUTHOR]

The Xixiangchi Formation is a significant replacement stratum for natural gas production of deep marine carbonate in the Sichuan basin, which is mainly composed of grain shoal. Basic characteristics and corresponding major controlling factors of the Xixiangchi reservoir are of great importance for hydrocarbon exploration, but the diagenesis sequence and evolution of the reservoir are poorly understood because of their complexity. Based on core and thin-section observations, cathodoluminescence (CL), scanning electron microscopy (SEM), and microbiologically induced calcium carbonate precipitation (MICP) data, it is suggested that the Xixiangchi reservoir is comprised of medium crystalline dolostone and grain dolostone in the Central Sichuan basin, with an average porosity of 3.6% and 2.2%, respectively. The corresponding pore-throat type is an intercrystalline pore with a flaky throat and a dissolved intergranular pore with a necking throat. The majority porosity ranges from 2% to 4% (with a distribution frequency of 64.9%), but the permeability distribution is relatively scattered (with a distribution frequency between 10% and 30%). The capillary pressure curve of medium crystalline dolostone is characterized by coarse skewness, relatively flat plateaus, low displacement pressures, and high mercury saturation at relatively low injection pressures. The capillary pressure curve of grain dolostone is characterized by fine skewness, which exhibits relatively poor connectivity and a small value of median pore radius. The deposition of intraplatform grain shoals determines the original property of the Xixiangchi Formation reservoirs. Destructive diagenesis, including compaction and multistage cementation, decreases the physical properties of the Xixiangchi reservoir. Constructive diagenesis, including Caledonian supergene karstification and late-stage burial dissolution, tremendously improves the reservoir quality. [ABSTRACT FROM AUTHOR]

Background. There is no effective therapy for silicosis, and Dahuang Zhechong pill (DHZCP), an ancient Chinese medicine prescription, may have a therapeutic effect on silicosis. This study aims to verify the efficacy and safety of DHZCP in silicosis. Methods. This is a randomized controlled clinical trial done at Panzhihua Second People's Hospital (Panzhihua City, Sichuan Province, China). Participants diagnosed with silicosis were recruited and randomized to the conventional treatment group (CG) or DHZCP combined with the conventional treatment group (DG). Forced vital capacity % predicted (FVC%), diffusing capacity of the lung for carbon monoxide % predicted (DLCO%), six-minute walk distance (6MWD), peripheral oxygen (SpO2), King's Brief Interstitial Lung Disease Questionnaire (K-BILD), and safety outcomes were measured at baseline and 9 weeks. Results. Fifty-six participants (28 in each group) completed the study, and 53 of them (26 in DG and 27 in CG) completed pulmonary function. At 9 weeks, compared with no DHZCP, DHZCP treatment was associated with significant improvements in FVC% (mean ± SD, 95%CI) (8.2 ± 3.9, 0.3 to 16.0), DLCO% (8.6 ± 3.5, 1.5 to 15.7), SpO2 (3.8 ± 0.7, 2.3 to 5.2), and K-BILD total score (6.0 ± 2.3, 1.4 to 10.7). And, there were no statistical differences of safety outcomes between the two groups. Eight patients accepting DHZCP developed mild diarrhea during the first week, which subsequently resolved on its own. Conclusion. DHZCP could improve the pulmonary function, the quality of life, and the exercise capacity of silicosis patients. [ABSTRACT FROM AUTHOR]

Background: The accelerated aging trend brought great chronic diseases burdens. Disabled Adjusted Life Years (DALYs) is a novel way to measure the chronic diseases burden. This study aimed to explore the cohort, socioeconomic status (SES), and gender disparities of the DALYs trajectories. Methods: A total of 15,062 participants (55,740 observations) comes from China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. Mixed growth curve model was adopted to predict the DALYS trajectories in 45–90 years old people influenced by different birth cohorts and SES. Results: We find significant cohort, SES (resident place, education level and income) disparities differences in the chronic diseases DALYs. For individuals of earlier cohort, DALYs are developed in a late age but grow fast with age but reversed for most recent cohorts. Living in urban, having higher SES level will decrease the growth rate with age, but converges for most recent cohorts. Meanwhile, DALYs disparities of resident place and education level show gender differentials that those for female are narrowed across cohort but for male are not. Conclusions: The cohort effects on chronic diseases DALYs are accumulated with China's unique social, and political settings. There are large inequalities in early experiences, SES and DALYs. Efforts of reducing these inequalities must focus on the lower SES individuals and those living in rural areas, which greatly benefit individuals from recent cohorts. [ABSTRACT FROM AUTHOR]

Research shows that social welfare crowdfunding is in the rising stage of development in China, showing a vigorous development trend. Social welfare crowdfunding owns advantages such as accuracy and efficiency that traditional social welfare forms do not have, but problems including imperfect relevant policies and regulations, lack of supervision of social welfare crowdfunding platform, and low process transparency still exist. From the perspective of PEST-SWOT model, this paper sums up the research trends and development status of social welfare crowdfunding, deconstructs the strengths, weaknesses, opportunities, and threats faced by social welfare crowdfunding from the aspects of politics, economy, society, and technology, and puts forward a feasible analysis of relevant development strategies to provide a reference for its future sustainable development. [ABSTRACT FROM AUTHOR]

Objective. Although increasing evidence reveals the efficacy of traditional Chinese medicine (TCM) and its safety on Tourette Syndrome (TS) patients, whether TCM is indeed improving TS remains unclear. The purpose of the current study is to perform a meta-analysis to evaluate the efficacy and safety of TCM on treating TS patients. Method. An elaborate search strategy was conducted based on several databases including Medline, Embase, Cochrane, Web of Science, CINAHL, CBM, VIP, CNKI, and Wanfang Data in order to identify the relevant randomized controlled trials (RCTs) from their inception to as late as May 1st, 2020. General information and data needing analysis were extracted simultaneously for the necessity of various analyses such as descriptive analysis and metaquantitative analysis. Results. Forty-seven trials with 5437 TS patients in total were eventually included according to our criteria. All trials were conducted in China, and the publication years ranged from 2004 to 2017. In terms of clinical efficacy, clinical symptoms of patients with TCM were more likely to be improved compared with the control group (odds ratio, OR = − 1.29 , 95% confidence interval, CI: -2.54 to -0.06, I 2 = 0.00 %). As to the outcome of recurrence rate, the pooled results revealed that the TCM group was more inclined to stabilize the recurrence (OR = 0.44 , 95% CI: 0.24 to 0.78, I 2 = 0.00 %). Similar results were observed in adverse reaction (OR = 0.32 , 95% CI: 0.24 to 0.43, I 2 = 32.90 %). Conclusion. The results of our study recommend applying TCM to treat TS patients for better efficacy and safety. Results need to be interpreted cautiously due to certain limitations in our study. [ABSTRACT FROM AUTHOR]

A new species Euxaldar daweishanensis Yang, Chang & Chen, sp. nov. is described and illustrated from southwestern China. The female genitalia of the genus Euxaldar is described and presented for the first time. A checklist and key to the known species of the genus are provided. A revised molecular phylogenetic analysis of the family Issidae based on combined partial sequences of 18S, 28S, COI, and Cytb is provided using both Maximum likelihood and Bayesian inference analyses. [ABSTRACT FROM AUTHOR]

Background and Aim: Globally, China has the highest chronic hepatitis C (CHC) burden, but its real‐world direct‐acting antiviral (DAA) data are limited. Our aim is to investigate the real‐world outcome of China Food and Drug Administration‐approved DAA therapies across mainland China including those with genotype (GT) 3. Methods: The REAL‐C is a multinational real‐world interferon‐free DAA‐treated CHC registry of several mainland China and other Asian centers. We evaluated the sustained virological response rate 12 weeks after end of treatment (SVR12), adverse events, and treatment effect on liver function and fibrosis (fibrosis‐4 index). Results: We analyzed 859 DAA‐treated CHC patients (6/1/2017–5/30/2019) from 12 mainland China centers (three municipalities and nine provinces): median age 52, 49.9% male, 33.1% cirrhosis, 95% treatment naïve, and 2.5% HBsAg+. The most common GT was GT1b (523, 62.2%), followed by GT2a (156, 18.5%), GT3b (74, 8.8%), GT3a (41, 4.9%), and GT6 (37, 4.4%). SVR12 rates were 98.0% overall (95% confidence interval 96.9–98.8%), 98.1% for GT1b, 96.8% GT2a, 100% GT3a, 97.3% GT3b, and 100% GT6. Baseline cirrhosis and male sex but not prior treatment history, renal dysfunction, age, and GTs were associated with SVR12. For both cirrhotic and non‐cirrhotic patients, there were significant improvement in liver function tests, alpha fetoprotein, and fibrosis‐4 index with SVR12. Serious adverse events were rare (1.1%) with only nine patients discontinuing therapy prematurely and anemia being the most common adverse event (13.1%, mostly with ribavirin). Conclusions: In real‐world Chinese patients with diverse GTs, Chinese Food and Drug Administration‐approved interferon‐free DAAs were well tolerated, provided high cure rates (98.0% overall) including GT3a/3b, and led to improvement of liver function. [ABSTRACT FROM AUTHOR]

Background: The pandemic of coronavirus disease 2019 (COVID-19) has posed a threat to global health. Increasing studies have shown that the mental health status of health professionals is very poor during the COVID-19 epidemic. At present, the relationship between somatic symptoms and symptoms of anxiety of health professionals during the COVID-19 has not been reported. The purpose of this study was to explore the frequency of somatic symptoms and its related factors in health professionals with symptoms of anxiety during COVID-19 in China. Methods: A total of 606 health professionals were assessed online with the Chinese version of the 7-item Generalized Anxiety Disorder (GAD-7) scale, 7-item Insomnia Severity Index (ISI) and the somatization subscale of Symptom Checklist 90 (SCL-90). Results: The percentage of symptoms of anxiety, somatic symptoms and insomnia in all health professionals was 45.4%, 12.0%, and 32%, respectively. The frequency of somatic symptoms in health professionals with symptoms of anxiety was 22.9%. The SCL-90 somatization subscale score was significantly positively correlated with history of somatic diseases, GAD-7 score and ISI score in participants with symptoms of anxiety. Conclusion: During the COVID-19, symptoms of anxiety, insomnia, and somatic symptoms are commonly observed in health professionals. Insomnia and symptoms of anxiety are independently associated with somatic symptoms of health professionals with symptoms of anxiety. [ABSTRACT FROM AUTHOR]

Background: A great number of studies have concentrated on the influence of socioeconomic status with health outcomes, but little on how socioeconomic status affects social relationship in adolescents' families, peers and schools. This study aimed to clarify more detailed information on the connection between social relationships and different dimensions of socioeconomic status.Methods: A school-based cross-sectional study was performed by 13-18 adolescents enrolled in East China from September, 2018 to May, 2019, which recruited 6902 students from junior and senior high schools and used the stratified random sampling method. Parent-child relationship (cohesion, expressiveness, conflict), peer relationship (interpersonal relationship, communication and interaction, social emotion) and student-teacher relationship (intimacy, support, satisfaction, conflict) were investigated. Besides, objective socioeconomic status (parental education and occupation, assessed by the adolescent) and subjective socioeconomic status (self-evaluation of family social class) were measured. More detailed information was used to clarify the link between social relationships and different dimensions of socioeconomic status.Results: All five indicators of socioeconomic status were slightly positively correlated with the quality of social relationships (r ranged from 0.036 to 0.189, all p < 0.001), except that maternal education was not correlated with the conflict dimension of parent-child relationship. Standardized regression coefficients indicated that paternal education (β = 0.08) and occupation (β = 0.07) were the predictors of parent-child relationship. And peer relationship model revealed that the corresponding effect size was slightly stronger for subjective socioeconomic status (β = 0.10), whereas the maternal education had a slightly stronger correlation with student-teacher relationship (β = 0.07) relative to other indicators.Conclusions: Adolescents with lower socioeconomic status had poorer social relationships compared to those with higher socioeconomic status. These findings have important public health implications for health policy makers to make sound decisions on resources allocation and services planning in improving adolescents' social relationships and promoting health outcomes. [ABSTRACT FROM AUTHOR]

Background. To eliminate mother-to-child transmission of syphilis, the Chinese government recommends a treatment regimen that slightly differs from the World Health Organization- (WHO-) recommended treatment. However, little is known about their difference in efficacy. This study is aimed at comparing the effect of China-recommended and WHO-recommend treatment regimens on adverse pregnancy outcomes (APOs) and at examining associated risk factors of APOs among syphilis-seropositive women. Methods. Using the syphilis registry data, we retrospectively collected data from 4488 syphilis-infected pregnant women in Guangzhou during 2011-2018. Multivariate analyses were used to investigate the association between treatment regimens and APOs (ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth or low birth weight, newborn smaller than gestational age, congenital syphilis, and infant death) and the association between risk factors and APOs. Results. Of 3474 participants, 27.3% had at least one APO. Compared to those receiving WHO-recommended treatment, women who received China-recommended treatment were less likely to have APOs (odds ratio (OR) 0.47, 95% confidence interval (CI) 0.38-0.57), whereas those who received no treatment had 1.6 times higher odds of experiencing APOs. One common risk factor across different APOs was high levels of log2-transformed toluidine red unheated serum test (TRUST) titers before treatment (OR 1.14, 95% CI 1.10-1.19). China-recommended treatment was effective in reducing APOs for those with TRUST ≥ 1 : 8 (OR 0.21, 95% CI 0.14-0.29) and those with TRUST < 1 : 8 (OR 0.62, 95% CI 0.50-0.77). Conclusions. Syphilis-seropositive women receiving China-recommended treatment had lower odds of APOs, especially when TRUST titers before treatment were high. Findings can be used to guide health professionals to reduce APOs among syphilis-infected mothers and promote nationwide use of China-recommended treatment. [ABSTRACT FROM AUTHOR]

Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice. [ABSTRACT FROM AUTHOR]

Two selected walnut cultivars (Xiangling and Jizhaomian) growing in China were analyzed in terms of proximate and mineral composition, fatty acid and amino acid profile. According to the higher kernel rate (61.22%), thinner shell (1.03 mm), higher content of fat (66.93%), protein (20.97%), essential amino acids (29.31% of total amino acids) and minerals such as manganese, zinc and copper, Xiangling would be the more nutritive cultivar with more commercial value. However, Jizhaomian would be the more healthful cultivar based on the higher content of polyunsaturated fatty acids (79.39% of total fatty acids), and it would be more sensitive to rancidity. Jizhaomian also showed higher content in potassium, calcium, magnesium and iron. Genotype is the major source of variability in morphology and chemical compositions. Regardless of the cultivar, consumption of walnuts is desirably encouraged, since all of them contain compounds potentially beneficial to health. [ABSTRACT FROM AUTHOR]

Electricity cross-subsidy policies have long been criticized for they involve subsidizing households by charging above-cost prices in industrial sectors. This paper examines the environmental and economic impacts of phasing out cross-subsidy in electricity prices in the context of China's Carbon Peaking and Neutrality goals by exploiting a large panel data from 2012 to 2020. We first adopt a price-gap approach to calculate the scale of negative cross-subsidy in China and different sectors. Next, we estimate the electricity demand price elasticity of high-, medium-, and low-emission industries to evaluate how the cross-subsidy affects electricity consumption, carbon emissions, and the output value. Finally, with the 2020 scenario as our baseline, we simulate three distinct policy change Schemes and evaluate the environmental and economic effects of phasing out electricity cross-subsidy in China. We find that if policy makers do not consider the emission levels of different industries when implementing cross-subsidy removal, great environmental harm will be caused. We also find that the potential burden on households of electricity cross-subsidy removal is likely to be relatively small at all implementation stages. This study provides timely policy implications for the ongoing electricity system reform in China. • This paper examines the environmental and economic impacts of phasing out cross-subsidy in electricity prices in the context of China's Carbon Peaking and Neutrality goals. • We find that if policymakers do not consider the emission levels of different industries in cross-subsidy removal, it will lead to large carbon emissions but small output in average. • If the cross-subsidy is fully borne by high-emission industries, the optimal Scheme is to reduce the cross-subsidy by approximately 50%–70% to obtain more economic output and less carbon emissions. • If high-emission bear twice as much cross-subsidy as the medium-emission industries, the carbon reduction and economic output will be maximised at 10%–30% of cross-subsidy removal. • We also find that the potential burden on households is relatively small at all implementation stages. [ABSTRACT FROM AUTHOR]

Aim: To determine the prevalence of dementia in the past two decades and provide updated estimates about older people (aged ≥60 years) with dementia in China from 2015 to 2050. Methods: The English and Chinese databases were retrieved. Published epidemiology surveys of dementia from 1990–2018 were screened. Meta‐analysis was used to calculate their pooled prevalence. The age‐moving method was used to estimate the population aged ≥60 years in 2020, 2030, 2040 and 2050 based on the data of the sampling survey of 1% of the population in 2015 released by the National Bureau of Statistics. The pooled prevalence of three age groups (60–69, 70–79, ≥80 years) from 2015 to 2018 was used as the basis to estimate the number of older people with dementia. Results: The pooled prevalence rate of dementia in Mainland China from 1985 to 2018 was 4.9% (95% CI 4.3–5.4), and the prevalence rate from 2015 to 2018 among them was 7.4% (95% CI 5.3–9.5). In 2020, 2030, 2040 and 2050, the number of people with dementia will be 16.93 million, 24.25 million, 31.98 million and 35.98 million, respectively. Furthermore, people with dementia aged ≥60 years in 2050 will be 2.13‐fold than that of 2015. Conclusion: The number of dementia patients in China will increase dramatically in the next 30 years without preventive measures. Geriatr Gerontol Int 2019; 19: 1096–1100. [ABSTRACT FROM AUTHOR]

Background: Alzheimer's disease (AD), as the most common cause of dementia, brings huge economic burden for patients and social health care systems, which motivates researchers to study multiple protective factors, among which physical activity and exercise have been proven to be both effective and economically feasible.Methods: A systematic literature search was performed for eligible studies published up to November 1st 2018 on three international databases (PubMed, Cochrane Library, and Embase) and two Chinese databases (Wanfang Data, China National Knowledge Infrastructure). All analyses were conducted using Stata 14.0. Due to heterogeneity between studies, a random-effects model was used for this meta-analysis. Meta-analysis was used to explore if physical activity and exercise can exert positive effects on cognition of elderly with AD and subgroup analyses were conducted to find out if there are dose-response effects.Results: A total of 13 randomized controlled trials were included with a sample size of 673 subjects diagnosed with AD. Intervention groups showed a statistically significant improvement in cognition of included subjects measured by the MMSE score (SMD = 1.12 CI:0.66~1.59) compared to the control groups. Subgroup analyses showed different amounts of physical activity and exercise can generate different effects.Conclusions: As one of few meta-analyses comparing different quantities of physical activity and exercise interventions for AD in details, our study suggests that physical activity and exercise can improve cognition of older adults with AD. While the concomitant effects on cognition functions of high frequency interventions was not greater than that of low frequency interventions, the threshold remains to be settled. However, more RCTs with rigorous study design are needed to support our findings. [ABSTRACT FROM AUTHOR]

Myxotrichum albicans sp. nov. is a slowly-growing fungal species that was isolated from forest litters in northeast of China. The new species is morphologically characterized by its white colonies on CMA, PCA, PDA, and YMA, thallic conidiogenous cells, simple, catenate and hyaline conidia. Phylogenetic analysis based on internal transcribed spacer (ITS) and large subunit (LSU) rDNA sequences also supported the placement of M. albicans as a new species in the genus Myxotrichum. To compare with related species, the optimal pH and temperature for growth were investigated. The differences among Myxotrichum (Oidiodendron) species producing hyaline conidia were discussed. • A new species of Myxotrichum producing hyaline conidia is described. • It is a slowly-growing and abundantly sporulating fungus from forest litters. • Phylogenetic analysis supports it is a new species of Myxotrichum. • Myxotrichum species producing hyaline conidia are discussed. [ABSTRACT FROM AUTHOR]

The environmental sustainability of megacities is a global problem, and megacities are experiencing increasing pressure and challenges with regard to providing a suitable living environment for people. Urban green space plays a crucial role in protecting urban ecological environments and in maintaining the physical and mental health of residents. In this study, a total of 94 soil samples from green spaces in Shanghai, including park green spaces and road green spaces in the eight central urban districts, were collected, and the contents of heavy metals and polycyclic aromatic hydrocarbons (PAHs) were analyzed to determine the distribution characteristics and influencing factors and to assess the associated health risks. The accumulation of heavy metals was greater in park green space soils than in road green space soils, although the variation coefficient of the former was lower than that of the latter. Conversely, the accumulation of PAHs was lower in park green space soils than that in road green space soils, although the variation coefficient of the former was higher than that of the latter. In particular, Cu, Zn, Pb, Cd, As, and PAHs have accumulated in Shanghai green space soils. With increasing soil depth (0–2 cm, 2–5 cm, 5–10 cm, and 10–30 cm), the PAH content increased in the park green space soils but decreased in the road green space soils. According to the "Technical guidelines for risk assessment of contaminated sites (MEP of China 2014)," the overall health risk posed by green space soils in urban areas in Shanghai can be considered safe, except at individual sampling sites. The PAH, Cu, and Zn contents of park green space soils might be related to the application of organic materials and to traffic and industry emissions. However, the soil pollutants in road green spaces are predominantly related to traffic and industrial emissions. Therefore, the monitoring and management of soil environmental quality must be strengthened. [ABSTRACT FROM AUTHOR]

Two new species of the tribe Hemisphaeriini: Ceratogergithus brachyspinus Yang & Chen, sp. nov. (Yunnan) and Neohemisphaerius clavatus Yang & Chen, sp. nov. (Guizhou) are described and illustrated. A checklist to Hemisphaeriini genera is provided. The generic characteristics of the genera Ceratogergithus Gnezdilov, 2017 and Neohemisphaerius Chen, Zhang & Chang, 2014 are redefined. Checklists and keys to the species of each genus are given. [ABSTRACT FROM AUTHOR]

Background: Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few studies have focused on postoperative long-term survival of RCC patients exclusively with RVTT. Our aim was to investigate the independent prognostic factors for locally advanced RCC with RVTT in China.Methods: Patients with locally advanced RCC with RVTT were enrolled for the study from January 2000 to December 2015. All patients underwent radical nephrectomy. Survival analysis was estimated using Kaplan-Meier. Univariable and multivariable survival analyses were performed using COX. Patients were divided into high-risk, middle-risk, and low-risk groups based on independent prognostic factors and then analyzed for survival.Results: One hundred twenty-eight consecutive patients (103 men & 25 women) were enrolled with a median age of 61 years. Thrombi were all graded 0 using the Mayo system, of which 23 were friable. None of the thrombi detached during surgery. 121 patients were successfully followed up, with a median follow-up period of 47 months. Median overall survival was 127 months (95%CI: 101-153). The 5-year and 10-year cancer-specific survival (CSS) rate was 67.9 and 57.0%. 59 patients had recurrence with median time of 40 months. Friable thrombus, paraneoplastic syndrome (PNS), modified Fuhrman grade 3/4 and perirenal fat invasion were independent prognostic factors (p < 0.05). The 5-year CSS for the Low-risk group (no factors) was 100%, Middle-risk group (1-2 factors) was 68.6%, while the High-risk group (3-4 factors) was 0%.Conclusions: After radical surgery, RCC patients with RVTT had a relatively fair prognosis except for patients with friable thrombus, PNS, higher modified Fuhrman grade and perirenal fat invasion. [ABSTRACT FROM AUTHOR]

Purpose:To compare the effectiveness and safety of loop electrosurgical excision procedures (LEEP) with four different excisions in treating cervical intraepithelial neoplasia (CIN) of different areas. Methods:Four hundred and sixty-six cases of CIN were treated with different types of LEEP. Following visual inspection with acetic acid and Lugol’s iodine, LEEP were performed to excise the transformation zone to a 20–25 mm depth with a 2–3 mm margin. Four categories of procedures are described below: (i) LEEP-A for lesion ≥2/3 of cervical area: conization of ≥2/3 of cervical tissue. (ii) LEEP-B for ≥1/3 but <2/3: conization of 1/3 to <2/3. (iii) LEEP-C for <1/3: conization of <1/3. (iv) LEEP-D: endocervical canal resection. Results:The cases included 108 of CIN I, 232 of CIN II, and 106 of CIN III (not including carcinomain situ) patients. No positive margin was found in any specimens. The cure rates for LEEP-A, B, C, and D were 99.1%, 98.5%, 100.0%, and 93.2%, respectively (p > .05). The pregnancy rate at two years after LEEP was significantly higher in groups C and D compared to group A (p < .05). Conclusions:Four categories of LEEP are highly effective in the treatment of CIN when appropriately applied. However, large loop excision may lead to adverse obstetric outcomes in pregnancy.ABSTRACT FROM PUBLISHERCopyright of Minimally Invasive Therapy & Allied Technologies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. [ABSTRACT FROM AUTHOR]

Aims. To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD. Objective and Methods. 65 CHB patients with NAFLD were divided into NASH group (34 patients) and non-NASH group (31 patients) according to the NAS score. Biochemical indexes, liver stiffness, and Controlled Attenuation Parameter (CAP) were determined. Data in the two groups were compared and subjected to multivariate analysis, to establish a score model for the prediction of NASH. Results. In the NASH group, ALT, TG, fasting blood glucose (FBG), M30 CK-18, CAP, and HBeAg positive ratio were significantly higher than in the non-NASH group (P<0.05). Multivariate analysis showed that CK-18 M30, CAP, FBG, and HBVDNA level were independent predictors of NASH. Therefore, a new model combining CK18 M30, CAP, FBG, and HBVDNA level was established using logistic regression. The AUROC curve predicting NASH was 0.961 (95% CI: 0.920–1.00, cutoff value is 0.218), with a sensitivity of 100% and specificity of 80.6%. Conclusion. A noninvasive score model might be considered for the prediction of NASH in patients with CHB combined with NAFLD. [ABSTRACT FROM AUTHOR]

The occurrence of phthalate esters (PAEs) in household tap water has been investigated via the presence of their geochemical characteristics in the pretreatment and transfer processes of water plants in the urban and suburban areas of the subtropical medium-sized city of Quanzhou, southeast China. The results for all approximately 300 tap water samples collected from 6 sampling stations at household kitchens from Nov. 30, 2017, to Dec. 6, 2018, showed that dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutylphthaate (DIBP), di-n-butyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP) could be identified and quantified among the 16 PAE congeners with the developed gas chromatography mass spectrometry method. The levels of the sum of 5 PAE congeners (Σ 5 PAEs) for all tap water ranged from 780.0 ng/L to 9180 ng/L, while DIBP and DEHP were the most abundant congeners, accounting for 82.2% in the dry season, 89.9% in the normal season, and 89.3% in the wet season. Factors of the transferring process, such as the spatial distance from the sampling station to the water plant, the material of pipelines, and the storage time of tap water in the pipeline, affected the levels of PAE congeners in tap water from the correlation of Σ 5 PAEs levels and transferring distance according to hierarchical cluster analysis. The seasonal variations in Σ 5 PAEs and each congener had good agreement with the temperature, suggesting that PAEs in tap water mainly come from raw water, which should be further explored in future work. Health risk assessment of PAEs in tap water with the HQ method showed that the occurrence of DEP and DBP has no noncarcinogenic risk for adults and children, while the concentration of DEHP might cause potential noncarcinogenic risk for adults and children, which should be given considerably more attention. • The occurrence of 16 phthalate esters investigated in household tap water. • Transferring process have effect on the levels of phthalate ester congeners. • Seasonal variation has good agreement with the levels of phthalate ester congeners. • Children have higher noncarcinogenic risk than adults. [ABSTRACT FROM AUTHOR]

Background: Evidence linking caries in primary dentition and children's anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school children in urban Guangzhou, China.Methods: This cross-sectional study enrolled 32,461 pupils (14,778 girls and 17,683 boys) aged 7-9 years from 65 elementary schools in Guangzhou. Dental caries was detected according to criteria recommended by the World Health Organization (WHO). The total mean decayed, missing or filled teeth (dmft) of primary dentition were assessed. Weight and height were measured and BMI was calculated. Children were classified into underweight, normal weight, overweight and obesity groups by BMI based on Chinese criteria. Z-score of BMI-for-age (BAZ) was calculated by WHO standardized procedure. Multivariable odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression. Restricted cubic spline regression was applied to evaluate the shape of the relationship between BAZ and primary dental caries.Results: The prevalence of primary dental caries was 30.7 % in total sample. Regarding dmft values, the mean ± standard deviation (SD) in the combined sample were 1.03 ± 2.05 in boys and 0.93 ± 1.92 in girls. Both indices decreased by age. Compared with normal BMI group, children in overweight and obesity groups have 27 % (OR = 0.73, 95 % CI: 0.66-0.81, P < 0.0001) and 34 % (OR = 0.66, 95 % CI: 0.59-0.74, P < 0.0001) lower odds for the presence of primary dental caries after adjustment for age and gender, respectively. Although in general, increased BAZ was associated with decreased risk of dental caries, full-range BAZ was associated with dental caries in an A-shaped manner with a zenith at around -1.4.Conclusion: Higher BMI was associated with lower odds of caries; overweight and obese children were more likely to be primary dental caries free among 7-9 years in Guangzhou, China. [ABSTRACT FROM AUTHOR]

Background: The recent emergence of azithromycin-resistant (AZM-R) N. gonorrhoeae isolates that have coevolved decreased susceptibility to extended-spectrum cephalosporins has caused great concern. Here we investigated the prevalence of decreased susceptibility to ceftriaxone (CRO(D)) in AZM-R isolates and genetically characterized AZM-R isolates in Guangzhou, China from 2009 to 2013.Methods: The minimum inhibitory concentration (MIC) of AZM and ceftriaxone was determined using an agar-dilution method. All AZM-R isolates were screened for mutations in 23S rRNA, mtrR and penA genes and genotyped using N. gonorrhoeae multi-antigen sequence typing (NG-MAST).Results: Of the 485 identified N. gonorrhoeae isolates, 445 (91.8%) were isolated from male urethritis subjects, and 77 (15.9%) were AZM-R (MIC ≥ 1 mg/L), including 33 (6.8%) with AZM low-level resistant (AZM-LLR, MIC = 1 mg/L) and 44 (9.1%) with AZM middle-level resistant (AZM-MLR, MIC ≥ 2 mg/L). Significantly more CRO(D) (MIC ≥ 0.125 mg/L) showed in AZM-MLR isolates (43.2%, 19/44) as compared with that in AZM-LLR isolates (18.2%, 6/33) (p < 0.05). For the 23S rRNA, mtrR, penA or combined 23S rRNA/MtrR/penA mutations, no significant difference was found between AZM-LLR isolates and AZM-MLR isolates (P > 0.05); similar results were detected between combined AZM-LLR/CRO(D) isolates and combined AZM-MLR/CRO(D) isolates (P > 0.05). No mutation A2059G or AZM high-level resistant (AZM-HLR, MIC ≥ 256 mg/L) isolate was detected. Among 77 AZM-R isolates, 67 sequence types (STs) were identified by NG-MAST, of which 30 were novel. Most STs were represented by a single isolate.Conclusions: The AZM-R together CRO(D) isolates are now present in Guangzhou, China, which deserve continuous surveillance and the mechanism of concurrent resistance needs further study. [ABSTRACT FROM AUTHOR]

Early menopause has been found to be associated with higher risk of cardiovascular disease. Our objective was to investigate the impact of early menopause on clinical outcomes for women undergoing percutaneous coronary intervention (PCI). We observed female patients with coronary artery disease (CAD) undergoing PCI and found that women with early menopause (≤46 years old) were more likely to have CAD risk factors and more severe coronary lesions. During the 18-month follow-up, early menopause was associated with similar risk of death and myocardial infarction but higher risk of target lesion revascularization (TLR; 7.8% vs 5.3%, P = .003) and major adverse cardiovascular events (MACEs; 11.3% vs 9.0%, P = .007). After adjustment, early menopause was an independent risk factor for 18-month MACEs (hazard ratio [HR], 1.54; 95% confidence interval [CI] 1.18-2.00) and TLR (HR 1.61; 95% CI 1.21-2.13). In conclusion, for women undergoing PCI, early menopause is associated with higher risk of MACE, which is mainly driven by risk of TLR. [ABSTRACT FROM AUTHOR]

We assessed the influence of insulin resistance (IR) on the development of contrast-induced nephropathy (CIN) in patients (n = 719) undergoing elective percutaneous coronary intervention (PCI). Patients were divided into diabetes mellitus (DM = 242), nondiabetic IR (IR = 120), and nondiabetic insulin sensitivity (IS = 357) groups according to medical history and homeostasis model assessment insulin resistance index. Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) were measured before and 72 hours after PCI. There were no differences in SCr and eGFR among the groups before PCI; SCr increased and eGFR decreased significantly in the DM and IR groups post-PCI (P < .001). The incidence of CIN in the IR group was as high as in the DM group and were both significantly higher than in the IS group (6.7% vs 8.7% vs 2.2%, P < .05). Multivariate logistic regression analysis showed DM (odds ratio [OR] = 1.19, 95%CI = 1.08-1.510, P < .001), HOMA-IR (OR = 1.39, 95%CI = 1.23-1.58, P < 0.001), and eGFR (OR = 0.88, 95%CI = 0.84-0.92, P < .001) were independent risk factors in predicting CIN. Screening IR patients and taking appropriate prophylactic strategy before PCI may reduce the incidence of CIN. [ABSTRACT FROM AUTHOR]

Copyright of Health Policy & Planning is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Changes in modern industrial production practices can easily lead to shoulder work-related musculoskeletal disorders (WMSD). The current reports on shoulder WMSD are limited to some industries are less well studied, and the sample size is usually small. This study aimed to describe the prevalence and severity of shoulder WMSD in a large sample of Chinese workers from 15 industries, analyze the possible correlations with sociodemographic and work-related variables, and compare the differences between industries.Methods: A cross-sectional study was conducted among a sample of 55,749 participants from 252 enterprises in 15 industries throughout China. A Chinese version of the musculoskeletal disease questionnaire was used to collect the demographic factors, shoulder symptoms in past 12 months, and work-related factors including posture-related factors, repetition, vibration, work organization, job control, and environmental factors as independent variables. Descriptive statistics were used, and the binary logistic regression analysis was performed to explore the association between shoulder WMSD and potential demographic and work-related factors.Results: Nearly 35.5% of participants reported shoulder pain and discomfort in the previous 12 months. Biopharmaceutical manufacturing (56.2%), medical services (54.4%), and aviation services (50.1%) were the three industries with the highest prevalence of shoulder WMSD. The pain score of aviation services workers was the highest. The related factors for shoulder WMSD varied among the different industries.Conclusion: Our study found a relatively high prevalence of shoulder WMSD in China. There were large differences in the prevalence of shoulder WMSD among industries, and the related factors were particular to each industry. Such information is useful to help occupational health practitioners and policymakers conduct preventive programs to reduce shoulder disorders in these working populations. [ABSTRACT FROM AUTHOR]

Background: In China, childhood obesity is a growing health issue. Eating behaviors among children can be influenced by both the family and school environment. We examine the association between these environments and eating habits among children. Methods: A total of 11 270 fourth to sixth grade school children, 11 270 of their fathers or mothers, and 1348 teachers from 48 schools were sampled using a multistage cluster random sampling method. Questionnaires collected information on eating behaviors among children, non-communicable chronic disease (NCD)-related health knowledge and behaviors among teachers, and education levels among parents. Mixed effect logistic regression models were used to describe the key associations between eating behaviors among children and teacher and parental characteristics. Results: Health awareness, positive health attitudes, never-smoking and regular-exercise among teachers was positively associated with healthy eating behaviors among their students (having breakfast, vegetables and dairy products every day; P < 0.05), and negatively associated with the unhealthy behaviors (daily intake of fried foods and desserts and sugary beverages; P < 0.05). More than one parent having a high school level or above was positively related to healthy eating behaviors among their children (P < 0.05), but its associations with high-calorie eating habits were negative in urban and positive in rural areas (P < 0.05). Conclusions: School-based interventions which target health-related awareness, attitude and behaviors among school teachers may help improve school-aged children’s eating behaviors. Parental education levels may help guide efforts to target children at higher risk of unhealthy eating habits. [ABSTRACT FROM AUTHOR]

Tungsten is one strategic metal with diverse applications ranging from military, infrastructure to chemical industry. China is the biggest tungsten supplier and consumer in the world, but few studies focus on the domestic tungsten supply and demand. By conducting a hybrid dynamic substance flow analysis, this study investigates China's tungsten flow patterns from 2001 to 2019. Various flows (transformation, loss, trade and recycling flows) and stocks are explored, covering all the relevant aspects of tungsten extraction, production, consumption, trade and waste management. Results present that China had extracted around 1344 metric kilo-tons (kt) tungsten ores from earth crust, consumed 634 kt domestically and exported 381 kt to other countries during the study period. Key findings include: 1) unstable production capacity had led to 136.16 kt of tungsten surplus during the study period; 2) 309 kt of tungsten were lost in tailings due to inefficient mining and beneficiation technologies; 3) domestic industry upgrade and rapid economic development induced dynamic changes of tungsten trade structure in China; 4) only 17.72% of end-of-life (EoL) products had been recycled during the study period. Finally, policy recommendations are raised to improve the overall tungsten resource efficiency from governance, economic instruments and technology perspectives. [Display omitted] [ABSTRACT FROM AUTHOR]

Objective: To evaluate the psychometric properties and clinical utility of Chinese Multidimensional Health Assessment Questionnaire (MDHAQ-C) in patients with rheumatoid arthritis (RA) in China. Methods: 162 RA patients were recruited in the evaluation process. The reliability of the questionnaire was tested by internal consistency and item analysis. Convergent validity was assessed by correlations of MDHAQ-C with Health Assessment Questionnaire (HAQ), the 36-item Short-Form Health Survey (SF-36) and the Hospital anxiety and depression scales (HAD). Discriminant validity was tested in groups of patients with varied disease activities and functional classes. To evaluate the clinical values, correlations were calculated between MDHAQ-C and indices of clinical relevance and disease activity. Agreement with the Disease Activity Score (DAS28) and Clinical Disease Activity Index (CDAI) was estimated. Results: The Cronbach's alpha was 0.944 in the Function scale (FN) and 0.768 in the scale of psychological status (PS). The item analysis indicated all the items of FN and PS are correlated at an acceptable level. MDHAQ-C correlated with the questionnaires significantly in most scales and scores of scales differed significantly in groups of different disease activity and functional status. MDHAQ-C has moderate to high correlation with most clinical indices and high correlation with a spearman coefficient of 0.701 for DAS 28 and 0.843 for CDAI. The overall agreement of categories was satisfying. Conclusion: MDHAQ-C is a reliable, valid instrument for functional measurement and a feasible, informative quantitative index for busy clinical settings in Chinese RA patients. [ABSTRACT FROM AUTHOR]

[Display omitted] • This study reveals the core bacteria related to volatile compounds in the traditional Chinese condiment red sour soup (RSS). • The two-stage fermentation strategy contributed to the generation of volatile substances in RSS. • Lactic acid bacteria (LAB) were the core bacteria in RSS during fermentation. • Esters were dominant in RSS, as detected by gas chromatography ion mobility spectrometry (GC-IMS). • The reason for the diversity of volatile compounds could be the coexistence of a variety of LAB in the second fermentation stage. Red sour soup (RSS) is a traditional fermented seasoning used by people in Guizhou Province, China. The volatile compounds were detected by gas chromatography ion mobility spectrometry (GC-IMS), while the bacterial community compositions were revealed by 16S sequencing. A total of 70 volatile substances were assessed, and esters, terpenes, and alcohols played a dominant role in RSS. Lactic acid bacteria (LAB) were dominant in the microbial community. During fermentation, multiple volatile flavour substances and various LAB were mainly derived from the secondary fermentation stage. The core bacteria with an important influence on volatile flavour substances were analysed by the Mantel test, identifying Bacteroides , Lactobacillus , Lactococcus , Enterobacteriaceae, Pantoea , Clostridium , Enterobacter , unclassified genera, Caproiciproducens , Nitriliruptoraceae, Halomonas , Bradyrhizobium , Pediococcus , Caulobacteraceae, Weissella , Ligilactobacillus , and Levilactobacillus and et al.. This study provides us with useful information about flavour-generating bacteria among RSS fermentation periods. The abundances of these bacteria may be controlled to enrich the desired flavour metabolites while eliminating unwanted metabolites. [ABSTRACT FROM AUTHOR]

Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal cancer (CRC). No studies to date have assessed the role of hMLH1 and hMSH2 genes in mass sporadic CRC (without preselection by MSI or early age of onset). We aimed to identify novel hMLH1 and hMSH2 DNA variants, to determine the mutation frequencies and sites in both sporadic and LS CRC and their relationships with clinicopathological characteristics of CRC in Northeast of China. 452 sporadic and 21 LS CRC patients were screened for germline and somatic mutations in hMLH1 and hMSH2 genes with PCR–SSCP sequencing. We identified 11 hMLH1 and seven hMSH2 DNA variants in our study cohort. Six of them were novel: four in hMLH1 gene (IVS8-16 A>T, c.644 GAT>GTT, c.1529 CAG>CGG and c.1831 ATT>TTT) and two in hMSH2 gene (−39 C>T, insertion AACAACA at c.1127 and deletion AAG at c.1129). In sporadic CRC, germline and somatic mutation frequencies of hMLH1/hMSH2 gene were 15.59% and 17.54%, respectively (p = 0.52). Germline mutations present in hMLH1 and hMSH2 genes were 5.28% and 10.78%, respectively (p<0.01). Somatic mutations in hMLH1 and hMSH2 genes were 6.73% and 11.70%, respectively (p = 0.02). In LS CRC, both germline and somatic mutation frequencies of hMLH1/hMSH2 gene were 28.57%. The most prevalent germline mutation site in hMSH2 gene was c.1168 CTT>TTT (3.90%), a polymorphism. Somatic mutation frequency of hMLH1/hMSH2 gene was significantly different in proximal, distal colon and rectal cancer (p = 0.03). Our findings elucidate the mutation spectrum and frequency of hMLH1 and hMSH2 genes in sporadic and LS CRC, and their relationships with clinicopathological characteristics of CRC. [ABSTRACT FROM AUTHOR]

PURPOSE: To establish a quick, sensitive method for quantifying root canal flora and investigate the effects of different root canal preparations on the pathogenic bacteria at RNA level. METHODS: A total of 24 single,-rooted teeth with chromic apical periodontitis were selected and prepared using 3% H2O2 combined with 1% NaCIO. EDTA combined with 3% H2O21% NaCIO, respectively, the samples were taken before and after root canal preparation. After isolation of total RNA from the root canal samples, eDNA was synthesized by reverse transcription, and detected by real-time PCR. The data were analyzed with SAS 6.12 software package. RESULTS: The number of bacteria in the root canal reduced dramatically after mechanical preparation and irrigated using 3% H2O2 and 1% NaClO(P<0.01 ). Further combined with EDTA, its effect was better than that of simply irrigated using 3% H2O2 and 1% NaC1O (P<0.05). CONCLUSIONS: Real-time PCR can be employed in file identification of bacteria flora in the root canal, both methods of root canal preparation can effectively reduce the number of bacteria flora. Supported by Research Fund of Shanghai Municipal Health Bureau(Grant No. 2007012) and Research Fund of Shanghai Municipal Education Commission (Grant No. jdy-07060). [ABSTRACT FROM AUTHOR]

Two new rotenoids, 2-hydroxy-5-aminorotenonone (1) and elliptoic acid (2), were isolated from the roots of Derris elliptica collected in Guangdong Province, China. Their structures were established by extensive spectral analysis. Compound 1 is the first N-containing rotenoid and compound 2 is the third rotenoid with the cleavage of C(12)-C(12a). [ABSTRACT FROM AUTHOR]

Abstract: According to the Chinese State Council''s “Building Energy Efficiency Management Ordinance”, a large-scale investigation of energy efficiency (EE) in buildings in contemporary China has been carried out in 22 provincial capitals and major cities in China. The aim of this project is to provide reliable information for drawing up the “Decision on reinforcing building energy efficiency” by the Ministry of Construction of China. The surveyed organizations include government departments, research institutions, property developers, design institutions, construction companies, construction consultancy services companies, facility management departments, financial institutions and those which relate to the business of building energy efficiency. In addition, representatives of the media and residents were also involved. A detailed analysis of the results of the investigation concerning aspects of the current situation and trends in building energy consumption, energy efficiency strategy and the implementation of energy efficiency measures has been conducted. The investigation supplies essential information to formulate the market entrance policy for new buildings and the refurbishment policy for existing buildings to encourage the development of energy efficient technology. [Copyright &y& Elsevier]