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Tourism integration is a trend in regional tourism economic development and cultural integration. Tourism economic linkages greatly influence regional tourism integration, becoming progressively obvious with the strength of linkages. However, their influence on regions with rich tourism resources and underdeveloped economies are understudied. This article takes the national tourism resources above 3A level in the Poyang Lake region, Jiangxi Province, as the research object, analysing the evolution of regional tourism economic linkages and the development process of tourism integration in the past 17 years by constructing a new gravity model of regional tourism economic linkages and research methods of transportation network accessibility. The results show that the evolution of regional tourism economic linkages and the accessibility of transportation networks significantly impact regional tourism economies and tourism integration evolution. The evolution process of regional tourism development had different stage models; four theoretical models of regional tourism integration evolution were extracted: point‐core model, point‐axis corridor model, multi‐centre ring‐axis model, and network integration model. The construction of the new regional tourism economic linkages model and the proposal of the evolutionary model for tourism integration provide references for study and for formulating the sustainable development of regional tourism integration locally and abroad. [ABSTRACT FROM AUTHOR]

Abstract: Infection with certain types of human papillomaviruses (HPVs) is a risk factor for the development of cervical cancer. HPV type 58 (HPV 58) is prevalent among Chinese women. The intratype sequence variants differ in oncogenic potential and their prevalences vary across geographic regions. The objective of this study was to analyze the variations of HPV 58 E6, E7, L1 genes and long control region (LCR) in a large samples collected from northeastern Chinese women with cervical lesions. A total of 2938 cervical samples were collected and tested for HPV type using a chip hybridization assay. The E6, E7, L1 genes and LCR of HPV 58 strains were amplified and the amplicons were subjected to direct nucleotide sequencing for variation identification. A total of 235 specimens were HPV 58 positive. High proportions of HPV 58 E6 (83.8%), E7 (76.7%), L1 (90.8%) genes and LCR (91.4%) variants were identified in strains from Chinese women. The most frequently observed variations were C307T (52.4%) in E6, T744G (74.9%) in E7, A6014C (56.9%) in L1 genes and C7266T, A7714G (55.2%) in LCR. For the E6 gene, nine nucleotide variations were identified. Among them, the A140G (T11A), A184C (E25D), G266C (V53L) and A313G were novel variations. Sequencing of the E7 gene revealed four typical nucleotide changes: G761A (G63D), G694A (G41R), T803C (V77A) and T744G. In the L1 gene, 39 nucleotide variations and 13 amino acid substitutions were identified. Among these mutations, 21 variations are reported here for the first time. Lineage A of HPV 58 was found in 142 of 174 strains (81.6%). The most prevalent HPV 58 variants in Chinese northeastern women belongs to lineage A. Novel variations in E6 and L1 genes were also reported. These findings provide new data regarding E6 and L1 gene variations of HPV 58 from women in northeast China. [Copyright &y& Elsevier]