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This article examines the relationship between US missile defense and the US-China security dilemma dynamics by developing the concept of diffuse signaling involving the Korean peninsula. We argue that the US' efforts to bolster deterrence against North Korea's growing threats through missile defense have resulted in China's countermeasures of enhancing survivability and penetrability of its second-strike capability, leading to downward spirals of tensions between Beijing and Washington. We explain how three structural factors – geography, the US alliance system, and nuclear asymmetry – have made diffuse signaling salient, thus making it very challenging for the United States to reassure China even when its actions targeted North Korea. The article empirically shows the action-reaction process through which China and the US have come to experience the aggravation of the security dilemma over the Korean peninsula. [ABSTRACT FROM AUTHOR]

Some argue a powerful China will likely reestablish a Sinocentric tribute system in pursuit of hegemony in Asia. This line of argument, however, rests on misleading images of the Chinese empire while assuming hegemony is a product of a single agent and its activities. But, why do actors comply with, defy, or challenge hegemonic authority? I argue hegemony is not just an outcome of the material power of the preponderant state, but is constructed in interaction with other actors’ pursuit of domestic legitimation. The tribute system and Chinese hegemony in early modern East Asia were built on symbolic domination—Chinese views of how international politics should work determined what was socially acceptable and legitimate while regulating the range of choices other actors could make due to domestic consequences. It shows that crafty political leaders engaged in a form of symbolic politics that manipulated external recognition from the hegemon, but in ways that strengthened their positions against domestic opponents. [ABSTRACT FROM PUBLISHER]

To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study.