1. Association Between CYP2D7 and TCF20 Polymorphisms and Coronary Heart Disease.
- Author
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Zhang W, Wan P, Zhang M, Chang Y, Du S, Jin T, and Wang Y
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Alcohol Drinking genetics, Alcohol Drinking adverse effects, Case-Control Studies, China epidemiology, Genetic Association Studies, Phenotype, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Smoking adverse effects, Smoking genetics, East Asian People genetics, Coronary Disease genetics, Coronary Disease enzymology, Coronary Disease epidemiology, Coronary Disease diagnosis, Genetic Predisposition to Disease, Cytochrome P-450 Enzyme System genetics, Transcription Factors genetics
- Abstract
One of the causes of coronary heart disease (CHD) is genetic factors. In this study, we explored the relationship between CYP2D7 and TCF20 gene polymorphisms and the risk of CHD in the Han Chinese population. Three single nucleotide polymorphisms (CYP2D7 rs1800754, CYP2D7 rs2743461, and TCF20 rs760648) were selected and genotyped from 490 cases and 480 controls. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between CYP2D7 and TCF20 polymorphisms and the risk of CHD. The association between clinical indicators and polymorphisms was analyzed using one-way ANOVA and Tukey's HSD. The SNP-SNP interactions were obtained by performing multifactor dimensionality reduction (MDR). CYP2D7 rs1800754 and rs2743461 were closely associated with increased risk of CHD (alleles: p = 0.014, p = 0.031). Stratified analysis showed that CYP2D7 rs1800754 and rs2743461 were associated with an increased risk of CHD in men, age > 60 years, BMI ≥ 24, and smoking. Rs1800754 is also associated with an increased risk of CHD associated with alcohol consumption. In addition, TCF20 rs760648 was associated with a reduced risk of CHD in patients aged ≤ 60 years and with CALs. A significant association was found between CYP2D7 rs1800754 and rs2743461 genotypes and levels of UREA, Cr, and LDL-C; TCF20 rs760648 genotypes and levels of RBC. The MDR analysis showed that the three-locus interaction model was the best in the multi-locus model. In conclusion, CYP2D7 rs1800754 and rs2743461 polymorphisms were associated with CHD risk., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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