Search

Background: Although the use of antibiotics during early life has been associated with increased risk of adipogenesis, effect of antibiotic exposure from various sources, including food or drinking water, on adiposity in children is largely unknown., Objective: To investigate associations between urinary biomarkers of multiple antibiotics and risk of adipogenesis in school children., Methods: This case-control study recruited 410 overweight/obese school children aged 6-9 years and 410 controls from Shandong and Guangdong Province, China, matched on sex, age and school. Diagnosis of overweight and obesity was based on body mass index-based criteria derived from national data. Urinary concentrations of 45 antibiotics from 8 categories (macrolides, β-lactams, tetracyclines, fluoroquinolones, sulfonamides, phenicols, lincosamides, and quinoxalines), including 6 human antibiotics (HAs), 6 antibiotics preferred as HAs (PHAs), 16 veterinary antibiotics (VAs), and 17 antibiotics preferred as VA (PVAs), were measured by ultra-performance liquid chromatography coupled to triple-quadrupole tandem mass spectrometry. Conditional logistic regression analyses were used to assess odds ratios (ORs) of childhood overweight/obesity in relation to urinary antibiotic concentrations., Results: A total of 32 antibiotics were found in urine samples with an overall detection frequency of 92.93 %. Children with overweight/obesity have higher veterinary antibiotic levels than those with normal weight. Compared with undetected levels of antibiotics, the multivariable-adjusted ORs (95 % confidence interval) of overweight/obesity for high levels of antibiotics divided according to median values were 1.63 (1.02, 2.62) for florfenicol, 1.62 (1.04, 2.54) for phenicols, and 1.41 (0.97, 2.04) for sum of VAs and PVAs. These associations predominantly existed in boys and remained significant in florfenicol after FDR multiple testing correction (FDR adjusted p < 0.05)., Conclusion: Exposure to certain antibiotic for veterinary use mainly from food or drinking water was associated with an increased risk of adipogenesis in children. Further studies are needed to confirm our findings and clarify the underlying mechanisms., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

Personal care products (PCPs) have shown adverse health effects on humans. However, their health risk associated with fish consumption and relevant water quality criteria are still not well documented. This study investigated the occurrence and health risk of six PCPs (triclosan, bisphenol-A, and four commonly used organic ultraviolet (UV) filters, i.e., homosalate (HMS), 4-methylbenzylidene camphor (4-MBC), oxybenzone (BP-3), and octocrylene (OC)). River water and three trophic levels of fish species were collected from Huangpu River in Shanghai. The concentration range of the six PCPs were 1.48-89.76 ng/L in water and 0.40-10.75 ng/g dry weight in fish. Estimated daily intake (EDI) and target hazard quotient (THQ) of the PCPs indicated that consuming these fish would not pose non-carcinogenic risks. The maximum allowable fish consumption rates ranged from 85 to 1760 and 155 to 3230 meals per month for children and adults, respectively. As to the four organic UV filters, it is the first time to report the fish consumption advisories. Finally, the human health ambient water quality criteria (AWQC) values of HMS, 4-MBC, BP-3, OC, TCS, and BPA (i.e., 0.1218, 0.7311, 0.3494, 0.0477, 235.8, and 154.7 μg/L, respectively) were proposed, and they can serve as a valuable technical reference for global development and revision of aquatic environmental quality standards for these emerging contaminants., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

The production and emission of short-chain perfluoroalkyl acids (PFAAs) has increased over the years to replace long-chain PFAAs, leading to frequent detection in the environment and raising global concerns about the potential impacts on human health. In this study, the specific urine levels of 10 PFAAs were obtained from 189 children (age 8-12 years) from two primary schools located in urban and suburban areas of Shanghai in 2019, and the contributions of dietary factors were investigated. Perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), and perfluorobutane sulfonate (PFBS) were detected in 100%, 99.5%, and 87.3% of the samples, with median concentrations of 20.20 ng/L, 46.50 ng/L, and 20.95 ng/L, respectively. The most abundant PFAA was perfluorooctanoic acid (PFOA), with a median concentration of 78.90 ng/L. The concentration of ∑PFAAs ranged from 61.10 to 4108.93 ng/L, with a median concentration of 253.12 ng/L. Children aged 8-9 years had higher median levels of PFBS, perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) than children aged 10-12 years. Obese/overweight children had lower levels of PFHpA, PFBS, and PFOS. The intake of red meats, tubers, sugared beverages, fish and seafood, and eggs contributed to higher concentrations of PFAAs, while frequent intake of poultry and soy milk was associated with lower PFAA concentrations.