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Volcanic rocks in the Bangxi-Chenxing tectonic zone provide important carries for better understanding the Late Paleozoic tectonic evolution in Hainan and its temporal-spatial pattern of the eastern Paleotethyan evolution. This paper presents a set of new geochronological and geochemical data on the andesitic and dacitic rocks along the Bangxi-Chenxing tectonic zone in central Hainan. The representative andesitic and dacitic samples yield similar zircon U-Pb ages of 353±3 and 351±7 Ma, respectively, being of Early Carboniferous origin. These volcanic rocks are characterized by low TiO2 and high Al2O3 contents and are enriched in LILEs and LREEs but depletion in HFSEs, along with negative εNd(t) values of -1.4- -4.7 and high 87Sr/86Sr(i) ratios of 0.707 2-0.710 1. Geochemical signatures suggest that the andesitic and dacitic samples might originate from a metasomatized wedge modified by the slab-derived component in a continental arc setting. In combination with the available data, it is proposed for the development of a Carboniferous continental arc in response to the eastern Paleotethyan evolution. The Bangxi-Chenxing tectonic zone might westerly link with the Jinshajiang-Ailaoshan-Song Ma suture zone, constituting an assemblage boundary between the South China and Indochina blocks. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate the knowledge, attitudes, and behaviors of Beijing-based obstetricians, gynecologists, and dentists regarding oral health care during pregnancy and to analyze their influencing factors., Methods: Questionnaires drawn from an existing research instrument and modified according to the current situation in China were distributed to obstetricians, gynecologists, and dentists in Beijing by mail or on-site. The questionnaire asked about the participants' knowledge, attitudes, and behaviors regarding oral health care. A χ2 test was used to compare distributional differences of the participants' epidemiological characteristics, and Fisher's exact test was used to calculate the consent rate of consultations for oral health and pregnancy and the safety awareness rate of oral treatment and drug use during pregnancy. Logistic regression analysis was used to study the factors affecting the participants' knowledge of maternal oral health care., Results: A total of 259 dentists and 146 obstetricians/gynecologists were included in the study. The results showed that 98.61% of obstetricians and gynecologists and 99.22% of dentists recognized the importance of oral health care during pregnancy. However, 79.17% of obstetricians and gynecologists thought they lacked knowledge of oral health care during pregnancy. All obstetricians, gynecologists, and dentists believed that the cost of treatment was one of the main barriers to offering oral health care during pregnancy. Dentists believed that medical disputes were their primary concern. Only a small number of doctors provided oral health care during pregnancy. The results of the logistic regression analysis showed that the professional title of doctor was negatively correlated with knowledge of maternal oral health care., Conclusions: The findings suggest that there is still a lack of knowledge regarding oral health care during pregnancy, which impacts the attitudes and behaviors of obstetricians, gynecologists, and dentists. Industry authorities should issue unified guidelines to strengthen the continued education of medical staff.

Hypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension in Tongdao Dong population. A total of 274 participants were involved in this study (135 hypertensive patients and 139 nonhypertensive adults). The single nucleotide polymorphism (SNP) was genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results showed that the genotypic and allelic frequencies of rs651821 were significantly different between the normotensives and hypertensive subjects ( P = 0.009, P = 0.003 respectively). TC/CC genotypes of rs651821 were associated with an elevated risk of hypertension (TC/CC vs. TT: adjusted odds ratio (AOR) = 1.791, 95%CI = 1.067-3.006, P = 0.009). Besides, the TC/CC genotypes were related to an increased plasma triglyceride (TG) level (TC/CC vs. TT: 2.47 ± 1.91 vs. 1.82 ± 1.07, P = 0.001).The results suggest that the C carriers of APOA5 rs651821 are associated with an increased serum TG concentration and may cause the increased susceptibility of the individual to hypertension in Chinese Dong population.

Background: Dental agenesis is the most common, often heritable, developmental anomaly in humans. Although WNT10A gene mutations are known to cause rare syndromes associated with tooth agenesis, including onycho-odontodermal dysplasia (OODD), Schöpf-Schulz-Passarge syndrome (SSPS), hypohidrotic ectodermal dysplasia (HED), and more than half of the cases of isolated oligodontia recently, the genotype-phenotype correlations and the mode of inheritance of WNT10A mutations remain unclear. The phenotypic expression with WNT10A mutations shows a high degree of variability, suggesting that other genes might function with WNT10A in regulating ectodermal organ development. Moreover, the involvement of mutations in other genes, such as EDA, which is also associated with HED and isolated tooth agenesis, is not clear. Therefore, we hypothesized that EDA mutations interact with WNT10A mutations to play a role in tooth agenesis. Additionally, EDA, EDAR, and EDARADD encode signaling molecules in the Eda/Edar/NF-κB signaling pathways, we also checked EDAR and EDARADD in this study., Methods: WNT10A, EDA, EDAR and EDARADD were sequenced in 88 patients with isolated oligodontia and 26 patients with syndromic tooth agenesis. The structure of two mutated WNT10A and two mutated EDA proteins was analyzed., Results: Digenic mutations of both WNT10A and EDA were identified in 2 of 88 (2.27%) isolated oligodontia cases and 4 of 26 (15.38%) syndromic tooth agenesis cases. No mutation in EDAR or EDARADD gene was found., Conclusions: WNT10A and EDA digenic mutations could result in oligodontia and syndromic tooth agenesis in the Chinese population. Moreover, our results will greatly expand the genotypic spectrum of tooth agenesis.