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Dryland agriculture is fundamental to global crop production and vital to food security. Conservation tillage is extensively practiced in USA wheat cultivation. Meanwhile, the adoption of conservation tillage by Chinese farmers is limited. This meta-analysis compared the yield and nitrogen use efficiency (NUE) between conservation tillage and conventional tillage (CT) with different types of cropping systems, mulching methods, levels of nitrogen fertilizer (NF), and addition of manure. The meta-analysis presented that conservation tillage at high-NF enhanced the yield and NUE, and reduced the yield and NUE at low-NF, compared to CT. The interaction of conservation tillage with leguminous cover crops (LCC) and manure application increased the yield and NUE at low-NF, compared to CT. Non-leguminous cover crops (NLCC) increased the yield and NUE under high-NF than low-NF. The interaction of conservation tillage with management practices showed that the no-tillage (NT) with leguminous cover crops (LCC) significantly increased wheat yield by 58% and NUE by 47% under low-NF compared to CT. However, increasing the rate of NF did not increase the yield under such interaction. Cropping systems, mulching types, and manure application mainly determined the effects of conservation tillage on wheat yield and NUE. The adverse impact of CT on yield and NUE could be alleviated with the application of LCC and manure under moderate NF. We demonstrate that adding LCC and manure have a generally substitutive relationship with N fertilizer, resulting in a significant increase in wheat yield and NUE at low-NF doses as at high N fertilizer dosages. Therefore, based on the obtained results, moderate NF with LCC and manure application is recommended for growing winter wheat in dryland regions of the USA and China., (© 2024. The Author(s).)