1. Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population.
- Author
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Guo WJ, Gong-ga-lan-zi, Ou-zhu-luo-bu, Ma XH, Wang YC, Pu Z, Wei G, Ji YL, Wang Z, Yan CY, Ba-sang-zhu-ma, Shi XM, Liu XH, Collier DA, Ball D, and Li T
- Subjects
- Adult, Alcohol Drinking epidemiology, Alcohol Drinking ethnology, Alleles, China epidemiology, China ethnology, Female, Humans, Male, Middle Aged, Polymerase Chain Reaction, Tibet epidemiology, Tibet ethnology, Alcohol Drinking genetics, Cytochrome P-450 CYP2E1 genetics, Polymorphism, Restriction Fragment Length
- Abstract
Objective: To investigate the relationship between the CYP2E1*c1/*c2 polymorphism and alcohol use disorders, and the potential influence of the CYP2E1*c1/*c2 polymorphism on the severity and dimensions of alcohol use disorders in Tibetan., Methods: Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test (AUDIT) score >or=10 and another 315 matched control subjects with AUDIT score
- Published
- 2008