1. Exploring Individualized Follow-up of Gastric Cancer After Radical Surgery Based on pTNM Stage: A Retrospective Cohort Study From China.
- Author
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Zheng, Cheng, Qian, Mengyi, Huang, Tongmin, Liu, Xingchen, Zeng, Xiangman, Chen, Xiaotong, Shen, Yan, Chen, Ping, Wu, Feng, and Gu, Lihu
- Subjects
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RISK assessment , *GASTRECTOMY , *PLATINUM compounds , *MEDICAL history taking , *BIOPSY , *STOMACH tumors , *CANCER relapse , *RESEARCH funding , *LYMPHADENECTOMY , *BLOOD testing , *CANCER invasiveness , *HUMAN dissection , *COMPUTED tomography , *MULTIPLE regression analysis , *CANCER patients , *RETROSPECTIVE studies , *TUMOR markers , *MAGNETIC resonance imaging , *POSITRON emission tomography computed tomography , *DESCRIPTIVE statistics , *AGE distribution , *LONGITUDINAL method , *VETERINARY dissection , *ADJUVANT chemotherapy , *KAPLAN-Meier estimator , *METASTASIS , *MEDICAL records , *ACQUISITION of data , *ENDOSCOPIC gastrointestinal surgery , *STATISTICS , *INDIVIDUALIZED medicine , *TUMOR classification , *FLUOROURACIL , *PROGRESSION-free survival , *CONFIDENCE intervals , *DATA analysis software , *PATIENT aftercare , *REGRESSION analysis , *PROPORTIONAL hazards models , *DISEASE risk factors - Abstract
Background: Patients with gastric cancer (GC) who underwent radical surgery require long-term follow-up (usually 5 years). The purpose of this study was to explore individualized follow-up strategies for patients with GC. Methods: This is a retrospective cohort study that established a clinicopathologic database of patients who underwent gastrectomy from January 2010 to December 2020 at Ningbo No. 2 Hospital. Follow-up was performed until March 2023. The rate of new-onset recurrence of patients with GC was explored annually according to different pTNM stages, defining a recurrence rate of less than 1% as adequate follow-up time. Results: Of the 1606 patients who were eligible, the total number of patients who completed the 5- and 10-year follow-up was 1107 and 586, respectively. A total of 444 cases were diagnosed with recurrence. The recurrence rate for stage IA patients was consistently less than 1% during the follow-up time. The adequate follow-up time (the rate of new-onset recurrence less than 1%) was 5 years for stage IB and IIA patients, and 8 years for stage IIB and IIIA patients, respectively. In contrast, stage IIIB patients were always at risk of recurrence during the follow-up time (>1%). Time to a new recurrence rate for stage IIIC patients was 6 years. Conclusion: Among patients who underwent radical gastrectomy, the rate of new-onset recurrence varied among patients with different pTNM stages. This study suggests that the follow-up of GC can be individualized and refer to pTNM stage. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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