1. The Most Valuable Predictive Factors for Bronchopulmonary Dysplasia in Very Preterm Infants.
- Author
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Chen, Wenwen, Zhang, Zhenhai, Xu, Liping, and Chen, Chao
- Subjects
BIOMARKERS ,STATISTICS ,C-reactive protein ,CHEST X rays ,NEONATAL intensive care ,ACADEMIC medical centers ,CONFIDENCE intervals ,PATENT ductus arteriosus ,MULTIVARIATE analysis ,MEDICAL screening ,NEONATAL intensive care units ,RETROSPECTIVE studies ,ACQUISITION of data ,GESTATIONAL age ,MANN Whitney U Test ,RISK assessment ,SEX distribution ,DOPPLER echocardiography ,T-test (Statistics) ,PUERPERIUM ,MEDICAL records ,DESCRIPTIVE statistics ,CHI-squared test ,RESEARCH funding ,BRONCHOPULMONARY dysplasia ,GRAM-negative bacterial diseases ,LOGISTIC regression analysis ,DATA analysis software ,ODDS ratio ,STATISTICAL models ,SENSITIVITY & specificity (Statistics) ,POLYMERASE chain reaction ,DISEASE risk factors - Abstract
Introduction: It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as Ureaplasma Urealyticum (UU) infection and chest radiograph images. Methods: A retrospective study was performed. Moderate to severe BPD or death was set as the main outcome. The association between putative variables and the main outcome were assessed by bivariate analyses and logistic regression. Results: A total of 134 infants were enrolled. Bivariate analyses showed the gestational age, birth weight, appearances of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies on chest radiographic images, a ductal diameter ≥1.5 mm and whether UU infection was associated with BPD. After adjustment by logistic regression, the risk of BPD with gestational age, sex and specific chest-radiographic manifestations remained significant. Conclusions: Chest radiograph images (appearance of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies) could provide a quick prediction of developing BPD in clinical practice, in addition to gestational age and sex. UU infection was not an independent risk factor for BPD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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