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• Integration between CO 2 mineralization and desalination. • Integrated process is designed and simulated. • Economic viability and CO 2 reduction potential are examined. • Using wind-based electricity significantly improves the process performance. This study presents a novel process integration scheme between CO 2 mineralization and brackish water reverse osmosis (BWRO). The integration is based on the reciprocal nature of these two processes: While CO 2 mineralization needs metal ions such as Na+ to convert CO 2 into mineral carbonates like sodium bicarbonate, BWRO is designed to reject such ions to produce fresh water. Thus, there is a potential synergy that can be gained through their integration. To examine the feasibility of such process integration, techno-economic analysis (TEA) and CO 2 life cycle assessment (LCA) are conducted for various possible configurations of the integrated process. A key requirement for TEA and CO 2 LCA is the availability of mass and energy balance data. Therefore, the process is simulated with the commercial simulation software tool of Aspen Plus combined MATLAB. Another requirement is the selection of appropriate evaluation scenarios. Based on a market analysis, the proposed process is assumed to be installed either in the US or in the China to replace a respective conventional benchmark process. Also, two sources of electricity (coal and wind onshore) are considered in the evaluation in order to investigate the sensitivity of the process performance on the type of electricity used. As a result of the analysis, the CO 2 avoidance cost of the designed process is calculated to be 132˜245$/metric ton of CO 2 with wind-based electricity. Given other advantages of the mineralization over the geological storage, the presented process integration between CO 2 mineralization and BWRO deserves further investigation as a means to produce useful chemicals and fresh water while curbing CO 2 emission. [ABSTRACT FROM AUTHOR]