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At the end of the 1970s, the People's Republic of China (PRC) promoted policies to attract investments from the developed capitalist world, aiming for technological transfer and offering a profitable environment in exchange. Although the TNC capital, know-how, and technology have been key factors for Chinese development, the State has planned and regulated those investments, so they can be aligned with an autonomous project of development, avoiding the classic centre-periphery dependency relationship. This paper analysis focuses on the Five-Year Plans, and the regulation policy laws for inward investment. At the end we analyse the FDI data, which allowed us to identify the main changes and distinct phases of the development of FDI and the State policy. [ABSTRACT FROM AUTHOR]

Audit disclosure requirements have increased across countries in recent years. In this study, we explore a disclosure pattern that has been adopted by approximately 23 percent of Chinese publicly listed companies and their auditors—the disclosure of up to three overlapping items both in the risk factor section of financial reports and in the key audit matters (KAM) section of the audit report. We predict and find that such disclosure overlaps increase auditor liability, using audit fees as a proxy for auditor liability, and that (1) both the magnitude and explicitness of overlapped disclosure are positively associated with auditor liability and (2) analyst following, Top 10 auditors, and auditor tenure play a moderating role in the association between overlapped disclosures and auditors' perceived liability. Collectively, our analysis supports our hypothesis that KAM disclosure increases auditor liability when coupled with management disclosure of related risk factors. Data Availability: Data are available from the sources cited in the text. JEL Classifications: M41; M42; K41. [ABSTRACT FROM AUTHOR]

China has been the first country to be affected by the COVID-19 outbreak. The pandemic resulted in significant disruption of Health Care Services worldwide, and this effect on treatments for urinary stones is currently unclear. This is the first retrospective study involving three tertiary referral centers for urolithiasis across China. We evaluated surgical volumes and peri-operative outcomes of procedures delivered for upper urinary tract stones. We compared trimester prior to restrictions for COVID-19 (October 1st, 2019 to December 31st, 2019, period A), during restrictions (February 1st, 2020 to March 31st, 2020, period B), and afterword (April 1st, 2020 to June 31st, 2020, period C). A total of 2,543 procedures have been carried out. We observed a loss of 743 cases during period B (−29.2%) and 201 during period C (−7.9%). Percutaneous surgery showed the worst reduction, with 507 mini-PCNLs delivered in period A, 168 in period B (−60.8%), and 389 (−18.3%) in period C (p = 0.001). A worst trend was shown for standard PCNLs with 84 procedures carried out in period A, 5 in period B (−95.2%), and 9 (−89.2%) in period C (p = 0.001). Retrograde surgery also decreased, from 420 cases in period A to 190 cases in period B (−54.8%). An increment was however seen in period C when 468 cases have been carried out (+ 11.4%, p = 0.008). In term of SFRs, a difference was noticed for RIRSs, being 69.2%, 80.5%, and 69.3% during three periods (p = 0.045) and semirigid ureteroscopies (90.3%, 97.1%, and 84.8%, p = 0.013). Charlson's Comorbidity Score could not show any difference between groups as well as no differences in term of post-operative complications have been noticed. [ABSTRACT FROM AUTHOR]

This study aims to trace how artists in postsocialist China have adopted the discourse of body art and reshaped its import of sociopolitical criticality. In this article, "body art" implies the use of the human body as the primary material of artistic creation and the performance of actions of cruelty, modification, and endangerment on the artist's body. Through an engagement with theories of embodiment, biopolitics, and postsocialism, this article argues that body art represents one way in which the corporeal assumes a new centrality in China's post‐1978 avant‐garde and popular culture, as both a reappropriated territory of self‐expression and an alienated object of consumption and surveillance. To do so, it discusses body art by Yang Zhichao 杨志超 (b. 1962), focusing in particular on a performance artwork titled Jiayuguan 嘉峪关 (Jiayu Pass, 1999 – 2000) and its documentation by the artist. As a result, this article shows how body art encapsulates the tension between dystopian negativity and regenerative potential at the heart of the postsocialist condition. [ABSTRACT FROM AUTHOR]

Simple Summary: COVID-19 emerged in late 2019 in China and rapidly spread across the globe. After 2 years, numerous advances have been made. First of all, the preventive vaccine, which has been implemented in record time, is effective in more than 95% of cases. Additionally, in the diagnostic field, there are numerous molecular and antigenic diagnostic kits available that are equipped with high sensitivity and specificity. Real Time-PCR-based assays for the detection of viral RNA are currently considered the gold-standard method for SARS-CoV-2 diagnosis while they can be used efficiently on pooled nasopharyngeal, or oropharyngeal samples for widespread screening. Moreover, additional, and more advanced molecular methods such as droplet-digital PCR (ddPCR), clustered regularly interspaced short palindromic repeats (CRISPR) and next-generation sequencing (NGS), are currently under development to detect SARS-CoV-2 RNA. However, as the number of subjects infected with SARS-CoV-2 is continuously increasing globally, health care systems are being placed under increased stress. Recent diagnostic strategies have been adopted to either detect viral antigens, i.e., antigen-based immunoassays, or human anti-SARS-CoV-2 antibodies, i.e., antibody-based immunoassays, in nasal or oropharyngeal swabs, as well as in blood or saliva samples. However, the role of mucosal sIgAs, which are essential in the control of viruses entering the body through mucosal surfaces, remains to be elucidated, and in particular the role of immune responses in counteracting SARS-CoV-2 infection, primarily at the site(s) of virus entry. COVID-19 emerged in late 2019 in China and quickly spread across the globe, causing over 521 million cases of infection and 6.26 million deaths to date. After 2 years, numerous advances have been made. First of all, the preventive vaccine, which has been implemented in record time, is effective in more than 95% of cases. Additionally, in the diagnostic field, there are numerous molecular and antigenic diagnostic kits that are equipped with high sensitivity and specificity. Real Time-PCR-based assays for the detection of viral RNA are currently considered the gold-standard method for SARS-CoV-2 diagnosis and can be used efficiently on pooled nasopharyngeal, or oropharyngeal samples for widespread screening. Moreover, additional, and more advanced molecular methods such as droplet-digital PCR (ddPCR), clustered regularly interspaced short palindromic repeats (CRISPR) and next-generation sequencing (NGS), are currently under development to detect the SARS-CoV-2 RNA. However, as the number of subjects infected with SARS-CoV-2 continuously increases globally, health care systems are being placed under increased stress. Thus, the clinical laboratory plays an important role, helping to select especially asymptomatic individuals who are actively carrying the live replicating virus, with fast and non-invasive molecular technologies. Recent diagnostic strategies, other than molecular methods, have been adopted to either detect viral antigens, i.e., antigen-based immunoassays, or human anti-SARS-CoV-2 antibodies, i.e., antibody-based immunoassays, in nasal or oropharyngeal swabs, as well as in blood or saliva samples. However, the role of mucosal sIgAs, which are essential in the control of viruses entering the body through mucosal surfaces, remains to be elucidated, and in particular the role of the immune response in counteracting SARS-CoV-2 infection, primarily at the site(s) of virus entry that appears to be promising. [ABSTRACT FROM AUTHOR]

An Italian male with no link to China Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic presented at Emergency Room (ER) with severe respiratory impairment. The RT-PCR on 20 February 2020, nasopharyngeal swab revealed SARS-CoV-2 infection, confirmed with viral culture and sequencing. This was the first identified autochthonous SARS-CoV-2 transmission in Italy, that unveiled global pathogen diffusion. This clinical case highlights an underestimation of SARS-CoV-2 circulation, making initial containment measures unfit to face the real situation and delaying the management of potentially affected SARS-CoV-2 patients. [ABSTRACT FROM AUTHOR]

Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.Case Presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6). [ABSTRACT FROM AUTHOR]

This paper contributes to the recent discussion concerning the interactions between China and Germany in the context of Industry 4.0, highlighting the most relevant innovation and trade trends and the policy implications of this collaboration. The qualitative analysis examines the features of the innovation systems in Germany and China and the strategies implemented to boost the innovation process. The quantitative analysis exploits trade, patent and publications data to identify trends related to China-Germany cooperation. The paper provides insights into the policy implications for both countries of Sino-German cooperation in relation to Industry 4.0. [ABSTRACT FROM AUTHOR]

Background: This study investigated the differences in clinicopathologic features and surgical treatment between an Italian and a Chinese cohort of premenopausal women with breast cancer, and highlighted the potential advantages of international medical exchange projects. Methods: Premenopausal women who underwent surgical treatment between 2012 and 2016 at one Italian and one Chinese institution participating in a medical exchange program were compared. Factors associated with the probability to receive mastectomy were determined via logistic analysis. Changes in surgical management at the Chinese institution in the period 2018–2019, after the exchange program, were also evaluated. Results: A total of 505 patients, 318 from Italy and 187 from China, were evaluated. The Chinese patients had more frequently advanced-stage tumours, large tumour size (30.9 vs. 18.1 mm, p < 0.01), invasive carcinoma (92.5 vs. 83.3%, p < 0.01), positive axillary lymph nodes (54.5 vs. 27.4%, p < 0.01), Her-2 positivity (36.4 vs. 22.0%, p < 0.01), and high proliferative index (55.1 vs. 30.2%, p < 0.01). Positive oestrogen receptor status and rates of triple-negative breast cancer did not differ (77.0 vs. 69.5%, p = 0.09 and 14.2 vs. 16%, p = 0.56, respectively). Mastectomy rates were higher among Chinese women (85 vs. 41%, p < 0.001), whereas use of sentinel node biopsy was more frequent among Italian women (77 vs. 33%, p < 0.001). Chinese women had more than 4-fold higher risk of receiving mastectomy. In the last 2 years, the rates of breast-conserving surgery and sentinel node biopsy at the Chinese institution increased from 15 to 23%, and from 33 to 42%, respectively. Conclusions: Tumour features and surgical strategies for premenopausal breast cancer may differ significantly between Italy and China. Since the international exchange program, patients from the Chinese institution have been offered more frequently less invasive surgery. International exchange programs can help in designing epidemiological studies which may be useful for strategies to improve breast cancer management and control. [ABSTRACT FROM AUTHOR]

The diffusion of innovative activities has been very fast in China since the mid-1990s. The literature nonetheless suggests that internationally-relevant innovation may have delayed gaining embeddedness in some places, depending on the strategy it was "seeded". This paper posits that different degrees of embeddedness are linked with different local patterns of innovation and investigates these linkages across Chinese prefectural cities. Four research hypotheses are stated, one for each indicator identified in the literature to investigate technological catching up. The empirical exercise is set as an ordered logistic regression of data rearranged from the OECD Patent Databases for the period 1981–2009. The results show that embeddedness is positively linked with innovation that increasingly relies on its own local past and negatively linked with innovative activities more concentrated across patent owners. The evidence of a nexus with originality and technology cycle time is less clear and requires appropriate investigation in future research. At the state of the art, the main hint is that embeddedness is gained where the knowledge paths increase in complexity. [ABSTRACT FROM AUTHOR]

To constrain models on global sea-level change regional proxy data on coastal change are indispensable. Here, we reconstruct the Holocene sea-level history of the northernmost China Sea shelf. This region is of great interest owing to its apparent far-field position during the late Quaternary, its broad shelf and its enormous sediment load supplied by the Yellow River. This study generated 25 sea-level index points for the central Bohai coastal plain through the study of 15 sediment cores and their sedimentary facies, foraminiferal assemblages and radiocarbon dating the basal peat. The observational data were compared with sea-level predictions obtained from global glacio-isostatic adjustment (GIA) models and with published sea-level data from Sunda shelf, Tahiti and Barbados. Our observational data indicate a phase of rapid sea-level rise from c. -17 to -4 m between c. 10 and 5 ka with a peak rise of 6.4 mm a -1 during 8.7 to 7.5 ka and slower rise of 1.9 mm a -1 during 7.5 to 5.3 ka followed by a phase of slow rise from 5 to 2 ka (∼0.4 mm a -1 from -3.58 m at 5.3 ka cal BP to -2.15 m at 2.3 ka cal BP). The comparison with the sea-level predictions for the study area and the published sea-level data is insightful: in the early Holocene, Bohai Bay's sea-level rise is dominated by a combination of the eustatic and the water load components causing the levering of the broad shelf. In the mid to late Holocene the rise is dominated by a combination of tectonic subsidence and fluvial sediment load, which masks the mid-Holocene highstand recorded elsewhere in the region. [ABSTRACT FROM AUTHOR]

Examining the conduits of production and circulation that link the extraction of copper in Chile to its storage and use in China, this article explores the political dimensions of the logistical techniques and technologies that enable these processes. We approach copper as a material element that due to its capacity to conduct electricity provides conditions of possibility for contemporary digital capitalism. At the same time, we consider the elements that constitute logistics as a political force by asking how logistics operates in parallel, partnership, and rivalry to forms of state and international order themselves in uncertain transformation. Empirically, the article stems from research conducted in Chile, specifically in the port of Valparaíso, the Andina mine run by the country's state owned copper mining company CODELCO, and the copper smelter run by the same company on the coast at Ventanas. On this basis, we ask how the production and circulation of copper has mutated with shifting logistical arrangements that respond to the geopolitical position of China, the financialization of trade in base metals, the rise of business models based in data extraction, and workers' struggles in times of labor precarization. [ABSTRACT FROM AUTHOR]

Drosophila suzukii is native to East Asia and an invasive pest of fruit crops widely established in the Americas and Europe. The lack of effective indigenous parasitoids of D. suzukii in the invaded regions prompted surveys for co-evolved parasitoids in Yunnan Province, China, from 2013 to 2016. From banana-baited traps (2013-2015), 458 parasitoids of drosophilids were reared, comprised of Braconidae (49.56%), Figitidae (37.55%), Diapriidae (7.42%), and Pteromalidae (5.46%). Larval parasitoids included seven braconid species, all Asobara and primarily Asobara mesocauda, and five figitid species, primarily Leptopilina japonica japonica. Pupal parasitoids were the diapriid Trichopria drosophilae and the pteromalid Pachycrepoideus vindemiae. Collections from wild fruits (2016) provided more interesting results. From the puparia of drosophilids collected, comprised of D. suzukii and Drosophila pulchrella, emerged 1354 parasitoids. The larval parasitoids Ganaspis brasiliensis and L. j. japonica were the prevalent species, reaching a fairly high percentage parasitism of fly puparia collected from berries of Rubus foliosus (22.35%), R. niveus (18.81%), Fragaria moupinensis (19.75%), and Sambucus adnata (63.46%). Ganaspis brasiliensis was the dominant species and was collected only from D. suzukii and D. pulchrella-infested fruits and never from banana-baited traps. Molecular analysis showed two G. brasiliensis lineages, which are discussed with respect to previous Japanese collections. Quarantine tests showed that G. brasiliensis developed from D. suzukii and two closely related hosts (Drosophila melanogaster and Drosophila simulans) but did not develop from seven non-target drosophilid species. Our results suggest that G. brasiliensis is a promising classical biocontrol agent for release in invaded regions. [ABSTRACT FROM AUTHOR]

This paper maps the emergence of ‘subnational innovation spaces’ in China as they result from the interaction between state restructuring and the diffusion of innovative activities. Several countervailing forces have played a part in outlining a number of supra-urban regions that diverge by their own capability to develop and govern innovation-related socio-economic processes. On the one hand, the downscaling of state power enables the local administrative units to plan place-based strategies to embed technological upgrading, such as driving indigenous innovative activities to cluster around industrial and technological parks. On the other hand, this clustering entails reconfiguring socio-spatial interactions, while experiencing new networked connections to be governed. Thus, technological upgrading and state restructuring are intertwined and mutually reinforcing. Following this perspective, the authors have rearranged various data sets at the prefectural level and processed them to disentangle some of the main underlying processes: first, the distribution of innovation-related ‘infrastructures’ across cities; second, the evolution of innovative activities; third, the transition towards a firm-centred Science and Technology system. These factors have been then combined together with neighbourhood relations to outline different subnational innovation spaces. The result is a country-wide map describing how the geography of innovative activities in China exhibits features that are connected to the long-term processes of transition, industrialisation and state restructuring. This picture suggests that the catching up with ‘upgraded development’ in laggard regions could be further promoted identifying ‘up-scaled’ regional hubs to coordinate the development of wider areas. [ABSTRACT FROM AUTHOR]

This paper describes the results of a research project to develop a set of goals and strategies aimed at policymakers, stakeholders, researchers, designers and/or some other groups of citizens' communities whose development actions are undertaken in a specific rural context. The aim of the project was to move beyond the knowledge of the articulated architectural and social evolution of the rural areas in both the EU and China, looking at the local and global challenges, at the need for continuous adaptation and at the experiences of resilience that the countryside faces today. The paper shows, through two-pronged methods, such as semantic analysis and a meta-project design, that a common strategy can be set to support actions for the development of rural areas both in China and the EU. In doing so, this study has defined a strategy system tool that is a type of interactive and generative key-checklist that can be used by stakeholders in specific contexts, becoming a reading tool, a set of design guidelines or a decision facilitator support system. The results achieved have been tested through design application in two meta-projects that confirm the validity of the whole research framework with the aim of promoting a sustainable development and enhancement of places and rural communities. [ABSTRACT FROM AUTHOR]

This article investigates artist and activist Ai Weiwei’s media politics. In 1997 Ai Weiwei imagined a modernist movement that would practise a “non-compromising vigilance on society and power” and since 2005 he has embraced blogging and micro-blogging to enact such intent. We argue that his “communication activism” is part of a broader artistic and political program that long predates his online presence. The study examines how the artist has experimented with blogging and micro-blogging to spread his message of “awakening” in defiance of censorship and surveillance. It shows how Ai Weiwei’s communication strategy combines an international celebrity status, criticism, irony and a round-the-clock interaction with his netizen audience and the media. It also critiques the effectiveness and coherence of this mode of activism from two perspectives – namely, Jean Baudrillard’s analysis of “private telematics” and Jodi Dean’s “blog theory” – and finally assesses its impact. The study aims to enhance our understanding of the web-based communication strategies of Chinese activists, shedding light on cultural production and consumption in Chinese cyberspace as a socio-political barometer. [ABSTRACT FROM PUBLISHER]

During the replication of human cytomegalovirus (HCMV) genome, the viral DNA polymerase subunit UL44 plays a key role, as by binding both DNA and the polymerase catalytic subunit it confers processivity to the holoenzyme. However, several lines of evidence suggest that UL44 might have additional roles during virus life cycle. To shed light on this, we searched for cellular partners of UL44 by yeast two-hybrid screenings. Intriguingly, we discovered the interaction of UL44 with Ubc9, an enzyme involved in the covalent conjugation of SUMO (Small Ubiquitin-related MOdifier) to cellular and viral proteins. We found that UL44 can be extensively sumoylated not only in a cell-free system and in transfected cells, but also in HCMV-infected cells, in which about 50% of the protein resulted to be modified at late times post-infection, when viral genome replication is accomplished. Mass spectrometry studies revealed that UL44 possesses multiple SUMO target sites, located throughout the protein. Remarkably, we observed that binding of UL44 to DNA greatly stimulates its sumoylation both in vitro and in vivo. In addition, we showed that overexpression of SUMO alters the intranuclear distribution of UL44 in HCMV-infected cells, and enhances both virus production and DNA replication, arguing for an important role for sumoylation in HCMV life cycle and UL44 function(s). These data report for the first time the sumoylation of a viral processivity factor and show that there is a functional interplay between the HCMV UL44 protein and the cellular sumoylation system. [ABSTRACT FROM AUTHOR]

The notion of 'productivity' is an essential one in the study of linguistic morphology, but its definition is indeed challenging, and there are different ways to measure different aspects of the productivity of a morphological process. In this paper we shall adopt Baayen's P measure of productivity for a corpus-based study of the productivity of three Mandarin derivational suffixes, namely the nominalizer/diminutive -...-r, -..., -huà-ise, -ify' and -...-tou, a 'dummy' nominal suffix (Lin 2001:82), in order to assess how this index relates to our received knowledge about the productivity of such forms, and, also, to compare our results with a previous study by Nishimoto (2003) on a small corpus of Modem Chinese. Moreover, in a diachronic perspective, we shall compare data from the Academia Sinica Tagged Corpus of Early Mandarin Chinese and from the Academia Sinica Balanced Corpus of Modern Chinese. We shall show that our P values mostly reflect what descriptive works tell us about the productivity of the affixes considered here in two different periods of the history of the language; when corpus data for previous stages of a language are available, they appear as a better basis for assessments on the profitability of a morphological process than dictionary data. [ABSTRACT FROM AUTHOR]

The role of China as a trading partner of sub-Saharan Africa is assessed using data on bilateral trade from the International Monetary Fund (1999-2007) and a gravity model. Trade with China is found to affect the intra-African market in different ways at different levels of China-Africa exports. Interaction variables are used to disentangle two opposite patterns: sub-Saharan Africa's exports to China have a negative effect on intra-African trade at higher levels of the trade between China and sub-Saharan Africa and a positive effect at lower levels. Oil-exporting countries, China's biggest African trading partners, tend to isolate themselves from the internal African market as their exports to China increase. Conversely, a rise in exports to China from non-oil-exporting countries increases intra-African trade, probably due to a wealth effect. Intra-African market performance is briefly analyzed as a robustness check on the data. The results are interesting, especially those concerning the differences in trade determinants between oil-exporting and non-oil-exporting sub-Saharan countries. [ABSTRACT FROM AUTHOR]

Even with the financial crisis of 2008, the steel consumption forecast for the BRIC countries - Brazil, Russia, India and China - is for a significant increase over the next decades, due to their present low per-capita consumption level. The start up of new mines to supply this increase in demand is likely to be limited due to legal and practical restrictions related to environmental, social, manpower and energy issues. Therefore, most of the new demand for iron ore will be supplied by increasing the productivity of mines currently in operation. The main challenges for managing mine productivity are related to the choice of the estimation method, due to the difficulties in collecting appropriate information and to the establishment of a representative model. This article presents an estimation approach for mine productivity estimation through multiple regressions over the operational database of the mine. The approach is proposed through a Mine Productivity Estimation and Management tool (MPEM) which can deliver savings related to increased production efficiency by the identification and removal of losses in the mine production flow. Production improvement has been actually achieved in practical applications by managing the discrepancies in the KPIs of different operating shift crews. The operational variables have been identified directly over the operational database of the mine and the model has been developed in a simple and easy-to-use fashion, with excellent levels of correlation between the estimated and actual values of the mine's productivity. The article describes the development approach as well as the application of the model in a case-study. [ABSTRACT FROM AUTHOR]

This article looks at childhood sex ratios in rural China and examines the factors that may affect the probability of a surviving child to be male or female. In particular the article studies the effect of the economic status of the parents on a surviving child's gender. The data used in this study come from the 1998 Chinese Household Income Project, a household survey conducted by Chinese and western researchers in the Spring of 1989. The original purpose of the survey was to study income distribution. Demographic and economic information was collected for 10,258 rural households residing in 28 of China's 30 provinces. The data, which refer to the year 1988, were collected by administering a questionnaire to heads of households, with the help of statistical assistants from China's State Statistical Bureau. The approach used in the empirical analysis involves treating the gender of a surviving child as the dependent variable. This variable equals one if the observed child is male and zero if the observed child is female. The unusually high ratio of boys to girls in China can be explained by parental behavior aimed at producing more male offspring than biologically normal. One of the conclusions that can be drawn from the analysis is that surviving children of higher-income parents in this sample are not more or less likely to be male than surviving children of lower-income children.

Investigates the private monetary transfers in rural China as an indication of altruism. Inadequacy of altruism factor to explain the observed transfers; Money flows from adult children to elderly parents; Child care services in exchange for money.

In this paper, we examine how robot adoption and Chinese import competition shaped employment patterns in 352 cities across the United Kingdom. We find that cities whose initial industry composition exposed them to industrial robots and China's integration into the world economy experienced significant employment declines. When pitched against other capital and technologies, the impact of robots remains distinct. Our findings suggest that one more robot per thousand workers reduced the employment-to-population ratio by 0.5 percentage points, while an increase of $1,000 imports from China per worker reduced the employment-to-population ratio by 0.11 percentage points. We also show that while these are sizable effects, penetration of both robots and Chinese imports are too small to account for Brexit. [ABSTRACT FROM AUTHOR]

The suitable groundwater exploitation scheme in freezing-thawing agricultural areas under the well-canal conjunctive irrigation conditions is confronted with two major challenges, which are computationally expensive local grid refinements along wells, and the model suitability problem in the freezing-thawing period. In this study, an empirical method for groundwater level prediction in the freezing-thawing period was developed and integrated with the local grid refinement groundwater model MODFLOW-LGR for the groundwater process prediction. The model was then applied to estimate the suitable groundwater exploitation scheme, including the size of well-irrigated area and the irrigation area of single well. The results showed that suitable size of well-irrigated area should be smaller than 15 × 106 m2, and the recommended irrigation area of single well as 15 × 104 m2 to 19 × 104 m2. The recommended layout parameters of groundwater exploitation were further used to plan the well-canal conjunctive irrigation scheme in Yongji irrigation district located in northern China. This study provides an important pilot example of the conjunctive use of groundwater and surface water in arid irrigation areas with a seasonal freezing-thawing period. [ABSTRACT FROM AUTHOR]

Earth Observation (EO) data is a critical information source for mapping and monitoring water resources over large inaccessible regions where hydrological in-situ networks are sparse. In this paper, we present a simple yet robust method for fusing optical and Synthetic Aperture Radar (SAR) data for mapping surface water dynamics over mainland China. This method uses a multivariate logistic regression model to estimate monthly surface water extent over a four-year period (2017 to 2020) from the combined usages of Sentinel-1, Sentinel-2 and Landsat-8 imagery. Multi-seasonal high-resolution images from the Chinese Gaofen satellites are used as a reference for an independent validation showing a high degree of agreement (overall accuracy 94%) across a diversity of climatic and physiographic regions demonstrating potential scalability beyond China. Through inter-comparison with similar global scale products, this paper further shows how this new mapping technique provides improved spatio-temporal characterization of inland water bodies, and for better capturing smaller water bodies (< 0.81 ha in size). The relevance of the results is discussed, and we find this new enhanced monitoring approach has the potential to advance the use of Earth observation for water resource management, planning and reporting. [ABSTRACT FROM AUTHOR]

Accurate estimation of the water conservation is of great significance for ecological red line planning. The water conservation of the Yellow River Basin has a vital influence on the development of the environment and the supply of ecological services in China. However, the existing methods used to estimate water conservation have many disadvantages, such as requiring numerous parameters, a complex calculation model, and using data that is often difficult acquire. It is often hard to provide sufficiently precise parameters and data, resulting in a large amount of calculation time and the difficulties in the study of large scale and long time series. In this study, a time series of the Normalized Difference Vegetation Index (NDVI) was applied to estimate water conservation in two aspects using the idea of wholeness and stratification, respectively. The overall fitting results can explain nearly 30% of the water conservation by partial least squares regression and nearly 50% of it by a support vector machine. However, the results of a stratified simulation showed that water conservation and the NDVI have a certain stratified heterogeneity among different ecosystem types. The optimal fitting result was achieved in a water/wetland ecosystem with the highest coefficient of determination (R2P) of 0.768 by the stratified support vector machine (SVM) model, followed by the forest and grassland ecosystem (both R2P of 0.698). The spatial mapping results showed that this method was most suitable for grassland ecosystem, followed by forest ecosystem. According to the results generated using the NDVI time series data, it is feasible to complete a spatial simulation of water conservation. This research can provide a reference for calculating regional or large-scale water conservation and in ecological red line planning. [ABSTRACT FROM AUTHOR]

A photoperiod- and thermo-sensitive genic male sterile (PTGMS) line is the basic material for two-hybrid rice and is an important genetic breeding resource. Peiai64S (PA64S) is an important germplasm resource of PTGMS rice, and it has been applied to two-line hybrid rice systems in China. Pollen fertility in PA64S is regulated by the temperature and photoperiod, but the mechanism of the fertility transition is unclear. In this study, we obtained the male fertile plant PA64S(F) and the male sterile plant PA64S(S) by controlling different temperatures under long light conditions and used the male fertile and sterile plants to investigate the role of microRNAs (miRNAs) in regulating male fertility in rice. We performed the small RNA library sequencing of anthers from PA64S(S) and PA64S(F). A total of 196 miRNAs were identified—166 known miRNAs among 27 miRNA families and 30 novel miRNAs. In the transcriptome analysis, the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes revealed significant enrichment in the synthesis and metabolism of fatty acids and some secondary metabolism pathways such as fatty acid metabolism and phenylalanine metabolism. With a comprehensive analysis of miRNA, transcriptome, and degradome sequencing, we identified that 13 pairs of miRNA/target genes regulated male fertility in rice by responding to temperature change, among which the miR156, miR5488, and miR399 affect the male fertility of PA64S by influencing SPLs, the lignin synthesis of anther walls, and the flavonoid metabolism pathway. The results provide a new understanding of PTGMS rice, which will help us better understand the potential regulatory mechanisms of male sterility in the future. [ABSTRACT FROM AUTHOR]

Background and Objectives: The landscape aesthetic service (LAS) is a crucial ecosystem service in subalpine forests of the mountain and ravine regions of the Tibetan Plateau, especially in autumn; it can provide important ecological and economic value, improving the livelihood of the local people. Canopy gap acts as a key role in the maintenance of species diversity and forest stability and ecosystem services. However, the mechanisms and interactions of forest stability maintained by gap formations and LAS via gap dynamics are not fully understood. The aim of this study was to explore the effects of canopy gaps on autumn color-leaved tree species diversity (ACTSD), color-leaved patch structure attributes (CPSA), LAS, and their interactions during the autumn viewing period, and to provide a fundamental basis for the management and protection of subalpine autumn color-leaved forests (SACF). Materials and Methods: We used very high-resolution images to quantify gap characteristics and examined the effects of canopy gaps on ACTSD, CPSA, and LAS in 21 SACF plots in southwestern China. We then used path analysis to determine the relationships between these factors. Results: The number of gaps and total gap area were the key gap characteristics affecting LAS; particularly, medium canopy gaps (51–100 m2) played a more important role. The path model showed that increasing the total gap area along with the number of medium canopy gaps had direct positive effects on ACTSD, color-leaved patch diversity, and total color-leaved patch area, thus improving the LAS. Conclusions: Canopy gaps indirectly improve LAS in autumn by significantly affecting ACTSD and CPSA. Our results suggest that forest managers may be able to manipulate the numbers and proportion of medium canopy gaps to protect and preserve ACTSD and color-leaved landscapes, promoting the LAS of SACF, and in turn, ensuring the coordinated development of economic, social, and ecological benefits for the underdeveloped rural montane areas of southwestern China. [ABSTRACT FROM AUTHOR]

On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). CRS represents an emergency scenario of a frequent challenge, which is the complex and interwoven link between infections and autoimmunity. Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. Several trials, evaluating the safety and effectiveness of immunosuppressants commonly used in rheumatic diseases, are ongoing in patients with COVID-19 and CRS, some of which are achieving promising results. However, such a use should follow a multidisciplinary approach, be accompanied by close monitoring, be tailored to patient's clinical and serological features, and be initiated at the right time to reach the best results. Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. [ABSTRACT FROM AUTHOR]

• There is significant variation in people's compliance with lockdown measures introduced by governments to curb the spread of the COVID-19. • Much of the variation can be explained by different cultural traits. • Individualism, which emphasises personal freedom, makes government intervention harder, whereas collectivism, which emphasises the wellbeing of the group, makes collective action easier. • We conclude that cultural factors play a critical role in successful policy implementation. In the first wave of the pandemic, places where geographic mobility declined more rapidly saw fewer cases of COVID-19. And yet, there is significant variation in people's compliance with the lockdown measures introduced by governments in order to curb the spread of the virus. In this paper, we show that much of this variation can be explained by different cultural traits. Specifically, we advance the hypothesis that individualism, which puts greater value on personal freedom, makes government intervention harder, whereas collectivism, which emphasises the wellbeing of the group, makes collective action easier. We find support for these ideas across 111 countries, but also when exploiting within country variation in the two largest economies in the world: China and the United States. Across a host of specifications, people were less abiding by the lockdown rules in places with greater prevalence of individualistic cultural traits. We conclude that cultural factors play a critical role in successful policy implementation. [ABSTRACT FROM AUTHOR]

18 years ago, in 2002, the world was astonished by the appearance of Severe Acute Respiratory Syndrome (SARS), supported by a zoonotic coronavirus, called SARS-CoV, from the Guangdong Province of southern China. After about 10 years, in 2012, another similar coronavirus triggered the Middle East Respiratory Syndrome (MERS-CoV) in Saudi Arabia. Both caused severe pneumonia killing 774 and 858 people with 8700 cases of confirmed infection for the former, and 2494 for the latter, causing significant economic losses. 8 years later, despite the MERS outbreak remaining in certain parts of the world, at the end of 2019, a new zoonotic coronavirus (SARS-CoV-2) and responsible of coronavirus Disease (COVID-19), arose from Wuhan, Hubei Province, China. It spread rapidly and to date has killed 3,242 persons with more than 81,000 cases of infection in China and causing over 126,000 global cases and 5,414 deaths in 166 other countries around the world, especially Italy. SARS-CoV-2 would seem to have come from a bat, but the intermediate reservoir continues to be unknown. Nonetheless, as for SARS-CoV and MERS CoV, the Spillover effect linked to animal-human promiscuity, human activities including deforestation, illegal bush-trafficking and bushmeat, cannot be excluded. Recently, however, evidence of inter-human only transmission of SARS-CoV-2 has been accumulated and thus, the outbreak seems to be spreading by human-to-human transmission throughout a large part of the world. Herein we will provide with an update on the main features of COVID-19 and suggest possible solutions how to halt the expansion of this novel pandemic. [ABSTRACT FROM AUTHOR]

China has one of the highest salt intake levels in the world, and Chinese people form one of the largest foreign-born communities now living in Europe. The present study was performed to assess 24-hour urinary sodium and potassium excretion in Chinese migrants in Italy and to explore possible associations with hypertension, hypertension awareness, and length of residence in Italy. A cross-sectional evaluation was conducted on 319 first-generation Chinese migrants (154 women and 165 men) aged 18–70 years. Subjects were asked to do a 24-hour urine collection and the relationships of urinary sodium and potassium and arterial blood pressure, hypertension (BP ≥ 140/90 mmHg or anti-hypertensive drug use), hypertension awareness, and years of residence in Italy were investigated with linear or logistic regression analysis. Sodium excretion was 145.2 mmol/day (95%CI 138.0–152.3) in men, and 134.7 (95%CI 127.6–141.8) in women corresponding to a dietary salt intake of 9.4 g/day (95%CI 9.0–9.9) and 8.8 (95%CI 8.3–9.2) respectively. Potassium excretion was 35.1 mmol/day (95%CI 33.6–36.5), with no significant difference by gender. At multivariable adjusted linear regression analysis body mass index, low education level, and hypertension were positive predictors of sodium urinary excretion; gender (women), and body mass index were positive predictors of potassium excretion. Sodium and potassium excretion were unaffected by hypertension awareness or years of residence in Italy. Sodium excretion in Chinese workers is higher than recommended and in line with high salt intake in Italy. Potassium consumption remains low. • Daily sodium excretion of Chinese migrants was in line with the high sodium intake in Italy, while potassium excretion was markedly lower. • The area of origin in China remains a proxy for sodium and potassium intake after migration • Hypertension awareness is a powerful drive to treatment for Chinese in Italy whereas the importance of salt intake reduction is not appreciated. [ABSTRACT FROM AUTHOR]

Pseudomonas syringae pv. actinidiae causes kiwifruit bacterial canker, with severe infection of the kiwifruit plant resulting in heavy economic losses. Little is known regarding the biodiversity and genetic variation of populations of P. syringae pv. actinidiae in China. A collection of 269 strains of P. syringae pv. actinidiae was identified from 300 isolates obtained from eight sampling sites in five provinces in China. The profiles of 50 strains of P. syringae pv. actinidiae and one strain of P. syringae pv. actinidifoliorum were characterized by Rep-, insertion sequences 50, and randomly amplified polymorphic DNA polymerase chain reaction (PCR). Discriminant analysis of principal coordinates, principal component analysis, and hierarchical cluster analysis were used to analyze the combined fingerprints of the different PCR assays. The results revealed that all isolates belonged to the Psa3 group, that strains of P. syringae pv. actinidiae from China have broad genetic variability that was related to source geographic region, and that Chinese strains can be readily differentiated from strains from France but are very similar to those from Italy. Multilocus sequence typing of 24 representative isolates using the concatenated sequences of five housekeeping genes (cts, gapA, gyrB, pfk, and rpoD) demonstrated that strain Jzhy2 from China formed an independent clade compared with the other biovars, which possessed the hopHl effector gene but lacked the ItopAI effector gene. A constellation analysis based on the presence or absence of the four loci coding for phytotoxins and a cluster analysis based on the 11 effector genes showed that strains from China formed two distinct clades. All of the strains, including K3 isolated in 1997 from Jeju, Korea, lacked the cfl gene coding for coronatine. In contrast, the tox-argK gene cluster coding for phaseolotoxin was detected in K3 and in the biovar 1 strains (K3, Kw30, and Psa92), and produced a falsepositive amplicon for the /topA A7/-like gene in this study. To date, only one biovar (biovar 3) is represented by the strains of P. syringae pv. actinidiae from China, despite China being the center of origin for kiwifruit. [ABSTRACT FROM AUTHOR]

Since coal will be widely used in the next decades, mainly in the developing countries such as China and India, carbon capture and storage (CCS) technologies will have a key role in the containment of global warming. This paper presents a techno-economic comparison between the most promising power generation technologies for a CO 2 -free power generation in a short-term future. In particular, three different power generation technologies have been considered in their conventional (without CCS) and CO 2 -free configurations: (a) ultra supercritical (USC) pulverized coal combustion, (b) oxy-coal combustion (OCC) and (c) integrated gasification combined cycle (IGCC). Process simulation, based on Aspen Plus and Gate Cycle commercial tools, allows to calculate plant performance, including the energy penalty due to the CCS system (10.9% points for USC and 8.7% points for IGCC). In parallel, a detailed economic assessment shows that, among the commercial-ready technologies, USC could be the most convenient solution for power generation without CCS (presenting a levelized cost of electricity – LCOE – of 38.6 €/MW h, significantly lower than 43.7 €/MW h of IGCC), whereas IGCC becomes competitive for CO 2 -free systems (with a LCOE of 59.6 €/MW h, to be compared with 63.4 €/MW h of USC). Moreover, oxy-coal combustion, which is currently not mature enough for commercial-scale applications, promises to become strongly competitive for CCS applications due to its relatively low levelized cost of electricity (62.8 €/MW h). This kind of analysis typically presents strong uncertainties, due to the variability of several key parameters (e.g. fuel and CCS prices, determined by the fluctuation of the international markets, or an improvement of the technologies). Therefore, a sensitivity analysis has been done to determine the effects of these potential fluctuation or the improvement on the economic performance of the plant. [ABSTRACT FROM AUTHOR]

Abstract: This paper focuses on the application of various biomonitoring techniques in China. We report a study in the Pearl River Basin (Guangzhou) based on the application of diatom indices as well as a study on the waterways in Wuhan based on evaluation of toxicity (using phytotoxicity, Daphnia magna and Microtox™ tests) and the Extended Biotic Index (EBI). Regarding the diatom indices, acceptable results were obtained based on comparison of the chemical water quality level and the European and Japanese indices, despite a lack of taxonomic information. The toxicity tests applied to the Wuhan waterways (Yangtze and Han Rivers) produced interesting results and can be considered to represent a useful tool for water pollution control in this area. Application of the EBI in Wuhan produced results that were contradictory to the toxicological analyses, as there were no indications of toxicity, whereas EBI indicated poor water quality. It can be concluded that in principle, certain European biological indicators can be considered to represent feasible tools to be applied in China. However, further studies will have to be carried out to develop bioindices based on Chinese data sets. The use of bioindices based on macroinvertebrates is limited to less polluted and smaller rivers with a lithic river substratum, whereas diatom indices are also applicable under extreme conditions (e.g., under high pollution loads or in large river streams with sandy riverbed sediments through installing artificial substrates). [Copyright &y& Elsevier]

Abstract: Around the end of XIII century (at the time of young Marco Polo''s first trip to China at the court of Khubilai Khan in Khan Baliq) a pocket Bible was delivered by a Franciscan friar to the Mogul Emperor, in the framework of the evangelization program of the Far East. Four centuries later, in 1685, this Bible was rediscovered by the Jesuit Philippe Couplet in the house of a rich Chinese in Nanchin and donated to Cosimo III, Grand Duke of Tuscany. This Bible was recently “unearthed” in the Biblioteca Medicea Laurenziana in Florence, wrapped up in a precious yellow silk cloth, in a rather ruined state. After two years of restoration, the Bible will return to China in 2012 for a celebration of its >700years of life and of its remarkable return trip on the Silk Road. On account of the thinness of the parchment (barely 80μm thickness, the size of each foil being 16.5×11cm) it was widely held that the pages were produced from foetal lambskins. On tiny fragments of the margins of a foil, after several unsuccessful attempts at digesting the vellum, we were able to obtain a tryptic peptide mixture, which, upon mass spectrometry analysis, yielded the identity of 8 unique proteins, belonging to the genus Bos taurus, thus confirming the origin of the vellum from calfskins rather than from foetal lambskins. Our results prove that it is possible to obtain reliable protein extraction and IDs from ancient parchment documents. [Copyright &y& Elsevier]

In this study, a statistical model, combining principal components analysis (PCA), stepwise-canonical discriminant analysis (stepwise-CDA), classification and regression tree (CART), partial least squares-discriminant analysis (PLS-DA) and an innovative multidimensional analysis (MDA), was build up to predict the geographical origin of edible porcini (Boletus sect. Boletus). To this purpose, the elemental signatures of 180 commercial and manually harvested samples from different Italian production areas, China and Poland, were chemometrically elaborated. PCA differentiated Italian products from Chinese and Polish mushrooms. Based on the fusion of PCA and hierarchical cluster analysis (HCA), MDA identified elements such as Na, Mn, Fe, Cu and Cd as powerful discriminating variables. Finally, highly accurate and trained stepwise-CDA, CART and PLS-DA models, were able to predict the geographical origin of a survey of commercial porcini, through few metals (Mg, Mn, and Fe). The provenance reported on the labelling of these products was confirmed. Nevertheless, both models revealed that a commercial sample, with a claimed Italian origin, consisted of Chinese mushrooms. Overall, the combination of standard and innovative chemometric techniques demonstrated to support a reliable authentication of the geographical origin of porcini, thus, protecting the Italian production from fraud. • A traceability system for protecting the Italian porcino was built up. • Porcini from China, Poland and Italy, including PGI mushrooms, were considered. • Samples were screened by ICP-MS and elaborated by multivariate statistics. • A restricted pool of traceability markers was determined. • The traceability model was applied on commercial porcini to reveal potential fraud. [ABSTRACT FROM AUTHOR]