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Out of all the different types of groups that visit history museums, families are the most frequent visitors to museums in China. Just like the "Dawn of Civilization" exhibit at the Jilin Provincial Museum, most permanent exhibits do not pay enough attention to families' needs (particularly the need for learning), nor do they encourage group interaction or accommodate multiple users. In this study, we observed 133 families during their exploration of one exhibition hall at a regional museum and pays attention to how they physically and verbally interacted. In addition, 456 questionnaires and 60 interviews were conducted. Our results indicate that although it seems impossible to thoroughly reject current designs to construct family-friendly exhibits, it remains necessary to treat our results as guidance for future development.

This study examines the relationship between filial piety (adult children's filial behaviours and attitudes as well as elderly mothers' overall evaluation of children's filial piety) and elderly mothers' reports of intergenerational ambivalence (positive feelings, negative feelings and combined ambivalence) in rural China. We analysed the data from a survey in 2016 covering 2,203 adult children and 802 elderly mothers in Sichuan Province using a two-level mixed-effects modelling analysis. The results indicate that most components of filial piety are associated with mothers' ambivalence, in that less ambivalence was reported by mothers when their adult children provided more emotional support to, had less conflict with and were evaluated as more filial by their mothers. Interestingly, mothers demonstrated greater positive feelings when their children were more filial in behaviour and attitude, but they also reported greater negative feelings and ambivalence when their children were more obedient, implying that absolute obedience to elderly parents might no longer be accepted by people. These findings may provide further understanding about the correlation between the culture of filial piety and intergenerational relationships in rural China. [ABSTRACT FROM AUTHOR]

Introduction: There are few investigations describing the pregnancy-associated listeriosis in China, and the molecular characteristics of Listeria monocytogenes causing such infections remain largely unknown. We aim to investigate the phenotypic and genomic profiles of pregnancy-associated L. monocytogenes isolates and their association with isolates recovered from human and non-human in China. Materials and Methods: In this study, we conducted a 3-year surveillance of listeriosis in a women's hospital in Zhejiang province, using whole genome sequencing and bioinformatics tools. Results: From 2016 to 2018, we identified 13 clinical L. monocytogenes isolates. Among these pregnancy-associated isolates, we found seven sequence types (STs), with the prevalent STs of ST87 and ST7. Serotyping divided the strains into four serotypes, including serotype 1/2a, 1/2b, 3a, and 4b. Antimicrobial resistance testing showed that all the isolates were susceptible to 10 antibiotics. Comparative genomics analysis clearly classified our genome collection into four distinct evolutionary lineages with most isolates grouping into lineages I and II. Interestingly, we found three pairs of isolates with high identity, although no evident epidemiological association was observed. Conclusion: This study reports for the first time the surveillance of pregnancy-associated listeriosis in Zhejiang province, China, which indicates that the infection rate is low in this region. Our findings provide insight into the evolution and genetic diversity of pregnancy-associated L. monocytogenes from Zhejiang province. Additional investigations involving more human and non-human isolates with a "one health" strategy are needed for prediction of the listeriosis risk associated with a typical prevalent clone in Zhejiang province, such as ST87. [ABSTRACT FROM AUTHOR]

Objective: We aimed to investigate whether Chinese endoscopists without narrow‐band imaging (NBI) experiences could achieve high accuracy in the real‐time diagnosis of colorectal polyps using NBI International Colorectal Endoscopic (NICE) classification after web‐based training. Methods: Altogether 15 endoscopists from five centers with no NBI experiences followed a short, web‐based training program on the NICE classification and took web‐based test. Their performances were compared with 15 matched experienced endoscopists with no NBI experience who received no NBI training. These 15 trained endoscopists then made real‐time diagnoses of colorectal neoplasia. A logistic regression was used to assess potential predictors of diagnostic performance. Results: Compared with those who received no training, trained endoscopists achieved comparable overall accuracy (85.3% vs 83.1%, P = 0.408) and accuracy at a high‐confidence level (87.0% vs 86.0%, P = 0.670), but had a higher confidence rate (86.1% vs 83.7%, P = 0.004) for the diagnosis of neoplasia. Real‐time diagnostic accuracy, sensitivity and specificity were 94.3% (95% confidence interval [CI] 91.5%‐96.2%), 96.2% (95% CI 93.4%‐97.9%) and 85.3% (95% CI 74.8%‐92.1%) at high‐confidence level. The high‐confidence level was the strongest predictor of real‐time diagnostic accuracy (odds ratio 12.66, P < 0.001). Conclusions: Web‐based training can improve the confidence level of endoscopists in accurately diagnosing colorectal polyps using the NICE classification. Chinese endoscopists can achieve high accuracy in diagnosing colorectal neoplasia at a high confidence level (ClinicalTrials ID: NCT02033980). [ABSTRACT FROM AUTHOR]

Cities have emerged as critical and challenging places for promoting the green and low-carbon transformation of the economy and society in the context of the "dual carbon" targets. Meanwhile, fiscal policy is also an indispensable component of the public policy framework supporting the green and low-carbon transformation. This paper uses the pilot project of "Comprehensive Demonstration Cities for Energy Conservation and Emission Reduction Fiscal Policies" ("ECER-CD" policy) implemented in China since 2011 as a quasi-natural experiment. This research theoretically analyzes and empirically tests the energy conservation and emission reduction effects of fiscal policies supporting green and low-carbon transformation utilizing methodologies such as time-varying DID and multiple periods and multiple groups of DID. The study finds that the pilot cities effectively reverse the behavioural bias of local governments and promote energy conservation and emission reduction efforts. This conclusion holds after undergoing robustness tests such as parallel trend analysis and heterogeneity treatment effects. The effectiveness of the pilot policy is attributed to the upgrade of industrial structure, improvement of energy efficiency, and the effects of green technology innovation. However, cities' geographic location and resource dependency can interfere with the effective implementation of policies. This paper also further explores the environmental dividends and economic consequences of the policy and finds that the pilot cities have certain environmental dividends and do not significantly restrain economic and social development. This study broadens the research perspective on fiscal policies in energy conservation and emission reduction and clarifies the pathways through which fiscal policies promoting green, low-carbon transformation drive energy conservation and emission reduction in cities. Moreover, it also improves the use of the Difference-in-Differences method in evaluating policy effects in scenarios such as the overlapping implementation of pilot policies and policy withdrawal. Finally, this paper proposes policy recommendations to provide more empirical evidence for China to accelerate the green and low-carbon transformation of the economy and society. [ABSTRACT FROM AUTHOR]

Background: The use of heroin during Methadone Maintenance Treatment (MMT) is a challenging problem that contributes to poor treatment outcomes. Families may play an important role in addressing concurrent heroin use during MMT, especially in collectivist societies such as China. Objectives: In this study, we explored the relationship between family-related factors and concurrent heroin use during MMT in China. Methods: This study was conducted at 68 MMT clinics in five provinces of China. There were 2,446 MMT clients in the analysis. Demographic information, MMT dosage, family members' heroin use status, family support of MMT, family problem, and self-reported heroin use were collected in a cross-sectional survey. The most recent urinalysis of opiate use was obtained from clinical records. Results: Of the 2,446 participants, 533 (21.79%) self-reported heroin use in the previous seven days or had a positive urine morphine test result in the clinic record. Participants whose family member[s] used heroin were 1.59 times (95% CI: 1.17, 2.15) more likely to use concurrently during treatment. Those with family members who totally support them on the MMT were less likely to use (AOR: 0.75, 95% CI: 0.60, 0.94). Having more family problems was positively associated with concurrent heroin use (AOR: 2.01, 95% CI: 1.03, 3.93). Conclusions: The results highlight the importance of the family's role in concurrent heroin use during MMT programs. The study's findings may have implications for family-based interventions that address concurrent heroin use. [ABSTRACT FROM AUTHOR]

Background: The validity and concordance of two main measures of drug use behavior, self-report and urinalysis, has long been discussed. More understanding is needed about the underlying factors associated with discordance between these two methods.Objectives: Describe the pattern and associated factors of discordance between self-reported heroin use and the urinalysis results of opiate use among methadone maintenance therapy (MMT) patients in China.Methods: A total of 2,448 MMT patients from 68 clinics in five provinces of China participated in a survey, which collected information on demographics, drug use and MMT-related factors, depressive symptoms, and drug avoidance self-efficacy. The most recent urine morphine test result was obtained from medical records and compared with self-reported heroin use. Participants who had urinalysis within 14 days of the survey were included in the analysis.Results: Among the 1,092 participants, 70 (6.4%) self-reported heroin use and 195 (17.9%) had positive urinalysis results. The over-reporters group had significantly higher education, and the under-reporters had significantly higher level of drug-avoidance self-efficacy and lower level of depressive symptoms. Among the participants who either self-reported heroin use or had positive urinalysis results, being young, having higher education, and having lower level of depressive symptoms were associated with discordance between self-reports and urinalysis results.Conclusion: The combination of both measures in assessing drug use behavior seems necessary. The validity of self-report should be considered differently based on demographic and psychosocial characteristics. [ABSTRACT FROM PUBLISHER]

Amur cork-tree bark is a natural medicine in China with a large market, whereas confusion about its origin limits its cultivation and commercial value. To trace the origin, the stable isotope ratios (δ 13C, δ 15N, δ 2H, and δ 18O) and multiple elements (As, Hg, Al, Ca, Fe, K, Mg, Na, Cr, Cd, Pb, Be, Cu, Zn, Sr, and Ba) of 83 batches of Amur cork-tree bark samples from 7 habitats were determined by stable isotope mass spectrometry and inductively coupled plasma mass spectrometry. The results showed that the two-dimensional combination of δ 13C and δ 15N in the scatter diagram of stable isotopes could obviously distinguish Amur cork-tree bark from Sichuan Province from other producing areas, and multielement radar map analysis could also be used to distinguish Amur cork-tree bark from different geographical sources. In this article, the data of stable isotope ratios and multielement content were combined for principal component analysis (PCA), linear discriminant analysis (LDA) and orthogonal partial least square discriminant analysis (OPLS-DA). The results of principal component analysis showed that all samples could be preliminarily distinguished. The prediction model established and verified by linear discriminant analysis realized 100% accurate classification for known samples. The correct rate of analysis and prediction for unknown samples was 94.5%. The effective feature discriminant markers of Amur cork-tree bark caused by VIP > 1 (Ca, K, Pb, Mg, Cr, As) were found by orthogonal partial least square discriminant analysis. It could accurately identify Amur cork-tree bark from different producing areas. [Display omitted] • The stable isotopes and multi-elements of Amur Cork-tree Bark were first determined. • The method was fisrt used to study the traceability of Amur Cork-tree Bark. • A set of traceability model was established for traceability of Amur Cork-tree Bark. • The method has guiding significance for the cultivation and clinical application. [ABSTRACT FROM AUTHOR]

Groundwater is an important water supply source in the northern part of China and many cities, and it is also an essential factor to maintain the regional ecological environment. China since 1972 began large-scale development of groundwater resources. By 2014, the amount of groundwater mining in China has exceeded 110000000000 m 3 , after the United States, India, ranking third in the world. In China's 31 provinces, the main groundwater over 6 provinces (He Bei, He Nan, Shan Dong, Xin Jiang, Gan Su, Hei Long Jiang) are located in the north of China, these 6 provinces of groundwater exploitation accounted for about 41% of the country, 6 provinces have accounted for about 30% of the total amount of these provinces. However, irrigation is a very important factor in the production of grain production, and it has irreplaceable foundation support and guarantee function, to ensure food production, water resources is the lifeblood. We are the choice of Shandong Province involving groundwater over exploitation of city as an example and analysis to 2020 in groundwater security at the same time, to ensure grain production measures. [ABSTRACT FROM AUTHOR]

The article discusses a study that determined patterns of HIV status disclosure to community members by a sample of HIV-infected men and women in rural China. Topics discussed include the association of age and family income with the extent of disclosure of HIV status to community members like neighbors, village leaders, and coworkers, the extent of disclosures among older age groups, and the tendency of people with less family income to disclose more to the community.

Based on a nationwide investigation of the current state of preservation of museum objects in China, around 51% of the 35 million museum objects show different degrees of deterioration. Although treatment of objects is necessary, treatment alone is not sufficient. In China's present situation, preventing damage to museum objects is much more cost-effective than allowing damage to happen and then treating it. The number of museums in China is increasing very fast: 23 000 exhibitions are held, 600 million visits are made, and 35 000 archaeological objects are excavated nationwide, each year. At the same time, these museums are widely distributed and have different levels of resources. We need both technical knowledge and preventive conservation to safeguard our precious museum objects. This paper introduces research achievements in preventive conservation, and traces the development of this discipline in China. Starting from the classification of museums in China, legislation is detailed on preventive measures such as selecting appropriate light sources, controlling temperature, relative humidity, light damage, and pollutants. This paper describes achievements in monitoring, analysis, evaluation, and control of museum environments in China. It also proposes future directions for museum environment studies during China's twelfth Five-Year Plan. [ABSTRACT FROM AUTHOR]

A rapid, simple and reliable analytical method was developed for the determination of cyantraniliprole and its major metabolite J9Z38 in pakchoi and soil by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The sample preparation approach is known as QuEChERS, which stands for quick, easy, cheap, effective, rugged and safe. Samples were extracted with acetonitrile, and cleaned up with dispersive primary and secondary amine sorbent before analysis by UPLC-MS/MS. The limit of quantitation for cyantraniliprole and J9Z38 was 0.01 mg/kg in both pakchoi and soil. Average recoveries of cyantraniliprole and J9Z38 at three fortified levels (0.01, 0.05, 0.1 mg/kg) ranged from 77.8 % to 102.5 % with relative standard deviation of 1.6 %-8.9 %. This method has been applied to the analysis of cyantraniliprole and J9Z38 residues in real pakchoi and soil samples selected from field. The results of the residue dynamic experiment showed that the half-life of cyantraniliprole ranged from 2.9 to 6.4 days in pakchoi and 8.7 to 18.2 days in soil, respectively. The final residual levels of cyantraniliprole in pakchoi and soil from Guangdong and Shanghai were below 0.20 and 0.10 mg/kg, respectively; similarly, the final residual levels of J9Z38 in pakchoi and soil from Guangdong and Shanghai were <0.07 and 0.01 mg/kg. These results will be helpful in setting maximum residue limit guidance for cyantraniliprole in pakchoi in China. [ABSTRACT FROM AUTHOR]

Using Moderate Resolution Imaging Spectroradiometer (MODIS) aerosol data, temporal variations and the spatial distribution of aerosol optical depth (AOD or τ) over the Hubei Province in China were investigated from 2003 to 2008. self-organizing maps (SOMs) and linear models were further used to analyse the relationships between AODs and elevation, normalized difference vegetation index (NDVI) and population density. The results were as follows: high AOD values were observed in south-central areas with lower elevations, lower NDVI and larger population densities, whereas low AOD values were observed in the western, northeastern and southeastern areas. The highest AOD values were observed in spring; summer was characterized by lower AOD values, but also the largest ratio of fine particles; in autumn, the coverage of AOD was only smaller than spring with most being fine particles; in winter, coarse particles were dominant when AOD values were the lowest. The AOD monthly average rose substantially in the winter–spring season and dropped sharply in the spring–winter season. Based on these data, both SOMs and linear models show that AOD distribution is influenced by the complex interactions that occur among various elements. The annual AODs are negatively related to ln(elevation) and NDVI and positively related to ln(population density). The ln(elevation) factor affects aerosol distribution more than do the other two factors. Compared to fine-particle aerosols, the selected three factors have a greater impact on the coarse particles. [ABSTRACT FROM AUTHOR]

Spatial and temporal variations of aerosol optical depth (AOD, or τ) in China were investigated using MODIS-derived aerosol data for a period of 2003-2006. The geographical distribution patterns of 4-year mean AOD for total, τ0.55 (AOD at 0.55 μm), fine, τ0.55-fine, and coarse, τ0.55-coarse, aerosols over China were addressed. These results indicate that the distribution of aerosol was largely affected by population, urban/industrial activity, agricultural biomass burning, spring dust, topography and humidity. τ0.55-fine in eastern China is significantly higher than in western China. Distribution of τ0.55-coarse reflected the influence of spring dust and urban/industrial pollution. The overall AOD in summer was higher than that in winter due to strong photochemical reactions producing secondary aerosols. In northern China, dust contributed to the mean τ0.55 in spring months. In some places, aggregated precipitation in the summer months caused a pronounced drop in the temporal profile of AOD. Coal combustion, industrial emission and vehicle exhaust produced coarse aerosols, while fine aerosols are mainly dominated by secondary particles. Smoke from open-fire straw burning produced fine aerosols in the harvest season. [ABSTRACT FROM AUTHOR]

The newest daily and monthly Moderate Resolution Imaging Spectroradiometer (MODIS) aerosol optical depths (AOD or τ) dataset over land, C005, retrieved using the second-generation operational algorithm, were evaluated using a ground-based Aerosol Robotic Network (AERONET) dataset from 13 sites over China. The dataset covers the period 2003-2006. Daily MODIS C005 AODs over China were found to have a positive bias with a relationship of τMODIS = 0.135 + 1.022τAERONET, for which the offset is larger than reported global validation results. However, the relationship τMODIS = 0.021 + 0.929τAERONET showed that monthly MODIS C005 AODs were an overestimation for small AOD and underestimation for high AOD. Both daily and monthly MODIS AOD retrievals showed poor performance in extreme aerosol conditions, e.g. under dust events or heavy urban/industrial haze. Nevertheless, both daily and monthly MODIS C005 AOD datasets can be used for investigation of aerosol spatial distribution and temporal variation over China. [ABSTRACT FROM AUTHOR]

Background: Drug use stigma among service providers has been recognized as a barrier to improving the accessibility and outcomes of addiction treatment. This study examined the stigmatizing attitudes towards people who use drugs (PWUD) among service providers in methadone maintenance treatment (MMT) clinics in China and its associated factors.Methods: The cross-sectional study used the baseline data of a randomized intervention trial conducted in China, and the data were collected from January 2012 to August 2013. A total of 418 MMT service providers were included in the study. Stigma towards PWUD was measured via a 10-item scale embedded in two case vignettes (PWUD and non-PWUD). The Wilcoxon signed-rank test was performed to evaluate the vignette difference for each item of the scale. The linear mixed model was used to identify the adjusted association between drug use stigma and other interested variables including demographics, professional background, and MMT knowledge of the service providers.Results: The Wilcoxon signed-rank tests showed that the participants had a higher level of stigmatizing attitudes towards PWUD than non-PWUD (p-value<0.001 for all items of the stigma scale). The linear mixed model identified that the reception of national MMT training was associated with a lower degree of drug use stigma (estimate=-1.79; 95% CI: -3.13, -0.45; p-value = 0.009).Conclusion: The findings of the study provide evidence of the existence of drug use stigma among MMT providers in China. The expansion of national-level training and the development of stigma reduction interventions are needed to address this issue. [ABSTRACT FROM AUTHOR]

Background: This study evaluated an intervention aiming to improve methadone maintenance therapy (MMT) service providers' interaction with their patients in China.Methods: Sixty-eight MMT clinics were randomized to either an intervention or a control condition. Providers in the intervention group attended three group training sessions to enhance their communication skills. Trained providers were encouraged to practice the taught communication skills through provider-initiated individual sessions with their patients. A total of 418 service providers completed assessments from baseline to 24-month. Linear mixed-effects regression models were used to compare self-reported short-term and sustained improvement in provider-patient interaction between the intervention and the control conditions.Results: The intervention group service providers perceived significantly greater short-term and sustained improvement in provider-patient interaction compared to the control group service providers (estimated difference (±SE): 1.20 (0.24) and 1.35 (0.33), respectively; p-values < 0.0001). Providers' baseline job satisfaction was significantly associated with a greater perceived improvement in provider-patient interaction for both periods (reg. coef. (±SE): 0.02 (0.01) and 0.04 (0.01) for short-term and sustained periods, respectively; p-values < 0.01).Conclusion: Study findings suggest that the intervention could be beneficial for improving perceived provider-patient interaction in MMT programs. Service providers' job satisfaction should be addressed in training programs for the improvement of provider-patient interaction. [ABSTRACT FROM AUTHOR]

It is well-known that metabolism of benzene is required for the induction of toxicity and consequent health problems. Therefore, genetic variation in benzene (BZ) metabolism genes can influence health outcomes. However, large population studies are needed to provide more evidence for such relationship. We have conducted a large population investigation (385 BZ-exposed shoe workers and 197 matched healthy controls) on the association between inheritance of certain BZ metabolizing genes and the expression of micronuclei (MN). The latter was based on the cytokinesis-blocked MN assay. We analyzed the polymorphisms of GSTM1, GSTT1, GSTP1 (rs1695), CYP2E1 (rs3813867), CYP2E1 (rs2031920), CYP2E1 (rs6413432), mEH exon 3 (rs1051740), mEH exon 4 (rs2234922). Univariate Poisson regression analysis demonstrated that the BZ-exposed workers had significantly increased MN frequency compared with the controls (FR=1.84, 95% CI: 1.56-2.18; P<0.001), and showed a cumulative exposure dose-response relationship. The CYP2E1 rs3813867 mutant allele (CC+GC) (FR 1.15, 95% CI 1.02-1.29; P=0.020) and rs2031920 variant allele (CT+TT) (FR=1.23, 95% CI: 1.09-1.37, P<0.01) was associated with higher MN frequency significantly compared with the wild genotype separately. Furthermore, the MN frequency in rs2031920 variant allele (CT+TT) (FR=1.17, 95% CI: 1.04-1.31, P<0.01) was also higher than the wild genotype when the age, gender and cumulative exposure dose was adjusted in Poisson regression. In addition, the CYP2E1, however, GSTM1null, GSTT1null, GSTP1 rs1695, rs6413432, rs1051740 and rs2234922 polymorphisms showed no association with MN frequency. Our results indicate that two promoter polymorphisms in the CYP2E1 gene, especially the rs2031920 variant allele, were involved with the BZ-induction of MN and may contribute to risk of cancer among exposed workers. [ABSTRACT FROM AUTHOR]

Highlights: [•] Results showed higher micronucleus frequencies in exposed workers than control. [•] Gene polymorphism was associated with higher level of induced chromosome damage. [•] Results exhibited combined effect of repair gene polymorphism and exposure dose. [Copyright &y& Elsevier]

Objectives: This study aims to explore the incidence of, and risk factors for medical adhesive-related skin injury (MARSI) at peripherally inserted central venous catheter (PICC) sites in patients with cancer., Design: A prospective observational cohort study was conducted at a tertiary hospital in Shenzhen, China., Setting: This was a single-centre study conducted in a tertiary hospital in Shenzhen, China., Participants: A total of 340 patients with cancer and PICC placement from January 2022 to June 2023 were selected using a convenience sampling method., Methods: Factors potentially associated with PICC-related MARSI (PICC-MARSI) were recorded, including patient demographics, and catheter placement and maintenance. Patients were divided into MARSI and non-MARSI groups. Univariate analysis was performed to screen for associated variables, and logistic regression analysis was used to identify independent risk factors for PICC-MARSI., Results: Of all 340 patients enrolled, 33 (9.7%) developed PICC-MARSI, including skin tear (8, 24.2%), tension injury (5, 15.2%), irritant contact dermatitis (10, 30.3%), allergic dermatitis (7, 21.2%) and maceration (3, 9.1%). Multivariable analysis showed that age (OR=1.058, p=0.001, 95% CI 1.023-1.094), wet skin (OR=4.873, p=0.003, 95% CI 1.728-13.742), dry skin (OR=6.247, p<0.0001, 95% CI 2.239-17.431), oedema (OR=3.302, p=0.008, 95% CI 1.365-7.985), allergy history (OR=6.044, p=0.001, 95% CI 2.040-17.906), dressing type (OR=3.827, p=0.003, 95% CI 1.595-9.185), body mass index (BMI) <18.5 (OR=4.271, p=0.015, 95% CI 1.327-13.742) and BMI 25-30 (OR=2.946, p=0.027, 95% CI 1.131-7.678) were independent risk factors for PICC-MARSI., Conclusions: Proper catheter maintenance and appropriate dressing selection are crucial for the prevention of this condition., Competing Interests: Competing interests: There is no conflict of interest between all authors. All authors have made substantial contributions for this article. Meanwhile, we have reviewed the final version of the manuscript and approve it for publication. The authors have approved the final article and acknowledge that all those entitled to authorship., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Background: Although studies conducted in developed countries have reported a negative relationship between social participation and depressive symptoms, few studies have examined rural-urban differences in the relationship between participation in various types of social activities and depressive symptoms among Chinese older adults., Objectives: This study examined the association between participation in paid work, political, and voluntary activities and depressive symptoms among Chinese older adults in urban and rural areas., Methods: Data were obtained from the China Longitudinal Ageing Social Survey conducted in 2014, and bivariate linear regression and multivariable linear regression analyses were conducted., Results: The prevalence of depressive symptoms was significantly higher among older adults residing in rural areas than among older adults in urban areas. Participation in paid work activities was significantly associated with fewer depressive symptoms among older adults in urban and rural areas, whereas participation in political or voluntary activities was negatively associated with depressive symptoms only among older adults in urban areas. Older adults who participated in two or three types of activities (paid work, political, and voluntary activities) tended to have fewer depressive symptoms both in urban and rural areas., Limitations: Because this study comprised a cross-sectional design, causality could not be established between social participation and depressive symptoms., Conclusions: Social participation plays a protective role against depressive symptoms among Chinese older adults, especially among those in urban areas. Urban-rural differences exist between participation in different types of social activities and depression symptoms., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Aim: To compare the effectiveness of needle-free incision suture closure with butterfly tape and traditional secondary suturing techniques in treating incision infection., Methods: Two hundred and twenty-three patients with incision infection following hepatobiliary surgery at a tertiary hospital were randomly divided into three groups: 90 patients were closed by needle-free incision suture closure, which gradually closed the incision wound when drainage from incision infection was visibly decreased and healthy granulation tissues had grown; 79 patients were closed by butterfly bandage; another 54 patients were closed by traditional secondary suturing technique. Healing time of incision infection was calculated from the beginning of dressing change to the healing of the incision., Results: Healing time in the needle-free incision suture closure group (24.2 ± 7.2 d) was significantly shorter than that in the butterfly bandage group (33.3 ± 11.2 d) and the traditional secondary suturing group (36.2 ± 15.3 d) (P < 0.05). Healing time in the butterfly bandage group appeared to be slightly shorter than that in the secondary suture group, but the difference was not statistically significant (P > 0.05)., Conclusion: Needle-free incision suture closure could gradually close the infection wound at the same time of drainage and dressing change, thereby shortening the healing time.

Endoplasmic reticulum (ER) stress is one of the contributing factors to the development of β-cell failure in type 2 diabetes. ER stress response through ATF6 has been shown to play an important role in insulin resistance and pancreatic β-cell function. We investigated whether genetic polymorphisms in ATF6 were associated with the risk of pre-diabetes in a Chinese Han population, and whether they had a synergistic effect with obesity. Our samples included 828 individuals who were diagnosed as pre-diabetic, and 620 controls. The minor allele A at rs2340721 was associated with increased risk for pre-diabetes(p = 0.013), and this association was still significant after adjusting for gender, age, body mass index (BMI), and waist-hip ratio(p' = 0.011). BMI, treated as a continuous variable, and rs2340721 had an interactive effect on pre-diabetic risk(p for interaction = 0.003, β = 0.106). Carriers of GG at rs7522210 were also at a higher risk compared to non-carriers (OR = 1.390, 95%CI:1.206-1.818, p = 0.013, adjusted OR' = 1.516, 95%CI:1.101-2.006, p' = 0.006). GG homozygotes had increased fasting blood glucose (FBG) levels(GG vs CX: 5.6 ± 0.52 vs 5.5 ± 0.57 mmol/L, p = 0.016), lower insulin levels (0,30,120 minutes after glucose load) (p < 0.05), and reduced areas under the insulin curve than non-carriers(GG vs CX:67.3(44.2-102.3) vs 73.1(49.4-111.4), p = 0.014). rs10918270 was associated with FBG, and rs4657103 with 2 hour glucose levels after a 75 g glucose load. We also identified a haplotype of TTAG composed of rs4657103, rs2134697, rs2340721, and rs12079579, which was associated with pre-diabetes. The genetic variation in ATF6 is associated with pre-diabetes and has interactive effects with BMI on pre-diabetes in the Chinese Han population.

Background: Insulin and glucagon-like peptide 1 (GLP-1), converted by proprotein convertase 1 (PC1/3) from proinsulin and proglucagon, are associated with type 2 diabetes (T2DM) and coronary artery disease (CAD). The aim of this study is to investigate the association of PCSK1 gene, which encodes PC1/3, with the risk of CAD in Chinese patients with T2DM., Methods: We selected and genotyped 5 haplotype-tagging single nucleotide polymorphisms (SNPs) at PCSK1 gene (across 39873bp locus) in a case-control study of Chinese Han population involving 425 diabetic patients (62.1% male, mean age 63.2 years) with CAD as positive cases and 258 diabetic patients (44.2% male, mean age 62.0 years) without CAD as controls., Results: The allele frequencies at rs3811951 were significantly different between cases and controls (30.7% vs. 37.2%), with the allele G associated with decreased risk for CAD (OR = 0.75, 95% CI = 0.59-0.94, p = 0.013). In recessive inheritance mode, the carriers of GG had a lower risk (OR = 0.50, 95%CI = 0.31-0.82, p = 0.005), even after adjusted for gender, age, BMI and smoking (OR = 0.43, 95%CI = 0.24-0.77, p = 0.004). The carriers of the minor allele A at rs156019 had a higher risk (OR = 1.66, 95%CI = 1.10-2.50, p = 0.016 after adjustment) in dominant inheritance mode. The SNP rs6234 was also significantly associated with CAD risk in women, with the carriers of the minor allele G at rs6234 associated with a reduced CAD risk in recessive inheritance mode (OR = 0.42, 95% CI = 0.18-0.95, p = 0.036 after adjustment)., Conclusions: Our results found that common genetic variants in PCSK1 were associated with CAD in Chinese patients with T2DM.

In this study, we estimated the possibility of using benchmark dose (BMD) to assess the dose-response relationship between vinyl chloride monomer (VCM) exposure and chromosome damage. A group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed control in Shandong Province northern China were examined for chromosomal damage in peripheral blood lymphocytes (PBL) using the cytokinesis-blocked micronucleus (CB-MN) assay of DNA damage. The exposed group (3.47 ± 2.65)‰ showed higher micronucleus frequency than the control (1.60 ± 1.30)‰ (P < 0.01). Occupational exposure level based on micronucleus occurrence in all individuals was analyzed with benchmark dose (BMD) methods. The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. Results showed a dose-response relationship between cumulative exposure and MN frequency, and a BMDL of 0.54 mg/m3 and 0.23 mg/m3 for males and females, respectively. Female workers were more susceptible to MN damage than male workers., (Copyright © 2012 Elsevier GmbH. All rights reserved.)

Objectives: The aim of this study was to estimate a benchmark dose (BMD) for chromosome damage induced by vinyl chloride monomer (VCM) in VCM-exposed workers in central China and validate the published results in Shanghai., Methods: VCM-exposed workers who had been exposed to VCM for at least one year (n=463) and matched subjects not exposed to VCM or other toxins (n=273) were asked to participate in this study. Micronucleus (MN) frequency based on the cytokinesis-block micronucleus assay (CBMN) was used as a biomarker for chromosome damage induced by VCM exposure., Results: The MN frequency in the VCM-exposed workers was significantly higher than that in the control group, and multivariate Poisson regression suggested that gender, smoking status and VCM exposure were the significant factors influencing the risk of increased MN frequency. When subjects were further stratified according to gender and smoking status, the results showed that female VCM-exposed workers were more susceptible than the males to the risk of increased MN frequency. The MN frequency of smokers was significantly higher than that of nonsmokers in the control group. Our study also suggested that there was a strong dose-response relationship between VCM CED and the increased risk of MN frequency in the total group, males and females. The BMDL(10) was found to be 630.6, 670.2 and 273.7 mg-year for all VCM-exposed workers, males and females, respectively., Conclusions: These results invite further scrutiny of the current VCM occupational exposure limits and warrant further study of the risk of VCM genotoxicity and carcinogenicity.

Objective: To explore the acceptability of male circumcision (MC) as an HIV prevention method and its related factors among young men of Yi ethnicity in Liangshan prefecture., Methods: 446 young men were selected in Butuo county, under stratified sampling method. Using a self-designed questionnaire, face to face interviews were taken to collect HIV-related risk behaviors, knowledge and acceptability of MC., Results: After an introduction on MC by interviewers, 40.6% of the interviewees expressed their willingness in taking this surgery. The main reason for acceptance was that they felt this surgery might reduce the risk of HIV infection (90.1%). For those who refused to take this surgery, most of them thought it was too sensitive and embarrassing (52.5%) and were afraid that it might affect their procreation ability. Data from logistic regression analysis indicated that the acceptability of MC was associated with the following factors as:age, income, experience of commercial sexual behavior. They also felt that messages related to male MC surgery could reduce the risk of being infected with HIV/STDs or induce pain when having sexual intercourse, or it might cause partial infection after surgery, or they might be mocked at if taking the surgery., Conclusion: It is the prerequisite in helping young people of Yi ethnicity to have a good understanding on MC as for Yi people, embarrassment attitudes towards sex appears to be one of the big obstacles against the popularization of this surgery. The operation should be provided by trained and professional doctors, with standardized procedure, in good sanitary conditions and free for service.

Objective: To evaluate the effect of a community-based intervention project among men who have sex with men (MSM) after two-year implementation., Methods: Comprehensive interventions among MSM in 18 cities of seven provinces were conducted. The pre-intervention questionnaire was conducted in September 2006 and 5178 subjects were investigated through snowball method. In May 2007, post-questionnaire was conducted and 5460 subjects were investigated through snowball or accompanied recommendation method. For each subject, a questionnaire was completed, including basic information, HIV/AIDS knowledge, behaviours and intervention status. At the same time, 5 ml intravenous blood sample was collected to detect HIV infection and evaluated the intervention effect., Results: After two-year implementation, the awareness rate of HIV/AIDS knowledge increased from 76.0% (3933/5178) in 2006 to 90.5% (4943/5460) in 2008 (chi(2) = 451.786, P < 0.001); the rate of condom use in the last anal sex with males increased from 58.0% (2382/4105) to 76.7% (3643/4750) (chi(2) = 215.491, P < 0.01); the rate of consistent condom use in the last six months increased from 28.2% (1163/4118) to 44.5% (2114/4753) (chi(2) = 264.606, P < 0.01); the proportion of MSM receiving HIV antibody test increased from 18.8% (973/5170) to 39.1% (2136/5454) (chi(2) = 530.181, P < 0.01); and the HIV infection rate increased from 2.3% (118/5178) to 5.0% (271/5427) (chi(2) = 47.613, P < 0.01)., Conclusion: The MSM community-based intervention project achieved some good results after two-year implementation and contributed to an increase in HIV/AIDS knowledge and safe sex.