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Simple Summary: Cadmium (Cd) is a major aquatic pollutant that can cause toxic effects on aquatic animals, including the economically important clam Meretrix meretrix. A transcriptomic analysis was performed on M. meretrix fertilized eggs, D-shaped larvae, pediveligers, and postlarvae following exposure to Cd2+-containing seawater. A number of genes related to the oxidative stress response were found to be differentially expressed in the fertilized egg and the different larval forms when exposed to Cd2+. These included the CCO, Ndh, HPX, A2M, STF, and pro-C3 genes, and changes in their expression levels in response to Cd2+ exposure were confirmed by qRT-PCR assays. In addition, qRT-PCR also revealed marked changes in the expression of two other oxidative stress-related genes, Nrf2 and MT, in the fertilized egg and different larval forms of M. meretrix in response to Cd2+ exposure. The results suggested that changes in oxidative stress-related genes might be crucial for M. meretrix to cope with the adverse effects of Cd during its development. Cadmium (Cd) is one of the major pollutants in the aquatic environment, and it can easily accumulate in aquatic animals and result in toxic effects by changing the metabolism of the body, causing a serious impact on the immune system, reproductive system, and the development of offspring. The clam Meretrix meretrix is one of the commercially important species that is cultivated in large-scale aquaculture in China. To elucidate the underlying molecular mechanisms of Cd2+ in the developmental processes, fertilized eggs and larvae of M. meretrix at different developmental stages were exposed to Cd2+ (27.2 mg L−1 in natural seawater) or just natural seawater without Cd2+ (control), and high-throughput transcriptome sequencing and immunohistochemistry techniques were used to analyze the toxic effects of Cd on larvae at different early developmental stages. The results revealed 31,914 genes were differentially expressed in the different stages of M. meretrix development upon treatment with Cd2+. Ten of these genes were differentially expressed in all stages of development examined, but they comprised only six unigenes (CCO, Ndh, HPX, A2M, STF, and pro-C3), all of which were related to the oxidative stress response. Under Cd exposure, the expression levels of CCO and Ndh were significantly upregulated in D-shaped and pediveliger larvae, while pro-C3 expression was significantly upregulated in the fertilized egg, D-shaped larva, and pediveliger. Moreover, HPX, A2M, and STF expression levels in the fertilized egg and pediveliger larvae were also significantly upregulated. In contrast, CCO, Ndh, HPX, A2M, STF, and pro-C3 expression levels in the postlarva were all downregulated under Cd exposure. Besides the genes with changes in expression identified by the transcriptome, the expression of two other oxidative stress-related genes (MT and Nfr2) was also found to change significantly in the different developmental stages of M. meretrix upon Cd exposure, confirming their roles in combating oxidative stress. Overall, the findings of this study indicated that Cd would interfere with cellular respiration, ion transport, and immune response through inducing oxidative stress, and changes in the expression of oxidative stress-related genes might be an important step for M. meretrix to deal with the adverse effects of Cd at different stages of its development. [ABSTRACT FROM AUTHOR]

As climate conditions deteriorate, human health faces a broader range of threats. This study aimed to determine the risk of death from metabolic syndrome (MetS) due to meteorological factors. We collected daily data from 2014 to 2020 in Wuhu City, including meteorological factors, environmental pollutants and death data of common MetS (hypertension, hyperlipidemia and diabetes), as well as a total number of 15,272 MetS deaths. To examine the relationship between meteorological factors, air pollutants, and MetS mortality, we used a generalized additive model (GAM) combined with a distributed delay nonlinear model (DLNM) for time series analysis. The relationship between the above factors and death outcomes was preliminarily evaluated using Spearman analysis and structural equation modeling (SEM). As per out discovery, diurnal temperature range (DTR) and daily mean temperature (T mean) increased the MetS mortality risk notably. The ultra low DTR raised the MetS mortality risk upon the general people, with the highest RR value of 1.033 (95% CI: 1.002, 1.065) at lag day 14. In addition, T mean was also significantly associated with MetS death. The highest risk of ultra low and ultra high T mean occured on the same day (lag 14), RR values were 1.043 (95% CI: 1.010, 1.077) and 1.032 (95% CI: 1.003, 1.061) respectively. Stratified analysis's result showed lower DTR had a more pronounced effect on women and the elderly, and ultra low and high T mean was a risk factor for MetS mortality in women and men. The elderly need to take extra note of temperature changes, and different levels of T mean will increase the risk of death. In warm seasons, ultra high RH and T mean can increase the mortality rate of MetS patients. [ABSTRACT FROM AUTHOR]

Soil microbial community composition plays a key role in the decomposition of organic matter, while the quality of exogenous organic matter (EOM: rice straw, roots and pig manure) can influence soil chemical and biological properties. However, the evidences of the effect of combination of crop residues and pig manure on the changes in soil microbial community and enzymes activities are scarce. A greenhouse pot experiment was conducted to investigate the potential effect of EOM by analyzing soil properties, enzyme activities and microbial communities. The experiment consisted of eight treatments: CK (control), S (1% (w/w) rice straw), R (1% (w/w) rice root), SR (1% (w/w) rice straw + 1% (w/w) rice root), and added 1% (w/w) pig manure to CK, S, R and SR, respectively. Results showed that the straw treatment significantly increased the microbial biomass (carbon and nitrogen) and total carbon and nitrogen contents, cellulase and β-1,4-glucosidase activities, bacteria (i.e., gram-positive bacteria and gram-negative bacteria) PLFAs contents relative to CK regardless of whether pig manure was added. Moreover, the interaction between crop residues (e.g., straw and roots) and pig manure significantly influenced the contents of microbial biomass nitrogen and microbial biomass phosphorus, and the ratio of gram-positive bacteria to gram-negative bacteria. Redundance analysis confirmed that pH, nitrate nitrogen, ammonium nitrogen and dissolve organic carbon contents were significantly associated with soil microbial community under crop residues without pig manure addition. Furthermore, the experiment results showed that pig manure application not only provided more abundant nutrients (C, N and P) but also induced higher microbial and enzymatic activity compared with no pig manure addition. Our findings suggest that the combination of above-ground straw and pig manure is a better option for improving the functions of soil ecosystem. [ABSTRACT FROM AUTHOR]

Considering the fact that only pores can transport water, pores in the homogeneous control volume are conceptualized as a three-dimensional orthogonal network of line elements, which is in contrast to the continuum hypothesis in traditional numerical approaches. The related flow velocity, hydraulic conductivity and continuity equation equivalent to the continuum model are formulated based on the principle of flow balance. Subsequently, the unified form for flow velocity and continuity equation is established based on the local coordinate system, and a finite line-element method is developed, in which three-dimensional steady free surface flow is reduced to one-dimensional form, and the numerical difficulty is greatly decreased. The proposed line-element model is validated by the good agreements of free surface locations with other methods through steady flow in a rectangular dam and a right trapezoidal dam, respectively. It is found that the proposed line-element model is not heavily dependent on the mesh size and penalty parameter. Steady free surface flow on the left bank abutment slope of the Kajiwa Dam in Southwestern China is further evaluated, and a parabolic variational inequality algorithm based on the continuum model is also employed for comparison. The consistent results indicate that the proposed line-element model can capture the steady free surface flow behavior as well as the continuum-based method. Moreover, the proposed line-element model can rapidly achieve accurate solutions whether for simple examples or for complicated engineering applications. [ABSTRACT FROM AUTHOR]

Objectives. Relationships between safety behavior and its antecedents have been widely studied. However, the psychological decision-making process of construction worker safety behavior (CWSB) is rarely examined from the systematic perspective. Thus, this study constructed the theoretical framework for the decision-making process of CWSB and systematically explored effects of individual factors (education, age and safety knowledge), organizational factors (safety climate and leader–member exchange [LMX]) and psychological factors (psychological capital [PsyCap] and communication competence [CommComp]) on the dynamic performance of CWSB. Methods. Data were collected from the literature and 536 construction workers in China. The theoretical model was tested with the agent-based simulation (ABS) technique. Results. High level of education, safety knowledge, safety climate, LMX, PsyCap and CommComp help to reduce unsafe behavior at the cut-off point. However, the age–safety relationship might present a U-shape, which denotes that reasonable age structure of construction worker groups may be an option for bettering safety performance. The results indicate that the psychological decision-making process of CWSB is not only the result of individual rational decision, but also the product of organizational and psychological impacts. Findings of this study shed lights on safety behavior management practices based on the psychological decision-making process of CWSB. [ABSTRACT FROM AUTHOR]

Objective: This pilot clinical trial investigated solution-focused brief therapy (SFBT) for psychological distress among adolescent and young adult (AYA) patients with cancer in China. Methods: Fifty Chinese AYA patients diagnosed with cancer were randomized into the treatment group (SFBT) and control group (active control). Psychological distress was measured by the brief symptom inventory and hope was measured by the Herth-Hope-Index. Treatment effects were analyzed using analysis-of-covariance and between-group small-sample-size corrected Hedges' g. Results: The results indicated that SFBT resulted in a significant reduction in the psychological distress and improvement in hope of AYA patients with cancer. Analyses of the 4-week posttreatment score suggest the short-term sustainability of SFBT for psychological distress among AYAs diagnosed with cancer. Conclusions and Implications. This study has demonstrated that SFBT's impact is statistically significant and clinically meaningful. The inclusion of positive emotions, i.e., hope, as part of the investigation also highlighted the significance of promoting positive emotions among AYA patients with cancer. [ABSTRACT FROM AUTHOR]

Background: Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China. At present, the efficacy of BBR against HLP is relatively clear, but there are few researches on its mechanism. The purpose of this study was to evaluate the potentially beneficial role of BBR in HLP hamster models, as well as investigate its possible mechanisms and potential lipid biomarkers in combination with network pharmacology.Methods: HLP hamster model was induced by high-fat diet. Hematoxylin-eosin (HE) staining was used to determine the degree of hepatic pathological injury. Liquid chromatography-mass spectrometry was used to analyze lipid metabolism profiles of liver samples, and multiple statistical analysis methods were used to screen and identify lipid biomarkers. The possible molecular mechanism was unraveled by network pharmacology.Results: The results showed that 13 metabolites, including CE (16:1), HexCer (D18:1/19:0) and LPC (O-22:0) were biomarkers of BBR regulation. CHPT1, PLA2G4A, LCAT and UGCG were predicted as the lipid-linked targets of BBR against HLP, whilst glycerophospholipid and sphingolipid metabolism were the key pathways of BBR against HLP.Conclusions: In summary, this study provides new insights into the protective mechanism of BBR against HLP through network pharmacology and lipidomic approaches. [ABSTRACT FROM AUTHOR]

Objectives: COVID-19 pandemic has already had a tremendous impact on the process of human society; the survival of mankind and the healthy living environment deterioration with the influence will last for many years. This meta-analysis aims to assess the risk of COVID-19 in patients with rheumatic diseases. Methods: PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Database (CBM) were systematically searched with no language restriction up to July 5, 2021. The pooled rates were synthesized by fixed effect model or random effect model depending on heterogeneity. Results: A total of 83 articles were included in this meta-analysis. The incidence of COVID-19 in patient with rheumatic diseases was 0.0190 (95% CI: 0.0136-0.0252), and the hospitalization rate, intensive care unit admission rate, mechanical ventilation rate, and case fatality rate of patients with rheumatic diseases infected with COVID-19 were 0.4396 (95% CI: 0.3899-0.4898), 0.0635 (95% CI: 0.0453-0.0836), 0.0461 (95% CI: 0.0330-0.0609), and 0.0346 (95% CI: 0.0218-0.0493), respectively. Conclusions: Our research shows that patients with rheumatic diseases have great risk of COVID-19. Differences in COVID-19 incidence, hospitalization rates, and mortality rates in regions were statistically significant. We still need to pay attention to the risk of COVID-19 in patients with rheumatic diseases. Key Points: • Although the risk of COVID-19 in patients with rheumatic diseases has been discussed in previous meta-analysis, their research directions were inconsistent, and few studies focus on prevalence or serious outcomes of COVID-19 in patient with rheumatic diseases, while the quality of these articles was variable. • The incidence of COVID-19 and serious clinical outcomes in patients with rheumatic diseases were still high along with differential risks in most regions. • The use of glucocorticoids and conventional synthetic disease-modifying antirheumatic drugs did not affect the hospitalization rate and mortality in rheumatism patients with COVID-19. [ABSTRACT FROM AUTHOR]

Volcanic rocks are generally characterized by significant spatial variations of lithofacies. The characterization of volcanic lithofacies is an important tool to achieve accurate reservoir prediction during hydrocarbon exploration because of the type of lithofacies strictly controls the porosity and other physical and chemical properties of reservoir rocks. Studying the lithofacies of rhyolitic volcanic rocks is essential for uncovering the genesis and characteristics of volcanic reservoirs. The Lower Cretaceous Shangkuli Formation is located on the western boundary of the Hailar Basin in NE China. This basin hosts oil-bearing rhyolitic volcanic rocks and represents a natural laboratory for investigating the spatial distribution of different lithologies and volcanic lithofacies. Here, we present detailed field observations, TESCAN Integrated Mineral Analysis (TIMA), and fluorescence imaging to characterize seven types of rhyolitic volcanic rocks belonging to four main lithofacies associations. We examine the relationship between lithofacies associations and reservoir rocks. Field observations reveal the existence of volcanic conduit, pyroclastic, effusive, and extrusive lithofacies associations within the Hailar Basin. These lithofacies associations can be further subdivided into nine distinct subfacies. Among these, the extrusive lithofacies association is dominant and it is followed by pyroclastic, effusive, and volcanic conduit lithofacies associations. Intra-spherulite microfractures and pores, lithophysa cavities in the extrusive lithofacies associations, and inter-clast pores of the volcanic conduit lithofacies associations constitute the primary reservoir spaces of rhyolitic reservoirs. The lithofacies associations exert a control on the reservoir spaces of rhyolitic volcanic rocks by limiting the degree of supercooling (Δ T) and volatile content, which impact the formation of different textures in rhyolitic magma during syn-eruptive processes. We conclude that spherulitic and lithophysa rhyolites in the extrusive lithofacies associations, and the crypto-explosive breccias in the volcanic conduit lithofacies associations are promising targets for oil and gas exploration. The facies model we obtain from the Hailar Basin may be extended to similar rhyolitic rocks in other basins hosting unconventional reservoirs. • A comprehensive lithofacies model for rhyolitic volcanic rocks was developed. • Distinctive features and types of reservoir spaces within lithofacies were elucidated. • Extrusive and explosive lithofacies were identified as potentially the most favorable targets. • Volcanic lithofacies exert control over reservoir spaces by influencing Δ T and volatiles. [ABSTRACT FROM AUTHOR]

The Eastern Depression in the Bayanhaote Basin in western Inner Mongolia has experienced multi-stage Meso-Cenozoic tectonic events and possesses considerable exploration potential. However, structural deformation patterns, sequences and the genesis of oil-bearing structures in the basin are still poorly understood. In this study, based on high-quality 2D seismic data and drilling and well-logging data, we elucidate the activities and structural styles of faults, the tectonic evolution and the distribution characteristics of styles, as well as assessing potential petroleum traps in the Eastern Depression. Five types of faults that were active at different stages of the Meso-Cenozoic faults have been recognized: long-lived normal faults active since the late Middle Jurassic; reverse faults and strike-slip faults active in the late Late Jurassic; normal faults active in the Early Cretaceous; normal faults active in the Oligocene; and negative inverted faults active in the Early Cretaceous and Oligocene. These faults constituted 12 geometric styles in NE-trending belts at various stratigraphic levels, and were formed by compression, strike-slip, extension and inversion. The temporal development of structural styles promoted the formation and reconstruction and finalization of structural traps, while regional unconformities and open reverse and strike-slip faults provided migration pathways for petroleum to fill the traps. In general, potential traps that formed by compressional movement and strike-slip movement in the late Late Jurassic are primarily faulted anticlines. Those traps developed in Carboniferous rocks and are located in the southwestern region of the Eastern Depression, being controlled by NNE-NE-striking reverse and transpressive faults. [ABSTRACT FROM AUTHOR]

As COVID-19 rapidly overwhelmed the world in 2020, medical social workers have fought against the disease on the front lines as a member of medical teams, but little is known about the impact of the pandemic on their mental health. This study investigated the resilience, perceived social support and professional quality of life of medical social workers in Mainland China under the influence of the COVID-19 pandemic. An online questionnaire survey was applied to 319 respondents and the results showed that informal support was positively related with compassion satisfaction (r = 0.67, p <.01) and negatively correlated with job burnout (r = −0.51, p <.01) while formal support was positively associated with compassion satisfaction (r = 0.61, p <.01) and negatively associated with job burnout (r = −0.44. p <.01). Resilience was positively correlated with compassion satisfaction (r = 0.56, p <.01) and negatively correlated with job burnout (r = −0.49, p <.01). Nevertheless, neither perceived social support nor resilience was associated with secondary traumatic stress. The regression results further highlighted the role of informal social support on job burnout. Measures should be taken to enhance the professional quality of life for medical social workers during a public health crisis. [ABSTRACT FROM AUTHOR]

Identifying lithology from well logs is an important step in deep prospecting and resource estimation. Various machine learning algorithms have been adopted to identify lithology in oil and gas fields. Such algorithms, however, are rarely used for mineral deposits because of their complex geological conditions. In this paper, we propose an application framework using the gradient boosting decision tree (GBDT) algorithm to identify lithology from well logs in a mineral deposit. The GBDT classifier was built via the procedure of grid search and cross-validation to optimize the hyperparameters. In the Zhaoxian gold deposit, as the study area, an optimized GBDT classifier was built to fit the association between a set of well logs and ten lithological classes. The results demonstrate that the GBDT classifier has good classification performance in lithology identification, with a precision of 93.55%, a recall of 93.49% and an F1-score of 93.27%. The GBDT classification results also indicate that the major features contributing to the lithology classification are resistivity, followed by spontaneous potential and natural gamma according to the model interpretation of feature importance and partial dependence plots. The study demonstrates that the GBDT model can enhance our understanding of lithology identification from well logs in mineral deposits, which provides significant implications for further exploration targeting the deep-seated parts of mineral deposits. [ABSTRACT FROM AUTHOR]

Background: CD161, encoded by killer cell lectin-like receptor B1 gene, is a newly reported candidate inhibitor of tumour-infiltrating T cells. Antibody-mediated CD161 blockade enhances T cell-mediated killing of cancer cells in vitro and in vivo in several tumour types. We evaluated the role of CD161 using The Cancer Genome Atlas (TCGA) Pan-Cancer Data. Methods: CD161 expression was analysed using RNAseq data from TCGA and the Genotype-Tissue Expression (GTEx) database. HPA, GeneCards, and String database were used to explore the protein information of CD161. The prognostic value of CD161 was analysed using clinical survival data from the TCGA. Enrichment analysis of CD161 was conducted using the R package "clusterProfiler". We downloaded the immune cell infiltration score of TCGA samples from published articles and online databases and performed a correlation analysis between immune cell infiltration levels and CD161 expression. We further assessed the association between CD161 and immune checkpoints, immune activating genes, immunosuppressive genes, chemokines, and chemokine receptors. Findings: CD161 was differentially expressed and predicted better survival status in most tumour types in TCGA. In addition, CD161 expression was significantly associated with immunoregulatory interactions between lymphoid and non-lymphoid cells. CD161 expression was closely correlated with T cell infiltration, immune checkpoints, immune activating genes, immunosuppressive genes, chemokines, and chemokine receptors. Interpretation: Our results suggest that CD161 is a potential cancer biomarker. CD161 might synergize with other immune checkpoints to regulate the immune microenvironment, which could be applied in the development of new-targeted drugs for immunotherapy. Funding: This work was supported by the National Nature Science Foundation of China (grant numbers 81773008, 81672756, 81872399, 81972897), the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2015), the Natural Science Foundation of Guangdong Province (grant number 2017A030311023), the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program: 2017BT01S131 and the Guangzhou Technology Project (grant number 201804010044), National Key R&D Program of China (Grant Nos. 2020YFC2006400), Key-Area Research and Development Program of Guangdong Province (2019B020227004). [ABSTRACT FROM AUTHOR]

Mongolian sheep are a breed of sheep in China known for their excellent cold and drought resistance. Sperm from Mongolian sheep are often cryopreserved to improve breeding outcomes. However, cryopreservation of sperm often results in issues such as reduced vitality and altered morphology. Therefore, the objective of this study was to investigate the impact of the cryoprotectant resveratrol on frozen sperm from Mongolian sheep, specifically examining its effects on key proteins during cryopreservation. In this study, sperm samples were obtained from three adult Mongolian rams and processed through semen centrifugation. The sperm motility parameters of Fresh Sperm Group (FR), Resveratrol added before freezing group (FF-Res), Resveratrol-free frozen sperm group (FT), and Resveratrol added after freeze-thawing group (FA-Res) were determined. The tandem mass tags (TMT) peptide labeling combined with LC-MS/MS was used for proteomic analysis of the total proteins in FR and FT groups. A total of 2651 proteins were identified, among which 41 proteins were upregulated and 48 proteins were downregulated after freezing. In-depth bioinformatics analysis of differentially abundant proteins (DAPs) revealed their close association with the tricarboxylic acid cycle (TCA) and oxidative phosphorylation pathway. The energy-related protein dihydrolipoamide dehydrogenase (DLD) and the reactive oxygen species (ROS)-related protein NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) exhibited significant decreases, indicating their potential role as key proteins contributing to reduced sperm vitality. The study demonstrated that the addition of resveratrol (RES) to semen could elevate the expression levels of DLD and NDUFB9 proteins. This study represents the pioneering proteomic analysis of Mongolian ram sperm before and after cryopreservation, establishing the significance of DLD and NDUFB9 as key proteins influencing the decline in vitality following cryopreservation of Mongolian ram sperm. These findings clarify that resveratrol can enhance the levels of DLD and NDUFB9 proteins in cryopreserved Mongolian ram sperm, consequently enhancing their vitality. • Adding Res to sperm prior to freezing can effectively enhance the post-thaw vitality of sperm. • Significant changes were observed in the proteins NDUFB9 and DLD during the process of sperm cryopreservation. • Adding Res to sperm before freezing reduced the changes in NDUFB9 and DLD. [ABSTRACT FROM AUTHOR]

Purpose: Given the critical role of parental care for pediatric cancer patients, this pilot study evaluated the feasibility and effectiveness of a hospital-based solution-focused brief therapy (SFBT) intervention for reducing psychological distress among parents of pediatric cancer patients in China. Differences between treatment and active control (AC) groups were assessed on dimensions of psychological distress. Parents' level of hope was also assessed.Methods: Participants (N = 44) were randomly assigned to SFBT or AC. Parents received four sessions of SFBT twice a week delivered by graduate-level hospital social workers. Pre- and post-intervention assessments measured change in distress (depression, anxiety, and somatization symptoms) of parents as well as their level of hope.Results: Analysis of covariance (ANCOVA) indicated the SFBT group had better outcomes than the AC group on overall distress of somatic, anxiety, depression symptoms and level of hope. Within- and between-group treatment effects reported significantly greater effect of the SFBT group than of the AC group.Conclusions: Considering the inherent limits of a pilot feasibility study, results suggest that SFBT is a feasible, culturally compatible, and promising intervention for alleviating distress among Chinese parents of children with cancer. Additional comprehensive trials are needed to draw more definitive conclusions.Relevance: SFBT may be beneficial for improving the critical support systems of parents of pediatric cancer patients. Thus, SFBT may have the potential to enhance children's well-being during cancer treatment and recovery. [ABSTRACT FROM AUTHOR]

[Display omitted] • The causes of seasonal changes in Faunal assemblages and food-web structures were analyzed in coral reefs. • Macroalgae and benthic microalgae were the primary food sources that feed the food web of coral reef ecosystems. • Climate change might be the primary reasons for the changes in consumer community composition and carbon and nitrogen isotopes. • Seasonal environmental changes did not affect the stability of the nutrient structure of the coral reef food web on WZZ. With a high species diversity of coral reefs, Wuzhizhou (WZZ) is a tropical marine ranch built by China. In the present study, we investigated the structure and function of coral reef food webs on WZZ in Sanya to understand how climate change and human activities affected coral reef ecosystems. Using carbon and nitrogen stable isotopes and the Bayesian mixture models, we assessed the major organic matter pathways and causes of seasonal variation in coral reef fauna and isotope values to delineate ecosystem function. Macroalgae and benthic microalgae were the primary food sources feeding this food web, while there were also some notable seasonal variations. Nutrient changes caused by temperature, upwelling, and tropical cyclones might be the primary reasons for the changes in consumer community composition and carbon or nitrogen isotopes. Seasonal environmental changes did not affect the stability of the nutrient structure of the coral reef food web on WZZ. [ABSTRACT FROM AUTHOR]

The Songshan Lake Science and Technology Industrial Park is a national economic transition demonstration area, which centers at a traditional industrial region, in Dongguan, China. We were interested in the involved atmospheric particulates-bound PAHs regarding their sources, cancer risk, and related cellular toxicity for those in other areas under comparable conditions. In this study, the daily concentrations of TSP, PM 10 , and PM 2.5 were averaged 127.95, 95.91, and 67.62 μg/m3, and the bound PAHs were averaged 1.31, 1.22, and 0.77 ng/m3 in summer and 12.72, 20.51 and 40.27 ng/m3 in winter, respectively. The dominant PAHs were those with 5–6 rings, and 4–6 rings in summer and winter, respectively. The incremental lifetime cancer risk (ILCR) (90th percentile probability) of total PAHs was above 1.00E-06 in each age group, particularly high in adolescents. Sensitivity analysis indicated that slope factor and body weight had greater impact than exposure duration and inhalation rate on the ILCR. Moreover, treatment of human bronchial epithelial BEAS-2B cells with mixed five indicative PAHs increased the formation of ROS, DNA damage (elevation in γ-H2AX), and protein levels of CAR, PXR, CYP1A1, 1A2, 1B1, while reduced the AhR protein, with the winter mixture more potent than summer. For the sources of PAHs, the stable carbon isotope ratio analysis and diagnostic ratios consistently pointed to petroleum and fossil fuel combustion as major sources. In conclusion, our findings suggest that particulates-bound PAHs deserve serious concerns for a cancer risk in such environment, and the development of new power sources for reducing fossil fuel combustion is highly encouraged. • Higher concentration of some PAH levels were observed in winter season than summer. • Life time cancer risk assessment depicts on carcinogenic health impacts, especially for adolescents. • Winter PAHs mixture caused cytotoxicity in vitro with potencies higher than summer. • Petroleum and fossil fuel combustion were observed to be the prominent sources of PAHs. [ABSTRACT FROM AUTHOR]

• Caregiver's language richness plays a supporting role on early child development. • Caregiver's language richness works better for boys and poverty households. • Caregiver language suitability has moderated effects. • Parent-child interaction videos were coded for language richness and suitability. There is rich literature on the predictive role of the caregiver's language richness in child development outcomes during caregiver-child interaction. However, it is unclear whether this is true in rural China, where many young children are still not developing to their fullest potential. Our study supplements the current evidence in rural China by answering three questions. First, is the rural caregiver's language richness associated with child development outcomes? Second, do different child characteristics, caregiver characteristics, and household poverty status affect the relationship between caregiver language richness and early child development outcomes? Third, does the caregiver's language suitability moderate the association between language richness and child development outcomes? We observed and recorded 10-minute-long videos of 591 rural children aged 6–30 months and their primary caregiver dyads in a free toy play session and collected their social-demographic information. Trained coders coded videotaped interactions to obtain measurements of the caregiver's language richness and suitability. Children were assessed for cognitive, language, motor, and social-emotional development. A multivariate linear regression model adjusted for covariates was used to estimate the association between the caregiver's language richness and child development outcomes. Interaction terms were then added to the adjusted model to explore the moderating role of caregivers' language suitability, child characteristics, caregiver characteristics, and household poverty status. The caregiver's language richness is positively associated with the child's cognitive, language, motor, and social-emotional development. The association is more pronounced for children who are boys, in later toddlerhood, or from registered poverty households. In addition, we found that the caregiver's language suitability could enhance the association between language richness and child development outcomes. [ABSTRACT FROM AUTHOR]

The vegetation coverage on the Loess Plateau (LP) of China has clearly increased since the implementation of the Grain for Green Project in 1999, but there is a debate about whether the improved greenness was achieved at the expense of the balance between the supply and demand of water resources. Therefore, developing reliable indicators to evaluate the water availability is a prerequisite for maintaining ecological sustainability and ensuring the persistence of vegetation restoration. This study was designed to evaluate water availability on the LP during 2000–2015, using the evaporative stress index (ESI) derived from a remote sensing dataset. The relative dependences of the ESI on climatic and biological factors (including temperature, precipitation and land cover change) were also analyzed. The results showed that the leaf area index (LAI) in most regions of the LP showed a significant increasing trend (p < 0.05), and larger gradients of increase were mainly detected in the central and eastern parts of the LP. The evapotranspiration also exhibited an increasing trend in the central and eastern parts of the LP, with a gradient greater than 10 mm/year. However, almost the whole LP exhibited a decreased ESI from 2000 to 2015, and the largest decrease occurred on the central and eastern LP, indicating a wetting trend. The soil moisture storage in the 0–289-cm soil profiles showed an increasing trend in the central and eastern LP, and the area with an upward trend enlarged with the soil depth. Further analysis revealed that the decreased ESI on the central and eastern LP mainly depended on the increase in the LAI compared with climatic influences. This work not only demonstrated that the ESI was a useful indicator for understanding the water availability in natural and managed ecosystems under climate change but also indicated that vegetation restoration might have a positive effect on water conservation on the central LP. [ABSTRACT FROM AUTHOR]

Quantitatively identifying the influences of vegetation restoration (VR) on water resources is crucial to ecological planning. Although vegetation coverage has improved on the Loess Plateau (LP) of China since the implementation of VR policy, the way vegetation dynamics influences regional evapotranspiration (ET) remains controversial. In this study, we first investigate long-term spatiotemporal trends of total ET (TET) components, including ground evaporation (GE) and canopy ET (CET, sum of canopy interception and canopy transpiration) based on the GLEAM-ET dataset. The ET changes are attributed to VR on the LP from 2000 to 2015 and these results are quantitatively evaluated here using the Community Land Model (CLM). Finally, the relative contributions of VR and climate change to ET are identified by combining climate scenarios and VR scenarios. The results show that the positive effect of VR on CET is offset by the negative effect of VR on GE, which results in a weak variation in TET at an annual scale and an increased TET is only shown in summer. Regardless of the representative concentration pathway (RCP4.5 or RCP8.5), differences resulted from the responses of TET to different vegetation conditions ranging from −3.7 to −1.2 mm, while climate change from RCP4.5 to RCP8.5 caused an increase in TET ranging from 0.1 to 65.3 mm. These findings imply that climate change might play a dominant role in ET variability on the LP, and this work emphasizes the importance of comprehensively considering the interactions among climate factors to assess the relative contributions of VR and climate change to ET. [ABSTRACT FROM AUTHOR]

Liver failure is a severe clinical syndrome with high mortality. 5-Hydroxytryptamine 3 receptor antagonists (5-HT3RAs) can reduce liver damage in animal models. We investigated whether 5-HT3RAs may improve the prognosis of liver failure. We analyzed the 28 and 90 days mortality of liver failure patients in relation to the use of 5-HT3RAs using data from a tertiary hospital in northwest China. According to the use of 5-HT3RAs, 419 patients with liver failure (46 acute, 93 sub-acute, 44 chronic, 236 acute on chronic) were divided into 5-HT3RA group (n = 105) and control group (n = 314). 5-HT3RAs were associated with decreased 28 days (HR 0.18, 95% CI 0.10-0.34, p < 0.001) and 90 days (HR 0.21, 95% CI 0.13-0.33, p < 0.001) mortality. After propensity score matching (PSM) (n = 67 in each group), 5-HT3RAs were still significantly associated with reduced 28 days (HR 0.10, 95%CI 0.04-0.26, p < 0.001) and 90 days (HR 0.16, 95%CI 0.08-0.31, p < 0.001) mortality. 5-HT3RA group patients had significantly higher 28 and 90 days survivals than controls both before and after PSM (all p < 0.001). This study shows that 5-HT3RAs are associated with increased survival of liver failure patients and thus may be used to treat liver failure if the findings are confirmed by additional studies. [ABSTRACT FROM AUTHOR]

Construction workers face a work environment of high risk and mental stress. Psychological capital (PsyCap) could influence employee's mental health and work performance. It would be helpful to determine whether PsyCap affects worker safety behavior. However, few studies empirically examined the impacts of the sub-dimensions of PsyCap on the safety behavior in construction settings, reducing the potential practicability of PsyCap to improve workplace safety performance. Thus, this study tested the relationship between sub-dimensions of PsyCap (self-efficacy, hope, resilience, optimism) and safety behaviors (safety compliance, safety participation), while the mediating role of communication competence was also explored. Method: Data were collected from 655 construction workers in China using a psychological capital questionnaire (PCQ). The theoretical model were tested with confirmatory factor analyses (CFA) and structural equation modeling (SEM) techniques. Results: Results show that: (a) the self-efficacy dimension of PsyCap positively affected safety compliance and safety participation, while the resilience dimension positively impacted safety participation; (b) the hope dimension was not directly related to safety behaviors, while the optimism dimension negatively associated with safety participation; and (c) communication competence mediated the relationships between the hope and optimism dimensions of PsyCap and safety participation. Conclusions: A multidimensional perspective on PsyCap should be taken while examining its effects on safety behavior and the individual communication competence helps to enhance construction safety. Findings of this study shed lights on safety behavior promotion practices based on the multidimensional model. Initiating flexible psychological capital training and intervention, and strengthening communication skills of construction employees are suggested to improve safety performance in the construction industry. [ABSTRACT FROM AUTHOR]

This study compared the hospitalization expenses of patients with chronic bronchitis in a central province (Province A) in China to estimate the direct medical cost of the family. Our data included hospitalization records of 30,341 patients with chronic bronchitis from five urban general hospitals in Province A. Using descriptive statistics and regression analysis, we explored the relevant factors affecting hospitalization expenses. Our study results have indicated that from 2016 to 2020, the medical expenditure of patients with chronic bronchitis increased annually, with an average annual growth rate of 22.65%. Among all kinds of expenses, the hospitalization expenses, drug cost, bed cost, test cost and other cost of UEMI (Urban Employee Medical Insurance) are higher than that of other types of medical insurance. The check-up fees of CMI (Commercial Insurance) are lower than that of other types of insurance. Between 2016 and 2019, the average medical expenses per patient with chronic bronchitis increased by 44%, which is the highest average medical expenses among patients aged 60-70. And the highest average medical expenditure emerged when the number of service days is between 5 and 10 days. The increase in expenditure could be attributed to the rapid development of medical technology and the increasing medical demand of the people. Overall, the results of our study implied a significant increase in medical expenses for patients with chronic bronchitis from 2015 to 2020, indicating that chronic bronchitis could bring heavy economic pressures to patients, their families and society., (© 2024. The Author(s).)

Fine particulate matter (PM 2.5 ) may disrupt women's reproductive hormones, posing potential reproductive risks. However, the exact compositions of PM 2.5 responsible for these effects remain unclear. Our investigation explored the long-term impacts of PM 2.5 constituents on reproductive hormones, based on a large longitudinal assisted reproductive cohort study in Anhui, China. We included 24,396 reproductive hormone samples from 19,845 women attending assisted reproductive technologies (ART) between 2014 and 2020. Using high-resolution gridded data (1-km resolution), we calculated the residence-specified PM 2.5 constituents during the year before the month of hormone testing. Relationships between PM 2.5 constituents [organic matter (OM), chloride (Cl - ), sulfate (SO 4 2- ), ammonium (NH 4 + ), black carbon, and nitrate] and reproductive hormones were investigated using the linear mixed model with subject-specific intercepts. The constituent-proportion model and the constituent-residual model were also constructed. Additionally, cubic spline analysis was used to examine the potential non-linear exposure-response relationship. We found that per interquartile range (IQR) increment in OM was associated with a 5.31 % (3.74 %, 6.89 %) increase in estradiol, and per IQR increment in Cl - and NH 4 + were associated with 13.56 % (7.63 %, 19.82 %) and 9.07 % (4.35 %, 14.01 %) increases in luteinizing hormone. Conversely, per IQR increment in OM and Cl - were associated with -7.27 % (-9.34 %, -5.16 %) and -8.52 % (-10.99 %, -5.98 %) decreases in progesterone, and per IQR increment in SO 4 2- was associated with a -9.15 % (-10.31 %, -7.98 %) decrease in testosterone. These associations were held in both proportional and residual models. Moreover, exposure-response curves for estradiol and progesterone with PM 2.5 constituents exhibited approximately U-shaped. These results suggested that specific PM 2.5 constituents might disrupt reproductive hormone homeostasis in women attending ART, providing new evidence for formulating PM 2.5 pollution reduction strategies that could benefit women's reproductive health., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Background: Artificial light at night, a well-recognized circadian clock disrupter, causes disturbances in endocrine homeostasis. However, the association of artificial light at night with polycystic ovary syndrome (PCOS) is still unknown. This study examines the effects of outdoor artificial light at night on sex hormones, glucose homeostasis markers, and PCOS prevalence in Anhui Province, China., Methods: We recruited 20,633 women of reproductive age from Anhui Medical University Reproductive Medicine Center. PCOS was diagnosed according to Rotterdam criteria. We estimated long-term (previous year) and short-term (previous month) artificial light at night values for residential addresses using 500 m resolution satellite imagery. We fitted multivariable models, using both linear and logistic regression, to estimate the association of artificial light at night with sex hormones, glucose homeostasis markers, and PCOS prevalence., Results: Both long-term and short-term exposure to outdoor artificial light at night were negatively associated with follicle-stimulating hormone and luteinizing hormone levels, while positively associated with testosterone, fasting insulin, homeostasis model assessment-insulin resistance, and homeostasis model assessment-insulin resistance-β levels. The second-highest quintile of artificial light at night was associated with increased PCOS prevalence (odds ratio [OR long-term ] = 1.4; 95% confidence interval [CI] = 1.2, 1.6 and OR short-term = 1.3; 95% CI = 1.1, 1.5) compared with the lowest quintile. In addition, prevalence of PCOS was linearly associated with long-term exposure to artificial light at night, but nonlinearly associated with short-term exposure. This association was more evident in younger, obese or overweight, moderately educated, rural women, and for the summer and fall seasons., Conclusion: Outdoor artificial light at night may be a novel risk factor for PCOS., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Objective: A case-control study was utilized to investigate the relationship between genetic variation of JAK-STAT signaling pathway-related genes and the susceptibility to ankylosing spondylitis (AS)., Methods: Fifteen SNPs in the JAK-STAT signaling pathway-related genes from 660 AS patients and 646 healthy controls were genotyped using iMLDR technology (JAK1: rs2230587, rs2230588, rs2780815, rs310241; JAK2: rs2274472, rs2230722, rs2230724, rs10758669; STAT1: rs10199181, rs1547550, rs2066802, rs45463799, rs6718902; STAT3: rs3744483; STAT5A: rs1135669)., Results: Allele analysis revealed that the T allele of STAT1 rs6718902 was a protective agent for male AS patients (OR = 0.765, 95% CI = 0.644-0.909). Inheritance models showed that GG + CG as well as GG genotypes of STAT1 rs1547550 had a significant risk of developing AS in males (OR = 5.374, 95%CI = 2.505-11.526; OR = 5.186, 95%CI = 2.412-11.153). The TT + CT and TT genotypes at STAT1 rs6718902 were observed to be associated with a significantly decreased risk of AS compared to CC genotypes among male patients and male controls (OR = 0.637, 95%CI = 0.485-0.837; OR = 0.597, 95%CI = 0.422-0.845). Furthermore, the genotypes of JAK1 gene rs2230588, rs2780815, and rs310241 were correlated with the severity of clinical conditions in female AS patients, while the JAK2 rs2230724 genotypes may affect disease ability in male AS patients., Conclusion: These findings indicated that JAK-STAT signaling pathway-related gene single nucleotide polymorphisms may be associated with AS susceptibility in eastern Chinese Han population. Key Points • The T allele of rs6718902 on the STAT1 gene may be a protective agent for male AS patients. • STAT1 rs1547550 GG + CG and GG genotypes were observed to be connected with a risk of male AS patients. However, STAT1 rs6718902 TT + CT and TT genotypes reduced the susceptibility risk of male AS patients compared to wild-type CC. • The JAK1 genes rs2230588, rs2780815, and rs310241 may affect disease functional status in female AS patients, while the JAK2 rs2230724 genotype was related to disease activity in male AS patients., (© 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).)

As the climate continues to change, suicide is becoming more frequent. In this study, absolute humidity (AH) was included for the first time and Wuhu, a typical subtropical city along the Yangtze River, was taken as the research object to explore the impact of suicide death risk on meteorological factors. The daily meteorological factors and suicide mortality data of Wuhu city from 2014 to 2020 were collected. Guided by structural equation model (SEM), a time series analysis method combining distributed lag nonlinear model (DLNM) and generalized additive model (GAM) was adopted. To investigate the correlation among different populations, we stratified age and gender at different meteorological levels. A total of 1259 suicide deaths were collected in Wuhu. The results indicated that exceedingly low and low levels of AH short-term exposure increased suicide mortality, with the maximum effect occurring at lag 14 for both levels of exposure, when the relative risk (RR) was 1.131 (95% CI: 1.030, 1.242) and 1.065 (95% CI: 1.006, 1.127), respectively. Exposure to exceedingly high and exceedingly low levels of temperature mean (T mean) also increased suicide mortality, with maximum RR values of 1.132 (lag 14, 95% CI: 1.015, 1.263) and 1.203 (lag 0, 95% CI: 1.079, 1.340), sequentially. As for diurnal temperature range (DTR), low-level exposure decreased the risk of suicide, while high-level exposure increased this risk, with RR values of 0.955 (lag 0, 95% CI: 0.920, 0.991, minimum) and 1.060 (lag 0, 95% CI: 1.018, 1.104, maximum), sequentially. Stratified analysis showed that AH and DTR increased the suicide death risk in male and elderly people, while the risk effect of T mean have no effect on young people only. In summary, male and elderly people appear to be more vulnerable to adverse weather effects., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

The influence of aridification and climatic oscillations on the genetic diversity and evolutionary processes of organisms during the Quaternary in northwestern China is examined using Haloxylon ammodendron . Based on the variation of two cpDNA regions (trnS-trnG and trnV) and one nDNA sequence (ITS1-ITS4) in 420 individuals from 36 populations, the spatial genetic structure and demographic history of H. ammodendron in arid China is examined. Median-joining network and Bayesian inference trees enabled the identification of three diverged lineages within H. ammodendron from 24 different haplotypes and 16 ribotypes, distributed across western (Xinjiang), eastern (Gansu and Inner Mongolia) and southern (Qinghai) regions. AMOVA analysis demonstrated that more than 80% of observed genetic variation related to lineage split was based on cpDNA and nDNA variation. Allopatric divergence among the three groups was mainly triggered by geographical isolation due to Xingxingxia rock and uplift of the Qilian Mountains during the Quaternary. Local adaptive differentiation among western, eastern and southern groups occurred due to gene flow obstruction resulting from arid landscape fragmentation accompanied by local environmental heterogeneity of different geographical populations. The southern margin of the Junggar Basin and the Tengger Desert possibly served as two independent glacial refugia for H . ammodendron . The distribution of genetic variation, coupled with SDMs and LCP results, indicated that H. ammodendron probably moved northward along the Junggar Basin and westward along Tengger Desert at the end of the last glacial maximum; postglacial re-colonization was probably westward and southward along the Hexi Corridor., Competing Interests: The authors declare there are no competing interests., (©2022 Chen et al.)

Rheumatoid arthritis (RA) is an autoimmune disease, mainly characterized by erosional arthritis. The proportion of adults suffering from RA is about 0.5%-1%. There have been reports on the association of rainfall and traffic-related air pollutants with RA hospitalization rates. However, there have been no studies on the association of diurnal temperature range (DTR) and relative humidity (RH) with RA hospitalization rates. This study aimed to examine the short-term association of DTR, RH and other meteorological factors with the hospital admission rate of RA patients, while excluding the interference of PM 2.5 , SO 2 , NO 2 , CO and O 3 atmospheric pollutants. We collected daily RA occupancy rate and meteorological factor data in Hefei city from 2015 to 2018 and used the generalized additive model (GAM) combined with the distributed lag nonlinear model (DLNM) for time series analysis, and further stratified analysis by gender and age. Single-day and cumulative-day risk estimates of RA admissions were expressed as relative risk (RR) and its 95% confidence interval (95% CI). For the cumulative-day lag model, high RH was statistically significant after cumulative lag 0-8 days, and the effect gradually increases. Stratified analysis shows that females seem to be more susceptible to high or extremely high DTR and RH exposure, and extremely high DTR exposure may increase the risk of RA admission in all populations. In conclusion, this study found that high DTR and high RH exposure increased the risk of hospitalization in RA patients and provided clues to the potential association between other meteorological factors and RA., (Copyright © 2021. Published by Elsevier Inc.)

This study was conducted to describe the association between the genetic variation of the recently identified immune checkpoint molecules B7-H3 and B7-H4, and the susceptibility to ankylosing spondylitis (AS). Two single nucleotide polymorphisms (SNPs) of B7-H3 gene and three SNPs of B7-H4 gene were genotyped in 649 AS patients and 646 age- and sex-matched healthy controls. Allele, genotype frequencies and different inheritance models were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and the demographic and clinical parameters of patients were recorded. Our data indicated that B7-H4 rs10801935 and rs3738414 polymorphisms were correlated with AS susceptibility. In the stratification analyses, the minor A allele and GA genotype of B7-H4 rs3738414 increased the risk of AS in male patients (OR = 1.244, 95%CI = 1.026-1.508; OR = 1.453, 95%CI = 1.120-1.886, respectively). However, the association did not reach statistical significance after Bonferroni correction. Furthermore, haplotype analysis revealed that B7-H4 haplotype block TAG was a risk factor for the onset of AS (OR = 1.190, 95%CI = 1.020-1.389). These findings suggested that B7-H4 gene polymorphism may contribute to AS susceptibility in eastern Chinese Han population., (© 2021 John Wiley & Sons Ltd.)

Background: The air pollution has become an important environmental health problem due to its adverse health effect. The objective of this study was to investigate the effects of ambient temperature and pollutants on mortality of respiratory diseases (RD) in Hefei, China, a typical inland city., Methods: Nonlinear exposure-response dependencies and delayed effects of urban daily mean temperature (DMT) and pollutants were evaluated by distributed lag non-linear models (DLNM). To further explore this effect, different genders and ages were also examined by stratified analysis., Results: A total of 12876 deaths from RD were collected from January 1, 2014 to December 31, 2018 in Hefei, China. There was a U-shaped correlation between DMT and RD mortality, and the RD mortality rised by 11.6% (95% CI: 2.2-22.0%) when the DMT was 35.8 °C (reference temperature is 20 °C). The results show that risk of death with short-term exposure to elevated concentrations of PM 10 and SO 2 was not significant. The maximum hysteresis and cumulative relative risk (RR) of RD mortality were 1.012 (95% CI: 1.003 ~ 1.021, lag 0 day) and 1.072 (95% CI: 1.014 ~1.133, lag 10 days) for each 10 μg/m 3 augment in NO 2 ; 1.005 (95% CI: 1.001-1.009, lag 0 day) and 1.027 (95% CI: 1.004-1.051, lag 10 days) for each 10 μg/m 3 augment in O 3; a negative association between CO exposure and the cumulative risk of death was observed (RR = 0.964, 95% CI: 0.935-0.993, lag 07 days). Subgroup analysis showed the effect of high temperatures, NO 2, O 3 and CO exposure was still statistically significant for the elderly and male., Conclusion: The present study found that short-term exposure to high temperature, NO 2, O 3 and CO were significantly associated with the risk of RD mortality and male as well as elderly are more susceptible to these factors., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)

Background: The epidemic of COVID-19 presents a special threat to older adults. However, information on kidney damage in older patients with COVID-19 is limited. Acute kidney injury (AKI) is common in hospitalized adults and associated with poor prognosis. We sought to explore the association between AKI and mortality in older patients with COVID-19., Methods: We conducted a retrospective, observational cohort study in a large tertiary care university hospital in Wuhan, China. All consecutive inpatients older than 65 years with COVID-19 were enrolled in this cohort. Demographic data, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between patients with AKI and without AKI. The association between AKI and mortality was analyzed., Results: Of 1764 in-hospital patients, 882 older adult cases were included in this cohort. The median age was 71 years (interquartile range: 68-77), 440 (49.9%) were men. The most presented comorbidity was cardiovascular diseases (58.2%), followed by diabetes (31.4%). Of 882 older patients, 115 (13%) developed AKI and 128 (14.5%) died. Patients with AKI had higher mortality than those without AKI (68 [59.1%] vs 60 [7.8%]; p < .001). Multivariable Cox regression analysis showed that increasing odds of in-hospital mortality are associated with higher interleukin-6 on admission, myocardial injury, and AKI., Conclusions: Acute kidney injury is not an uncommon complication in older patients with COVID-19 but is associated with a high risk of death. Physicians should be aware of the risk of AKI in older patients with COVID-19., (© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Objectives: High-risk patients ≥65 y of age with coronavirus disease 2019 (COVID-19) tended to have lower serum prealbumin concentrations. The aim of this study was to investigate the association of prealbumin at baseline on COVID-19-related mortality in elderly patients (≥65 y of age)., Methods: We non-selectively and consecutively collected participants from Tongji Hospital in Wuhan from January 17 to February 17, 2020. Univariate and multivariate logistic regression models were employed to evaluate the correlation between prealbumin and in-hospital outcomes (in-hospital mortality, admission to the intensive care unit [ICU], and mechanical ventilation) in elderly patients with COVID-19. Linear trend was performed by entering the median value of each category of prealbumin tertile as a continuous variable and was visually confirmed by using generalized additive models. Interaction and stratified analyses were conducted as well., Results: We included 446 elderly patients with COVID-19 in the final analyses. In-hospital mortality was 14.79%. Of the 446 patients, 15.47% were admitted to the ICU and 21.3% required mechanical ventilation. Compared with patients in the highest tertile, the prealbumin of patients in the lowest tertile had a 19.09-fold higher risk for death [odds ratio (OR), 20.09; 95% confidence interval (CI), 3.62-111.64; P = 0.0006], 25.39-fold higher risk for ICU admission (OR, 26.39; 95% CI, 4.04-172.39; P = 0.0006), and 1.8-fold higher risk for mechanical ventilation (OR, 2.8; 95% CI, 1.15-6.78; P = 0.0227) after adjustment for potential confounders. There was a linear trend correlation between serum prealbumin concentration and risk for in-hospital mortality, ICU admission, and mechanical ventilation in elderly patients with COVID-19 infection., Conclusion: Prealbumin is an independent risk factor of in-hospital mortality for elderly patients with COVID-19. Assessment of prealbumin may help identify high-risk individuals ≥65 y of age with COVID-19., (Copyright © 2020 Elsevier Inc. All rights reserved.)

This paper empirically investigates the relationships between caregivers' parenting skills and early cognitive, language, motor, and social-emotional development of children aged 6-24 months. The study is based on data from a survey conducted in 100 villages in a typical poor rural area in western China. A total of 1715 households were enrolled in the study. In the study, Parent and Family Adjustment Scales (PAFAS), Bayley Scales of Infant Development version III (BSID-III), and a socioeconomic questionnaire were used to measure caregiver's parenting skills, child's development outcomes, and socioeconomic characteristics in sample households, respectively. Multivariate regression was used to estimate the relationship between a caregiver's parenting skills and the child's development outcomes. The results show that, first, parenting skills are positively and significantly associated with children's cognitive, language, motor, and social-emotional development, and the link between parenting skills and social-emotional development is the strongest; second, the correlation between parenting skills and development outcomes varies across socioeconomic characteristics and parenting skill dimensions. The results provide evidence for the relationship between parenting skills and early childhood development in rural households in western China. Our findings also suggest that interventions aimed at improving caregivers' parenting skills during the early stages are necessary for human capital development in rural China.

Chinese parents of children with congenital heart disease (CHD) experience significant psychological distress due to the child's illness and hospitalization. Unfortunately, there are few psychosocial interventions for parental distress in China. This pilot study aimed to examine the efficacy of solution-focused brief therapy (SFBT) in a Chinese hospital for parental distress using a randomized controlled trial design. The participants included 40 Chinese parents of a currently hospitalized child diagnosed with CHD who were assessed to have psychological distress. Parents were randomized into either the intervention (n = 25) or the hospital medical social work treatment as usual (TAU) (n = 28) group. The Chinese Brief Symptom Inventory-18 and Chinese version of Herth Hope Index were administered before and after the interventions. Results of the intent-to-treat analysis indicated a significant decrease in parental distress and increase in parents' levels of hope in the intervention group compared with the TAU group. This study supported SFBT administered in a hospital setting as a promising intervention for reducing distress among Chinese parents with children diagnosed with CHD., (© 2017 National Association of Social Workers.)

The psychosocial well-being of parents remains integral to the treatment and recovery of children diagnosed with cancer. However, limited research addresses the unique needs of this population. To better understand the supportive care needs of parents of children with cancer, this study tested the reliability and stability of the factorial structure of a revised version of the Cancer Patient Needs Questionnaire (rCPNQ) with Chinese parents of children who have cancer. Analysis of the generalizability of the rCPNQ with this population was determined through principle components analysis with varimax rotation. Reliability coefficient and split sample analyses were performed to determine reliability and stability of the resulting factors. The principal components analysis resulted in a 6-dimension, 8-factor, 29-item survey. Each of the factors had Cronbach's α ≥ .74, indicating satisfactory internal consistency and reliability of the survey with the Chinese population. Similar loadings on splitting of the samples reflects the stability of the factors. Study results provided a preliminary understanding of the needs of Chinese parents of children with cancer and demonstrated that the rCPNQ offers a reliable measure for nurses and other health care providers to partner with Chinese parents throughout their children's treatment and survivorship to determine areas for support.