1. Highly oxygenated cyclohexenes from Uvaria dac Pierre ex Finet & Gagnep. and their α-glucosidase inhibitory activity.
- Author
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Champakam S, Teerapongpisan P, Suthiphasilp V, Kumboonma P, Maneerat T, Patrick BO, Duangyod T, Charoensup R, Promnart P, Tontapha S, Andersen RJ, and Laphookhieo S
- Subjects
- Molecular Structure, Plant Extracts chemistry, Plant Extracts pharmacology, Plant Stems chemistry, China, Glycoside Hydrolase Inhibitors pharmacology, Glycoside Hydrolase Inhibitors isolation & purification, Glycoside Hydrolase Inhibitors chemistry, Molecular Docking Simulation, Uvaria chemistry, Plant Leaves chemistry, Phytochemicals pharmacology, Phytochemicals isolation & purification, Cyclohexenes isolation & purification, Cyclohexenes pharmacology, Cyclohexenes chemistry
- Abstract
Phytochemical investigations of the twig and leaf extracts of Uvaria dac Pierre ex Finet & Gagnep. resulted in the isolation and identification of five new highly oxygenated cyclohexenes, uvaridacols M - Q (1-3, 5, and 6), and six known compounds (4 and 7-11). All new structures were elucidated by spectroscopic methods and HRESITOFMS data. The absolute configuration of 1, 5, and 6 was confirmed by single X-ray diffraction analysis with Cu Kα radiation. In contrast, other compounds were established by comparing their specific rotation and ECD spectra with those of known compounds. Some of the isolated compounds with sufficient quantity were evaluated for their α-glucosidase inhibitory activity. Of these, (-)-1,6-desoxypipoxide (10) showed α-glucosidase inhibitory activity with an IC
50 value of 28.6 μM. The in silico molecular docking of active compounds was also studied., Competing Interests: Declaration of competing interest The authors declare no competing financial interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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