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Air pollution is one of the most severe environmental problems that Mexico is currently facing. The objective of this paper is to quantify the most relevant socioeconomic driving forces behind air polluting emissions and, more specifically, 7 local pollutants in Mexico. We do so in a multilevel version of the Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT) model that accounts for the spatial heterogeneity at the municipal level across the country. The results show that the most relevant variables to determine the emissions of atmospheric pollutants are the population, the harvested area and the number of cars, while technological development helps to mitigate such emissions. The ecological elasticities are, in all cases, smaller than one. Our purpose is to provide quantitative information about these socioeconomic driving forces of air deterioration as a basis to establish some recommendations for environmental policy decision-making., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Vega-Campa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)