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Background: The overall benefits of the newly introduced family‐based Helicobacter pylori (H. pylori) infection control and management (FBCM) and screen‐and‐treat strategies in preventing multiple upper gastrointestinal diseases at national level in China have not been explored. We investigate the cost‐effectiveness of these strategies in the whole Chinese population. Materials and Methods: Decision trees and Markov models of H. pylori infection‐related non‐ulcer dyspepsia (NUD), peptic ulcer disease (PUD), and gastric cancer (GC) were developed to simulate the cost‐effectiveness of these strategies in the whole 494 million households in China. The main outcomes include cost‐effectiveness, life years (LY), quality‐adjusted life year (QALY), and incremental cost‐effectiveness ratio (ICER). Results: When compared with no‐screen strategy, both FBCM and screen‐and‐treat strategies reduced the number of new cases of NUD, PUD, PUD‐related deaths, and the prevalence of GC, and cancer‐related deaths. The costs saved by these two strategies were $1467 million and $879 million, quality‐adjusted life years gained were 227 million and 267 million, and life years gained were 59 million and 69 million, respectively. Cost‐effectiveness analysis showed that FBCM strategy costs −$6.46/QALY and −$24.75/LY, and screen‐and‐treat strategy costs −$3.3/QALY and −$12.71/LY when compared with no‐screen strategy. Compared to the FBCM strategy, the screen‐and‐treat strategy reduced the incidence of H. pylori‐related diseases, added 40 million QALYs, and saved 10 million LYs, but at the increased cost of $588 million. Cost‐effectiveness analysis showed that screen‐and‐treat strategy costs $14.88/QALY and $59.5/LY when compared with FBCM strategy. The robustness of the results was also verified. Conclusions: Both FBCM and screen‐and‐treat strategies are highly cost‐effective in preventing NUD, PUD, and GC than the no‐screen strategy in Chinese families at national level. As FBCM strategy is more practical and efficient, it is expected to play a more important role in preventing familial H. pylori infection and also serves as an excellent reference for other highly infected societies. [ABSTRACT FROM AUTHOR]

The Late Mesozoic subduction of Izanagi slab beneath East Asia formed large-scale intraplate magmatism in SE South China and subduction mélanges outcropped in SW Japan to eastern Taiwan Island, but the accompanying arc remains uncertain. We conducted LA-ICP-MS U–Pb zircon dating and trace element analyses of proximal sandstones from the SW East China Sea to trace a Jurassic to Cretaceous magmatic arc. Newly acquired data reveal that arc magmatism mostly developed in episodes of 150–124 and 124–102 Ma, exhibiting characteristics of low-T, high Th/U, U/Yb, Sc/Yb, Th/Nb, and low Nb/Yb, Nb/Hf ratios. This magmatic arc, combined with the SE South China intraplate and residual subduction mélanges, spatially forms a Late Mesozoic trench–arc–intraplate architecture responding to the Izanagi subduction. Its identified tectonic scenarios mainly include slab strike-slip subduction (200–170 Ma), slab stagnation and intraplate foundering (170–150 Ma), slab rollback and arc-root removal (150–102 Ma), and arc migration (102–86 Ma). Both the western East China Sea and Cathaysia block share a unified Paleoproterozoic basement that formed at ca. 1.85 Ga, and the Cathaysia-based magmatic arc occurred then. [ABSTRACT FROM AUTHOR]

Geopolitical conflicts and power games among major nations present substantial challenges to cross-border trade and global economic development; however, the existing literature has paid limited attention to the role of geopolitical risk in agricultural exports, especially the underlying macroimpact mechanisms from the perspective of agricultural land. This paper utilizes China's agricultural export data spanning 1995–2020 to empirically investigate the influence of geopolitical risk on China's agricultural exports and unveil its specific internal mechanisms. The findings reveal that China's agricultural exports are negatively affected when its trading partners are exposed to geopolitical risk. Notably, trading partners' agricultural land is instrumental in mitigating the adverse effects of geopolitical risk on China's agricultural exports. Moreover, a heterogeneity analysis shows that the impact of geopolitical risk on China's agricultural exports is more significant in non-Belt and Road countries than in Belt and Road countries. Given China's status as one of the world's major agricultural exporting nations, the results of this study hold significant importance in proactively addressing and alleviating the impact of geopolitical risks on both Chinese and global agricultural exports. [ABSTRACT FROM AUTHOR]

Since the advent of COVID-19 vaccine, the long-term monitoring and evaluation of vaccine effectiveness worldwide has never stopped. Real-world research of the mainstream vaccines in China (BBIBP-CorV and CoronaVac) is extremely valuable as a supplement to clinical research data. Venous blood of this study was collected from 111 blood donors and from 6 volunteers, who had received 2 doses of SAR-CoV-2 vaccine. Cross-sectional study and cohort study was adopted. Venous blood of 11 COVID-19 convalescent plasma donors was collected as a positive control. The seroconversion rate of neutralizing antibodies in 111 vaccine recipients was 90.99% (101/111); The level of SAR-CoV-2 antibodies peaked around 28 days after inoculation, then fast descended followed by gentle descended until it was still detectable around 280 days later. The changes in antibody levels were similar to those of the 6 participants and those of convalescent plasma donors after infection. 5 of the 6 participants still maintained a high level of neutralizing antibodies (> 60% of the peak value) around 28 days after receiving 2 doses of vaccine; one participant had an antibody reaction that was almost always negative for 4 weeks. BBIBP-CorV and CoronaVac can produce good immune effects in most vaccinators aged 20 to 59 years in Nanjing area. Nevertheless, significant individual discrepancies of the humoral immunity are still existed. [ABSTRACT FROM AUTHOR]

Background: Although the 308 nm excimer laser is commonly used to cure vitiligo, its clinical efficacy is limited. Experts have found that the efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser in the treatment of vitiligo is significantly enhanced, but the specific research methods and clinical data must be clarified. Objective: To determine the clinical efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser in the treatment of vitiligo. Methods: Until August 2022, studies were searched in PubMed, the Cochrane Library, the Chinese Biomedical Literature Database, the China National Knowledge Infrastructure, the Chinese Scientific Journal Database, and the Wan Fang Database. We also searched for clinical RCTs involving compound glycyrrhizin tablets combined with the 308 nm excimer laser for the treatment of vitiligo. The meta‐analysis was conducted in accordance with the Cochrane Handbook's recommendations. Two reviewers regulated the study selection, data extraction, and assessment of bias risk, and consulted a third reviewer as necessary. For the meta‐analysis, Review Manager 5.4 was utilized. Results: Finally, 9 articles and 1052 patients were included. A systematic review compared the efficacy of compound glycyrrhizin tablets combined with the 308 nm excimer laser to that of the 308 nm excimer laser alone: OR = 3.33, p < 0.00001, 95% confidence interval [2.25, 4.92]. Conclusion: In the treatment of vitiligo, compound glycyrrhizin tablets combined with the 308 nm excimer laser are more effective than the 308 nm excimer laser alone, and there are no serious adverse reactions. It is a safe and efficient way of treatment. [ABSTRACT FROM AUTHOR]

To reveal the influence of freeze–thaw cycles (FTCs) on soil carbon and nitrogen changes, six typical soils in Northeast China were selected as the research objects to conduct a FTC simulation test in an artificial climate chamber. Three soil volumetric water contents (10%, 20%, 30%) and eight FTCs (0, 2, 4, 6, 8, 10, 15, 20) were set. The results showed that the soil organic carbon (SOC) and microbial biomass carbon (MBC) contents of different soil types under the FTCs initially exhibited a downward and then an upward trend, while the dissolved organic carbon (DOC) content exhibited an upward and then a downward trend. Otherwise, the fourth and sixth FTCs were the key points of change. The SOC, MBC and DOC contents in paddy fields were higher than those in dry fields, showing upward and then downward trends spatially from northeast to southwest. The SOC and MBC contents in each soil type were the highest at the 20% water content, and the DOC content gradually increased with increasing water content. The ammonium nitrogen (NH4+‐N) content in different soil types at different water contents under the FTCs showed an upward trend first, then a downward trend and finally an upward trend. The NH4+‐N content in paddy fields was higher than that in dry fields. The nitrate nitrogen (NO3‒‐N) content showed a downward trend first, then an upward trend and finally a downward trend. The NO3‒‐N content in dry fields was higher than that in paddy fields. The NH4+‐N contents in the three soil types on the Sanjiang Plain were significantly higher than those on the Songnen Plain. The NH4+‐N and NO3‒‐N contents showed upward trends with increasing water content, but the differences were not significant. The results have implications for the study of different types of soils and provide references for research on the mechanism of soil carbon and nitrogen transformation in typical farming areas in Northeast China. [ABSTRACT FROM AUTHOR]

Purpose: Preference-based measures have been increasingly recommended to measure health outcomes for economic evaluation. However, none of existing cardiovascular disease (CVD)-specific health-related quality of life (HRQoL) instruments are preference-based. This study aimed to develop the descriptive system of preference-based HRQoL instrument for Chinese patients with CVDs under the Initiative of China Health Related Outcomes Measures (CHROME). Methods: Qualitative face-to-face interviews were conducted with Chinese patients with CVDs. Content analysis was employed to generate candidate items for the instrument. Then expert consultation and cognitive debriefing interviews were conducted to guide further selection and revision of the items. Results: We interviewed 127 CVD patients with 67.7% being male and 63.8% living in the urban area. A hierarchical code book comprised of four themes, 20 categories, 62 sub-categories, and 207 codes, was developed. Candidate items were selected based on the criteria set by the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) methodology and ISPOR PRO guidance. An online survey and meeting with an expert advisory panel (n = 15) followed by cognitive debriefing interviews with 20 patients and 13 physicians were conducted to further select and revise the candidate items. The descriptive system of CHROME-CVD consists of 14 items, namely frequency and severity of chest pain, chest tightness, palpitation, shortness of breath, dizziness, fatigue, appetite, sleeping, mobility, daily activities, depression, worry, and social relationship. Four or five level responses were selected based on cognitive debriefing results to each item. Conclusion: The current study developed the descriptive system (items and response options) of CHROME-CVD, the future CVD-specific preference-based HRQoL instrument for Chinese CVD patients. [ABSTRACT FROM AUTHOR]

In the process of rapid advancement of agricultural production, the dynamic evolution characteristics of land and water resources in the main grain-producing areas and the influencing factors are less studied. This study takes Heilongjiang Province, the main grain-producing area in China, as an example, constructs an index system from three functions: production, life, and ecology, uses information entropy to determine the weights and importance of each index, uses the rate of change of the index to determine the basic data of the dynamic development of the system, combines the weights to determine the dynamic evolution characteristics, and compares and analyzes them with the static evolution characteristics determined by the actual data. The results showed that there were differences in the important indicators under different conditions, and the important indicators under static and dynamic conditions were the proportion of the tertiary industry to GDP(A7) and GDP per unit area(A8), with importance weights of 7.45% and 8.0%, respectively. The static evolution index of the land and water resource system increased slowly from 0.16 to 0.91, while the dynamic evolution index fluctuated and declined from 0.58 to 0.34, indicating that the ability of the land and water resource system in the study area to maximize comprehensive benefits is constantly weakening. Managers can pre-control the development speed of the important indicators under dynamic conditions and promote the sustainable development of the land and water resource system. [ABSTRACT FROM AUTHOR]

The prediction of crop yield plays a crucial role in national economic development, encompassing grain storage, processing, and grain price trends. Employing multiple sensors to acquire remote sensing data and utilizing machine learning algorithms can enable accurate, fast, and nondestructive yield prediction for maize crops. However, current research heavily relies on single-type remote sensing data and traditional machine learning methods, resulting in the limited robustness of yield prediction models. To address these limitations, this study introduces a field-scale maize yield prediction model named the convolutional neural network–attention–long short-term memory network (CNN-attention-LSTM) model, which utilizes multimodal remote sensing data collected by multispectral and light detection and ranging (LIDAR) sensors mounted on unmanned aerial vehicles (UAVs). The model incorporates meteorological data throughout the crop reproductive stages and employs the normalized difference vegetation index (NDVI), normalized difference red edge (NDRE), soil-adjusted vegetation index (SAVI), and enhanced vegetation index (EVI) for the initial part of the vegetative stage (initial part of the V period), the later part of the vegetative stage (later part of the V period), the reproductive stage (R period), and the maturity stage (M period), along with LIDAR data for Point75–100 in the later part of the V period, Point80–100 in the R period, and Point50–100 in the M period, complemented by corresponding meteorological data as inputs. The resulting yield estimation demonstrates exceptional performance, with an R2 value of 0.78 and an rRMSE of 8.27%. These results surpass previous research and validate the effectiveness of multimodal data in enhancing yield prediction models. Furthermore, to assess the superiority of the proposed model, four machine learning algorithms—multiple linear regression (MLR), random forest regression (RF), support vector machine (SVM), and backpropagation (BP)—are compared to the CNN-attention-LSTM model through experimental analysis. The outcomes indicate that all alternative models exhibit inferior prediction accuracy compared to the CNN-attention-LSTM model. Across the test dataset within the study area, the R2 values for various nitrogen fertilizer levels consistently exceed 0.75, illustrating the robustness of the proposed model. This study introduces a novel approach for assessing maize crop yield and provides valuable insights for estimating the yield of other crops. [ABSTRACT FROM AUTHOR]

China's health system is facing severe challenges from social transition and the double burden of population aging and non-communicable diseases. Addressing the tension between the public's increasing demand for health services and the limited availability of medical resources has become a critical issue for health care policymakers and medical insurance fund administrators. In promoting its medical insurance system reform, China is actively developing health technology assessment (HTA) with principles and applications adapted to the Chinese context. This study aims to analyze the evolution of HTA in China with a focus on context, actors, process, content, and challenges encountered through applying a modified verson of Walt and Gilson's policy triangle framework. Currently, HTA plays an indispensable part in the reform of China's health care and medical insurance system, especially in the formulation and adjustment of the National Reimbursement Drug List (NRDL). While HTA is increasingly used in China, there remain challenges, such as the slow development of HTA related disciplines, lack of an independent national HTA authority, and limited scope in the use of HTA. Despite the identified challenges, HTA has the potential to support a wide range of applications in China's health care sector, building on the progress achieved over the last three decades. [ABSTRACT FROM AUTHOR]

Summary: As the COVID‐19 variant Omicron surge in Beijing, China, a better understanding of risk factors for adverse outcomes may improve clinical management in patients with haematological malignancies (HM) diagnosed with COVID‐19. The study sample includes 412 cases, mainly represented by acute leukaemia, chronic myeloid leukaemia (CML), plasma cell disorders and lymphoma and chronic lymphocytic leukaemia. COVID‐19 pneumonia was observed in 10.4% (43/412) of patients, and severe/critical illness was observed in 5.3% (22/412). Among the 86 cases with advanced malignancies, 17.6% (12/86) of patients developed severe/critical COVID‐19, which was significantly higher than reported in patients with stable malignancies (9/326, 2.70%, p < 0.001). Similarly, the advanced malignancy cohort had a higher mortality rate (9/86, 10.5% vs. 0/326, 0%, p < 0.001) and a poor 30‐day overall survival (OS) compared with the stable malignancy cohort (74.2% vs. 100.0%, p < 0.0001). Overall, nine patients (2.2%) died. The primary cause of death was progressive HM in four patients and a combination of both COVID‐19 and HM in five patients. In the multivariable analysis, over 65 years of age, comorbidities and advanced malignancy were correlated with severe/critical COVID‐19 in HM patients. This study sheds light on the poor outcomes among COVID‐19 HM patients with the leading cause of advanced malignancy. [ABSTRACT FROM AUTHOR]

Among the elderly, depression is one of the most common mental disorders, which seriously affects their physical and mental health and quality of life, and their suicide rate is particularly high. Depression in the elderly is strongly associated with surgery. In this study, we aimed to explore the risk factors and establish a predictive model of depressive symptoms 1 month after video-assisted thoracoscopic surgery (VATS) in elderly patients. The study participants included 272 elderly patients (age > 65 years) undergoing VATS from April 2020 to May 2021 at 1 of 18 medical centers in China. The patients were divided into a depression group and a nondepression group according to the Chinese version of the nine-item Patient Health Questionnaire (PHQ-9). The patients' pre- and postoperative characteristics and questionnaires were collected and compared. Then, binary logistic regression was used to determine the risk factors that affect postoperative depressive symptoms, and the predictive model was constructed. The prediction efficiency of the model was evaluated by drawing the receiver operating characteristic curve (ROC), and the area under the curve (AUC) was calculated to evaluate the value of the predictive model. Among all of the included patients, 16.54% (45/272) suffered from depressive symptoms after VATS. The results of the univariate analysis showed that body mass index (BMI), chronic pain, leukocyte count, fibrinogen levels, prothrombin time, ASA physical status, infusion volume, anxiety, sleep quality, and postoperative pain were related to postoperative depressive symptoms (all p < 0.05). The results of multivariate logistic regression analysis showed that a high fibrinogen level (OR = 2.42), postoperative anxiety (OR = 12.05), poor sleep quality (OR = 0.61), and pain (OR = 2.85) were risk factors of postoperative depressive symptoms. A predictive model was constructed according to the regression coefficient of each variable, the ROC curve was drawn, and the AUC value was calculated to be 0.889. The prediction model may help medical personnel identify older patients at risk of developing depressive disorders associated with VATS and may be useful for clinical purposes. [ABSTRACT FROM AUTHOR]

The projection pursuit model is an important tool for processing high-dimensional nonnormal and nonlinear data, and it has a wide range of applications. In this paper, clustering analysis and information entropy theory are simultaneously introduced into the projection pursuit model. The K-means clustering method is used to cluster high-dimensional data, and information entropy is used to measure the overall dispersion and local aggregation of projection data. A projection pursuit model based on clustering and information entropy is proposed. The new model has both the classification advantages of clustering analysis and the evaluation advantages of the projection pursuit model. In the case test, different cases are tested by using the Shapiro-Wilk test, Kolmogorov-Smirnov test, Epps-Pulley test, etc. The results show that in most cases, the new model is better than the original model, and the advantage is clearer when the data dimension is higher. Finally, the new model is applied to the agricultural drought risk assessment of Qiqihar, a major grain-producing area in China that is prone to drought. The regional agricultural drought risk shows a downward trend over time. Spatially, the risk of the central and southern regions is low, while the risk of the northern and western regions is high. Regional ability to resist disasters is the main reason for the spatial and temporal differences. This paper extends projection pursuit model theory, analyzes the characteristics of the spatiotemporal variation in regional agricultural drought risk, and provides a reference for identifying the hidden dangers of drought disasters and disaster reduction. [ABSTRACT FROM AUTHOR]

Hydnobolites is an ectomycorrhizal fungal genus with hypogeous ascomata in the family Pezizaceae (Pezizales). Molecular analyses of Hydnobolites using both single (ITS) and concatenated gene datasets (ITS-nLSU) showed a total of 223 sequences, including 92 newly gained sequences from Chinese specimens. Phylogenetic results based on these two datasets revealed seven distinct phylogenetic clades. Among them, the ITS phylogenetic tree confirmed the presence of at least 42 phylogenetic species in Hydnobolites. Combined the morphological observations with molecular analyses, five new species of Hydnobolites translucidus sp. nov., H. subrufus sp. nov., H. lini sp. nov., H. sichuanensis sp. nov. and H. tenuiperidius sp. nov., and one new record species of H. cerebriformis Tul., were illustrated from Southwest China. Macro- and micro-morphological analyses of ascomata revealed a few, but diagnostic differences between the H. cerebriformis complex, while the similarities of the ITS sequences ranged from 94.4 to 97.2% resulting in well-supported clades. [ABSTRACT FROM AUTHOR]

Mineral licks are important components of terrestrial ecosystems that have special value to the maintenance of fluid balance of mammals, by providing them with essential mineral nutrients such as sodium, calcium, and magnesium. In the Anzihe Nature Reserve, southwest China, seven species of ungulates and one species of primates were frequently observed visiting the mineral licks in high densities. As a consequence, mineral licks have attracted illegal hunters and facilitated the spread of parasites and diseases, leading to a depletion of local populations. Therefore, we suggest that regions with abundant mineral licks should be designated as key protected areas in the Anzihe Nature Reserve and relevant zones for animal health surveillance. [ABSTRACT FROM AUTHOR]

Long non-coding RNA (lncRNA) play vital regulatory roles in various biological processes. Intestine is one of the most sensitive organs to environmental and homeostatic disruptions for fish. However, systematic profiles of lncRNAs in the intestine of teleost in responses to pathogen infections is still limited. Turbot (Scophthalmus maximus L.), an important commercial fish species in China, has been suffering with Vibrio anguillarum infection, resulted in dramatic economic loss. Hereinto, the intestinal tissues of turbot were sampled at 0 h, 2 h, 12 h, and 48 h following V. anguillarum infection. The histopathological analysis revealed that the pathological trauma was mainly present in intestinal tunica mucosal epithelium. After high-throughput sequencing and bioinformatic analysis, a total of 9722 lncRNAs and 21,194 mRNAs were obtained, and the average length and exon number of lncRNAs were both less than those of mRNAs. Among which, a set of 158 lncRNAs and 226 mRNAs were differentially expressed (DE-lncRNAs and DEGs) in turbot intestine at three time points, related to many immune-related genes such as complement, interleukin, chemokine, lysosome, and macrophage, indicating their potential critical roles in immune responses. In addition, 2803 and 1803 GO terms were enriched for DEGs and co-expressed target genes of DE-lncRNAs, respectively. Moreover, 127 and 50 KEGG pathways including cell adhesion molecules (CAMs), phagosome, JAK-STAT signaling pathway, cytokine-cytokine receptor interaction, and intestinal immune network for IgA production, were enriched for DEGs and co-expressed target genes of DE-lncRNAs, respectively. Finally, qRT-PCR was conducted to confirm the reliability of sequencing data. The present study will set the foundation for the future exploration of lncRNA functions in teleost in response to bacterial infection. • Intestine tissues of turbot were sampled at different time points following V. anguillarum infection. • The pathological trauma was mainly present in intestinal tunica mucosal epithelium. • A total of 158 lncRNAs and 226 mRNAs were differentially expressed, many of which were involved in immune activities. • qRT-PCR was conducted to confirm the reliability of sequencing data. [ABSTRACT FROM AUTHOR]

Gomphus matijun, a new edible species, is described from southwestern China based on phylogenetic and morphological evidence. Phylogenetic analyses of the nrLSU and ITS datasets indicated that G. matijun is related to G. crassipes and G. ludovicianus with weak statistical support in maximum likelihood but strong statistical support in Bayesian analyses. Gomphus matijun is characterized by its gray-blue to blue or blue-purple pileus with a round or irregular outline, relatively smaller basidiospores [9-11(-13) × 6-7(-8) µm], mostly 2-spored basidia, and occurs in subtropical fagaceous forests. A key to the known species of Gomphus is provided. [ABSTRACT FROM AUTHOR]

This research investigates the short-term and long-term performance and volatility of publicly traded firms engaged in blockchain business. In particular, it examines how ownership structure impacts performance and volatility in such firms. We manually collected the data of Chinese A-listed companies participating in blockchain development during 2013–2018 as samples, and find that both short- and long-term performance and volatility significantly decrease among these firms after involvement in blockchain business. Ownership concentration has a positive correlation with stock returns, return on assets, and volatilities, whereas the state as a controlling shareholder strengthens these positive links. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical efficacy and safety of pembrolizumab plus albumin-bound paclitaxel and nedaplatin as a first-line therapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Methods: 35 patients with advanced ESCC and evaluable foci admitted in Changhai Hospital from March 2020 to September 2021 were included in this study. All patients were given pembrolizumab 200 mg and albumin-bound paclitaxel 130 mg/m² on day 1 and 8, and nedaplatin 70 mg/m² on day 1. The treatment was repeated every 21 days. Evaluation of tumor response was performed according to Response Evaluation Criteria in Solid Tumors 1.1 (RECIST1.1). Adverse effects were graded using version 5.0 of the National Cancer Institute Common Toxicity Criteria (NCI-CTC). Results: All 35 patients were available for evaluation, with 4 patients (11.4%) achieving complete response (CR), 21 patients (60.0%) partial response (PR), 10 patients (28.6%) stable disease (SD) and 0 patients progression disease (PD). The objective response rate (ORR) was 71.4%. The disease control rate (DCR) was 100%. The median progression free survival (PFS) was 13.4 months. The main adverse effects include bone marrow suppression, thyroid dysfunction, rash, fever, arthralgia, myalgia and alopecia. Treatment-related adverse events of grade 3 or higher occurred only in 3 patients (8.6%). Conclusion: Pembrolizumab plus albumin- bound paclitaxel and nedaplatin as a first-line treatment demonstrated feasible anti-tumor efficacy and manageable safety in patients with advanced ESCC. Randomized trials with expanded samples to evaluate this new combination strategy are warranted. [ABSTRACT FROM AUTHOR]

The production of a distinct profile of volatile organic compounds plays a crucial role in the ecology of hypogeous Ascomycetes, and is also key to their gastronomic relevance. In this study, we explored the aroma components of two rarely investigated Chinese desert truffles, namely Mattirolomyces terfezioides and Choiromyces cerebriformis, using headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). Our investigation revealed the significant presence of sulphur-containing volatiles in the aroma of M. terfezioides but not in C. cerebriformis. We discussed available information on the distribution of these interesting truffles in China and their use as choice food by local people. [ABSTRACT FROM AUTHOR]

The increasing prevalence and transmission of tick-borne diseases, especially those emerging ones, have posed a significant threat to public health. Thus, the discovery of neglected pathogenic agents carried and transmitted by ticks is urgently needed. Using unbiased high-throughput sequencing, a novel Orthonairovirus designated as Meihua Mountain virus (MHMV), was identified in bloodsucking ticks collected from cattle and wild boars in Fujian province, Southeastern China. The full-length genome was determined by RT-PCR and RACE. Genomic architecture of MHMV shares typical features with orthonairoviruses. Phylogenetic analyses suggested that MHMV is clustered into the Nairobi sheep disease (NSD) genogroup of the genus Orthonairovirus and is closely related to the Hazara virus. The RdRp, GPC, and N protein of MHMV shares 62.3%-83.5%, 37.1%-66.1%, and 53.4%-77.3% amino acid identity with other NSD genogroup viruses, respectively, representing a novel species. The overall pooled prevalence of MHMV in ticks was 2.53% (95% CI: 1.62%-3.73%, 22 positives of 134 tick pools), with 7.38% (95% CI: 3.84%-12.59%, 11 positives of 18 pools) in Haemaphysalis hystricis, 6.02% (95% CI: 1.85%-14.22%, four positives of eight pools) in H. formosensis, 25.03% (95% CI: 9.23%-54.59%, six positive of eight pools) in Dermacentor taiwanensis, and 0.16% (95% CI: 0.01%-0.72%, one positive of 100 pools) in Rhipicephalus microplus. This study presented the first report of tick-carried Orthonairovirus in Fujian province and highlighted the broad geographic distribution and high genetic diversity of orthonairoviruses in China. [ABSTRACT FROM AUTHOR]

Legume pasture species have been widely used to re‐establish vegetation cover and control soil erosion in semiarid degraded ecosystems. Nevertheless, the long‐term effects of revegetation on aboveground biomass (AB) and the soil properties under different topographies remain unclear. We conducted a 16‐year in situ experiment to evaluate soil properties and biomass dynamics under fallow, sweet clover (Melilotus officinalis L.) and alfalfa (Medicago sativa L.), in northeast‐facing, southeast‐facing, and horizontal landscapes from 2003 to 2018. After 16 years of revegetation, soil organic carbon (SOC), soil total nitrogen (TN), soil total phosphorus (TP) concentrations were higher in alfalfa fields in the northeast‐ and southeast‐facing landscapes and greater in sweet clover fields in the horizontal landscape alongside soil profiles. In the 0–20 cm, the SOC, TN, and TP concentrations in alfalfa fields increased at rates of 0.322, 0.034, and 0.010 g kg−1 yr−1 in the northeast‐facing landscape and at rates of 0.189, 0.022, and 0.011 g kg−1 yr−1 in the southeast‐facing landscape. The SOC, TN, and TP concentrations in sweet clover fields increased at rates of 0.129, 0.023, and 0.009 g kg−1 yr−1 in the horizontal. Alfalfa introduction is recommended for northeast‐facing landscapes whereas alfalfa and fallow are recommended in southeast‐facing landscapes, introduce sweet clover is recommended in a horizontal landscape to improve the soil nutrient concentrations at mid‐long time. These results suggest that topography influences vegetation restoration by affecting plant growth and soil nutrient and should be considered during the revegetation process to ensure revegetation success and sustainable land use. [ABSTRACT FROM AUTHOR]

The evolution of the average freezing depth and maximum freezing depth of seasonal frozen soil and their correlations with the average winter half-year temperature in Heilongjiang Province in China are analyzed. Linear regression, the Mann–Kendall test, and kriging interpolation are applied to freezing depth data from 20 observation stations in Heilongjiang Province from 1972 to 2016 and daily average temperature data from 34 national meteorological stations collected in the winters of 1972–2020. The results show that the average freezing depth decreases at a rate of 4.8 cm (10 yr)−1 and that the maximum freezing depth decreases at a rate of 10.1 cm (10 yr)−1. The winter half-year average temperature generally shows a fluctuating upward trend in Heilongjiang Province, increasing at a rate of 0.3°C (10 yr)−1. The correlations between the average and maximum freezing depths and the winter half-year average temperature are −0.53 and −0.49, respectively. For every 1°C increase in the average temperature during the winter half of the year, the average freezing depth decreases by 3.85 cm and the maximum freezing depth decreases by 7.84 cm. The average freezing depth sequence mutated in 1987, and the maximum freezing depth sequence mutated in 1988. The average temperature in the winter half-year displayed multiple abrupt changes from 1972 to 2020. The spatial variations in the average and maximum freezing depths are basically consistent with those in the average winter half-year temperature. These research results provide a theoretical basis for the design and site selection of hydraulic structures in cold areas and for regional development and agricultural planning. Significance Statement: The freeze–thaw balance in the frozen soil environment has been disrupted in recent years, and various degrees of degradation have occurred in the frozen soil. The degradation of frozen soil will further aggravate the greenhouse effect, which in turn will affect the accumulation of water in the soil and will have a significant impact on local agricultural production. This article uses Heilongjiang Province in China as an example. The results show that 1) the temperature in the winter half-year has exhibited an upward trend in recent years, 2) the temperature in the winter half-year has a considerable impact on the frozen soil environment, and 3) the response of the spatial distribution of frozen soil to temperature changes in the winter half-year is revealed. [ABSTRACT FROM AUTHOR]

Atlantic salmon is one of the most famous and economically important fish species globally. However, bacterial diseases constantly constrain salmon aquaculture. Thereinto, Aeromonas salmonicida subsp. masoucida (ASM), classified as atypical A. salmonicida , caused huge losses to salmonid industry in China. In this regard, we conducted transcriptome analysis in Atlantic salmon head kidney following the administration of ASM vaccination to reveal genes, their expression patterns, and pathways involved in immune responses. A total of 448.71 million clean reads were obtained, and 397.69 million reads were mapped onto the Atlantic salmon reference genome. In addition, 117, 1891, 741, 207, and 377 genes were significantly up-regulated, and 183, 1920, 695, 83, and 539 genes were significantly down-regulated post ASM vaccination at 12 h, 24 h, 1 m, 2 m, and 3 m, respectively. Furthermore, KEGG pathway analysis revealed that many differentially expressed genes (DEGs) following ASM vaccination were involved in cell adhesion molecules (H2-Aa-l and CD28-l),cytokine-cytokine receptor interaction (IL10 , CXCL9 , CXCL11 , CXCR3 , and CCL19), herpes simplex infection (IL1B , SOCS3-l , and C3-l), HTLV-I infection (Il1r2 and BCL2L1), influenza A (CXCL8 and Il12b) , and PI3K-Akt signaling pathway (PIK3R3-l and Ddit4-l). Finally, the results of qRT-PCR showed a significant correlation with RNA-Seq results, suggesting the reliability of RNA-Seq for gene expression analysis. This study sets the foundation for further study on the vaccine protective mechanism in Atlantic salmon as well as other teleost species. • RNA-seq was conducted to reveal the immune responses in Atlantic salmon head kidney following the administration of vaccine. • A total of 300, 3811, 1436, 290, and 916 genes were differentially expressed following vaccination at 12 h, 24 h, 1 m, 2 m, and 3 m, respectively. • Many DEGs were involved in immune-related pathways such as Cytokine-cytokine receptor interaction and PI3K-Akt signaling pathway. • The results of RT-qPCR showed a significant correlation with RNA-Seq results, suggesting the reliability of RNA-Seq. [ABSTRACT FROM AUTHOR]

Vegetation, a key intermediary linking water, the atmosphere, and the ground, performs extremely important functions in nature and for our existence. Although satellite-based remote-sensing technologies have become important for monitoring vegetation dynamics, selecting the correct remote-sensing vegetation indicator has become paramount for such investigations. This study investigated the consistencies between a photosynthetic activity index (the solar-induced chlorophyll fluorescence (SIF) indicator) and the traditional vegetation index (the Normalized Difference Vegetation Index (NDVI)) among different land-cover types and in different seasons and explored the applicability of NDVI and SIF in different cases by comparing their performances in gross primary production (GPP) and grain-yield-monitoring applications. The vegetation cover and photosynthesis showed decreasing trends, which were mainly concentrated in northern Xinjiang and part of the Qinghai–Tibet Plateau; a decreasing trend was also identified in a small part of Northeast China. The correlations between NDVI and SIF were strong for all land-cover types except evergreen needleleaf forests and evergreen broadleaf forests. Compared with NDVI, SIF had some advantages when monitoring the GPP and grain yields among different land-cover types. For example, SIF could capture the effects of drought on GPP and grain yields better than NDVI. To summarize, as the temporal extent of the available SIF data is extended, SIF will certainly perform increasingly wide applications in agricultural-management research that is closely related to GPP and grain-yield monitoring. [ABSTRACT FROM AUTHOR]

By selecting typical seismic sections to carry out detailed structural interpretation, the structural style features of the Wunansha Uplift in the South Yellow Sea basin were systematically combined, and the compressional structures (imbricate, opposite/back thrust, and Y-shaped structures), strike-slip faults (positive flower-shaped faults), and extensional normal faults (listric-shaped normal faults) were identified. On this basis, combined with the characteristics of the regional stress field and the background of deep geodynamics, the genetic mechanism and structural evolution of the structural style in the Wunansha Uplift were defined. The stress mechanism of the compressional structures originated from the initial high-speed and low-angle NW subduction of the paleo-Pacific plate during the early Yanshanian movement in the Early Jurassic. The regional strike-slip fault was mainly a positive flower structure with compression and torsion characteristics, and its stress mechanism originated from sinistral shear caused by the Early Cretaceous low-angle NNW subduction of the paleo-Pacific plate. The Tan-Lu fault in eastern China also had sinistral shear characteristics in this period. The extensional normal fault was characterized by a listric shape, which developed along the northern boundary of the Wunansha Uplift, that is, the connection between the Wunansha Uplift and the Southern Depression of the South Yellow Sea basin. The stress mechanism was derived from the transition of the paleo-Pacific plate from low-angle to high-angle subduction during the late Yanshanian movement in the Late Cretaceous. Simultaneously, the tectonic stress system in eastern China also changed from compressional to tensional. [ABSTRACT FROM AUTHOR]

Introduction: Preoperative α-adrenergic blockade is thought to decrease perioperative risks and mortality in surgeries for adrenal pheochromocytoma. However, there are limited data on the efficacy of α-blockers in surgeries for retroperitoneal paragangliomas. The aim of this study was to evaluate the effects of the preoperative α-adrenergic blockade on outcomes in patients undergoing surgery for extra-adrenal retroperitoneal paraganglioma. Methods: We searched the clinical database for patients diagnosed with extra-adrenal retroperitoneal paraganglioma by postoperative histopathology in the General Hospital of People's Liberation Army in China from 2000 to 2017. We compared the preoperative status of patients, preoperative examination, preoperative preparation, intraoperative and postoperative cardiovascular events, intake and output, length of stay in the intensive care unit, length of hospital stays, and short-term outcomes between patients who received preoperative treatment with α-adrenergic blockade and those who did not. Results: Of the 167 patients enrolled in the study, 61 received preoperative α-adrenergic blockade therapy. Intraoperative heart rate elevation and highest heart rate were higher in patients undergoing tumor manipulation with preoperative α-adrenergic blockade than those who did not (p < 0.05). However, there were no significant differences between these 2 groups in terms of intraoperative blood pressure elevation and systolic blood pressure decrease following tumorectomy (p > 0.05). Moreover, there were no significant differences in postoperative complications and outcomes (p > 0.05). Conclusion: Under the current medical practice, resection of extra-adrenal retroperitoneal paraganglioma can be successfully carried out with or without preoperative α-adrenergic blockade. [ABSTRACT FROM AUTHOR]

Mesoscale convective systems (MCSs) contribute a large fraction of warm‐season precipitation and generate hazardous weather with substantial socioeconomic impacts. Uncertainties in convection parameterizations in climate models limit our understanding of MCS characteristics and reliability of future projection. We examine MCSs simulated by the global 14 km Nonhydrostatic ICosahedral Atmospheric Model (NICAM) without cumulus parameterization against satellite observation from Global Precipitation Measurement during 2001–2008. We focus on MCSs over the central United States and eastern China where MCSs are prevalent from March to August. A process‐oriented tracking method incorporating both cloud and precipitation criteria is used to identify and track MCSs. About 140/100 MCSs initiate in the central United States/eastern China per warm season and most of them initiate in the east of high mountains and in coastal regions. The frequency distribution of MCS lifetime is well captured by NICAM. However, the simulated MCSs have stronger precipitation, smaller precipitation area, and larger cold cloud system than that observed in both regions, which may be caused by weak entrainment as it is not well resolved at 14 km resolution. The simulated MCS number is also underestimated in summer. By examining the climatological and MCS large‐scale environments, the significant underestimation of MCS number in summer over the central United States may be attributed to the large climatological dry bias in the atmosphere. For China, mean moisture in summer is well simulated but deficiency in capturing the dynamic condition related to the coastal topography for triggering convection may have contributed to underestimation of MCS even in a sufficiently moist environment. Key Points: The Non‐hydrostatic Icosahedral Atmospheric Model underestimates mesoscale convective systems (MCSs) initiation number in the central United States in the warm season but the bias is small in eastern ChinaThe simulated MCSs have stronger precipitation, smaller precipitation area, and larger cold cloud system than observed in both regionsDeficiency in climatological moisture in the central United States and dynamic condition in South China contributes to underestimation of MCS [ABSTRACT FROM AUTHOR]

Background: Recent evidence of genetics and metabonomics indicated a potential role of apolipoprotein M (ApoM) in the pathogenesis of Alzheimer's disease (AD). Here, we aimed to investigate the association between plasma ApoM with AD. Methods: A multicenter, cross-sectional study recruited patients with AD (n = 67), age- and sex-matched cognitively normal (CN) controls (n = 73). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, we examined and compared the plasma levels of ApoM, tau phosphorylated at threonine 217 (p-tau217) and neurofilament light (NfL). Multivariate logistic regression analysis was applied to determine the association of plasma ApoM with the presence of AD. The correlation analysis was used to explore the correlations between plasma ApoM with cognitive function [Mini–Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)], activities of daily living (ADL), and the representative blood-based biomarkers (plasma p-tau217 and NfL). Receiver operating characteristic (ROC) analysis and Delong's test were used to determine the diagnostic power of plasma ApoM. Results: Plasma ApoM and its derived indicators (ratios of ApoM/TC, ApoM/TG, ApoM/HDL-C, and ApoM/LDL-C) were significantly higher in AD group than those in CN group (each p < 0.0001). After adjusted for the risk factors of AD, the plasma ApoM and its derived indicators were significantly associated with the presence of AD, respectively. ApoM (OR = 1.058, 95% CI: 1.027–1.090, p < 0.0001), ApoM/TC ratio (OR = 1.239, 95% CI: 1.120–1.372, p < 0.0001), ApoM/TG ratio (OR = 1.064, 95% CI: 1.035–1.095, p < 0.0001), ApoM/HDL-C ratio (OR = 1.069, 95% CI: 1.037–1.102, p < 0.0001), and ApoM/LDL-C ratio (OR = 1.064, 95% CI:1.023–1.106, p = 0.002). In total participants, plasma ApoM was significantly positively correlated with plasma p-tau217, plasma NfL, and ADL (each p < 0.0001) and significantly negatively correlated with MMSE and MoCA (each p < 0.0001), respectively. In further subgroup analyses, these associations remained in different APOE ϵ 4 status participants and sex subgroups. ApoM/TC ratio (ΔAUC = 0.056, p = 0.044) and ApoM/TG ratio (ΔAUC = 0.097, p = 0.011) had a statistically remarkably larger AUC than ApoM, respectively. The independent addition of ApoM and its derived indicators to the basic model [combining age, sex, APOE ϵ 4, and body mass index (BMI)] led to the significant improvement in diagnostic power, respectively (each p < 0.05). Conclusion: All the findings preliminarily uncovered the association between plasma ApoM and AD and provided more evidence of the potential of ApoM as a candidate biomarker of AD. [ABSTRACT FROM AUTHOR]

The strong disturbance of upward mining of the short-distance multiseam results in frequent fractures in the coal seam to be mined, jeopardizing the operation safety due to the instability of the surrounding rock of the overlying stope and risks of coal and gas outburst. A lucrative alternative is the downward mining of multiseam, which wide implementation is limited by the lack of reliable data on stress evolution characteristics. In this paper, the evolution, nonlinear interaction, and superposition characteristics of mining-induced stress after multiple pressure relief in the short-distance multi-seam were investigated by the numerical simulation and physical simulation, taking the endowment and mining technology characteristics of group B short-distance multiseam in Pan'er Coal Mine in Anhui Province of China as an example. The numerical and physical models of multiple (2—5 times) mining activities in pressure relief multiseam (with five main coal layers) under downward mining are constructed and implemented with the FLAC3D software and 1 : 100 scaling, respectively. The results showed that a pressure relief arch, which bears and transfers stresses, is formed on the coal seam's roof and floor. In downward mining, the local arch expands to the long arch, which bearing capacity within the influence range of multiple mining disturbances is weak, and the arch structure is prone to instability. If a coal pillar is left in the upper coal seam after its mining, the lower coal seam mining will switch from the large-scale low-stress area under the goaf to the small-scale high-stress area of nonlinear interaction of the multiple mining stresses with the stress under the coal pillar. [ABSTRACT FROM AUTHOR]

Marek's disease virus (MDV) is an important oncogenic poultry pathogen that can generally be controlled by vaccination. However, MDV infections still occur occasionally on vaccinated farms, possibly due to genetic variation among MDV strains or management-related issues. In this study, a novel MDV strain, designated LZ1309, was isolated from a poultry flock that had been vaccinated with the HVT and CVI988 vaccine strains. Animal experiments showed that LZ1309 infection led to high morbidity (100%) and mortality (90%). Moreover, existing vaccines provided only partial protection against LZ1309, with protection rates of 68.4%, 85%, and 90% for HVT, CVI988, and HVT plus CVI988, respectively. This study demonstrates the presence of a more virulent strain of MDV in vaccinated chickens in China that poses a new potential threat to poultry farms. In future studies, the development of new treatment strategies should be of high priority. [ABSTRACT FROM AUTHOR]

Accurate identification of edible ectomycorrhizal (ECM) mushrooms and their host trees in nature is key to commercial production for consumption. For the first time we describe the ectomycorrhizal association of the three most common species of edible matsutake mushrooms with their native host trees in Yunnan Province in China. We collected ECM samples from three different localities in subtropical forests known to be highly productive areas of Tricholoma. Additionally, we collected basidiomata of Tricholoma from the field and markets in Yunnan. ECM samples were analyzed using morphological and molecular methods. We conducted phylogenetic analyses of nuc rDNA internal transcribed spacer region ITS1-5.8S-ITS2 (ITS) and analyzed the intergenic spacer of cpDNA psbA-trnH to identify basidiomata and plant hosts, respectively. Three species of Tricholoma were identified: T. bakamatsutake, T. fulvocastaneum, and T. matsutake. Four ECM associations in the study area were detected: Tricholoma bakamatsutake + Castanopsis tibetana, T. fulvocastaneum + C. tibetana, T. fulvocastaneum + Pinus yunnanensis, and T. matsutake + P. yunnanensis. Detailed descriptions and illustrations of the ECM associations are presented. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to comprehensively evaluate Chinese coronary heart disease (CHD) patients' health-related quality of life (HRQoL) using various measures and explore influencing factors associated with HRQoL. Methods: A cross-sectional study was conducted from April to September 2019 in the General Hospital of Tianjin Medical University. A convenience sampling framework was used to successively recruit 316 inpatients with CHD. Two generic preference-based instruments (EQ-5D-5L and 15D), a disease-specific instrument (Seattle Angina Questionnaire, SAQ), and the WHO-5 well-being index (WHO-5) were administered. Tobit regression model and multiple linear regression were used for data analyses. Results: A total of 305 patients (mean age was 62.9) with CHD participated in this study. The mean health state utility (HSU) scores of EQ-5D-5L and 15D were 0.85 (SD=0.14) and 0.89 (SD=0.07), respectively. For EQ-5D-5L, pain/discomfort was the most frequently reported, followed by anxiety/depression. As for 15D, discomfort and symptoms was the most severely impaired dimension. For SAQ, more limitations were found in the domains of angina stability and disease perception. For WHO-5, the mean score was 16.93. Marital status, disease state and comorbidity were influencing factors associated with HRQoL, patient's subjective well-being had a positive impact on HRQoL. Conclusion: To improve the HRQoL of CHD patients in China, more attention needs to be paid to unmarried and relapsed patients, especially those with comorbidity of hypertension. Additionally, more social support and psychological counseling should be provided to patients. [ABSTRACT FROM AUTHOR]

Shenlian (SL) decoction is a herbal formula composed of Coptis and ginseng, of which berberine and ginsenoside are the main constituents. Even though SL decoction is widely used in treating diabetes in China, the mechanism of its antidiabetes function still needs further study. Gut microbiota disorder is one of the important factors that cause diabetes. To explore the effect of SL decoction on intestinal microbiota, gut microbiota of mice was analyzed by sequencing the gut bacterial 16S rRNA V3+V4 region and metagenomics. In this study, results demonstrated that SL decoction had a better hypoglycemic effect and β cell protection effect than either ginseng or Coptis chinensis. Alpha diversity analysis showed that all interventions with ginseng, Coptis, and SL decoction could reverse the increased diversity and richness of gut microbiota in db/db mice. PCoA analysis showed oral SL decoction significantly alters gut microbiota composition in db/db mice. 395 OTUs showed significant differences after SL treatment, of which 37 OTUs enriched by SL decoction showed a significant negative correlation with FBG, and 204 OTUs decreased by SL decoction showed a significant positive correlation with FBG. Results of KEGG analysis and metagenomic sequencing showed that SL decoction could reduce the Prevotellaceae, Rikenellaceae, and Helicobacteraceae, which were related to lipopolysaccharide biosynthesis, riboflavin metabolism, and peroxisome, respectively. It could also upregulate the abundance of Bacteroidaceae, which contributed to the metabolism of starch and sucrose as well as pentose-glucuronate interconversions. In the species level, SL decoction significantly upregulates the relative abundance of Bacteroides_acidifaciens which showed a significant negative correlation with FBG and was reported to be a potential agent for modulating metabolic disorders such as diabetes and obesity. In conclusion, SL decoction was effective in hypoglycemia and its mechanism may be related to regulating gut microbiota via upregulating Bacteroides_acidifaciens. [ABSTRACT FROM AUTHOR]

The risk analysis of flood and drought disasters and the study of their influencing factors enhance our understanding of the temporal and spatial variation law of disasters and help identify the main factors affecting disasters. This paper uses the provincial administrative region of China as the research area. The proportion of the disaster area represents the degree of the disaster. The statistical distribution of the proportions was optimized from 10 alternative distributions based on a KS test, and the disaster risk was analyzed. Thirty-five indicators were selected from nature, agriculture and the social economy as alternative factors. The main factors affecting flood and drought disasters were selected by Pearson, Spearman and Kendall correlation coefficient test. The results demonstrated that the distribution of floods and drought is right-skewed, and the gamma distribution is the best statistical distribution for fitting disasters. In terms of time, the risk of flood and drought disasters in all regions showed a downward trend. Economic development and the enhancement of the ability to resist disasters were the main reasons for the change in disasters. Spatially, the areas with high drought risk were mainly distributed in Northeast and North China, and the areas with high flood risk were mainly distributed in the south, especially in Hubei, Hunan, Jiangxi and Anhui. The distribution of floods and drought disasters was consistent with the distribution characteristics of precipitation and water resources in China. Among the natural factors, precipitation was the main factor causing changes in floods and drought disasters. Among the agricultural and socioeconomic factors, the indicators reflecting the disaster resistance ability and regional economic development level were closely related to flood and drought disasters. The research results have reference significance for disaster classification, disaster formation mechanisms and flood and drought resistance. [ABSTRACT FROM AUTHOR]

With the expansion of the coal mining depth and scales, the content of coal mine methane (CMM) is increasing, bringing the great challenge to the safe coal mining and greenhouse gas control. Researching CMM emission laws and its drainage technologies in underground coal mining is essential. This paper analyzed the sources of CMM emission in the workface and then put forward the grid method to measure the CMM emission laws in the single coal seam, which error was verified by the integral method. The CMM emission laws of the S2107 workface of the Yuwu mine, northeastern Qinshui basin, China were researched as a case study and it is found that the upper corner was the key position of CMM control in the workface. The sub-source CMM drainage methods by the strike high-level roadway and long vertical buried pipes were applied against the different CMM sources in the S2107 workface. The gas concentration in the return air was less than 0.6% during the CMM drainage, verifying the effectiveness of the sub-source CMM drainage methods. [ABSTRACT FROM AUTHOR]

Purpose: Shadow banking has been evolving rapidly in China, with banks actively using wealth management products (WMPs) to evade regulatory restrictions. These products are the largest constituent of China's shadow banking sector. A large number of these products are off-balance-sheet and considered a substitute for bank deposits. China's banking sector, especially the small and medium-sized banks (SMBs), uses these products to avoid regulatory restrictions and sustainability risk in the deposit market. Design/methodology/approach: This study empirically examined how banks in China, specifically SMBs, utilize these products on a short and long-run basis to manage and control their deposit levels. This study utilized a quarterly panel dataset from 2010 to 2019 for the top 30 Chinese banks, by first implementing a Panel ARDL-PMG model. For cross-sectional dependence, this study further executed a cross-sectional augmented autoregressive distributive lag model (CS-ARDL). Findings: Under regulations avoidance theory, the findings revealed that WMPs and deposits have a stable long-run substitute relationship. Furthermore, the WMP–Deposit substitute relationship was only significant and consistent for SMBs, but not for large four banks. The findings further revealed that the WMP–Deposit substitute relationship existed, even after the removal of the deposit rate limit imposed by the People's Bank of China (PBOC) to control the deposit rates. Research limitations/implications: The individual bank-issued WMPs' amount data is not available in any database. Therefore, this study utilized the number of WMPs as a proxy for China's banking sector's exposure to the wealth management business. Practical implications: This research helps policymakers to understand the Deposit–WMP relationship from the off-balance-sheet perspective. During the various stages of interest rate liberalization, banks were given more control to establish their deposit and loan interest rates. However, the deposit rates are still way below the WMP returns, making WMPs more competitive. This research suggests that policymakers should formulate a more balanced strategy regarding deposit rates and WMPs returns. Originality/value: This study contributes to the existing literature on China's shadow banking by concentrating on the WMPs. This research represents one of the few studies that analyze regulatory arbitrage in terms of the WMP–Deposit relationship. Moreover, the implementation of CS-ARDL panel data models and multiple data sources makes this study's findings more reliable and significant. [ABSTRACT FROM AUTHOR]

Background: To investigate the current diagnostic and therapeutic approaches to anterior urethral strictures of Chinese urologists and to compare with developed countries and the American Urologic Association guidelines.Methods: Anonymous questionnaires were distributed to members of Official Wechat Account of urology from March 19, 2020 to April 10, 2020. Descriptive and multiple correspondence analysis were used to analyze the data.Results: A total of 1276 online questionnaires were received. The response rate was 21.7% (1276/5878). The most common diagnostic methods for anterior urethral stricture were urethrography (90.7%) and urethrocystoscopy (85.4%), while urethral dilation (92.3%) and internal urethrotomy (60.1%) were the main therapeutic procedures. End-to-end urethroplasty (45.2%) was the most common open surgery, followed by skin flap urethroplasty (14.9%) and free graft urethroplasty (12.4%). 76.2% of urologists used urethroplasty only after the failure of minimally invasive surgery (reconstructive ladder treatment strategy). Furthermore, middle-aged or elderly urologists who had attended trainings, had senior practice roles, and who utilized a reconstructive ladder treatment approach were most likely to perform urethroplasties.Conclusions: Anterior urethral stricture treatment in China is still dominated by minimally invasive surgery, with most urologists using the reconstructive ladder treatment strategy. In general, the overall diagnostic and therapeutic strategies were similar between China and developed countries, with some deviations from the American Urologic Association guidelines. [ABSTRACT FROM AUTHOR]

The aim of the study was to develop an algorithm to predict postoperative pneumonia among elderly patients with lung cancer after video-assisted thoracoscopic surgery. We analyzed 3,009 patients from the Thoracic Perioperative Database for Geriatrics in our hospital and finally enrolled 1,585 elderly patients (age≧65 years) with lung cancer treated with video-assisted thoracoscopic surgery. The included patients were randomly divided into a training group (n = 793) and a validation group (n = 792). Patients in the training group were used to develop the algorithm after screening up to 30 potential risk factors, and patients in the validation group were used to internally validate the algorithm. External validation of the algorithm was achieved in the external validation dataset after enrolling 165 elderly patients with lung cancer treated with video-assisted thoracoscopic surgery from two hospitals in China. Of all included patients, 9.15% (145/1,585) of patients suffered from postoperative pneumonia in the Thoracic Perioperative Database for Geriatrics, and 10.30% (17/165) of patients had postoperative pneumonia in the external validation dataset. The algorithm consisted of seven variables, including sex, smoking, history of chronic obstructive pulmonary disease (COPD), surgery duration, leukocyte count, intraoperative injection of colloid, and intraoperative injection of hormone. The C-index from the receiver operating characteristic curve (AUROC) was 0.70 in the training group, 0.67 in the internal validation group, and 0.71 in the external validation dataset, and the corresponding calibration slopes were 0.88 (95% confident interval [CI]: 0.37–1.39), 0.90 (95% CI: 0.46–1.34), and 1.03 (95% CI: 0.24–1.83), respectively. The actual probabilities of postoperative pneumonia were 5.14% (53/1031) in the low-risk group, 15.07% (71/471) in the medium-risk group, and 25.30% (21/83) in the high-risk group (p < 0.001). The algorithm can be a useful prognostic tool to predict the risk of developing postoperative pneumonia among elderly patients with lung cancer after video-assisted thoracoscopic surgery. [ABSTRACT FROM AUTHOR]

With the increasing demand from aging population and seasonal blood shortage, recruiting and retaining blood donors has become an urgent issue for the blood collection centers in China. This study aims to understand intention to donate again from a social cognitive perspective among whole blood donors in China through investigating the association between the blood donation fear, perceived rewards, self-efficacy, and intention to return. A cross-sectional survey was conducted in six cities, which are geographically and socioeconomically distinct areas in Jiangsu, China. Respondents completed a self-administrated questionnaire interviewed by two well-trained medical students. A total of 191 blood donors were included in the current study. Descriptive analysis, correlation analysis, and a generalized linear regression model were used to explore the association between demographic characteristics, psychological factors, and intention to donate again. After controlling other covariates, donors with higher fear scores reported lower intention to return (p = 0.008). Association between self-efficacy and intention to return was statistically significant (p < 0.001), whereas the association between intrinsic rewards (p = 0.387), extrinsic rewards (p = 0.939), and intention to return were statistically insignificant. This study found that either intrinsic rewards or extrinsic rewards are not significantly associated with intention to donate again among whole blood donors in China, and fear is negatively associated with intention to donate again. Therefore, purposive strategies could be enacted beyond appeals to rewards and focus on the management of donors' fear. [ABSTRACT FROM AUTHOR]

This study empirically investigates the effect of external financial market friction on restructuring activities, based on panel data of listed Chinese firms from 2004 to 2018. The results show that there is a positive correlation between financial market friction and the number of restructuring deals. We also find that high financial market friction increases preference for cash payments and the likelihood of mergers and acquisitions. These findings add to the restructuring literature by capturing heterogenous restructuring forms. They also deepen the understanding of the firm boundary theory, by suggesting that firms have incentives to increase their scopes when facing external market distress. [ABSTRACT FROM AUTHOR]

Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration, cancer, and pathogen infection. Small chemical modulators of autophagy show the potential to treat autophagy-associated diseases. Diterpenoids, nature products found in various plants, exhibit a wide range of bioactivity, and we have recently isolated and characterized over 150 diterpenoids from Isodon species distributed in China. Here, we applied a high-content fluorescence imaging-based assay to assess these diterpenoids' ability to affect autophagic flux in HeLa cells. We found that enanderinanin J, an ent-kauranoid dimer, is an autophagy inhibitor, manifested by its ability to increase lysosomal pH and inhibit the fusion between autophagosomes and lysosomes. Autophagy has been shown to be either positively or negatively involved in the life cycle of Zika virus (ZIKV), Japanese encephalitis virus (JEV), Dengue virus (DENV), and enterovirus-A71 (EV-A71). We found that enanderinanin J significantly inhibited the infection of ZIKV, DENV, JEV, or EV-A71. Interestingly, although ATG5 knockdown inhibited ZIKV or JEV infection, enanderinanin J further inhibited the infection of ZIKV or JEV in ATG5-knockdown cells. Taken together, our data indicate that enanderinanin J inhibits autophagosome-lysosome fusion and is a potential antiviral agent. [ABSTRACT FROM AUTHOR]

The environmental pollution and ecological risk of riverine systems are of growing concern in China and worldwide. Previous studies have mainly focused on urban and rural rivers. However, suburban rivers differ from urban and rural rivers as they are subject to complex pollution sources, random discharge of domestic garbage, improper handling of agricultural means of production and imperfect municipal engineering facilities; thus, identifying the complex pollution sources and ecological risk in suburban rivers might help improve environmental quality and inform management decisions. The occurrence and spatial distribution of six heavy metals were investigated and analysed. The average concentrations of target heavy metals in surface sediments were in the order of Zn (1,198.7) > Cr (84.6) > Pb (40.0) > Cu (25.6) > Ni (11.8) > Cd (0.5) (mg/kg, dry weight). The concentrations of all heavy metals in the study area except Ni and Pb were significantly higher (p <.05) than the environmental background values. The pollution load index (PLI) indicated that the sediments were "moderately polluted", which was mainly caused by Zn and Cd. The potential ecological risk index (RI) showed that there was a "high" ecological risk of heavy metals in sediments, of which Cd accounted for 83% of the RI. A principal component analysis coupled with Pearson's correlations indicated that Pb and Zn were mainly associated with domestic, traffic and agricultural sources; Cr, Cu and Ni were mainly derived from traffic and natural sources, and Cd was likely from coal combustion and agricultural sources. The results from this study will provide the scientific knowledge needed to control and manage the emissions or discharge from multiple heavy metal pollution sources and identify their potential ecological risk in the sediment of suburban rivers. [ABSTRACT FROM AUTHOR]

High-resolution optical cameras have always been important scientific payloads in Mars exploration missions, which can obtain detailed images of Martian surface for the study of geomorphology, topography and geological structure. At present, there are still many challenges for Mars high-resolution images in terms of global coverage, stereo coverage (especially for colour images), and data processing methods. High Resolution Imaging Camera (HiRIC) is a high-quality, multi-mode, multi-functional, multi-spectral remote sensing camera that is suitable for the deep space developed for China's first Mars Exploration Mission (Tianwen-1), which was successfully launched in July 2020. Here we design special experiments based on the in-orbit detection conditions of Tianwen-1 mission to comprehensively verify the detection capability and the performance of HiRIC, from the aspects of image motion compensation effect, focusing effect, image compression quality, and data preprocessing accuracy. The results showed that the performance status of HiRIC meets the requirements of obtaining high resolution images on the Martian surface. Furthermore, proposals for HiRIC in-orbit imaging strategy and data processing are discussed to ensure the acquisition of high-quality HiRIC images, which is expected to serve as a powerful complementation to the current Mars high-resolution images. [ABSTRACT FROM AUTHOR]

Truffle cultivation is successfully applied throughout the world for several truffles of European origin. However, just two Chinese black truffles (Tuber indicum and T. himalayense) have been cultivated with a favorable outcome so far. Tuber pseudohimalayense is a black truffle of significant economic relevance in China, but little is known about its mycorrhizal ecology and it is not cultivated in orchards yet. Here, we selected seven broad-leaved tree species (Quercus fabrei, Q. aliena, Castanea mollissima, Carya illinoinensis, Q. glauca, Castanopsis orthacantha, Betula costata), and one coniferous tree (Pinus armandii), and inoculated them with T. pseudohimalayense spore suspension using axenically germinated seedlings under greenhouse conditions. The obtained mycorrhizae, well-developed, were analyzed from the morpho-anatomical and molecular points of view, and their main characteristics described. Synthesized T. pseudohimalayense mycorrhizae showed similar characters on all tree species, with a typical interlocking pseudoparenchymatous mantle and Hartig net, swollen appearance, yellow-brownish color, and long hyaline emanating hyphae with right-angle ramifications. These features are similar to those reported for mycorrhizae formed by related black truffle species. The successful mycorrhizal synthesis of T. pseudohimalayense on multiple trees species indicates that it has potential for cultivation in China. [ABSTRACT FROM AUTHOR]

Nile tilapia is an important economically farmed fish worldwide, and Streptococcus agalactiae has become the most serious disease problem for the tilapia industry in China. Therefore, a better understanding of the innate immune mechanisms and their functions in the context of pathogen invasion is needed. In this study, a high-throughput proteomic strategy was developed for determining the differential expression proteins (DEPs) of the genetically improved farmed tilapia (GIFT) (susceptible and resistant GIFT species) splenic responses to S. agalactiae infection. The results showed 1608 proteins were identified with high confidence (P < 0.05). A total of 441 and 382 DEPs were characterized in susceptible and resistant GIFT tilapia species, respectively. Gene ontology (GO) annotation showed that the DEPs covered many biological functions, including cellular process, metabolism, and immune process. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that the DEPs were mainly enriched in the lysosome, apoptosis, and complement and coagulation cascade pathways during S. agalactiae infection. By group comparisons, the proteins related to immune response, cytoskeleton, and energy metabolism of disease-resistant strains were upregulated compared with those of susceptible strain. The content determination of immune-related enzyme activity was consistent with the results obtained throughout the study. More active innate immune system and cell defense is the basis of S. agalactiae resistance for disease-resistant GIFT tilapia species. Furthermore, 34 proteins involved in disease resistance were characterized. Therefore, the present study contributes to a better understanding of the immune system and defense mechanisms of GIFT tilapia in response to S. agalactiae infection and provides valuable recommendations for breeding disease-resistant GIFT tilapia species. [ABSTRACT FROM AUTHOR]

Fenneropenaeus chinensis is one of the most important aquaculture species in China. Research on its genomic and genetic structure not only helps us comprehend the genetic basis of complex economic traits, but also offers theoretical guidance in selective breeding. In the present study, a genome survey sequencing was performed to generate a rough reference genome utilized for groping preliminary genome characteristics and facilitate linkage and quantitative trait locus (QTL) mapping. Linkage mapping was conducted using a reduced-representation sequencing method 2b-RAD. In total, 36,762 SNPs were genotyped from 273 progenies in a mapping family, and a high-resolution linkage map was constructed. The consensus map contained 12,884 markers and spanned 5257.81 cM with an average marker interval of 0.41 cM, which was the first high-resolution genetic map in F. chinensis to our knowledge. QTL mapping and association analysis were carried out in 29 characters including body size, sex and disease resistance. 87 significant QTLs were detected in several traits and they were also evaluated by association analysis. Results of this study provide us valuable suggestions in genetic improvement and breeding of new varieties and also lay a basic foundation for further application of cloning of economic genes in selective breeding program and marker-assisted selection. [ABSTRACT FROM AUTHOR]

Frozen soil infiltration widely occurs in hydrological processes such as seasonal soil freezing and thawing, snowmelt infiltration, and runoff. Accurate measurement and simulation of parameters related to frozen soil infiltration processes are highly important for agricultural water management, environmental issues, and engineering problems in cold regions. Temperature changes cause soil pore size distribution variations and consequently dynamic infiltration capacity changes during different freeze–thaw periods. To better understand these complex processes and to reveal the freeze–thaw action effects on soil pore distribution and infiltration capacity, black soils, meadow soils, and chernozem were selected as test subjects. These soil types account for the largest arable land area in Heilongjiang Province, China. Laboratory tests of soils at different temperatures were conducted using a tension infiltrometer and ethylene glycol aqueous solution. The stable infiltration rate and hydraulic conductivity were measured, and the soil pore distribution was calculated. The results indicated that for the different soil types, macropores, which constituted approximately 0.1 % to 0.2 % of the soil volume under unfrozen conditions, contributed approximately 50 % of the saturated flow, and after soil freezing, the soil macropore proportion decreased to 0.05 % to 0.1 %, while the saturated flow proportion decreased to approximately 30 %. Soil moisture froze into ice crystals inside relatively large pores, resulting in numerous smaller-sized pores, which reduced the number of macropores but increased the number of smaller-sized mesopores, so that the frozen soil infiltration capacity was no longer solely dependent on the macropores. After the ice crystals had melted, more pores were formed within the soil, enhancing the soil permeability. [ABSTRACT FROM AUTHOR]

Background: The plasma concentration of patients treated with efavirenz (EFV) 600 mg was found to exceed the upper limit of the proposed therapeutic window in most Chinese HIV-infected individuals; thus, dosage reduction of EFV to 400 mg daily warranted consideration. This study aimed to assess the pharmacodynamics of EFV 400 mg for HIV-1-infected patients in China. Method: Twenty cART-naïve individuals were enrolled in this study. EFV 400 mg combined with tenofovir (TDF) and lamivudine (3TC) as an initial antiretroviral regimen was administered for 48 weeks. EFV concentration and T cell subsets as well as HIV RNA load were evaluated at baseline and at 4, 12, 24, and 48 weeks. Moreover, neuropsychiatric adverse effects were also assessed by the Hamilton depression (HAMD) scale and Pittsburgh sleep quality index (PSQI). Results: Eighteen males and two females whose median age was 26 (interquartile range [IQR]: 23–32) years completed 48 weeks of follow-up. The median EFV concentrations were 1.88 (IQR: 1.54–2.42), 1.74 (IQR: 1.36–1.93), 1.93 (IQR: 1.66–2.22), and 1.85 (IQR: 1.54–2.14) mg/L at weeks 4, 12, 24, and 48, respectively. The viral load was 4.59 (IQR: 4.10–5.19) log10 copies/mL at baseline, and it decreased by 4.6 (IQR: 3.98–5.18) log10 copies/mL from baseline to week 48. Three of 20 (15%), 10 of 20 (50.0%), 17 of 20 (85%), and 18 of 19 (95%) participants had a plasma viral load less than 50 copies/mL at weeks 4, 12, 24, and 48, respectively. The median CD4 cell count was 330 (IQR: 237–410) cells/μL at baseline, and it increased to 473 (IQR: 344–574) cells/μL at 48 weeks. The HAMD score was 5 (IQR: 3–9.8) and 3 (IQR: 2.25–4) at baseline and 48 weeks, respectively. The PSQI score was 4 (IQR: 2–5.8) and 3 (IQR: 2–4) at baseline and 48 weeks, respectively. Dizziness was the most common event, occurring in 70% of patients within the first 2 weeks of treatment. Conclusion: Patients prescribed with EFV 400 mg-containing agents demonstrated favourable virological and immunological responses. And the plasma EFV concentration was within the recommended therapeutic range, with fewer adverse reactions than with EFV 600 mg. EFV 400 mg was effective and safe in Chinese HIV-infected patients. Trial registration: NCT04596488; Registered 21 October, 2020; Retrospectively registered. [ABSTRACT FROM AUTHOR]