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Objectives: It is common for patients with schizophrenia to exhibit symptoms of autism. Both autism spectrum disorders and schizophrenia share similar patterns of empathy deficits. This study purposed to explore the association between autistic features and empathy in Chinese patients with chronic schizophrenia., Methods: We enrolled 857 patients with chronic schizophrenia. The Positive and Negative Syndrome Scale (PANSS), Repeatable Battery for the Assessment of Neuropsychological 7 Status (RBANS), and Interpersonal Reactivity Index (IRI) were employed to assess the participants' clinical symptoms, neurocognition, and empathy, respectively. The severity of autistic symptoms was assessed with the PANSS Autism Severity Scale (PAUSS), with PAUSS scores ≥ 30 were considered to have significant autistic features., Results: 114 schizophrenia patients (13.3%) had autistic features. Compared to schizophrenia patients without autistic features, those with autistic features had more severe clinical symptoms, and poorer neurocognition and empathic abilities. Female sex and empathic concerns were independently associated with autistic features in patients with chronic schizophrenia., Conclusions: Our results suggest that autistic features tend to manifest quite commonly among patients with chronic schizophrenia. Empathy deficits are strongly associated with autistic features in patients with chronic schizophrenia, strengthening the view that autistic features may characterize a subgroup of schizophrenia patients., Competing Interests: Declarations. Conflict of interest: No conflict of interest was disclosed for each author. Ethical Statement: This study was approved by the Ethics Committee of the First Affiliated Hospital of Shanxi Medical University. The authors asset that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Each patient signed a written informed consent form before participating in the trial and after they had been provided with a detailed explanation of the study., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

Aims: This two-wave, longitudinal study aimed to examine the potential moderating and mediating effects of resilience on the association between perceived school bullying and psychotic-like experiences among Chinese sexual minority adolescents. Methods: A total of 4192 senior high students were included and 984 (23.5%) of them were identified as a sexual minority (mean age = 16.68 years, SD = 0.71). Participants completed two online surveys during April 21 to May 12, 2021 and December 17 to 26, 2021, respectively, as well as completed self-report measures of sample characteristics, perceived school bullying, resilience, and psychotic-like experiences (including two dimensions: delusional experiences and hallucinatory experiences). Results: Perceived school bullying and resilience were associated with psychotic-like experiences in sexual minority adolescents. Resilience mediated the relationship between perceived school bullying and subsequent psychotic-like experiences (b = 0.03, 95% CI = 0.01 ~ 0.04)/ delusional experiences (b = 0.03, 95% CI = 0.01 ~ 0.04)/ hallucinatory experiences (b = 0.02, 95% CI = 0.01 ~ 0.03). Additionally, resilience only moderated the associations of perceived school bullying with hallucinatory experiences (b = −0.06, 95% CI = −0.12 ~ −0.01). Conclusions: These findings indicated that resilience plays a crucial role in mediating or moderating the relationship between perceived school bullying and psychotic-like experiences. Assessing and reducing school bullying, as well as promoting resilience, may have important clinical implications for reducing the risk of psychotic-like experiences in sexual minority adolescents. [ABSTRACT FROM AUTHOR]

Objectives: Genetic factors play an important role in the etiology of schizophrenia (SZ). Catenin Delta 2 (CTNND2) is one of the genes regulating neuronal development in the brain. It is unclear whether CTNND2 is involved in SZ. With the hypothesis that CTNND2 may be a risk gene for SZ, we performed a case-control association analysis to investigate if CTNND2 gene single nucleotide polymorphisms (SNPs) are implicated in SZ in a Han Chinese population. Materials and Methods: We recruited subjects from 2010 to 2022 from the Han population of northern Henan and divided them into two case-control samples, including a discovery sample (SZ = 528 and controls = 528) and replication sample (SZ = 2458 and controls = 6914). Twenty-one SNPs were genotyped on the Illumina BeadStation 500G platform using GoldenGate technology and analyzed by PLINK. The Positive and Negative Syndrome Scale (PANSS) was used to assess clinical symptoms. Results: Rs16901943, rs7733427, and rs2168878 SNPs were associated with SZ (Chi2 = 7.484, 11.576, and 5.391, respectively, df = 1; p = 0.006, 0.00067, and 0.02, respectively) in the two samples. Rs10058868 was associated with SZ in male patients in the discovery sample (Chi2 = 6.264, df = 1, p =.044). Only the relationship with rs7733427 survived Bonferroni correction. Linkage disequilibrium block three haplotypes were associated with SZ in the discovery and total sample. PANSS analysis of the four SNPs implicated rs10058868 and rs2168878 in symptoms of depression and excitement, respectively, in the patients with SZ. Conclusion: Four SNPs of the CTNND2 gene were identified as being correlated with SZ. This gene may be involved in susceptibility to SZ. [ABSTRACT FROM AUTHOR]

Government leadership and grassroots participation are the most typical institutional arrangements in natural resource management, a topic which has been the subject of vigorous debate for a long time. Individually, these systems are referred to as scientization and parametrization. This paper takes the reform of China's state-owned forest farms (SSFs) as a pointcut, comparing the effects of the 2011 policy (representing scientization) and the 2015 policy (representing parametrization) on environmental conservation. For the period from 2006 to 2018, China's provinces are analyzed via difference-in-differences (DID) and principal components difference-in-differences (PCDID) empirical strategies. The results show that the 2015 policy increased new afforestation by an average of 0.903 units, but the 2011 policy had no significant impact. The influence path of the 2015 policy was to curb corruption, relieve fiscal stress, and stimulate innovation, playing mechanism effects of 20.49%, 14.17%, and 33.55%, respectively. However, the 2015 policy was not ideal in terms of its goal of incentivizing multi-agent participation in investments in conservation. Investors prefer to attempt afforestation projects with shorter payback periods, especially projects related to open forest land. Overall, this study supports the belief that parametric management is a better approach to natural resource management than scientific management, but the latter approach still has limitations. Therefore, we propose to prioritize the promotion of parametric management on the closed forest lands of SSFs, but there is no need to hastily mobilize grassroots participation in open forest land management projects. [ABSTRACT FROM AUTHOR]

Science and technology innovation are crucial components underpinning agriculture. We constructed an evaluation framework including 4 pillars and 21 indicators, taking 31 provinces in China as examples to examine the level of agriculture science and technology development from a regional perspective. We found that there is an obvious gap between east and west nationwide, and that only about half of the provinces have reached the high and medium levels. It was worth noting that the innovation conditions in Shanghai and Beijing presented huge advantages, of vital importance to a first-class talent team, a complete innovation system, a stable and prosperous market, and active exchanges and cooperation. In addition, to maximize the transformation of agricultural science and technology achievements into real productivity, local government should also strengthen the construction of agricultural research and innovation platforms, technology transfer, and transformation of results. The findings advance understanding of the strengths and weaknesses of the evaluation subjects' agricultural science and technology development from a regional perspective and are expected to provide some basis for the government and stakeholders to make relevant decisions. [ABSTRACT FROM AUTHOR]

The harm of childhood parental neglect to emerging adults' maladjustment has garnered empirical support. For college students who have left‐behind experience (LBE), this relationship is rarely discussed and the psychological process underlying this relationship is not well understood. Using a longitudinal study and guided by the Risky Families model, this study aimed to explore the mediating roles of anxious attachment and perceived social support in the link between parental neglect and maladjustment of LBE college students. We used two‐wave longitudinal data, with a time lag of 3 months, collected among Chinese college students with LBE in Chongqing (N = 391). The results revealed that parental neglect in wave one was positively associated with maladjustment (depression, anxiety, and stress) in wave two. Anxious attachment and perceived social support in wave two separately mediated the relationship between parental neglect in wave one and maladjustment in wave two. Anxious attachment and perceived social support in wave two only sequentially mediated the pathway from parental neglect to later depression. These findings emphasize the importance of anxious attachment and social support in resilience and have significant implications for LBE college students' social work practice in China. [ABSTRACT FROM AUTHOR]

The development level of the high-tech industry affects the comprehensive competitiveness of a country and a region. It has great theoretical and practical significance to grasp the status quo and differences in technological innovation capability of regional high-tech industries in R&D and transformation and to provide a basis for relevant departments to formulate differentiated policies for developing high-tech industries. In order to comprehensively reflect the innovation capability and fully excavate and extract the differentiated information of China's regional high-tech industry. According to the characteristics and laws of panel data on the high-tech industry, from the two dimensions of technology R&D and achievement transformation, the grey incidence analysis method is exploited to a novel grey matrix type incidence clustering model based on the panel data for high-tech innovation capability assessment and differences extraction. The result shows that the high-tech innovation capability is not strong on the whole, and there are obvious regional differences and imbalances in R&D and transformation, the ranking is in the order of eastern, central, and northwestern provinces and cities. [ABSTRACT FROM AUTHOR]

Background Various epidemiological studies have focused on the adverse health outcomes of meteorological factors. However, there has been little research on the impact of humidex on allergic conjunctivitis, especially in child and adolescent populations. We aimed to explore the impact of humidex, a comprehensive index of relative humidity and temperature, on child and adolescent allergic conjunctivitis admissions. Methods Outpatient visit data for allergic conjunctivitis, meteorological factors and air pollutants in Shanghai for the 2017-2022 period were retrieved. For the purpose of analysing the nonlinear connection and lag impact between humidex and admissions for paediatric and adolescent allergic conjunctivitis, the distributed lag nonlinear model (DLNM) was fitted. Results A total of 147 090 cases were included in our cohort. We found a significantly nonlinear effect on humidex and allergic conjunctivitis. In the single-day lag pattern, the relative risks (RR) of allergic conjunctivitis were significant at lag 0 (RR = 1.08, 95% confidence interval (CI) = 1.05-1.11) to lag 2 (RR = 1.01, 95% CI = 1.00-1.01), lag 5 (RR = 1.01, 95% CI = 1.00-1.01) to lag 9 (RR = 1.01, 95% CI = 1.00-1.01), and lag 14 (RR = 1.02, 95% CI: 1.01-1.03). In the cumulative-lag day pattern, the RR of allergic conjunctivitis were significant at lag 0-0 (RR = 1.08, 95% CI = 1.05-1.11) to lag 0-14 (RR = 1.21, 95% CI = 1.13-1.28). We found that boys, children aged 7-17 years, and children in the warm season were more vulnerable to humidex. In addition, the highest attributable fraction (AF) and attributable number (AN) of humidex are at lag 0-14 (AF = 0.17, AN = 25 026). Conclusions Humidex exposure markedly increased the risk of allergic conjunctivitis, especially in highly high humidex. Appropriate public health management is needed for disease management and early intervention. [ABSTRACT FROM AUTHOR]

In China, channel catfish (Ictalurus punctatus) is an important aquaculture species; however, haemorrhagic disease (Aeromonas hydrophila induced disease) in these fish has caused tremendous economic loss due to high morbidity and mass mortality in the breeding industry. The role of cortisol in bacterial diseases, particularly in the acute phase, remains unclear. In this study, liver transcriptome (RNA-seq) and chromatin accessibility (ATAC-seq) analyses were employed to investigate the early functional role of cortisol in Aeromonas hydrophila-stimulated responses. Our experiments confirmed that A. hydrophila infection can initially significantly increase serum cortisol levels at 1 h after infection. At this time point, the increased serum cortisol levels can significantly regulate A. hydrophila-regulated genes by affecting both transcriptome and chromatin accessibility. Cross-analysis of RNA-seq and ATAC-seq revealed that a certain gene group (92 target_DEGs) was regulated at an early time point by cortisol. KEGG enrichment analysis revealed that the top three pathways according to target_DEGs were cancer, glutathione metabolism, and the Notch signalling pathway. The proteinprotein interaction analysis of target_DEGs revealed that they may be primarily involved in cell proliferation, CD8+ T cell function, glutathione synthesis, and activation of the NF-κB signalling pathway. This suggests that after the emergence of immune stress, the early regulation of cortisol is positive against the immune response. It is possible that in this situation, the animal is attempting to avoid dangerous situations and risks and then cope with the imbalance produced by the stressor to ultimately restore homeostasis. Our results will contribute to future research on fish and provide valuable insight regarding the mechanism of immune regulation by cortisol and the study of bacterial haemorrhagic disease in channel catfish. [ABSTRACT FROM AUTHOR]

Laser-induced breakdown spectroscopy (LIBS) coupled with chemometrics is an efficient method for rock identification and classification, which has considerable potential in planetary geology. A great challenge facing the LIBS community is the difficulty to accurately discriminate rocks with close chemical compositions. A convolutional neural network (CNN) model has been designed in this study to identify twelve types of rock, among which some rocks have similar compositions. Both the training set and the testing set are constructed based on the LIBS spectra acquired by Mars Surface Composition Detector (MarSCoDe) for China's Tianwen-1 Mars exploration mission. All the spectra were collected from dedicated rock pellet samples, which were placed in a simulated Martian atmospheric environment. The classification performance of the CNN has been compared with that of three alternative machine learning algorithms, i.e., logistic regression (LR), support vector machine (SVM), and linear discriminant analysis (LDA). Among the four methods, it is on the CNN model that the highest classification correct rate has been obtained, as assessed by precision score, recall score, and the harmonic mean of precision and recall. Furthermore, the classification accuracy is inspected more quantitatively via Brier score, and the CNN is still the best performing model. The results demonstrate that the CNN-based chemometrics are an efficient tool for rock identification with LIBS spectra collected in a simulated Martian environment. Despite the relatively small sample set, this study implies that CNN-supported LIBS classification is a promising analytical technique for Tianwen-1 Mars mission and more planetary explorations in the future. [ABSTRACT FROM AUTHOR]

Bronze drums of Types Beiliu and Lingshan, two of the eight types of bronze drums in China, represent the highest level of bronze industry in Guangxi during the Han and Tang dynasties. Because of their distinctive ethnic features and generous size, they have received significant attention. Through the study of 12 drums of Type Beiliu and 7 drums of Type Lingshan, the provenance of ore sources, ethnic characteristics, and their correlations are further discussed. According to the analysis results, the above two types of bronze drum share some common features in alloying patterns, lead isotope ratios, and trace elements. However, they exhibit differences in decorative traditions. This research concludes that although the above two types of bronze drums belong to different local powers, extensive communication existed regarding the boundary. A complex relationship of integration, separation, and confrontation existed among them, which was typical of ancient ethnic society. [ABSTRACT FROM AUTHOR]

Based on long-term lidar (light detection and ranging) observations at Yanqing (40.5°N, 116°E) and Pingquan (41°N, 118.7°E), cloud events occurred in the vicinity of the stratopause above Beijing were reported for the first time. These events occurred with tenuous and sparse layers within the altitude range of 33–65 km, and the maximum VBSC value ranged from 1 × 10 − 10 m − 1 sr − 1 to 5.5 × 10 − 9 m − 1 sr − 1 . Considering temperature and water vapor measurements from SABER/TIMED, the occurrence mechanism of these lidar-observed cloud events was examined. It was found that some cloud layers resulted from the nucleation of water vapor due to the local meteorological changes in the middle atmosphere, while other lidar-observed clouds could comprise floating clusters of cosmic dust, hydrate droplets, volcanic ash, space traffic exhaust, etc. These cloud events are rare cloud-like phenomena in the middle atmosphere observed by lidars at midlatitudes in China; they differ from NLCs and PSCs in terms of altitude distribution and seasonal variation, and the relevant microphysics processes behind their occurrence are likely meaningful to meteorology at midlatitudes. [ABSTRACT FROM AUTHOR]

Two years of observational data from the 532 nm Rayleigh lidar were used to study the vertical profile characteristics of atmospheric gravity wave potential energy density (GWPED) between 40–80 km above Jiuquan (40° N, 95° E) for the first time. The atmospheric gravity waves (AGWs) characteristics are presented in terms of the atmospheric relative temperature perturbation, along with the estimated annual and seasonal GWPED with high spatial and temporal resolution (0.5 km and 1 h). The annual potential energy mass density E pm and volume density E pv vertical profiles show that the GWPED in the upper mesosphere is close to the adiabatic growth rate. The seasonal vertical profiles result shows that E pm is higher in autumn–winter than in spring–summer in all the observed altitudes. The GWPED approaches adiabatic growth above 61 and 65 km in spring–summer and autumn–winter, respectively. The AGWs severely dissipate below the turning altitudes and transfer energy into the background atmosphere. The GWPED scale heights show that the AGWs dissipation rate of spring–summer is close to that of autumn–winter. Furthermore, based on the wind data from SD–WACCM, the influence of critical level filtering on AGWs is discussed. It plays an important role in affecting the seasonal variation in GWPED. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to analyze the influence of cheerleading on female college students' physical self-esteem and mental health. Materials and Methods: In total, 63 female college students from the University of Electronic Science and Technology of China were trained in cheerleading for 16 weeks. The scores of each sub-field of physical self-esteem and psychological symptoms were analyzed by using Physical Self-Perception Profile (PSPP) and Symptom Checklist 90 (SCL-90), respectively, at 0 and 16 weeks of the experiment. Results: After 16 weeks of cheerleading exercise, female college students had significant differences in physical attractiveness (T = 4.18), physical quality (T = 4.39), and physical self-worth (T = 3.35) before and after the experiment (P < 0.01). There were significant differences in physical condition (T = 3.87) and athletic ability (t = 2.88) before and after the experiment (P < 0.05). Somatization (T = 6.485), obsessive-compulsive symptoms (T = 11.716), interpersonal sensitivity (T = 10.077), depression (T = 8.403), anxiety (T = 10.767), hostility (T = 10.866), terror (T = 9.260), paranoia (T = 10.414), psychosis (T = 9.610), sleep and eating disorders (T = 9.323), total symptom index (T = 13.245), and mean score of positive symptoms (T = 12.237) were significantly different (P < 0.01). Conclusion: Cheerleading can significantly improve the level of female college students' physical self-esteem, especially the self-esteem level of physical attractiveness, physical quality, and physical self-worth. They also experienced significant improvement in their psychological disorders, especially somatization, depression, and sleep and eating disorders, which effectively improved their overall mental health. [ABSTRACT FROM AUTHOR]

Potassium is the active element of potash fertilizer, its concentration determines the quality of the product. Self-absorption occurs in laser-induced breakdown spectroscopy (LIBS) analysis of potash, since potassium is the major element with a concentration that can reach the level of 95 wt.%. The present work simulated an online analysis of potassium in potash with a laboratory setup, LIBS spectra were recorded on 27 potash samples collected from a factory in Qinghai province in China with different potassium concentrations in the range from 90 to 97 wt.%. The self-absorption correction was applied to the spectra for K I 404.4 nm and K I 693.9 nm lines. Multivariate regression based on machine learning were processed with the self-absorption corrected spectra in order to get a better potassium determination performance compared to that with uncorrected spectra. The results show the effectiveness of self-absorption correction in the improvement of the analytical performance. The obtained multivariate regression model presents a satisfactory performance to fill the requirements of the aimed application of online and real-time analysis of potash on a product transportation belt in a production site with respect to the specific requirements of the related current national standards. [ABSTRACT FROM AUTHOR]

The high-quality development of agriculture is closely related to technological innovation, but the evolutionary characteristics of the relationship between agricultural transformation and technological innovation have received little study. This study takes 13 main grain-producing areas of China as the research object. Data collection was from 2004 to 2019. Based on the coupling coordination and responsiveness models, we analyze the spatio-temporal agriculture comprehensive level and the associated response degree of agricultural transformation to technological innovation. The results showed that (1) the comprehensive development of technological innovation showed a growth trend, while the agricultural transformation showed a U-shaped growth trend; (2) the coordinated development of these two systems has been significantly improved, but there are differences in the development speed of each province; (3) the coordinated gravity center moved southward in the spatial pattern, eventually presenting the characteristics of "higher level in the east and lower level in the west, while the higher level in the south and lower level in the north"; (4) the influence of technological innovation on agricultural transformation gradually changed from inhibition to positive promotion. In the end, this paper puts forward suggestions on the high-quality development of agriculture from the relationship of technological innovation and agricultural transformation. [ABSTRACT FROM AUTHOR]

Dysphagia is one of the most common symptoms in patients after stroke onset, which has multiple unfavorable effects on quality of life and functional recovery. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that is widely used to improve deglutition function. Recently, some studies have confirmed that tDCS enhances deglutition function after stroke. However, the number of evaluation indexes used in those studies was small, and the number of trials included was limited. Most importantly, the optimal stimulation protocol is still uncertain and the safety of tDCS has not been reviewed. Therefore, we conducted a systematic review and meta-analysis to address these shortcomings. Methods: Seven databases were searched entirely, including Pubmed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Service System (SinoMed), Wan-fang database, and the Chinese Scientific Journals Database (VIP) from inception to 31 December 2021. Two reviewers independently evaluated the eligibility of retrieved data according to the selection criteria and assessed the methodological quality of the studies using the Cochrane risk of bias tool. Outcomes, measures, and indicators used in this study included the dysphagia outcome and severity scale (DOSS), modified Mann assessment of swallowing ability (MMASA), functional oral intake scale (FOIS), functional dysphagia scale (FDS), and Kubota's water-drinking test (KWDT). Sensitivity and subgroup analyses were performed to evaluate the intervention effect more specifically. Results: Fifteen trials with a total of 787 participants (394 subjects in the tDCS groups were treated with true tDCS, and 393 subjects in the control groups were wait-listed or treated with sham tDCS) involving tDCS for dysphagia after stroke and were included in the meta-analysis. Results of this meta-analysis confirmed that tDCS had a positive effect on post-stroke dysphagia. Subgroup analyses revealed that bilateral and high-intensity stimulation with tDCS had a more significant impact on post-stroke dysphagia. Furthermore, no adverse events occurred during the application of tDCS for post-stroke dysphagia. Conclusion: tDCS can promote the recovery of deglutition function in patients with dysphagia after stroke. In addition, bilateral stimulation and high-intensity stimulation may have better effects. However, the safety evidence for tDCS and post-stroke dysphagia is insufficient. [ABSTRACT FROM AUTHOR]

Nitrogen (N) content is a significant indicator for evaluating eutrophication. However, the conventional methods, such as alkaline potassium persulfate digestion ultraviolet (UV) spectrophotometry and the Kjeldahl method, always require chemical reagents especially acid or alkaline solution for sample pretreatment. Laser-induced breakdown spectroscopy (LIBS), as an all element analysis technology, is also applied to the detection of N. However, the detection sensitivity for N is poor by conventional atomic LIBS. Therefore, we proposed molecular LIBS to determine N in water. The results showed that the detection sensitivity could be improved by about three orders of magnitude using molecular LIBS compared to atomic LIBS. Optimal limits of detection (LoDs) of 0.6 μg mL−1 in argon (Ar) gas and 1.5 μg mL−1 in helium (He) gas were obtained, respectively. The optimal limits of quantification (LoQs) were 1.98 μg mL−1 and 4.95 μg mL−1 in Ar gas and He gas, respectively. The results indicated that the LoQ of 1.98 μg mL−1 in Ar gas met the surface water environmental quality standards of China (2 μg mL−1 for N). Furthermore, real waters including tap water and river water were analyzed by molecular LIBS. Compared with UV spectrophotometry, the average standard deviation was 8.16%. The work demonstrated the feasibility of molecular LIBS to realize the reliable determination of N in water eutrophication. Molecular LIBS is a promising in situ method for the detection of N in solution. [ABSTRACT FROM AUTHOR]

KBG syndrome (KBGS) is a rare autosomal dominant inherited disease that involves multiple systems and is associated with variations in the ankyrin repeat domain 11 (ANKRD11) gene. We report the clinical and genetic data for 13 Chinese KBGS patients diagnosed by genetic testing and retrospectively analyse the genotypes and phenotypes of previously reported KBGS patients. The 13 patients in this study had heterozygous variations in the ANKRD11 gene, including seven frameshift variations, three nonsense variations, and three missense variations. They carried 11 variation sites, of which eight were previously unreported. The clinical phenotype analysis of these 13 patients and 240 previously reported patients showed that the occurrence rates of craniofacial anomalies, dental anomalies, global developmental delays, intellectual disability/learning difficulties, limb anomalies, and behavioural anomalies were >70%. The occurrence rates of short stature, delayed bone age, and spinal vertebral body anomalies were >50%. The frequency of global developmental delays and intellectual disability/learning difficulties in patients with truncated ANKRD11 gene variation was higher than that in patients with missense variation in the ANKRD11 gene (p < 0.05). Collectively, this study reported the genotypic and phenotypic characteristics of the largest sample of KBGS patients from China and discovered eight new ANKRD11 gene variations, which enriched the variation spectrum of the ANKRD11 gene. Variation in the ANKRD11 gene mainly caused craniofacial anomalies, growth and developmental anomalies, skeletal system anomalies, and nervous system anomalies. Truncated variation in the ANKRD11 gene is more likely to lead to global growth retardation and intellectual disability/learning difficulties than missense variation in ANKRD11. [ABSTRACT FROM AUTHOR]

Rapid industrialization and urbanization in China have resulted in labor migrants leaving children behind. For left-behind children (LBC), disrupted parental attachment may increase the risk of psychiatric morbidity in adulthood. To investigate psychopathological consequences for university students who were LBC and to estimate the effects of one or both parents being migrants, the duration of left-behind experience, and parental absence during critical periods of growth on psychiatric morbidity. We conducted an annual survey of all freshmen at a Chinese university from 2014 to 2018. The questionnaire collected information on left-behind experiences and psychiatric morbidity using standardized self-report instruments. Regression coefficients derived from logistic regression were used to measure the associations among total time left behind, absence of one parent or both parents, age when left behind and psychopathological consequences. A total of 42,505 students were included. Students who were LBC had more psychopathology, including depression, anxiety, somatoform disorder, obsessive–compulsive disorder, self-reported suicide attempts and deliberate self-harm, than those who were not. Students for whom one or both parents were migrants showed a greater risk of psychiatric morbidity. The risk of psychiatric morbidity increased with the length of parental absence. Left-behind experience during childhood represents sustained impacts for university students into early adulthood. The higher prevalence of psychiatric morbidity in young adults who experienced the absence of one or both of their parents, especially in their early childhood, suggests that other factors besides attachment, such as protection from other risks, are important and that further research is necessary. [ABSTRACT FROM AUTHOR]

Background and Objective: To analyze the relationship between brain MRI, clinical symptoms, and cerebrospinal fluid (CSF) and to provide a reference for early diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.Materials and Methods: A total of 62 patients with anti-NMDAR encephalitis in Zhengzhou, China (2016-2018) were observed and registered prospectively. First, we analyzed the characteristics of clinical symptoms. Second, according to the disease duration, patients were divided into two groups, and then we analyzed the CSF features. In addition, they were divided into two groups according to the brain MRI, and then the CSF features were analyzed. Finally, the characteristics of cerebrospinal fluid in patients with seizure as the initial symptom were analyzed.Results: Seizure presents as the initial symptom in 14 patients (22.5%), including 11 males (78.57%). The proportion and concentration of CSF total protein abnormalities in the early stage group were significantly higher than those in the middle and late group (P < 0.05). The total protein concentration in the abnormal brain MRI group was significantly higher than that in the normal MRI group (P < 0.05).Conclusion: Anti-NMDAR encephalitis should be suspected, when male patients complain of seizure as an initial symptom and have simultaneously had headaches or fever prior to onset. The sensitivity of anti-NMDAR antibody is higher in CSF than in serum. Total CSF protein is more prone to elevation in the middle and late stages of anti-NMDAR encephalitis. Brain MRI abnormalities with anti-NMDAR encephalitis are related to the total protein concentration of CSF, which may be related to the disease duration. [ABSTRACT FROM AUTHOR]

Study Question: Are there any differences between in vivo (IVV) and in vitro (IVT) matured metaphase II (MII) oocytes at the molecular level?Summary Answer: Between IVV and IVT oocytes, 507 differentially expressed genes (DEGs) were identified; the non-CpG methylomes were significantly different, but the CpG methylomes and genomic copy number variations (CNVs) were similar.What Is Known Already: A previous study using microarray and single-cell RNA-seq analysis revealed that numerous genes were differentially expressed between IVV and IVT oocytes. Independent studies of DNA methylation profiling in human oocytes have revealed negative correlations between gene transcription and the DNA methylation level at gene promoter regions. No study has compared global CpG or non-CpG methylation between these two groups of oocytes. Although a high level of aneuploidy has been reported in MII oocytes, no direct comparison of IVV and IVT oocytes based on single-cell sequencing data has been performed.Study Design, Size, Duration: We collected eight IVV oocytes from six patients and seven IVT oocytes from seven patients and then analysed each oocyte using the previously established single-cell triple omics sequencing (scTrioseq) analysis to determine associations among the transcriptome, DNA methylome and chromosome ploidy in the oocytes.Participants/materials, Setting, Methods: All IVV oocytes were donated by patients who received 150 IU gonadotropin per day from the third day of their menstrual cycle, followed by GnRH antagonist after 5 days of gonadotropin stimulation. All IVT oocytes were from immature oocytes which were donated by volunteers undergoing delivery by caesarean section then cultured in oocyte maturation medium containing 75 mIU/ml hMG for 24 to 48 h. Every single oocyte was analysed using the previously established single-cell multiomic sequencing analysis.Main Results and the Role Of Chance: There were 507 genes differentially expressed between the IVV (n = 8) and IVT (n = 7) oocytes, even though their global transcriptome profiles were similar. The enriched genes in IVV oocytes were related to the cell cycle process while those in IVT oocytes were related to mitochondrial respiration biogenesis. Although the global CpG methylation of the two groups of oocytes was similar, the non-CpG methylation level in IVV oocytes was higher than that in IVT oocytes. A high aneuploidy ratio was found in both groups, but the aneuploidy did not affect transcription according to the correlation analysis.Large-scale Data: N/A.Limitations and Reasons For Caution: Due to the difficulty in collecting MII oocytes, especially IVV matured oocytes, the sample size was limited.Wider Implications Of the Findings: Our findings indicate that single-cell multiomic sequencing can be utilised to examine the similarity and differences between IVV and IVT matured MII oocytes.Study Funding/competing Interest(s): This work was supported by the Ministry of Science and Technology of China, National Key R&D Program of China (No. 2017YFC1001601). The donated oocytes were collected by Shanghai Tenth People's Hospital. The authors declare no competing interests. [ABSTRACT FROM AUTHOR]

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Objective: We conducted this study to analyze the clinical characteristics of the psychiatric symptoms of patients with anti-NMDAR encephalitis. Methods: A retrospective study of anti-NMDAR encephalitis in China was performed. The clinical characteristics of the psychiatric symptoms, the relationship between the antibodies titers and clinical characteristics of patients with anti-NMDAR encephalitis were determined. Results: A total of 108 patients with a definitive diagnosis of anti-NMDAR encephalitis were included in this study. 103 patients (95%) developed one or several psychiatric symptoms. The comparison of the high titer group and the low titer group showed that more patients presented psychiatric symptoms as the initial symptom in the high titer group (P = 0.020), the prevalence of the symptoms such as depressive, catatonic, and central hypoventilation were also higher in the high titer group than the low titer group (P = 0.033, 0.031 and 0.006, respectively). Meanwhile, more patients received a combination treatment of IVIg and corticosteroids in the high titer group than the low titer group and patients in high titer group were prescript with anti-psychiatric drugs more often than the patients in low titer group (P = 0.026 and 0.003, respectively). Conclusions: Psychiatric symptoms are the most common clinical characteristics of patients with anti-NMDAR encephalitis. Patients with higher antibodies titers more often presented with psychiatric symptoms as the initial symptom, and showed a more severe clinical feature. Screening for the anti-NMDAR antibodies is essentially important in patients who present psychiatric symptoms with or without other neurological symptoms. [ABSTRACT FROM AUTHOR]

Platinum group element (PGE) mineralization occurs associated with mafic-ultramafic rocks in different environments. Although the PGE enrichment is primarily caused by magmatic processes, remobilization of Pd and Pt by hydrothermal fluids has likely been an important mechanism in increasing the precious metal grade in many cases. However, the timing of PGE enrichment by hydrothermal fluid processes is commonly difficult to constrain. The Jinchuan ultramafic intrusion in Northwest China is ranked the world’s third largest magmatic Ni-Cu sulfide deposit. Besides the main ore body consisting of net-textured and disseminated sulfides, there is hydrothermal mineralization associated with sheared contact zones of the intrusion, which shows elevated Cu and Pt concentrations. The unusually high Pt is hosted mainly in sperrylite within altered silicates. In this study, we applied the Pt-Os geochronometer to a Cu-Pt-rich ore body, yielding an isochron age of 436 ± 23 Ma. This age is significantly younger than the main ore formation age of ca. 825 Ma, but similar to that of the continental collision event between the Qaidam-Qilian Block and Alax Block of North China. This indicates that the intrusion may have been uplifted during the Paleozoic orogenic processes from deeper crust, resulting in the generation of the Cu-Pt-rich hydrothermal ore body. Our new data provide the first strong age constraints on the hydrothermal PGE enrichment, showing that the Pt-Os isotope system is potentially a powerful tool for dating hydrothermal overprinting on Ni-Cu-PGE sulfide deposits. [ABSTRACT FROM AUTHOR]

The origins of the copper, tin and lead for China's rich Bronze Age cultures are a major topic in archaeological research, with significant contributions being made by archaeological fieldwork, archaeometallurgical investigations and geochemical considerations. Here, we investigate a recent claim that the greater part of the Shang‐period metalwork was made using metals from Africa, imported together with the necessary know‐how to produce tin bronze. A brief review of the current status of lead isotopic study on Shang‐period bronze artefacts is provided first, clarifying a few key issues involved in this discussion. It is then shown that there is no archaeological or isotopic basis for bulk metal transfer between Africa and China during the Shang period, and that the copper and lead in Shang bronze with a strongly radiogenic signature is not likely to be from Africa. We call for collaborative interdisciplinary research to address the vexing question of the Shang period's metal sources, focusing on smelting sites in geologically defined potential source regions and casting workshops identified at a number of Shang settlements. [ABSTRACT FROM AUTHOR]

Lead isotope and element composition analyses were performed by thermal ionization mass spectrometry (TIMS) and inductively coupled plasma optical emission spectroscopy (ICP-OES) on bronze helmets from royal tomb No. 1004 at Yin Ruins, the last capital of China's Shang Dynasty (17th to 11th centuriesbc). The data show that the copper-based alloy helmets can be divided into two categories: tin bronze and leaded tin bronze; and the lead isotope ratios for both categories are in the range of highly radiogenic lead (HRL). This result offers some important clues to answering questions concerning the provenance of raw metal materials, as well as the chronology of this famous royal tomb. [ABSTRACT FROM AUTHOR]

Abstract  The Jinchuan ultramafic intrusion in western China hosts the third-largest magmatic Ni–Cu deposit in the world. The crystallization age of the intrusion has long been debated. Here, we present a U–Pb ID-TIMS zircon age of 831.8 ± 0.6 Ma obtained on thermally annealed and chemically etched zircons from a lherzolite sample. The coexisting baddeleyite in the sample is indistinguishable from the age of zircon. Our new results confirm that the emplacement of the Jinchuan ultramafic intrusion was temporally related to the breakup of the Rodinia supercontinent. [ABSTRACT FROM AUTHOR]

Aiming at further systematically comparing the similarities and differences of the chemical components in ginseng of different ages, especially comparing the younger or the older and mountain-cultivated ginseng (MCG), 4, 5, 6-year-old cultivated ginseng (CG) and 12, 20-year-old MCG were chosen as the analytical samples in the present study. The combination of UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analysis were developed to profile CGs and MCGs. By the screening analysis based on UNIFI, 126 chemical components with various structural types were characterized or tentatively identified from all the CG and MCG samples for the first time. The results showed that all the CG and MCG samples had the similar chemical composition, but there were significant differences in the contents of markers. By the metabolomic analysis based on multivariate statistical analysis, it was shown that CG4–6 years, MCG12 years and MCG20 years samples were obviously divided into three different groups, and a total of 17 potential age-dependent markers enabling differentiation among the three groups of samples were discovered. For differentiation from other two kinds of samples, there were four robust makers such as α-linolenic acid, 9-octadecenoic acid, linoleic acid and panaxydol for CG4–6 years, five robust makers including ginsenoside Re1, -Re2, -Rs1, malonylginsenoside Rb2 and isomer of malonylginsenoside Rb1 for MCG20 years, and two robust makers, 24-hydroxyoleanolic acid and palmitoleic acid, for MCG12 years were discovered, respectively. The proposed approach could be applied to directly distinguish MCG root ages, which is an important criterion for evaluating the quality of MCG. The results will provide the data for the further study on the chemical constituents of MCG. [ABSTRACT FROM AUTHOR]