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Objective: To evaluate the performance of a detailed ultrasound examination during the second trimester as a screening test for Down syndrome in an unselected Chilean population. Methods: This was part of an ongoing longitudinal study. Included were 3071 women with singleton pregnancies who underwent routine ultrasound examination between 21 + 0 and 25 + 6 gestational weeks as a screening test for chromosomal abnormalities and major congenital structural defects, and who were diagnosed as having trisomy 21 or being chromosomally normal. Maternal age, and eight soft markers and cardiac defects associated with Down syndrome were evaluated as a screening test using logistic regression analysis. Results: The incidence of Down syndrome was 0.6%, and the mean maternal age was 29.4 +/- 6.2 years. At least one of four soft markers (absent nasal bone, nuchal edema, short femur, echogenic foci) and/or cardiac defects was present in 77.8% of Down syndrome fetuses and in 3.1% of normal fetuses. Furthermore, with a false-positive rate of 1%, the detection rate using the combined model of ultrasound markers and maternal age was 72.2%. Conclusions: Second-trimester ultrasound markers are able to detect over 70% of Down syndrome fetuses with only a 1% false-positive rate. [ABSTRACT FROM AUTHOR]

The objective was to evaluate lung volume with O/E LHR in Chile, double check with Leuven and report survival. Five pregnancies with left CDH and <25% O/E had 0% survival. There was a significant correlation between O/E LHR and survival in Left and Right CDH (pearson p<0.05). [Extracted from the article]

The relationship between the forest sector and the well-being of people that depend on it for their economic livelihoods in rural areas is of strong interest in forest policy. In this sense, Chile has developed a forest policy that has had positive impacts, particularly on economic and productive aspects, but also negative impacts, such as the reduction of natural forest area, biodiversity, and provision of ecosystem services, as well as the increase in social conflicts and land abandonment. However, there are few studies that have evaluated the impacts of forest policy on rural population and development of the territory. Therefore, the objective of this research is to evaluate the impacts of Chilean forest policy on rural communities, particularly in terms of demographic variables and indicators of community well-being. The study area corresponds to the Bio Bio and Ñuble Regions (Chile), and the analysis includes productive, demographic, socioeconomic, and educational characteristics of population. The results show that the forestry policy implemented was able to generate a significant increase in the proportion of forest area. However, when this increase is mainly of the type of exotic forest plantations, it is associated with a demographic and socio-economic detriment of the population in some counties of the study area. [ABSTRACT FROM AUTHOR]