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Objective: To verify whether triponderal mass index (TMI) has a greater accuracy than body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR) as predictors of obesity in young people and older adults in a region of Chile., Material and Methods: A cross-sectional descriptive study was carried out in 1176 adults (565 men and 611 women) from the Maule region (Chile). Their ages ranged from 20 to 80 years. The percentage of fat mass (%FM) was evaluated by means of dual energy X-ray absorptiometry (DXA). Weight, height and waist circumference (WC) were evaluated. TMI, BMI and WHtR were calculated., Results: The %FM predictions for BMI were 0.47% for men and 0.50% for women; for TMI, it was 0.50% for men and 0.51% for women; for WC, it was 0.28% for men and 0.21% for women; and finally, for WHtR, it was 0.28% in men and 0.21% in women. The area under the curve (AUC) for BMI was 0.85 in men and 0.85 in women; for TMI, it was 0.87 in men and 0.86 in women; for WHtR, it was 0.76 in men and 0.72 in women; and for WC, the AUC was 0.72 in men and 0.71 in women., Conclusion: It was shown that TMI is the indicator that presented the greatest association with %FM and estimates body fat levels with greater precision than BMI, WC and WHtR. The results suggest its use and application as an indicator that discriminates obesity in young, middle-aged and elderly adults., (Copyright © 2021 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)