1. Two new antiinflammatory elemanolides from Centaurea chilensis.
- Author
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Negrete RE, Backhouse N, Cajigal I, Delporte C, Cassels BK, Breitmaier E, and Eckhardt G
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Benzofurans pharmacology, Carrageenan, Chile, Edema chemically induced, Edema pathology, Female, Guinea Pigs, Male, Plant Extracts analysis, Anti-Inflammatory Agents, Non-Steroidal isolation & purification, Benzofurans isolation & purification, Plants, Medicinal chemistry
- Abstract
Two previously undescribed elemanolide esters, the 2-methylpropanoate and 2-methyl-2-propenoate of 11,13-dehydromelitensin, were isolated in the course of a bioassay-guided fractionation from the aerial parts of Centaurea chilensis Hook. et Arn., used traditionally to treat 'gout and rheumatism'. The mixture of both substances exhibits anti-inflammatory activity in the carrageenan-induced paw edema assay.
- Published
- 1993
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