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Glacial geologic studies in the Southern Hemisphere (SH) mid-latitudes (40-54°S) indicate renewed glacial activity in southern South America (Patagonia) and New Zealand's (NZ) South Island starting at ∼7 kyr, the so-called neoglaciation. Available data indicate that neoglacial advances in these regions occurred during a rising trend in atmospheric CO and CH concentrations, lower-than-present but increasing summer insolation and seasonality contrasts. In this paper we examine the climatological context in which neoglaciations occurred through analysis of the complete Paleoclimate Modelling Inter-comparison Project (PMIP2) database of simulations at 6 kyr for the SH. We observe that the amplitude of the annual insolation cycle in the SH did not change significantly at 6 kyr compared to the pre-industrial values, the largest difference occurring in autumn (MAM, negative anomalies) and spring (SON, positive anomalies). The simulated changes in temperatures over the SH respond to the insolation changes, with a 1-2 month delay over the oceans. This results in a reduced amplitude of the annual cycle of temperature and precipitation over most continental regions, except over Patagonia and NZ, that show a slight increase. In contrast, large-scale circulation features, such as the low and upper level winds and the subtropical anticyclones show an amplified annual cycle, as a direct response to the increased/decreased insolation during the transitional seasons SON/MAM. In the annual mean, there is a small but consistent equatorward shift of the latitude of maximum wind speed of 1-3° over the entire SH, which results in a small increase of wind speed over the South Pacific and Atlantic Oceans north of ∼50°S and a widespread decline south of 50°S. PMIP2 simulations for 6 kyr, indicate that in the annual mean, the SH mid-latitudes were colder, wetter and with stronger winds north of about 50°S. These conditions are consistent with the observed neoglacial advances in the region, as well as with terrestrial paleoclimate records from Patagonia that indicate cooling and a multi-millennial rising trend in Southern Westerly Wind intensity starting at ∼7.8 kyr. [ABSTRACT FROM AUTHOR]