1. Conference report on contractures in musculoskeletal and neurological conditions.
- Author
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Nuckolls GH, Kinnett K, Dayanidhi S, Domenighetti AA, Duong T, Hathout Y, Lawlor MW, Lee SSM, Magnusson SP, McDonald CM, McNally EM, Miller NF, Olwin BB, Raghavan P, Roberts TJ, Rutkove SB, Sarwark JF, Senesac CR, Vogel LF, Walter GA, Willcocks RJ, Rymer WZ, and Lieber RL
- Subjects
- Cerebral Palsy diagnosis, Cerebral Palsy physiopathology, Cerebral Palsy therapy, Chicago, Contracture diagnosis, Contracture therapy, Humans, Muscular Dystrophy, Duchenne diagnosis, Muscular Dystrophy, Duchenne physiopathology, Muscular Dystrophy, Duchenne therapy, Musculoskeletal Diseases diagnosis, Musculoskeletal Diseases therapy, Nervous System Diseases diagnosis, Nervous System Diseases therapy, Contracture physiopathology, Education trends, Musculoskeletal Diseases physiopathology, Nervous System Diseases physiopathology, Research Report trends
- Abstract
Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19-20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development., (© 2020 Wiley Periodicals, Inc.)
- Published
- 2020
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