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The aspheric balance curve design IOL in comparison with the posterior aspheric design IOL affected the Strehl ratio minimally, especially in eyes with a large angle α. Purpose: To study the effect of decentration on the quality of vision in 2 aspheric intraocular lenses (IOLs): aspheric balance curve (ABC) design Vivinex iSert XY1 (Hoya Surgical Opticals, Inc.) and posterior aspheric design AcrySof IQ SN60WF (Alcon Laboratories, Inc.) Setting: Advanced Eye Centre, PGIMER, Chandigarh, India. Design: Randomized prospective trial using a random number table. Methods: 85 eyes were randomized to group 1 (Vivinex XY1) and group 2 (AcrySof IQ) with 40 and 45 eyes, respectively. The higher-order aberration (HOA) profile, Strehl ratio, decentration of the IOL from the visual axis (decentration from the visual axis [DVA]) and the geometric axis (decentration from the geometric axis [DGA]), angle α, and κ were recorded on the iTrace aberrometer, and contrast sensitivity was measured using the Functional Acuity Contrast Test at 12 weeks postsurgery. Results: A total of 85 eyes in 60 patients were evaluated in this study. The mean values of the Strehl ratio (P =.48) and the HOAs (P =.12) of both IOLs were comparable. The HOAs gradually increased with increasing DVA for both lenses at 3.0 mm, 4.0 mm, and 5.0 mm pupil sizes. On comparing the HOAs with the DGA, a statistically insignificant positive correlation was observed. The Strehl ratio did not deteriorate with an increasing angle α in the Vivinex XY1 group; however, it worsened in the AcrySof IQ group. Contrast sensitivity was comparable in both the IOLs except at 1.5 cycles per degree under photopic conditions where the AcrySof IQ was better. Conclusions: Decentration of the lens was best measured with respect to the visual axis. In eyes with a large α, the ABC design induced lesser HOAs and maintained a better Strehl ratio. [ABSTRACT FROM AUTHOR]

Purpose: To compare the outcomes of contact lens-assisted corneal crosslinking (CACXL) and transepithelial CXL (TECXL) with standard epithelium-off (epi-off) CXL for progressive keratoconus. Setting: Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Design: Retrospective, comparative study. Methods: Patients with progressive keratoconus undergoing CXL with a minimum follow-up of 24 months were included. CACXL and TECXL were performed in patients with epithelium-on minimal pachymetry between 350 [mu]m and 450 [mu]m. The main outcome measures included change in maximum keratometry (Kmax), corrected distance visual acuity (CDVA), and efficacy in halting progression (increase in Kmax >=1 diopter [D]). Results: Standard epi-off CXL, CACXL, and TECXL were performed in 34, 14, and 10 eyes, respectively. Baseline Kmax and CDVA were comparable for all groups. Kmax reduced significantly by -2.83 +/- 3.35 D, -3.18 +/- 2.74 D, and -2.02 +/- 1.66 D in the standard epi-off CXL (P <.01), CACXL (P =.001), and TECXL (P =.004) groups, respectively; the reduction was comparable for all groups (P =.63). CDVA improved by -0.14 +/- 0.24, -0.04 +/- 0.19, and -0.12 +/- 0.17 logMAR in the standard epi-off CXL (P =.006), CACXL (P =.42), and TECXL (P =.05) groups, respectively; the reduction was comparable for all groups (P =.46). Progression was documented in 2 eyes (6%) in the standard epi-off CXL group and in 0 eyes of the CACXL and TECXL groups (P =.61). Conclusions: CACXL and TECXL were comparable with the standard epi-off CXL for progressive keratoconus. [ABSTRACT FROM AUTHOR]