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A recent report from Ohio State University explores the role of Canopy Homolog 2 (CNPY2) in liver oncogenesis. The study found that CNPY2 is up-regulated in hepatocellular carcinoma (HCC) and negatively correlated with survival rates in liver cancer patients. Deletion of Cnpy2 in mice prevented HCC development, indicating its crucial role in liver oncogenesis. Mechanistic studies revealed that CNPY2 promotes unfolded protein response (UPR)-dependent destabilization of tumor protein p53, leading to cell-cycle progression and activation of oncogenes. The findings provide insights into potential therapeutic targets for HCC. [Extracted from the article]

Keywords: Newark; State:Delaware; United States; North and Central America; Biological Products; Health and Medicine; Immunization; Vaccines EN Newark State:Delaware United States North and Central America Biological Products Health and Medicine Immunization Vaccines 2023 FEB 22 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Weekly -- Current study results on Immunization - Vaccines have been published. Newark, State:Delaware, United States, North and Central America, Biological Products, Health and Medicine, Immunization, Vaccines. [Extracted from the article]

Impaired mitochondrial protein import leads to proteotoxic stress in both mitochondria and cytosol, inducing mitochondrial unfolded protein response (UPRmt)." Keywords: University of South Alabama; Mobile; Alabama; United States; North and Central America; Organelles; Cellular Structures; Intracellular Space; Subcellular Fractions; Cytoplasmic Structures; Mitochondrial Proteins; Cytoplasm; Mitochondria EN University of South Alabama Mobile Alabama United States North and Central America Organelles Cellular Structures Intracellular Space Subcellular Fractions Cytoplasmic Structures Mitochondrial Proteins Cytoplasm Mitochondria New study results on mitochondrial proteins have been published. [Extracted from the article]