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Research conducted at Washington University focused on cognitive development in lambdoid craniosynostosis, a condition affecting approximately 1 in 33,000 live births per year. The study found that patients with lambdoid craniosynostosis may score slightly below average on tests of general cognition compared to normal controls, but results in other domains are variable. The research suggests that multidisciplinary care and involvement of a child psychologist may be beneficial in identifying areas of concern and providing scholastic support. Further research with larger cohorts is needed to confirm and extend these findings to other developmental domains. [Extracted from the article]

A study conducted by researchers at the University of Toronto examined the outcomes of posterior cranial vault distraction as a treatment for craniosynostosis, a condition characterized by the premature fusion of the skull bones. The study included 41 patients, both with syndromic and nonsyndromic craniosynostosis, who underwent the procedure. The results showed that posterior cranial vault distraction was effective in increasing intracranial volume and correcting turricephaly (a type of cranial deformity) in these patients. The procedure was considered safe and effective as a first-stage cranial operation for children with syndromic craniosynostosis. [Extracted from the article]

A new report from Weill Cornell Medicine discusses research findings on craniosynostosis, a group of disorders characterized by premature fusion of the skull sutures. The study reveals that craniosynostosis involves the interaction of two separate stem cell lineages: cathepsin K (CTSK) lineage CSC1 and discoidin domain-containing receptor 2 (DDR2) lineage stem cells. Deletion of the Twist1 gene in CTSK+ CSCs leads to craniosynostosis in mice, while an expansion of DDR2+ CSCs occurs in the sites destined to fuse. The research highlights the importance of these two stem cell populations in calvarial mineralization and suture patency. [Extracted from the article]