1. First data on HIV-1 resistance mutations to antiretroviral drugs in Central African Republic.
- Author
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Moussa S, Pinson P, Pelembi P, Gody JC, Mbitikon O, Fikouma V, Mbay P, and Fleury HJ
- Subjects
- Adolescent, Adult, Amino Acid Substitution genetics, Anti-Retroviral Agents therapeutic use, Central African Republic, Child, Child, Preschool, Genotype, HIV Infections drug therapy, HIV-1 isolation & purification, Humans, Middle Aged, Molecular Sequence Data, Sequence Analysis, DNA, Treatment Failure, Young Adult, Anti-Retroviral Agents pharmacology, Drug Resistance, Viral, HIV Infections virology, HIV-1 drug effects, HIV-1 genetics, Mutation, Missense
- Abstract
In a background of high genomic HIV-1 variability with a predominance of CRF11_cpx and CRF22_01A1, we have studied the emergence of resistance mutations in isolates from Central African patients at failure of d4T-AZT/3TC/NVP-EFV plus two at failure of a PI-including regimen; the resistance mutations observed are those which are expected on HIV-1 subtype B.
- Published
- 2010
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