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This study was carried out in the Lom series in Cameroon, at the border with Central African Republic, located between the latitudes 5 ∘ 30 ′ –6 ∘ N and the longitudes 13 ∘ 30 ′ –14 ∘ 45 ′ E. A multi-scale analysis of aeromagnetic data combining tilt derivative, Euler deconvolution, upward continuation, and 2.75D modelling was used. The following conclusions were drawn. (1) Several major families of faults were mapped. Their orientations are ENE–WSW, E–W, NW–SE, and N–S with a NE–SW prevalence. The latter are predominantly sub-vertical with NW and SW dips and appear to be prospective for future mining investigations. (2) The evidence of compression, folding, and shearing axis was concluded from superposition of null contours of the tilt derivative and Euler deconvolution. The principal evidence of the local tectonics was due to several deformation episodes (D1, D2, and D4) associated with NE–SW, E–W, and NW–SE events, respectively. (3) Depths of interpreted faults range from 1000 to 3400 m. (4) Several linear structures correlating with known mylonitic veins were identified. These are associated with the Lom faults and represent the contacts between the Lom series and the granito-gneissic rocks; we concluded the intense folding was caused by senestral and dextral NE–SW and NW–SE stumps. (5) We propose a structural model of the top of the crust (schists, gneisses, granites) that delineates principal intrusions (porphyroid granite, garnet gneiss, syenites, micaschists, graphite, and garnet gneiss) responsible for the observed anomalies. The 2.75D modelling revealed many faults with a depth greater than 1200 m and confirmed the observations from reduced-to-Equator total magnetic intensity (RTE-TMI), tilt derivative, and Euler deconvolution. (6) We developed a lithologic profile of the Bétaré-Oya basin. [ABSTRACT FROM AUTHOR]

Copyright of Ankara Review of European Studies (ARES) / Ankara Avrupa Çalışmaları Dergisi (AAÇD) is the property of Ankara University European Union Research Centre and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de Paz y Conflictos is the property of Revista de Paz y Confilictos and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The Central African Republic (CAR) suffers a protracted conflict and has the second lowest human development index in the world. Available mortality estimates vary and differ in methodology. We undertook a retrospective mortality study in the Ouaka prefecture to obtain reliable mortality data. Methods: We conducted a population-based two-stage cluster survey from 9 March to 9 April, 2020 in Ouaka prefecture. We aimed to include 64 clusters of 12 households for a required sample size of 3636 persons. We assigned clusters to communes proportional to population size and then used systematic random sampling to identify cluster starting points from a dataset of buildings in each commune. In addition to the mortality survey questions, we included an open question on challenges faced by the household. Results: We completed 50 clusters with 591 participating households including 4000 household members on the interview day. The median household size was 7 (interquartile range (IQR): 4—9). The median age was 12 (IQR: 5—27). The birth rate was 59.0/1000 population (95% confidence interval (95%-CI): 51.7—67.4). The crude and under-five mortality rates (CMR & U5MR) were 1.33 (95%-CI: 1.09—1.61) and 1.87 (95%-CI: 1.37–2.54) deaths/10,000 persons/day, respectively. The most common specified causes of death were malaria/fever (16.0%; 95%-CI: 11.0–22.7), violence (13.2%; 95%-CI: 6.3–25.5), diarrhoea/vomiting (10.6%; 95%-CI: 6.2–17.5), and respiratory infections (8.4%; 95%-CI: 4.6–14.8). The maternal mortality ratio (MMR) was 2525/100,000 live births (95%-CI: 825—5794). Challenges reported by households included health problems and access to healthcare, high number of deaths, lack of potable water, insufficient means of subsistence, food insecurity and violence. Conclusions: The CMR, U5MR and MMR exceed previous estimates, and the CMR exceeds the humanitarian emergency threshold. Violence is a major threat to life, and to physical and mental wellbeing. Other causes of death speak to poor living conditions and poor access to healthcare and preventive measures, corroborated by the challenges reported by households. Many areas of CAR face similar challenges to Ouaka. If these results were generalisable across CAR, the country would suffer one of the highest mortality rates in the world, a reminder that the longstanding "silent crisis" continues. [ABSTRACT FROM AUTHOR]

Background: The term Nodding Syndrome (NS) refers to an atypical and severe form of childhood epilepsy characterized by a repetitive head nodding (HN). The disease has been for a long time limited to East Africa, and the cause is still unknown. The objective of this study was to confirm the existence of NS cases in Central African Republic (CAR). Methodology/Principal findings: This was a cross-sectional descriptive study in the general population. The identification of NS cases was conducted through a door-to-door survey in a village near Bangui along the Ubangui River. Based on Winkler's 2008 and the World Health Organization (WHO)'s 2012 classifications, the confirmation of cases was done by a neurologist who also performed the electroencephalograms. No laboratory tests were done during this investigation. Treatment was offered to all patients. A total of 6,175 individuals was surveyed in 799 households. After reviewing the cases, we identified 5 NS cases in girls aged between 8 and 16. The age of onset of the seizures was between 5 and 12 years of age. Two cases were classified as "HN plus" according to Winkler's 2008 classification. Four NS cases were classified as probable and one as confirmed according to the WHO's 2012 classification. Three of them presented with developmental delay and cognitive decline, and one had an abnormally low height-for-age z-score. Electroencephalographic abnormalities were found in four patients. Conclusions/Significance: Nodding Syndrome cases were described in CAR for the first time. Despite certain peculiarities, these cases are similar to those described elsewhere. Given that only a small part of the affected area was investigated, the study area along the Ubangui River needs to be expanded in order to investigate the association between Onchocerca volvulus and NS and also evaluate the real burden of NS in CAR. Author summary: Nodding Syndrome (NS) is a form of severe epilepsy that affects children in Africa. Thousands of children have been affected since its first description 60 years ago in East Africa, particularly Tanzania, South Sudan, and Uganda. Its evolution is marked by the appearance of many serious complications such as stunting, wasting, delayed sexual development, and psychiatric illness that can lead to death in some cases. Both the future of the affected children and the present of the adults in charge of them are hampered by an intolerable level of social and economic harm. Here, we describe new cases of NS that emerged in a context of extreme poverty in the Central African Republic (CAR). Because the area at risk of NS was partially investigated in this study, we urge to carry out a larger-scale study in order to assess the real burden of NS in CAR and draw the attention of public authorities. [ABSTRACT FROM AUTHOR]

Background: African trypanosomes are parasites mainly transmitted by tsetse flies. They cause trypanosomiasis in humans (HAT) and animals (AAT). In Chad, HAT/AAT are endemic. This study investigates the diversity and distribution of trypanosomes in Mandoul, an isolated area where a tsetse control campaign is ongoing, and Maro, an area bordering the Central African Republic (CAR) where the control had not started. Methods: 717 human and 540 cattle blood samples were collected, and 177 tsetse flies were caught. Trypanosomal DNA was detected using PCR targeting internal transcribed spacer 1 (ITS1) and glycosomal glyceraldehyde-3 phosphate dehydrogenase (gGAPDH), followed by amplicon sequencing. Results: Trypanosomal DNA was identified in 14 human samples, 227 cattle samples, and in tsetse. Besides T. b. gambiense, T. congolense was detected in human in Maro. In Mandoul, DNA from an unknown Trypanosoma sp.-129-H was detected in a human with a history of a cured HAT infection and persisting symptoms. In cattle and tsetse samples from Maro, T. godfreyi and T. grayi were detected besides the known animal pathogens, in addition to T. theileri (in cattle) and T. simiae (in tsetse). Furthermore, in Maro, evidence for additional unknown trypanosomes was obtained in tsetse. In contrast, in the Mandoul area, only T. theileri, T. simiae, and T. vivax DNA was identified in cattle. Genetic diversity was most prominent in T. vivax and T. theileri. Conclusion: Tsetse control activities in Mandoul reduced the tsetse population and thus the pathogenic parasites. Nevertheless, T. theileri, T. vivax, and T. simiae are frequent in cattle suggesting transmission by other insect vectors. In contrast, in Maro, transhumance to/from Central African Republic and no tsetse control may have led to the high diversity and frequency of trypanosomes observed including HAT/AAT pathogenic species. Active HAT infections stress the need to enforce monitoring and control campaigns. Additionally, the diverse trypanosome species in humans and cattle indicate the necessity to investigate the infectivity of the unknown trypanosomes regarding their zoonotic potential. Finally, this study should be widened to other trypanosome hosts to capture the whole diversity of circulating trypanosomes. Author summary: Sleeping sickness (HAT) is a public health problem in 36 African countries. In Chad, 5 active foci are present in the Southern part. It is caused by trypanosomes, parasites causing disease in humans and livestock. Tsetse flies, the vectors of trypanosomes, declined in the Mandoul focus due to the impact of vector control coupled with active/passive screening and treatment campaigns. In the Maro focus, where such campaigns were absent during these surveys, HAT cases were reported recently. We carried out a study on circulating trypanosomes in humans, cattle and tsetse in these two foci. The results confirmed a reduction of the tsetse population and pathogenic trypanosomes of human and cattle in Mandoul. However, an unknown trypanosome was identified in a human and high frequency of T. theileri (known as non-pathogenic) was found in cattle. In contrast, in Maro, a high diversity of trypanosomes was observed, including T. b. gambiense and T. congolense in humans and several unknown trypanosomes in tsetse. These observations provide evidence of the circulating trypanosomes in the area that recommend widening the investigation to other mammalian hosts and mechanical vectors and considering and monitoring a possible zoonotic potential with the unknown trypanosome and T. congolense in humans. [ABSTRACT FROM AUTHOR]

Background: Thyroid cancer (TC) is the most prevalent malignancy of the endocrine system. Over the past decades, TC incidence rates have been increasing. TC quality of care (QOC) has yet to be well understood. We aimed to assess the quality of TC care and its disparities. Methods: We retrieved primary epidemiologic indices from the Global Burden of Disease (GBD) 1990–2017 database. We calculated four secondary indices of mortality to incidence ratio, disability‐adjusted life years (DALYs) to prevalence ratio, prevalence to incidence ratio, and years of life lost (YLLs) to years lived with disability (YLD) ratio and summarized them by the principal component analysis (PCA) to produce one unique index presented as the quality of care index (QCI) ranged between 0 and 100, to compare different scales. The gender disparity ratio (GDR), defined as the QCI for females divided by QCI for males, was applied to show gender inequity. Results: In 2017, there were 255,489 new TC incident cases (95% uncertainty interval [UI]: 245,709–272,470) globally, which resulted in 41,235 deaths (39,911–44,139). The estimated global QCI was 84.39. The highest QCI was observed in the European region (93.84), with Italy having the highest score (99.77). Conversely, the lowest QCI was seen in the African region (55.09), where the Central African Republic scored the lowest (13.64). The highest and lowest socio‐demographic index (SDI) regions scored 97.27 and 53.85, respectively. Globally, gender disparity was higher after the age of 40 years and in favor of better care in women. Conclusion: TC QOC is better among those countries of higher socioeconomic status, possibly due to better healthcare access and early detection in these regions. Overall, the quality of TC care was higher in women and younger adults. Countries could adopt the introduced index of QOC to investigate the quality of provided care for different diseases and conditions. [ABSTRACT FROM AUTHOR]

This article examines the role of radios in conflict by exploring the tenets of peace journalism in the United Nations sponsored Radio Okapi (Democratic Republic of Congo) and Radio Ndeke Luka (Central African Republic) run by the Swiss Fondation Hirondelle. It is a qualitative research that interviewed journalists on how they perceive their role in society and margin of autonomy. It aims at answering the question: To what extent do the conventions of professional practice of journalism affect the way newsmaking is shaped under the peace journalism approach in conflict-stressed environments? The findings pointed that peace journalism encompasses the idea of a symbolic rapprochement and reconcilement. Reporters stressed the notion of using journalism as a pedagogical tool. Many of the journalists have gone through life-threatening situations caused by opposition groups. Nonetheless, the testimonies accounted for a willingness to carry on with their commitment to a responsible journalism. [ABSTRACT FROM AUTHOR]

This article looks narrowly at whether a 'human security' approach can be seen in a UN peace operation that pursues stabilization, namely the United Nations Multidimensional Integrated Stabilization Mission in the Central African Republic (MINUSCA). The UN's interpretation of stabilization has not been expressly set out, but stabilization missions typically work alongside the host state to extend state authority and use robust force to counter spoilers. Human security is a concept which is rights-based, promotes the 'vital core', has a concern for vulnerability, utilizes preventative protection methods, and empowers local persons to have agency in the peace process. Attempts have been made to institutionalize and mainstream human security practices within the UN. An analytical framework of human security is outlined in this article and used to assess to what extent the mandate of MINUSCA pursues human security-based goals. An extensive review of UN documentation looks at the mandate and practice of MINUSCA and it is argued that the mission does seek to empower local people, engage in a bottom-up manner and entrench the rule of law. The analytical framework also casts light on aspects of the stabilization mandate which are problematic such as militarization and cooperation with the host state. [ABSTRACT FROM AUTHOR]

The "Lacustricola" hutereaui species complex is herein defined by the possession of banded dorsal, anal, and caudal fins in males and also by the pointed premaxilla ascending process, in which the premaxilla medial surface is slightly convex. "Lacustricola" pygmaeus, new species, known from the Okavango, Cuando, and upper Zambezi Rivers, is distinguished from the other species belonging to the "L." hutereaui species complex by the following exclusive character states: an inconspicuous reticulate pattern on scale margins (vs. conspicuous); banded anal, dorsal, and caudal fin in females (vs. hyaline); faint bands in the middle rays of caudal fin in males (vs. conspicuous bands); rounded caudal fin in males (vs. slender); bright green-blue color in some of the flank scales (vs. absent); quadrate posterior margin with a deep concavity (vs. convex or about straight); and first dorsal-fin ray inserted in a vertical to second and third anal-fin ray (vs. fourth to eighth). Additionally, other morphometric, meristic, and osteological characters in combination proved to be useful in distinguishing the new species. Through the analysis of type material and recently collected specimens, the little known species "L." chobensis is considered as a valid species and redescribed. It is easily distinguished from the other species belonging to the "L." hutereaui species complex by a combination of external morphology, osteology, and coloration pattern characters. Comprehensive information on the osteology and external morphology of topotypes of "L." hutereaui are presented, and description of coloration in life is provided for specimens from the Ubangui River, in the Central African Republic. [ABSTRACT FROM AUTHOR]

One of the defining features of the crisis in the Central African Republic (CAR) since 2013 has been massive displacement. Currently, about a quarter of the country's population is displaced. People who have been forcibly displaced, whether internally or abroad, and people who stayed behind this time (but frequently have their own memories of displacement) provide particular kinds of information about war and its not particularly peaceful aftermath. In this article, based on interviews with a broad range of people affected by displacement, we show that Central African views about the prospects for peace are deeply affected by how displacement has shaped tensions over the political senses of distribution (who has a right to what, and on what basis). Who should pay for war, in senses both material and otherwise, and who should be compensated? However, distribution and belonging are not the issues prioritized in the aftermath of war, when elite deals, punitive justice and technocratic recovery plans crowd out treatment of the material justice and belonging questions that dominate neighbourhoods. The political dimensions of material justice in the aftermath of war require more thorough treatment, as listening to people who have experienced displacement makes abundantly clear. [ABSTRACT FROM AUTHOR]

We examine the opportunities children have for interacting with others and the extent to which they are the focus of others' visual attention in five societies where extended family communities are the norm. We compiled six video-recorded datasets (two from one society) collected by a team of anthropologists and psychologists conducting long-term research in each society. The six datasets include video observations of children among the Yasawas (Fiji), Tanna (Vanuatu), Tsimane (Bolivia), Huatasani (Peru), and Aka (infants and children 4–12 years old; Central African Republic). Each dataset consists of a series of videos of children ranging in age from 2 months to 12 years in their everyday contexts. We coded 998 videos and identified with whom children had opportunities to interact (male and female adults and children) as well as the number of individuals and the proportion of observed time that children spent with these individuals. We also examined the proportion of time children received direct visual gaze (indicating attention to the child). Our results indicate that children less than 5 years old spend the majority of their observed time in the presence of one female adult. This is the case across the five societies. In the three societies from which we have older children (Aka, Yasawa, Peru), we find a clear shift around 5 years of age, with children spending the majority of their time with other children. We also coded the presence or absence of a primary caregiver and found that caregivers remained within 2 ft of target children until 7 years of age. When they were in the company of a primary caregiver, children older than seven spent the majority of their time more than 2 ft from the caregiver. We found a consistent trend across societies with decreasing focal attention on the child with increasing child age. These findings show (1) remarkable consistency across these societies in children's interaction opportunities and (2) that a developmental approach is needed to fully understand human development because the social context is dynamic across the lifespan. These data can serve as a springboard for future research examining social development in everyday contexts. [ABSTRACT FROM AUTHOR]

With the number of multi-facetted crises on the rise, with an international governance system deteriorating, how is the EU performing in putting its acts together to respond to these challenging times? In building up its foreign policy over the last two decades, the European Union has gone a long way from seeking 'coherence' between Members States to an 'integrated approach to conflicts and crises' embedded into the 2016 Global Strategy for the European Union's Foreign and Security Policy. Whilst still at an infant stage, the 'integrated approach' has led to institutional changes within the European External Action Service (EEAS), in particular the creation of a dedicated Integrated Approach for Security and Peace Directorate. Its aims for a given crisis are promoting a comprehensive political and strategic plan shared by theEUand its Member States, acting in a unified manner and leading to synchronized actions. To be successful, including in the Union's neighbourhood, the integrated approach will need to be based on strong, clear and common EU foreign affairs objectives aiming at securing sustainable peace. [ABSTRACT FROM AUTHOR]

Although historically a contested concept, it has been argued that civil society has become a victim of its own ubiquity in development; its potential for radicalism and innovation blunted by donor-driven narratives and the unquestioning acceptance of those narratives by donor-dependent NGOs. Donor influence is charged with weakening civil society as an arena for political debate and citizen-driven change. This article presents findings from qualitative research undertaken with forest sector civil society organisations in the Central African Republic. It unearths and examines perceptions of the roles and values of civil society among practitioners themselves and the underlying drivers of consensual or contested understandings. [ABSTRACT FROM AUTHOR]

The Central African region remains one of the most chaotic parts of Africa. Countries in the Economic Community of Central African States (ECCAS) region have taken steps to address the security crisis regionally. Although the regional security mechanisms put in place have been tested significantly only in the Central African Republic (CAR), they have failed to deliver security and address the growing humanitarian crisis in this country. The approach adopted has been statist, focusing on the state apparatus and the interests of its managers over those of the economic classes and civil society. This case study uses a qualitative research strategy. Data for the study was obtained from secondary sources via desk research. Focusing on the core issues of societal security in the CAR, the study demonstrates that continued reliance on the statist approach explains why ECCAS has not been successful in addressing the crisis. It is recommended that efforts focus on developing resilient social structures. [ABSTRACT FROM AUTHOR]

The present study aimed at using plant waste (Musa Paradisiaca) for manufacturing clay‐based ceramics in order to promote lower sintering temperature while preserving the properties of use. Two kaolinic‐illitic clays (NZ1 and KO) from Central African Republic were used mixed with 1 to 10 mass% of the plant waste (MP). The clays and the waste exhibited accessory phases: quartz and iron oxides, and K2O respectively. MP was collected, dried and sieved (<100 μm) previously to its mixture with clays. According to the sintering behavior of KO and NZ1 derived from thermodilatometry, the densification was obtained after firing at 1200°C. Results showed that open porosity decreased from 35% to 17% with increasing temperature in the range 900 to 1200°C for KO and NZ1. This porosity remained in the range 30%‐40% while increasing the MP content (firing at 1000°C for 1h.). The optimized MP content was 3 and 5 mass% for KO and NZ1 clay materials respectively. The compressive strength and thermal conductivities were improved compared to clay samples without MP fired at 1200°C. Moreover a significant decrease in the sintering temperature was achieved, leading to energy saving in line with sustainability issues. [ABSTRACT FROM AUTHOR]

When seeking to ensure financial sustainability of a health programme, existence of a line item in the Ministry of Health (MOH) budget is often seen as an essential, first step. We used immunization as a reference point for cross-country comparison of budgeting methods in Sub-Saharan African countries. Study objectives were to (1) verify the number and types of budget line items for immunization services, (2) compare budget execution with budgeted amounts and (3) compare values with annual immunization expenditures reported to WHO and UNICEF. MOH budgets for 2016 and/or 2017 were obtained from 33 countries. Despite repeated attempts, budgets could not be retrieved from five countries (Chad, Eritrea, Guinea Bissau, Somalia and South Sudan), and we were only able to gather budget execution from eight countries. The number of immunization line items ranged between 0 and 42, with a median of eight. Immunization donor funding was included in 10 budgets. Differences between budgeted amounts and expenditures reported to WHO and UNICEF were greater than 50% in 66% of countries. Immunization budgets per child in the birth cohort ranged from US$1.37 (Democratic Republic of Congo) to US$67.51 (Central African Republic), with an average of US$10.05. Out of the total Government health budget, immunization comprised between 0.04% (Madagascar) and 5.67% (Benin), with an average of 1.98% across the countries, when excluding on-budget donor funds. It was challenging to obtain MOH budgets in many countries and it was largely impossible to access budget execution reports, preventing us from assessing budget credibility. Large differences between budgets and expenditures reported to WHO and UNICEF are likely due to inconsistent interpretations of reporting requirements, diverse approaches to reporting donor funds, challenges in extracting the relevant information from public financial management systems and broader issues of public financial management capacity in MOH staff. [ABSTRACT FROM AUTHOR]

What factors explain the institutional shape of military interventions spearheaded by France? This article suggests that Intervention Entrepreneurs are the deciding agents. To secure the viability of their intervention proposal, they select an intervention venue based on pragmatic grounds. Most importantly, they carefully study possible domestic and international opposition to their intervention plans and conceive institutional intervention choices accordingly. The result is an ad hoc selection of intervention venues with little impact of political ideology, norms, organisational interests, or historical learning. Moreover, on many occasions, little attention is paid to which intervention format would most benefit the peace and prosperity in the conflict theatre in the medium to long term. The article illustrates this argument by tracing French institutional decision-making for interventions in Chad/CAR, Mali, and Libya. [ABSTRACT FROM AUTHOR]

Specimens belonging to the genus Leiodontocercus are rare or even absent in natural history museum collections; this is likely due to at least two reasons, notably, their relatively small size, and, the sheer difficulty in finding them in dense Afrotropical forests. Until recently, three species from less than fifteen specimens were known from this genus, whose identification relied on a singular diagnostic character, that is, the shape of the male cerci. The present contribution is based on the examination of thirty specimens collected from various countries, ranging from central to west Africa; apart from the male cerci, a second diagnostic character - the stridulatory file - is used to distinguish species, even though it is difficult to examine in mounted specimens. As a result, four new species were detected, namely, L. vicii sp. nov., L. spinicercatus sp. nov. (from the Central African Republic), L. muticus sp. nov. (from Gabon and Cameroon) and L. philipporum sp. nov. (from Côte d'Ivoire). Moreover, L. condylus is recorded from the Central African Republic, the only country where three species of this genus co-occur. It is suggested that population isolation during fluctuating humid and dry periods, consequent to the influence of Ice Age impact during the Pleistocene in tropical central Africa, is the best explanation for the adaptive radiation of the group. [ABSTRACT FROM AUTHOR]

The article tackles the development of varieties of Sango. The language developed following the scramble for the area on both sides of the Ubangi river. Its development and expansion was enhanced by French colonial administration and Christian missions. From the beginning of colonisation it functioned as a means of communication all over UbangiShari between Europeans, their non-local auxiliaries and the local population. Its use as a vehicular made the language very homogenous. When Catholic and Protestant missionaries separately reduced Sango to writing and published religious and educational texts, written varieties developed, which show clear religiolectal features. The vernacularisation of the language in Bangui was accompanied by socio-economic and educational stratification which led to the emergence of three varieties: Common Sango, the language used for everyday communication; Standard Sango, an idealised form of the language; and SangoGodobé, a low-prestige variety. [ABSTRACT FROM AUTHOR]

Background: Over the last decade, artemisinin-based combination therapy (ACT) has contributed substantially to the decrease in malaria-related morbidity and mortality. The emergence of Plasmodium falciparum parasites resistant to artemisinin derivatives in Southeast Asia and the risk of their spread or of local emergence in sub-Saharan Africa are a major threat to public health. This study thus set out to estimate the proportion of P. falciparum isolates, with Pfkelch13 gene mutations associated with artemisinin resistance previously detected in Southeast Asia. Methods: Blood samples were collected in two sites of Bangui, the capital of the Central African Republic (CAR) from 2017 to 2019. DNA was extracted and nested PCR were carried out to detect Plasmodium species and mutations in the propeller domain of the Pfkelch13 gene for P. falciparum samples. Results: A total of 255 P. falciparum samples were analysed. Plasmodium ovale DNA was found in four samples (1.57%, 4/255). Among the 187 samples with interpretable Pfkelch13 sequences, four samples presented a mutation (2.1%, 4/187), including one non-synonymous mutation (Y653N) (0.5%, 1/187). This mutation has never been described as associated with artemisinin resistance in Southeast Asia and its in vitro phenotype is unknown. Conclusion: This preliminary study indicates the absence of Pfkelch13 mutant associated with artemisinin resistance in Bangui. However, this limited study needs to be extended by collecting samples across the whole country along with the evaluation of in vitro and in vivo phenotype profiles of Pfkelch13 mutant parasites to estimate the risk of artemisinin resistance in the CAR. [ABSTRACT FROM AUTHOR]

Sexual violence is commonly described as an epidemic in the Central African Republic (CAR) and other conflict settings. In response, the government and the international community have launched major efforts to combat sexual violence, including the investigation and prosecution of sexual crimes and offences by the ordinary justice system, the Special Criminal Court in the Central African Republic, and the International Criminal Court. Yet, little is known about how these efforts are perceived among the population and about their effectiveness at reducing exposure in a context of ongoing violence. This article builds on a unique series of four surveys conducted at six-month intervals between 2017 and 2018 with a total of 25,143 randomly selected adults. It assesses the magnitude of sexual violence and shows that respondents positively perceive efforts to combat sexual violence and increasingly understand and trust the justice system. Disclosure of sexual violence is increasing, but only one in five victims files a formal complaint with security and justice actors. Factors undermining disclosing or filing of complaints about these widespread events include fear of retaliation, re-traumatization, and stigmatization. Investigating sexual crimes in a context of insecurity is extremely challenging and the work of the various courts is hindered by practical, procedural, and social challenges detailed in this article, as well as the need to coordinate prosecutorial strategies. There is an urgent need to build capacity and to ensure appropriate and compassionate treatment towards those who have been assaulted. Monitoring perception of criminal justice efforts is an important step towards understanding their contribution to ending sexual violence and to peace. [ABSTRACT FROM AUTHOR]

When bringing armed conflicts to a peaceful end, the inclusion of civil society in peacemaking is a vital task. However, whereas previous research on civil society inclusion has made significant advancements, surprisingly little attention has been paid to analyzing how civil resistance and mass action may interact with more elite-driven approaches during peace processes. This study addresses this research gap by examining the interplay between elite and mass-based civil society approaches in three different peace processes in civil wars in Africa in the post-Cold War period: Liberia, the Central African Republic (CAR), and Burundi. We advance the literature by developing a framework that focuses on coordination of these different efforts and we explore this interplay empirically. With this study, we aim to broaden the research agenda, allowing for future synergies at the research frontier of mass action and the inclusion of civil society in peace processes. [ABSTRACT FROM AUTHOR]

Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity and mortality in countries with poor access to clean water and sanitation. Our study aimed to investigate the situation of HEV infections in the Central African Republic (CAR).Methods: A retrospective analysis of the blood samples and notification forms collected through the national yellow fever (YF) surveillance program, but for which a diagnosis of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific RT-PCR.Results: Of 2883 YF-negative samples collected between January 2008 and December 2012, 745 (~ 26%) tested positive by at least either of the 2 tests used to confirm HEV cases. The results revealed that the CAR was hit by a large HEV outbreak in 2008 and 2009. The results also showed a clear seasonal pattern with correlation between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that the circulating strains belonged to genotypes 1e and 2b.Conclusions: Overall, this study provides further evidences that HEV can be a significant cause of acute febrile jaundice, particularly among adults during rainy season or flood, in a country from Sub-Saharan Africa. [ABSTRACT FROM AUTHOR]

Copyright of ZooKeys is the property of Pensoft Publishers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background This last decade's ongoing conflict in the Central African Republic (CAR) has led to gradual and continuous destruction of health services. With severe gaps in qualified health professionals, community health workers (CHWs) have become essential to ensuring health care access to the affected population. This article aims to evaluate the effectiveness of a 10-y CHW program in the CAR. Methods Routine case management data from CHWs were collected in the Paoua district from January 2012 to December 2017 and analysed. Structured interviews were conducted in the Paoua and Carnot health districts among individuals from three different groups (health service beneficiaries, CHWs and health facility managers). Results From 2012 to 2017, 353 948 people consulted for malaria suspicion with CHWs and 86% were found to be malaria positive after a rapid diagnostic test. Among those diagnosed patients, 98.5% received adequate treatment and nearly 1.5% were referred to health facilities. Also, 94.5% of respondents identified fever as the major malaria symptom. About 70% of the population could identify three malaria signs/symptoms and 84.4% accepted and used CHW services. Interviews with CHWs revealed that 45.8% of them received at least four training sessions per month as part of their capacity building. Conclusions CHWs can be a resourceful solution when other health professional are scarce. This study showed that CHWs are not only able to deliver curative and preventive health services, but they are also well accepted by the served communities. [ABSTRACT FROM AUTHOR]

A new species of the genus Setelacher Bouček, S. lasalleisp. nov. Gumovsky and van Noort, is described from the Afrotropical region (Central African Republic, Gabon and Uganda). It confirms the presence of the genus in the region. The only described species of the genus, S. fasciatus Bouček, is of Australasian and Indo-Malayan distribution, and one undescribed species was previously recorded from South Africa. All images presented here are available on [ABSTRACT FROM AUTHOR]

In ratifying the ILO Convention 169 on Indigenous and Tribal Peoples Convention (ILO 169) in 2010, the Central African Republic (CAR) became the first African country to join the Convention. Following the ratification of the Convention, the CAR has engaged in a process of integration of the Convention within its national political and legal system. However, due to the widespread conflicts that has marked the country since 2013, the process of implementation of the Convention and the rights of indigenous peoples have greatly suffered. The conflict has had seriously impact on indigenous peoples of the country who have been severely affected by the violence. With this in mind, the aim of this article is to offer an overview on some of the main issues faced by indigenous peoples in the country and to offer some analysis on the potential impact that the ILO 169 has had and could have in the future. [ABSTRACT FROM AUTHOR]

The article discusses the World Bank loans in Central African Republic in Africa. The author mentions that International Developmeny Association will provide a grants-in-aid amounting to $7.9 million. He explains that the main purpose of the grant is to provide support to the implementation of the country's Poverty Reduction Strategy Paper. The author also mentions that the grant focuses on strengthening public finance management. He explains that the grant also aims to improve public sector and economic governance.

It is still unclear to what extent animals possess knowledge of death. Primates display a large variety and often contradictory behaviors toward conspecific corpses, particularly those of infants (e.g., prolonged carrying and care). This study reports on reactions in a wild, habituated western gorilla group (Gorilla gorilla, 11–13 individuals) in the Central African Republic to an unanimated conspecific infant, and to an allospecific corpse. Individuals' reactions were compared to their usual behavior using both continuous focal animal sampling and 10-min instantaneous scan sampling. In the first observation, an infant gorilla fell out of a tree and looked dead. The mother retrieved it and remained unusually close to another adult female, until the infant started to move again, almost 1 h later. Cases of infants regaining consciousness after almost-fatal accidents may act as positive reinforcement for continued carrying by mothers, which might be socially learned. In the second case, three immature gorillas reacted to a dead red river hog. For 20 min they stared at the corpse from tree branches above, while chest beating, defecating, and urinating several times. They showed fear and did not approach the corpse. These observations show that non-predatory species, such as gorillas, may be able to acquire and develop some knowledge about death even though they do not kill other vertebrates. [ABSTRACT FROM AUTHOR]

Background: Repeated outbreaks of emerging pathogens underscore the need for preparedness plans to prevent, detect, and respond. As countries develop and improve National Action Plans for Health Security, addressing subnational variation in preparedness is increasingly important. One facet of preparedness and mitigating disease transmission is health facility accessibility, linking infected persons with health systems and vice versa. Where potential patients can access care, local facilities must ensure they can appropriately diagnose, treat, and contain disease spread to prevent secondary transmission; where patients cannot readily access facilities, alternate plans must be developed. Here, we use travel time to link facilities and populations at risk of viral hemorrhagic fevers (VHFs) and identify spatial variation in these respective preparedness demands.Methods and Findings: We used geospatial resources of travel friction, pathogen environmental suitability, and health facilities to determine facility accessibility of any at-risk location within a country. We considered in-country and cross-border movements of exposed populations and highlighted vulnerable populations where current facilities are inaccessible and new infrastructure would reduce travel times. We developed profiles for 43 African countries. Resulting maps demonstrate gaps in health facility accessibility and highlight facilities closest to areas at risk for VHF spillover. For instance, in the Central African Republic, we identified travel times of over 24 h to access a health facility. Some countries had more uniformly short travel times, such as Nigeria, although regional disparities exist. For some populations, including many in Botswana, access to areas at risk for VHF nationally was low but proximity to suitable spillover areas in bordering countries was high. Additional analyses provide insights for considering future resource allocation. We provide a contemporary use case for these analyses for the ongoing Ebola outbreak.Conclusions: These maps demonstrate the use of geospatial analytics for subnational preparedness, identifying facilities close to at-risk populations for prioritizing readiness to detect, treat, and respond to cases and highlighting where gaps in health facility accessibility exist. We identified cross-border threats for VHF exposure and demonstrate an opportunity to improve preparedness activities through the use of precision public health methods and data-driven insights for resource allocation as part of a country's preparedness plans. [ABSTRACT FROM AUTHOR]

Monkeypox is a vesicular-pustular illness that carries a secondary attack rate in the order of 10% in contacts unvaccinated against smallpox. Case fatality rates range from 1 to 11%, but scarring and other sequelae are common in survivors. It continues to cause outbreaks in remote populations in Central and West Africa, in areas with poor access and weakened or disrupted surveillance capacity and information networks. Recent outbreaks in Nigeria (2017-18) and Cameroon (2018) have occurred where monkeypox has not been reported for over 20 years. This has prompted concerns over whether there have been changes in the biology and epidemiology of the disease that may in turn have implications for how outbreaks and cases should best be managed. A systematic review was carried out to examine reported data on human monkeypox outbreaks over time, and to identify if and how epidemiology has changed. Published and grey literature were critically analysed, and data extracted to inform recommendations on outbreak response, use of case definitions and public health advice. The level of detail, validity of data, geographical coverage and consistency of reporting varied considerably across the 71 monkeypox outbreak documents obtained. An increase in cases reported over time was supported by literature from the Democratic Republic of Congo (DRC). Data were insufficient to measure trends in secondary attack rates and case fatality rates. Phylogenetic analyses consistently identify two strains of the virus without evidence of emergence of a new strain. Understanding of monkeypox virulence with regard to clinical presentation by strain is minimal, with infrequent sample collection and laboratory analysis. A variety of clinical and surveillance case definitions are described in the literature: two definitions have been formally evaluated and showed high sensitivity but low specificity. These were specific to a Congo-Basin (CB) strain–affected area of the DRC where they were used. Evidence on use of antibiotics for prophylaxis against secondary cutaneous infection is anecdotal and limited. Current evidence suggests there has been an increase in total monkeypox cases reported by year in the DRC irrespective of advancements in the national Integrated Disease Surveillance and Response (IDSR) system. There has been a marked increase in number of individual monkeypox outbreak reports, from outside the DRC in between 2010 and 2018, particularly in the Central African Republic (CAR) although this does not necessarily indicate an increase in annual cases over time in these areas. The geographical pattern reported in the Nigeria outbreak suggests a possible new and widespread zoonotic reservoir requiring further investigation and research. With regards to outbreak response, increased attention is warranted for high-risk patient groups, and nosocomial transmission risks. The animal reservoir remains unknown and there is a dearth of literature informing case management and successful outbreak response strategies. Up-to-date complete, consistent and longer-term research is sorely needed to inform and guide evidence-based response and management of monkeypox outbreaks. Monkeypox is a zoonotic infectious disease characterised by a pustular rash indistinguishable from smallpox, and systemic illness that can range from mild to fatal. Outbreaks predominantly affect remote populations in Central and West Africa. In 2017 and 2018, outbreaks were reported in Nigeria and Cameroon having been unreported for 20 years. We review monkeypox outbreak events occurring since 1970 to investigate if the pattern of outbreaks, person-to-person transmission and virus strain has changed and if so, whether this has implications for outbreak response strategies in low-resource settings. We found that recent literature continues to support an increase in reported outbreaks and number of cases by year in the Democratic Republic of Congo and number of outbreak reports per year in the Central African Republic. We highlight the importance of prioritising high-risk patient groups, remaining vigilant of nosocomial transmission and present that genetic strains remain unchanged. This study informs epidemiologists and outbreak response teams of the source and nature of the limited epidemiological data available on monkeypox outbreaks and may allow optimisation of public health advice and inform choice of suspected case definitions in field settings. Several recommendations are also made for further research efforts. [ABSTRACT FROM AUTHOR]

A frequent sight along many roads, roadblocks form a banal yet persistent element across the margins of contemporary global logistical landscapes. How, this article asks, can we come to terms with roadblocks as a logistical form of power? Based on an ongoing mapping of roadblocks in the Democratic Republic of Congo and the Central African Republic, it sketches a political geography of "roadblock politics": a spatial pattern of control concentrated around trade routes, where the capacity to disrupt logistical aspirations is translated into other forms of power, financial and political. While today's roadblocks are tied up with the ongoing conflict in both countries, the article shows, roadblock politics has a much deeper history. Before colonization, African rulers manufactured powerful polities out of control over points of passage along long-distance trade routes crisscrossing the continent. The article traces how since precolonial times control over long-distance trade routes was turned into a source of political power, how these routes were forcefully appropriated through colonial occupation, how after the crumbling of the colonial order new connections were engineered between political power and the circulation of goods in Central Africa, and how control over these flows ultimately became a key stake in ongoing civil wars in the region. [ABSTRACT FROM AUTHOR]

Objective: Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed treatment onset or its absence. We hypothesized that the enhanced sensitivity of detergent-enhanced loop-mediated isothermal amplification (LAMP) will allow for point of care (POC) detection of African trypanosomes in the CSF of HAT patients where the probability for detecting a single parasite or parasite DNA molecule in 1 μL of CSF sample is negligible by current methods. Methodology: We used LAMP targeting the multicopy pan-T. brucei repetitive insertion mobile element (RIME LAMP) and the Trypanosoma brucei gambiense 5.8S rRNA-internal transcribed spacer 2 gene (TBG1 LAMP). We tested 1 μL out of 20 μL sham or Triton X-100 treated CSFs from 73 stage-1 and 77 stage-2 HAT patients from the Central African Republic and 100 CSF negative controls. Results: Under sham conditions, parasite DNA was detected by RIME and TBG1 LAMP in 1.4% of the stage-1 and stage-2 gambiense HAT CSF samples tested. After sample incubation with detergent, the number of LAMP parasite positive stage-2 CSF’s increased to 26%, a value which included the 2 of the 4 CSF samples where trypanosomes were identified microscopically. Unexpected was the 41% increase in parasite positive stage-1 CSF’s detected by LAMP. Cohen’s kappa coefficients for RIME versus TBG1 LAMP of 0.92 (95%CI: 0.82–1.00) for stage-1 and 0.90 (95%CI: 0.80–1.00) for stage-2 reflected a high level of agreement between the data sets indicating that the results were not due to amplicon contamination, data confirmed in χ2 tests (p<0.001) and Fisher’s exact probability test (p = 4.7e-13). Conclusion: This study detected genomic trypanosome DNA in the CSF independent of the HAT stage and may be consistent with early CNS entry and other scenarios that identify critical knowledge gaps for future studies. Detergent-enhanced LAMP could be applicable for non-invasive African trypanosome detection in human skin and saliva or as an epidemiologic tool for the determination of human (or animal) African trypanosome prevalence in areas where chronically low parasitemias are present. [ABSTRACT FROM AUTHOR]

Oxygyne Schltr. (Thismiaceae) is a rare and little-known genus of achlorophyllous mycoheterotrophic perennial herbs with one of the most remarkable distributions of all angiosperm plant genera globally, being disjunct between Japan and West–Central Africa. Each species is known only from a single location, and in most cases from a single specimen. This monographic study names, describes and maps two new species, Oxygyne duncanii Cheek from cloud forest in SW Region Cameroon and O. frankei Cheek from gallery forest in the Central African Republic, representing the first new Oxygyne species described from Africa in 112 years, and raising the number of described Oxygyne species from four to six. Oxygyne duncanii is remarkable for sharing more morphological characters with two of the three Japanese species (O. hyodoi C.Abe & Akasawa, O. shinzatoi (H. Ohashi) Tsukaya) than with the geographically much closer type species of the genus, O. triandra from Mt Cameroon. Based mainly on herbarium specimens and field observations made in Cameroon and Japan during a series of botanical surveys, we provide descriptions, synonymy, mapping and extinction risk assessments for each species of Oxygyne, together with keys to the genera of Thismiaceae and the species of Oxygyne. The subterranean structures of African Oxygyne are described for the first time, and found to be consistent with those of the Japanese species. We review and reject an earlier proposal that the Japanese species should be segregated from the African species as a separate genus, Saionia Hatus. The only character that separates the two disjunct species groups is now flower colour: blue or partly-blue in the Japanese species compared with orange-brown in the African species. Studies of the pollination biology and mycorrhizal partners of Oxygyne are still lacking. Two of the six species, O. triandra Schltr. and O. hyodoi, appear to be extinct, and the remaining four are assessed as Critically Endangered using the IUCN 2012 criteria. To avoid further extinction, an urgent requirement is for conservation management of the surviving species in the wild. Since few achlorophyllous mycoheterotrophs have been successfully cultivated from seed to maturity, ex situ conservation will not be viable for these species and protection in the wild is the only viable option. While natural habitat survives, further botanical surveys could yet reveal additional new species between Central Africa and Japan. [ABSTRACT FROM AUTHOR]

The Central African Republic experienced unprecedented violence between 2012 and 2014. We analyse three recent ruptures that developed as a result of this crisis, suggesting a break with the country's past. First, the Séléka rebellion that started in 2012; second, the establishment of a robust UN Peacekeeping mission in 2014; and finally, the democratic election of a civilian president in 2016. However, three deep-rooted patterns of governance have in each case transformed these ruptures. A history of outsourced politics, a plurality of violence and peripheral neglect push actors to perpetuate the violent past rather than breaking with it. We conclude that after an initial attempt to break with the CAR's long-term political economic trends, rebel groups, the UN mission and the democratic government have backtracked and now risk reinforcing the violence that mark politics and everyday life in the country. [ABSTRACT FROM AUTHOR]

Mbororo nomadic pastoralists have fled the Central African Republic (CAR) since 2003 because of atrocities perpetrated against them. Conflict has, in fact, always been a major motor behind nomadism for the Mbororo, along with the quest for pasture. The "normal" severity of Mbororo life, however, has been compounded by the "exceptional" severity caused by the situation in the CAR. This article analyzes the way in which the Mbororo distinguish between the two types of severity, and how these different forms of experienced hardship are accommodated in the pastoralists' way of life. I show how historical trajectories with conflict and nomadic hardship allow refugee Mbororo to adjust to recurrent hardship by adapting their pathways and livelihood strategies. This illustrates the way in which duress is central in nomadic society. [ABSTRACT FROM AUTHOR]

Oxygyne Schltr. (Thismiaceae) is a rare and little-known genus of achlorophyllous mycoheterotrophic perennial herbs with one of the most remarkable distributions of all angiosperm plant genera globally, being disjunct between Japan and West–Central Africa. Each species is known only from a single location, and in most cases from a single specimen. This monographic study names, describes and maps two new species, Oxygyne duncanii Cheek from cloud forest in SW Region Cameroon and O. frankei Cheek from gallery forest in the Central African Republic, representing the first new Oxygyne species described from Africa in 112 years, and raising the number of described Oxygyne species from four to six. Oxygyne duncanii is remarkable for sharing more morphological characters with two of the three Japanese species (O. hyodoi C.Abe & Akasawa, O. shinzatoi (H. Ohashi) Tsukaya) than with the geographically much closer type species of the genus, O. triandra from Mt Cameroon. Based mainly on herbarium specimens and field observations made in Cameroon and Japan during a series of botanical surveys, we provide descriptions, synonymy, mapping and extinction risk assessments for each species of Oxygyne, together with keys to the genera of Thismiaceae and the species of Oxygyne. The subterranean structures of African Oxygyne are described for the first time, and found to be consistent with those of the Japanese species. We review and reject an earlier proposal that the Japanese species should be segregated from the African species as a separate genus, Saionia Hatus. The only character that separates the two disjunct species groups is now flower colour: blue or partly-blue in the Japanese species compared with orange-brown in the African species. Studies of the pollination biology and mycorrhizal partners of Oxygyne are still lacking. Two of the six species, O. triandra Schltr. and O. hyodoi, appear to be extinct, and the remaining four are assessed as Critically Endangered using the IUCN 2012 criteria. To avoid further extinction, an urgent requirement is for conservation management of the surviving species in the wild. Since few achlorophyllous mycoheterotrophs have been successfully cultivated from seed to maturity, ex situ conservation will not be viable for these species and protection in the wild is the only viable option. While natural habitat survives, further botanical surveys could yet reveal additional new species between Central Africa and Japan. [ABSTRACT FROM AUTHOR]

Copyright of African Journal of Ecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Fragile states have been raising increasing concern among donors since the mid-2000s. The policies of the Global Fund to fight HIV/AIDS, Malaria, and Tuberculosis (GF) have not excluded fragile states, and this source has provided financing for these countries according to standardized procedures. They represent interesting cases for exploring the meaning and role of measurement in a globalized context. Measurement in the field of HIV/AIDS and its treatment has given rise to a private outsourcing of expertise and auditing, thereby creating a new form of value based on the social process of registration and the creation of realities produced by the intervention itself. These "scriptural economies" must be questioned in terms of the production of knowledge, but also in terms of social justice. Governing HIV/AIDS treatments by numbers in a fragile state is explored in this article through the experience of the Central African Republic (CAR) in terms of epidemiology and access to antiretroviral drugs. The unexpected effects of performance-based programs in this context underline the need for global health governance to be re-embedded into a social justice framework. [ABSTRACT FROM AUTHOR]

Background: Major chikungunya outbreaks have affected several Central African countries during the past decade. The chikungunya virus (CHIKV) was isolated from humans and sylvan mosquitoes in the Central African Republic (CAR) during the 1970 and 1980s but has not been found recently, despite the presence of Aedes albopictus since 2010. The risk of a massive chikungunya epidemic is therefore potentially high, as the human populations are immunologically naïve and because of the presence of the mosquito vector. In order to estimate the risk of a large outbreak, we assessed the vector competence of local Ae. aegypti and Ae. albopictus populations for ancient local strains of CHIKV in CAR. Mosquitoes were orally infected with the virus, and its presence in mosquito saliva was analysed 7 and 14 days post-infection (dpi) by quantitative reverse transcriptase polymerase chain reaction. Results: The two species had similar infection rates at 7 and 14 days, and the dissemination rate of both vectors was = 80% at 14 dpi. Only females followed up to 14 dpi had CHKV in their saliva. Conclusion: These results confirm the risk of transmission of enzootic CHIKV by anthropophilic vectors such as Ae. aegypti and Ae. albopictus. [ABSTRACT FROM AUTHOR]

Background: Breast cancer (breast Ca) is recognised as a major public health problem in the world. Data on reproductive factors associated with breast Ca in the Central African Republic (CAR) is very limited. This study aimed to identify reproductive variables as risk factors for breast Ca in CAR women.Methods: A case-control study was conducted among 174 cases of breast Ca confirmed at the Pathology Unit of the National Laboratory in Bangui between 2003 and 2015 and 348 age-matched controls. Data collection tools included a questionnaire, interviews and a review of medical records of patients. Data were analysed using SPSS software version 20. Odd ratios and 95% confidence intervals (CI) for the likelihood of developing breast Ca were obtained using unconditional logistic regression.Results: In total, 522 women with a mean age of 45.8 (SD = 13.4) years were enrolled. Women with breast Ca were more likely to have attained little or no education (AOR = 11.23, CI: 4.65-27.14 and AOR = 2.40, CI: 1.15-4.99), to be married (AOR = 2.09, CI: 1.18-3.71), to have had an abortion (AOR = 5.41, CI: 3.47-8.44), and to be nulliparous (AOR = 1.98, CI: 1.12-3.49). Decreased odds of breast Ca were associated with being employed (AOR = 0.32, CI: 0.19-0.56), living in urban areas (AOR = 0.16, CI: 0.07-0.37), late menarche (AOR = 0.18, CI: 0.07-0.44), regular menstrual cycles (AOR = 0.44, CI: 0.23-0.81), term pregnancy (AOR = 0.26, CI: 0.13-0.50) and hormonal contraceptive use (AOR = 0.62, CI: 0.41-0.93).Conclusion: Breast Ca risk factors in CAR did not appear to be significantly different from that observed in other populations. This study highlighted the risk factors of breast Ca in women living in Bangui to inform appropriate control measures. [ABSTRACT FROM AUTHOR]

The Special Criminal Court in the Central African Republic can be viewed in two ways. The optimistic view is that it is a vindication of the idea that the international community should complement the efforts of states in the fight against impunity. The pessimistic view is that its establishment represents the International Criminal Court (ICC)'s failure to catalyze accountability at the national level. Against the backdrop of these two opposing narratives, this article examines the main legal features of this new 'hybrid' court and its relationship to the principle of complementarity enshrined in the ICC Statute. It addresses the following questions: the hybrid court's legal basis under Central African law, its jurisdictional mandate, the mixed composition of its staff, immunities and amnesties, and the Special Criminal Court's concurrent jurisdiction with the ICC. The article suggests that, although it is a promising example of international - national cooperation, the Special Criminal Court calls into question legal and systemic assumptions underpinning complementarity, the principle that gives states priority in prosecuting international crimes, which in turn raises questions about the relevance of complementarity in analogous conflict and post-conflict situations. [ABSTRACT FROM AUTHOR]