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Objective: This study investigates the relationship of child, caregiver, and caring context measurements with the care-related quality of life (CRQoL) and health-related quality of life (HRQoL) of caregivers of children with juvenile idiopathic arthritis (JIA). Methods: We performed a cross-sectional analysis of baseline data on caregivers of children with JIA from Canada and the Netherlands collected for the "Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Diseases" study from June 2019 to September 2021. We used the CRQoL questionnaire (CarerQoL), adult EQ-5D-5L, and proxy-reported Youth 5-Level version of EuroQoL (EQ-5D-5L-Y) to assess caregiver CRQoL, caregiver HRQoL, and child HRQoL, respectively. We used a multivariate analysis to assess the relationship between both caregiver CRQoL and HRQoL and patient, caregiver, and caring context measurements. Results: A total of 250 caregivers were included in this study. Most of the caregivers were from the Netherlands (n = 178, 71%) and 77% were females (n = 193). The mean CarerQoL scores was 82.7 (standard deviation (SD) 11.4) and the mean EQ-5D-5L utility score was 0.87 (SD 0.16). Child HRQoL and employment had a positive relationship with both caregiver CarerQoL and EQ-5D-5L utility scores (p < 0.05), while receiving paid or unpaid help had a negative relationship with both scores (p < 0.05). Conclusion: Our findings indicated that to understand the impact of JIA on families, we need to consider socio-economic factors, such as employment and support to carry caregiving tasks, in addition to child HRQoL. [ABSTRACT FROM AUTHOR]

Spodoptera frugiperda (J.E. Smith) is an invasive pest species that threatens maize production by small holder farmers in Africa. Bt maize that express Cry proteins have been used effectively for control of this pest in the United States, Canada, and several countries in South America. Spodoptera frugiperda has evolved resistance to Cry1F Bt maize in Puerto Rico, Brazil and United States, and Cry1Ab Bt maize in Brazil. This study provides the first data on the efficacy of Bt maize for the control of S. frugiperda in Africa. Susceptibility levels of nine S. frugiperda populations were evaluated between January 2018 and May 2018, including a laboratory reared reference population. Larval feeding bioassays were conducted in which plant tissue of maize expressing Cry1Ab (single-toxin event - designated Bt1) or Cry1A.105 + Cry2Ab2 (pyramid-toxin event - designated Bt2), were fed to larvae. Survival and different life history parameters were recorded. Results indicate moderate survival on Bt1 maize, which supports field observations of commercial level control provided by this event. Very high levels of S. frugiperda larval mortality occurred on Bt2 maize (<1% survival). The moderate susceptibility of S. frugiperda to Cry1Ab could be ascribed to the latter being a low-dose event for this pest, as well as the fact that the individuals which initially arrived on the continent may have carried alleles with resistance to this protein. Moderate overall survivorship (4-35%) of S. frugiperda on Cry1Ab maize in South Africa reflects the possible presence of alleles resistant to this toxin, indicating the importance of future resistance monitoring., (© The Author(s) 2019. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)