1. Triterpene glycosides from the underground parts of Caulophyllum thalictroides.
- Author
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Matsuo Y, Watanabe K, and Mimaki Y
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Canada, Drug Screening Assays, Antitumor, Glycosides chemistry, Glycosides pharmacology, HL-60 Cells, Humans, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Triterpenes chemistry, Triterpenes pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Caulophyllum chemistry, Glycosides isolation & purification, Plants, Medicinal chemistry, Triterpenes isolation & purification
- Abstract
A total of 22 triterpene glycosides, including 10 new compounds (1-10), were isolated from the underground parts of Caulophyllum thalictroides. The structures of the new glycosides were determined on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses. All 22 compounds were evaluated for cytotoxicity against HL-60 human leukemia cells. The triterpene monodesmosides based on oleanolic acid (1 and 11-16) showed cytotoxic activity against HL-60 cells with IC(50) values that ranged from 3.4 to 15.9 microg/mL.
- Published
- 2009
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