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The article presents an examination into the history of mid-20th century Canadian psychology, focusing on the innovations of researchers Abram Hoffer and Humphry F. Osmond regarding their 1952 adrenocrome hypothesis of biogenesis for schizophrenia. Details are given overviewing the study presented by Hoffer and Osmond, critically examining the ideological framework of the theory, and offering an integrative analysis of the system into contemporary psychopharmacology by adapting it to the transmethylation theory.